Rhythm Pharmaceuticals, Inc.
RYTM- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001649904
In the last 90 days, Rhythm Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 305 institutions reported holding it in 13F filings for Q2 2026, worth $8.55B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q1 2025
Institutional positions in Rhythm Pharmaceuticals, Inc. as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 228
- +26 vs. Q4 2024
- Shares held
- 64.8M
- +48.3K (+0.1%) vs. Q4 2024
- Total value
- $3.44B
- −$189.2M (−5.2%) vs. Q4 2024
- New holders
- 45
- 86 more added
- Sold out
- 19
- 69 more reduced
1 institution that held it in Q4 2024 haven't filed for Q1 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting RYTM on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 305 | $8.55B |
| Q1 2026 | 285 | $6.42B |
| Q4 2025 | 281 | $7.80B |
| Q3 2025 | 264 | $7.20B |
| Q2 2025 | 227 | $4.20B |
| Q1 2025 | 228 | $3.44B |
| Q4 2024 | 203 | $3.63B |
| Q3 2024 | 176 | $3.55B |
| Q2 2024 | 165 | $2.85B |
| Q1 2024 | 167 | $2.95B |
| Q4 2023 | 169 | $3.07B |
| Q3 2023 | 144 | $1.56B |
| Q2 2023 | 116 | $1.09B |
| Q1 2023 | 126 | $1.08B |
| Q4 2022 | 115 | $1.81B |
| Q3 2022 | 101 | $1.45B |
| Q2 2022 | 90 | $190.8M |
| Q1 2022 | 111 | $562.7M |
| Q4 2021 | 98 | $483.6M |
| Q3 2021 | 97 | $626.3M |
| Q2 2021 | 105 | $905.6M |
| Q1 2021 | 124 | $1.01B |
Institutions, Q1 2025
Shares, value and share of portfolio for each institution holding Rhythm Pharmaceuticals, Inc.; share changes are against Q4 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Sofinnova Investments, Inc. | 446,839 | $23.7M | 1.78% | +49,411+12.4% | Added |
| Opaleye Management Inc. | 490,000 | $26.0M | 5.78% | −10,000−2.0% | Reduced |
| Polar Capital Holdings Plc | 500,000 | $26.5M | 0.16% | −1,000,000−66.7% | Reduced |
| Morgan Stanley | 504,049 | $26.7M | 0.00% | −56,038−10.0% | Reduced |
| Marshall Wace, LLP | 535,103 | $28.3M | 0.04% | −157,700−22.8% | Reduced |
| Northern Trust Corp | 536,206 | $28.4M | 0.00% | −9,108−1.7% | Reduced |
| Loomis Sayles & Co L P | 605,764 | $32.1M | 0.05% | −12,721−2.1% | Reduced |
| Hood River Capital Management LLC | 659,431 | $34.9M | 0.60% | +15,740+2.4% | Added |
| Frazier Life Sciences Management, L.P. | 678,760 | $36.0M | 1.64% | −1,191,048−63.7% | Reduced |
| Alkeon Capital Management LLC | 817,700 | $43.3M | 0.26% | −350,000−30.0% | Reduced |
| Rock Springs Capital Management LP | 834,188 | $44.2M | 2.53% | −328,530−28.3% | Reduced |
| Checkpoint Capital L.P. | 907,240 | $48.1M | 26.37% | +179,258+24.6% | Added |
| Price T Rowe Associates Inc | 1,199,053 | $63.5M | 0.01% | +513,901+75.0% | Added |
| Geode Capital Management, LLC | 1,287,168 | $68.2M | 0.01% | +31,369+2.5% | Added |
| Westfield Capital Management Co LP | 1,341,092 | $71.0M | 0.35% | +1,341,092 | New |
| Driehaus Capital Management LLC | 1,458,022 | $77.2M | 0.74% | +167,047+12.9% | Added |
| Federated Hermes, Inc. | 1,591,871 | $84.3M | 0.18% | +42,236+2.7% | Added |
| Goldman Sachs Group Inc | 1,637,908 | $86.8M | 0.02% | −174,298−9.6% | Reduced |
| FMR LLC | 1,688,375 | $89.4M | 0.01% | +1,575,266+1,392.7% | Added |
| Janus Henderson Group PLC | 1,655,350 | $90.7M | 0.05% | +435,796+35.7% | Added |
| State Street Corp | 1,970,733 | $104.4M | 0.00% | +129,863+7.1% | Added |
| Perceptive Advisors LLC | 2,548,445 | $135.0M | 4.79% | −1,132,028−30.8% | Reduced |
| NEA Management Company, LLC | 2,909,956 | $154.1M | 11.87% | 00.0% | Unchanged |
| Vanguard Group Inc | 3,444,926 | $182.5M | 0.00% | +2,326+0.1% | Added |
| Baker Bros. Advisors LP | 5,604,483 | $296.9M | 3.29% | −479,766−7.9% | Reduced |
| Primecap Management Co | 5,787,322 | $306.6M | 0.25% | −783,868−11.9% | Reduced |
| Ra Capital Management, L.P. | 6,084,412 | $322.3M | 5.38% | 00.0% | Unchanged |
| BlackRock, Inc. | 6,854,755 | $363.1M | 0.01% | −95,960−1.4% | Reduced |
| Integral Health Asset Management, LLC | 0 | $0 | 0.00% | −150,000−100.0% | Sold out |
| EAM Global Investors LLC | 0 | $0 | 0.00% | −56,936−100.0% | Sold out |
| Crestline Management, LP | 0 | $0 | 0.00% | −25,062−100.0% | Sold out |
| Bryce Point Capital, LLC | 0 | $0 | 0.00% | −19,607−100.0% | Sold out |
| Castleark Management LLC | 0 | $0 | 0.00% | −18,390−100.0% | Sold out |
| Omers Administration Corp | 0 | $0 | 0.00% | −7,600−100.0% | Sold out |
| Farringdon Capital, Ltd. | 0 | $0 | 0.00% | −6,854−100.0% | Sold out |
| Jain Global LLC | 0 | $0 | 0.00% | −6,700−100.0% | Sold out |
| Virtus ETF Advisers LLC | 0 | $0 | 0.00% | −6,280−100.0% | Sold out |
| Texas Treasury Safekeeping Trust Co | 0 | $0 | 0.00% | −4,230−100.0% | Sold out |
| Raymond James Financial Inc | 0 | $0 | 0.00% | −3,892−100.0% | Sold out |
| Freestone Capital Holdings, LLC | 0 | $0 | 0.00% | −3,700−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −2,475−100.0% | Sold out |
| ORG Wealth Partners, LLC | 0 | $0 | 0.00% | −1,206−100.0% | Sold out |
| State of Wyoming | 0 | $0 | 0.00% | −1,084−100.0% | Sold out |
| Natixis | 0 | $0 | 0.00% | −997−100.0% | Sold out |
| R Squared Ltd | 0 | $0 | 0.00% | −780−100.0% | Sold out |
| Raleigh Capital Management Inc. | 0 | $0 | 0.00% | −500−100.0% | Sold out |
| IFP Advisors, Inc | 0 | $0 | 0.00% | −1−100.0% | Sold out |
| Nuveen Asset Management, LLC | – | – | – | – | Not filed |