Prime Medicine, Inc.
PRME- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001894562
No open-market purchases or sales by Prime Medicine, Inc. insiders were filed in the last 90 days; 187 institutions reported holding it in 13F filings for Q2 2026, worth $393.5M in total; ARK Invest is the only superinvestor holding it.
13F holders, Q1 2026
Institutional positions in Prime Medicine, Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 192
- +14 vs. Q4 2025
- Shares held
- 98.6M
- +9.86M (+11.1%) vs. Q4 2025
- Total value
- $342.6M
- +$34.8M (+11.3%) vs. Q4 2025
- New holders
- 39
- 74 more added
- Sold out
- 25
- 49 more reduced
5 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PRME on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 187 | $393.5M |
| Q1 2026 | 192 | $342.6M |
| Q4 2025 | 183 | $336.5M |
| Q3 2025 | 167 | $511.5M |
| Q2 2025 | 121 | $145.0M |
| Q1 2025 | 125 | $120.4M |
| Q4 2024 | 132 | $188.0M |
| Q3 2024 | 116 | $265.9M |
| Q2 2024 | 122 | $354.0M |
| Q1 2024 | 115 | $466.6M |
| Q4 2023 | 105 | $431.4M |
| Q3 2023 | 83 | $472.3M |
| Q2 2023 | 79 | $675.7M |
| Q1 2023 | 76 | $512.1M |
| Q4 2022 | 66 | $767.8M |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Prime Medicine, Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Jones Financial Companies LLLP | 40,307 | $136.2K | 0.00% | −96−0.2% | Reduced |
| DRW Securities, LLC | 40,964 | $142.6K | 0.01% | +40,964 | New |
| IvyRock Asset Management (HK) Ltd | 41,800 | $145.5K | 0.08% | 00.0% | Unchanged |
| VARCOV Co. | 41,964 | $146.0K | 0.05% | +41,964 | New |
| MetLife Investment Management | 44,208 | $153.8K | 0.00% | −13,362−23.2% | Reduced |
| Vanguard Global Advisers, LLC | 44,269 | $154.1K | 0.00% | +44,269 | New |
| Mutual Advisors, LLC | 45,200 | $157.3K | 0.00% | 00.0% | Unchanged |
| Quadrature Capital Ltd | 46,893 | $163.2K | 0.00% | −5,973−11.3% | Reduced |
| Citigroup Inc | 47,232 | $164.4K | 0.00% | −3,997−7.8% | Reduced |
| Ameriprise Financial Inc | 49,584 | $172.6K | 0.00% | −4,498−8.3% | Reduced |
| Los Angeles Capital Management LLC | 52,615 | $183.1K | 0.00% | +52,615 | New |
| Aquatic Capital Management LLC | 54,230 | $188.7K | 0.01% | +54,230 | New |
| Vanguard Asset Management, Ltd | 59,021 | $205.4K | 0.00% | +59,021 | New |
| Wiley Bros.-Aintree Capital, LLC | 59,470 | $207.0K | 0.00% | −882−1.5% | Reduced |
| Janus Henderson Group PLC | 60,900 | $211.6K | 0.00% | 00.0% | Unchanged |
| Tudor Investment Corp Et Al | 61,546 | $214.2K | 0.00% | +61,546 | New |
| Barclays PLC | 63,773 | $221.9K | 0.00% | −300,053−82.5% | Reduced |
| Russell Investments Group, Ltd. | 64,273 | $223.7K | 0.00% | +57,446+841.5% | Added |
| Legal & General Group Plc | 66,444 | $230.9K | 0.00% | −14,305−17.7% | Reduced |
| LPL Financial LLC | 66,424 | $231.2K | 0.00% | +33,500+101.7% | Added |
| Virtus Investment Advisers, Inc. | 66,508 | $231.4K | 0.06% | +1,622+2.5% | Added |
| Ieq Capital, LLC | 74,013 | $257.6K | 0.00% | +36,877+99.3% | Added |
| Concurrent Investment Advisors, LLC | 74,177 | $258.1K | 0.00% | +74,177 | New |
| Mariner, LLC | 78,398 | $272.7K | 0.00% | +42,108+116.0% | Added |
| UBS Asset Management Americas Inc | 85,300 | $296.8K | 0.00% | −13,800−13.9% | Reduced |
| California State Teachers Retirement System | 86,473 | $300.9K | 0.00% | −456−0.5% | Reduced |
| Rockefeller Capital Management L.P. | 91,401 | $318.1K | 0.00% | −29,990−24.7% | Reduced |
| Squarepoint Ops LLC | 94,066 | $327.4K | 0.00% | −123,976−56.9% | Reduced |
| TD Asset Management Inc | 94,148 | $327.6K | 0.00% | 00.0% | Unchanged |
