Rhythm Pharmaceuticals, Inc.
RYTM- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001649904
In the last 90 days, Rhythm Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 304 institutions reported holding it in 13F filings for Q2 2026, worth $8.55B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q3 2025
Institutional positions in Rhythm Pharmaceuticals, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 264
- +41 vs. Q2 2025
- Shares held
- 70.9M
- +4.57M (+6.9%) vs. Q2 2025
- Total value
- $7.20B
- +$3.01B (+71.8%) vs. Q2 2025
- New holders
- 57
- 99 more added
- Sold out
- 16
- 82 more reduced
4 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting RYTM on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 304 | $8.55B |
| Q1 2026 | 285 | $6.42B |
| Q4 2025 | 281 | $7.80B |
| Q3 2025 | 264 | $7.20B |
| Q2 2025 | 227 | $4.20B |
| Q1 2025 | 228 | $3.44B |
| Q4 2024 | 203 | $3.63B |
| Q3 2024 | 176 | $3.55B |
| Q2 2024 | 165 | $2.85B |
| Q1 2024 | 167 | $2.95B |
| Q4 2023 | 169 | $3.07B |
| Q3 2023 | 144 | $1.56B |
| Q2 2023 | 116 | $1.09B |
| Q1 2023 | 126 | $1.08B |
| Q4 2022 | 115 | $1.81B |
| Q3 2022 | 101 | $1.45B |
| Q2 2022 | 90 | $190.8M |
| Q1 2022 | 111 | $562.7M |
| Q4 2021 | 98 | $483.6M |
| Q3 2021 | 97 | $626.3M |
| Q2 2021 | 105 | $905.6M |
| Q1 2021 | 124 | $1.01B |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Rhythm Pharmaceuticals, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Millennium Management LLC | 133,161 | $13.4M | 0.01% | −64,949−32.8% | Reduced |
| Ameriprise Financial Inc | 137,967 | $13.9M | 0.00% | −35,102−20.3% | Reduced |
| Algert Global LLC | 140,284 | $14.2M | 0.24% | +80,065+133.0% | Added |
| Barclays PLC | 142,385 | $14.4M | 0.01% | −208,813−59.5% | Reduced |
| Invesco Ltd. | 143,555 | $14.5M | 0.00% | +74,631+108.3% | Added |
| Russell Investments Group, Ltd. | 157,678 | $15.9M | 0.02% | +26,680+20.4% | Added |
| Marshall Wace, LLP | 171,834 | $17.4M | 0.02% | −204,408−54.3% | Reduced |
| First Light Asset Management, LLC | 180,484 | $18.2M | 1.72% | +180,484 | New |
| Bank of New York Mellon Corp | 182,365 | $18.4M | 0.00% | −1,744−0.9% | Reduced |
| Logos Global Management LP | 200,000 | $20.2M | 2.00% | +70,000+53.8% | Added |
| Comerica Bank | 209,325 | $21.1M | 0.08% | −92,336−30.6% | Reduced |
| OrbiMed Advisors LLC | 215,152 | $21.7M | 0.52% | −33,360−13.4% | Reduced |
| Integral Health Asset Management, LLC | 220,000 | $22.2M | 1.62% | +100,000+83.3% | Added |
| Voya Investment Management LLC | 221,593 | $22.4M | 0.02% | −22,410−9.2% | Reduced |
| Candriam Luxembourg S.C.A. | 221,863 | $22.4M | 0.12% | −90,589−29.0% | Reduced |
| BNP Paribas Arbitrage, SA | 223,681 | $22.6M | 0.02% | +121,442+118.8% | Added |
| Assenagon Asset Management S.A. | 224,128 | $22.6M | 0.03% | −13,870−5.8% | Reduced |
| Bank of America Corp | 233,150 | $23.5M | 0.00% | +10,998+5.0% | Added |
| Hood River Capital Management LLC | 235,836 | $23.8M | 0.28% | −307,852−56.6% | Reduced |
| Artisan Partners Limited Partnership | 236,841 | $23.9M | 0.03% | +62,362+35.7% | Added |
| Qube Research & Technologies Ltd | 238,819 | $24.1M | 0.03% | −1,526−0.6% | Reduced |
| Sofinnova Investments, Inc. | 246,966 | $24.9M | 1.53% | −339,044−57.9% | Reduced |
| Balyasny Asset Management LLC | 350,008 | $35.3M | 0.07% | +295,920+547.1% | Added |
| Voloridge Investment Management, LLC | 368,263 | $37.2M | 0.12% | +29,459+8.7% | Added |
| Silverarc Capital Management, LLC | 369,996 | $37.4M | 5.41% | −30,776−7.7% | Reduced |
| Jennison Associates LLC | 411,550 | $41.6M | 0.02% | +411,550 | New |
| UBS Group AG | 420,336 | $42.4M | 0.01% | +167,754+66.4% | Added |
| UBS Asset Management Americas Inc | 437,472 | $44.2M | 0.01% | +209,845+92.2% | Added |
| Opaleye Management Inc. | 461,700 | $46.6M | 6.59% | −13,300−2.8% | Reduced |
| Morgan Stanley | 465,190 | $47.0M | 0.00% | −59,290−11.3% | Reduced |
| Clearbridge Investments, LLC | 484,732 | $49.0M | 0.04% | +172,287+55.1% | Added |
| Siren, L.L.C. | 499,975 | $50.5M | 1.98% | +90,233+22.0% | Added |
