Rhythm Pharmaceuticals, Inc.
RYTM- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001649904
In the last 90 days, Rhythm Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 304 institutions reported holding it in 13F filings for Q2 2026, worth $8.55B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q2 2025
Institutional positions in Rhythm Pharmaceuticals, Inc. as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 227
- 0 vs. Q1 2025
- Shares held
- 66.5M
- +1.72M (+2.7%) vs. Q1 2025
- Total value
- $4.20B
- +$767.9M (+22.3%) vs. Q1 2025
- New holders
- 33
- 93 more added
- Sold out
- 33
- 74 more reduced
1 institution that held it in Q1 2025 haven't filed for Q2 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting RYTM on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 304 | $8.55B |
| Q1 2026 | 285 | $6.42B |
| Q4 2025 | 281 | $7.80B |
| Q3 2025 | 264 | $7.20B |
| Q2 2025 | 227 | $4.20B |
| Q1 2025 | 228 | $3.44B |
| Q4 2024 | 203 | $3.63B |
| Q3 2024 | 176 | $3.55B |
| Q2 2024 | 165 | $2.85B |
| Q1 2024 | 167 | $2.95B |
| Q4 2023 | 169 | $3.07B |
| Q3 2023 | 144 | $1.56B |
| Q2 2023 | 116 | $1.09B |
| Q1 2023 | 126 | $1.08B |
| Q4 2022 | 115 | $1.81B |
| Q3 2022 | 101 | $1.45B |
| Q2 2022 | 90 | $190.8M |
| Q1 2022 | 111 | $562.7M |
| Q4 2021 | 98 | $483.6M |
| Q3 2021 | 97 | $626.3M |
| Q2 2021 | 105 | $905.6M |
| Q1 2021 | 124 | $1.01B |
Institutions, Q2 2025
Shares, value and share of portfolio for each institution holding Rhythm Pharmaceuticals, Inc.; share changes are against Q1 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Woodline Partners LP | 514,381 | $32.5M | 0.17% | +514,381 | New |
| Morgan Stanley | 524,480 | $33.1M | 0.00% | +20,431+4.1% | Added |
| Hood River Capital Management LLC | 543,688 | $34.4M | 0.48% | −115,743−17.6% | Reduced |
| Franklin Resources Inc | 543,802 | $34.4M | 0.01% | +217,642+66.7% | Added |
| Sofinnova Investments, Inc. | 586,010 | $37.0M | 2.52% | +139,171+31.1% | Added |
| Loomis Sayles & Co L P | 591,454 | $37.4M | 0.05% | −14,310−2.4% | Reduced |
| JPMorgan Chase & Co | 783,559 | $49.5M | 0.00% | +639,919+445.5% | Added |
| Rock Springs Capital Management LP | 861,153 | $54.4M | 3.39% | +26,965+3.2% | Added |
| Alkeon Capital Management LLC | 1,017,700 | $64.3M | 0.31% | +200,000+24.5% | Added |
| Checkpoint Capital L.P. | 1,060,000 | $67.0M | 31.21% | +152,760+16.8% | Added |
| Polar Capital Holdings Plc | 1,250,870 | $79.0M | 0.41% | +750,870+150.2% | Added |
| Driehaus Capital Management LLC | 1,269,952 | $80.2M | 0.64% | −188,070−12.9% | Reduced |
| Geode Capital Management, LLC | 1,311,253 | $82.9M | 0.01% | +24,085+1.9% | Added |
| Price T Rowe Associates Inc | 1,341,392 | $84.8M | 0.01% | +142,339+11.9% | Added |
| Janus Henderson Group PLC | 1,411,902 | $89.3M | 0.04% | −243,448−14.7% | Reduced |
| Westfield Capital Management Co LP | 1,629,468 | $103.0M | 0.43% | +288,376+21.5% | Added |
| Federated Hermes, Inc. | 1,686,494 | $106.6M | 0.20% | +94,623+5.9% | Added |
| Goldman Sachs Group Inc | 1,733,722 | $109.6M | 0.02% | +95,814+5.8% | Added |
| State Street Corp | 1,907,601 | $120.5M | 0.00% | −63,132−3.2% | Reduced |