| Northern Trust Corp | 510,906 | $51.6M | 0.01% | +660+0.1% | Added |
| Loomis Sayles & Co L P | 527,439 | $53.3M | 0.06% | −64,015−10.8% | Reduced |
| Charles Schwab Investment Management Inc | 527,922 | $53.3M | 0.01% | +66,484+14.4% | Added |
| Adage Capital Partners GP, L.L.C. | 544,000 | $54.9M | 0.09% | +203,000+59.5% | Added |
| Renaissance Technologies LLC | 546,593 | $55.2M | 0.07% | +231,700+73.6% | Added |
| Franklin Resources Inc | 567,782 | $57.3M | 0.01% | +23,980+4.4% | Added |
| Lord, Abbett & Co. LLC | 575,984 | $58.2M | 0.17% | +371,709+182.0% | Added |
| Woodline Partners LP | 580,183 | $58.6M | 0.28% | +65,802+12.8% | Added |
| Capital Research Global Investors | 598,247 | $60.4M | 0.01% | +598,247 | New |
| Pictet Asset Management Holding SA | 683,017 | $69.0M | 0.07% | +266,902+64.1% | Added |
| Rock Springs Capital Management LP | 717,102 | $72.4M | 4.23% | −144,051−16.7% | Reduced |
| Checkpoint Capital L.P. | 763,707 | $77.1M | 25.84% | −296,293−28.0% | Reduced |
| Alliancebernstein L.P. | 979,682 | $98.9M | 0.03% | +918,212+1,493.8% | Added |
| Alkeon Capital Management LLC | 1,017,700 | $102.8M | 0.46% | 00.0% | Unchanged |
| Westfield Capital Management Co LP | 1,069,004 | $108.0M | 0.45% | −560,464−34.4% | Reduced |
| Janus Henderson Group PLC | 1,160,887 | $117.2M | 0.05% | −251,015−17.8% | Reduced |
| JPMorgan Chase & Co | 1,188,069 | $120.0M | 0.01% | +404,510+51.6% | Added |
| Polar Capital Holdings Plc | 1,244,932 | $125.7M | 0.61% | −5,938−0.5% | Reduced |
| Geode Capital Management, LLC | 1,362,829 | $137.7M | 0.01% | +51,576+3.9% | Added |
| Driehaus Capital Management LLC | 1,383,775 | $139.7M | 1.00% | +113,823+9.0% | Added |
| Price T Rowe Associates Inc | 1,399,897 | $141.4M | 0.02% | +58,505+4.4% | Added |
| Federated Hermes, Inc. | 1,727,885 | $174.5M | 0.31% | +41,391+2.5% | Added |
| Goldman Sachs Group Inc | 1,893,663 | $191.2M | 0.03% | +159,941+9.2% | Added |
| State Street Corp | 2,028,651 | $204.9M | 0.01% | +121,050+6.3% | Added |
| FMR LLC | 2,145,183 | $216.6M | 0.01% | +191,742+9.8% | Added |
| Perceptive Advisors LLC | 2,438,969 | $288.4M | 8.33% | +20,670+0.9% | Added |
| NEA Management Company, LLC | 2,909,956 | $293.9M | 16.13% | 00.0% | Unchanged |
| Primecap Management Co | 4,262,859 | $430.5M | 0.33% | −615,178−12.6% | Reduced |
| Vanguard Group Inc | 4,996,427 | $504.6M | 0.01% | +1,407,313+39.2% | Added |
| Baker Bros. Advisors LP | 5,604,483 | $566.0M | 4.09% | 00.0% | Unchanged |
| Ra Capital Management, L.P. | 5,681,359 | $573.8M | 7.07% | +120,000+2.2% | Added |
| BlackRock, Inc. | 6,302,215 | $636.5M | 0.01% | +34,677+0.6% | Added |
| Point72 Asset Management, L.P. | 0 | $0 | 0.00% | −170,832−100.0% | Sold out |
| Schonfeld Strategic Advisors LLC | 0 | $0 | 0.00% | −77,983−100.0% | Sold out |
| Cubist Systematic Strategies, LLC | 0 | $0 | 0.00% | −64,577−100.0% | Sold out |
| Jump Financial, LLC | 0 | $0 | 0.00% | −17,671−100.0% | Sold out |
| Atom Investors LP | 0 | $0 | 0.00% | −14,866−100.0% | Sold out |
| Point72 (DIFC) Ltd | 0 | $0 | 0.00% | −13,149−100.0% | Sold out |
| Caption Management, LLC | 0 | $0 | 0.00% | −7,540−100.0% | Sold out |
| Axq Capital, LP | 0 | $0 | 0.00% | −4,560−100.0% | Sold out |
| Tudor Investment Corp Et Al | 0 | $0 | 0.00% | −4,272−100.0% | Sold out |
| Ameriflex Group, Inc. | 0 | $0 | 0.00% | −360−100.0% | Sold out |
| Compagnie Lombard Odier SCmA | 0 | $0 | 0.00% | −250−100.0% | Sold out |
| South State Corp. | 0 | $0 | 0.00% | −71−100.0% | Sold out |
| Caitong International Asset Management Co., Ltd | 0 | $0 | 0.00% | −58−100.0% | Sold out |
| Skopos Labs, Inc. | 0 | $0 | 0.00% | −21−100.0% | Sold out |
| Whipplewood Advisors, LLC | 0 | $0 | 0.00% | −11−100.0% | Sold out |
| Twin Peaks Wealth Advisors, LLC | 0 | $0 | 0.00% | −5−100.0% | Sold out |
| Norges Bank | – | – | – | – | Not filed |
| CIBC World Markets Corp | – | – | – | – | Not filed |
| E Fund Management Co., Ltd. | – | – | – | – | Not filed |
| First Horizon Advisors, Inc. | – | – | – | – | Not filed |