| FMR LLC | 1,953,441 | $123.4M | 0.01% | +265,066+15.7% | Added |
| Perceptive Advisors LLC | 2,418,299 | $152.8M | 5.73% | −130,146−5.1% | Reduced |
| NEA Management Company, LLC | 2,909,956 | $183.9M | 13.84% | 00.0% | Unchanged |
| Vanguard Group Inc | 3,589,114 | $226.8M | 0.00% | +144,188+4.2% | Added |
| Primecap Management Co | 4,878,037 | $308.2M | 0.24% | −909,285−15.7% | Reduced |
| Ra Capital Management, L.P. | 5,561,359 | $351.4M | 5.92% | −523,053−8.6% | Reduced |
| Baker Bros. Advisors LP | 5,604,483 | $354.1M | 3.44% | 00.0% | Unchanged |
| BlackRock, Inc. | 6,267,538 | $396.0M | 0.01% | −587,217−8.6% | Reduced |
| Frazier Life Sciences Management, L.P. | 0 | $0 | 0.00% | −678,760−100.0% | Sold out |
| Cormorant Asset Management, LP | 0 | $0 | 0.00% | −150,000−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −91,118−100.0% | Sold out |
| Citadel Advisors LLC | 0 | $0 | 0.00% | −70,068−100.0% | Sold out |
| Artia Global Partners LP | 0 | $0 | 0.00% | −50,000−100.0% | Sold out |
| Diadema Partners LP | 0 | $0 | 0.00% | −50,000−100.0% | Sold out |
| EAM Investors, LLC | 0 | $0 | 0.00% | −45,108−100.0% | Sold out |
| Walleye Capital LLC | 0 | $0 | 0.00% | −35,828−100.0% | Sold out |
| XTX Topco Ltd | 0 | $0 | 0.00% | −29,949−100.0% | Sold out |
| Corebridge Financial, Inc. | 0 | $0 | 0.00% | −26,821−100.0% | Sold out |
| Squarepoint Ops LLC | 0 | $0 | 0.00% | −24,413−100.0% | Sold out |
| Fox Run Management, L.L.C. | 0 | $0 | 0.00% | −19,172−100.0% | Sold out |
| Jefferies Financial Group Inc. | 0 | $0 | 0.00% | −17,100−100.0% | Sold out |
| Quantinno Capital Management LP | 0 | $0 | 0.00% | −17,086−100.0% | Sold out |
| HSBC Holdings PLC | 0 | $0 | 0.00% | −15,570−100.0% | Sold out |
| Voleon Capital Management LP | 0 | $0 | 0.00% | −13,819−100.0% | Sold out |
| American Century Companies Inc | 0 | $0 | 0.00% | −13,282−100.0% | Sold out |
| Exchange Traded Concepts, LLC | 0 | $0 | 0.00% | −11,912−100.0% | Sold out |
| Persistent Asset Partners Ltd | 0 | $0 | 0.00% | −11,501−100.0% | Sold out |
| Bridgefront Capital, LLC | 0 | $0 | 0.00% | −6,414−100.0% | Sold out |
| Springhill Fund Asset Management (HK) Co Ltd | 0 | $0 | 0.00% | −6,277−100.0% | Sold out |
| Fieldview Capital Management, LLC | 0 | $0 | 0.00% | −6,037−100.0% | Sold out |
| BIT Capital GmbH | 0 | $0 | 0.00% | −6,013−100.0% | Sold out |
| Y-Intercept (Hong Kong) Ltd | 0 | $0 | 0.00% | −5,966−100.0% | Sold out |
| Entropy Technologies, LP | 0 | $0 | 0.00% | −5,502−100.0% | Sold out |
| Quadrature Capital Ltd | 0 | $0 | 0.00% | −5,278−100.0% | Sold out |
| Verition Fund Management LLC | 0 | $0 | 0.00% | −4,424−100.0% | Sold out |
| SIH Partners, LLLP | 0 | $0 | 0.00% | −3,980−100.0% | Sold out |
| BI Asset Management Fondsmaeglerselskab A/S | 0 | $0 | 0.00% | −648−100.0% | Sold out |
| Northwestern Mutual Wealth Management Co | 0 | $0 | 0.00% | −48−100.0% | Sold out |
| Coldstream Capital Management Inc | 0 | $0 | 0.00% | −30−100.0% | Sold out |
| Stephens Consulting, LLC | 0 | $0 | 0.00% | −20−100.0% | Sold out |
| Hexagon Capital Partners LLC | 0 | $0 | 0.00% | −11−100.0% | Sold out |
| Lindbrook Capital, LLC | – | – | – | – | Not filed |