| Profund Advisors LLC | 95,806 | $333.4K | 0.01% | +26,201+37.6% | Added |
| Invesco Ltd. | 96,875 | $337.1K | 0.00% | +40,096+70.6% | Added |
| Palumbo Wealth Management LLC | 102,246 | $355.8K | 0.09% | +16,707+19.5% | Added |
| Engineers Gate Manager LP | 110,348 | $384.0K | 0.00% | +49,858+82.4% | Added |
| Rhumbline Advisers | 114,269 | $397.6K | 0.00% | +5,860+5.4% | Added |
| FIL Ltd | 115,206 | $400.9K | 0.00% | −396−0.3% | Reduced |
| Steward Partners Investment Advisory, LLC | 117,456 | $408.7K | 0.00% | −950−0.8% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 122,463 | $421.2K | 0.00% | +7,403+6.4% | Added |
| Alliancebernstein L.P. | 122,460 | $424.9K | 0.00% | +13,770+12.7% | Added |
| Price T Rowe Associates Inc | 133,755 | $466.0K | 0.00% | +29,202+27.9% | Added |
| Bridgeway Capital Management, LLC | 134,800 | $469.1K | 0.01% | 00.0% | Unchanged |
| Marshall Wace, LLP | 141,957 | $494.0K | 0.00% | +141,957 | New |
| Elevate Capital Advisors, LLC | 151,069 | $525.7K | 0.34% | +108,403+254.1% | Added |
| XTX Topco Ltd | 157,282 | $547.3K | 0.01% | +84,347+115.6% | Added |
| Deutsche Bank AG | 157,440 | $547.9K | 0.00% | +9,497+6.4% | Added |
| Keystone Financial Group | 166,010 | $577.7K | 0.04% | +36,345+28.0% | Added |
| Swiss National Bank | 178,600 | $621.5K | 0.00% | +8,500+5.0% | Added |
| Green Alpha Advisors, LLC | 191,171 | $665.3K | 0.66% | +288+0.2% | Added |
| Davy Global Fund Management Ltd | 205,389 | $714.8K | 0.05% | +26,870+15.1% | Added |
| Rafferty Asset Management, LLC | 215,582 | $750.2K | 0.00% | +27,871+14.8% | Added |
| Bank of New York Mellon Corp | 267,219 | $929.9K | 0.00% | +20,449+8.3% | Added |
| Nuveen, LLC | 275,931 | $960.2K | 0.00% | +24,295+9.7% | Added |
| Wellington Management Group LLP | 278,120 | $967.9K | 0.00% | +29,893+12.0% | Added |
| Dimensional Fund Advisors LP | 304,522 | $1.06M | 0.00% | +220,468+262.3% | Added |
| Wells Fargo & Company | 319,550 | $1.11M | 0.00% | +25,054+8.5% | Added |
| Citadel Advisors LLC | 336,358 | $1.17M | 0.00% | +223,488+198.0% | Added |
| HighTower Advisors, LLC | 340,255 | $1.18M | 0.00% | −59,855−15.0% | Reduced |
| Bollard Group LLC | 361,136 | $1.26M | 0.04% | 00.0% | Unchanged |
| Alessandra Capital Management, LLC | 425,510 | $1.48M | 1.26% | +425,510 | New |
| Chelsea Counsel Co | 462,340 | $1.61M | 0.72% | +235,340+103.7% | Added |
| Moore Capital Management, LP | 500,000 | $1.74M | 0.06% | 00.0% | Unchanged |
| AQR Capital Management LLC | 554,935 | $1.93M | 0.00% | +139,114+33.5% | Added |
| Bank of America Corp | 577,004 | $2.01M | 0.00% | −71,008−11.0% | Reduced |
| HRT Financial LP | 612,769 | $2.13M | 0.01% | −42,582−6.5% | Reduced |
| Morgan Stanley | 639,457 | $2.23M | 0.00% | −530,441−45.3% | Reduced |
| Susquehanna International Group, LLP | 715,829 | $2.49M | 0.00% | −460,898−39.2% | Reduced |
| Vanguard Fiduciary Trust Co | 717,002 | $2.50M | 0.00% | +717,002 | New |
| Renaissance Technologies LLC | 741,039 | $2.58M | 0.00% | −408,120−35.5% | Reduced |
| Greenwich Wealth Management LLC | 750,001 | $2.61M | 0.11% | +10,000+1.4% | Added |
| JPMorgan Chase & Co | 844,154 | $2.66M | 0.00% | +408,444+93.7% | Added |
| Vanguard Portfolio Management LLC | 862,204 | $3.00M | 0.00% | +862,204 | New |
| Northern Trust Corp | 886,716 | $3.09M | 0.00% | +44,563+5.3% | Added |
| Charles Schwab Investment Management Inc | 917,212 | $3.19M | 0.00% | −19,603−2.1% | Reduced |
| Goldman Sachs Group Inc | 970,425 | $3.38M | 0.00% | −785,343−44.7% | Reduced |
| Farallon Capital Management, L.L.C. | 1,240,843 | $4.32M | 0.03% | 00.0% | Unchanged |
| D. E. Shaw & Co., Inc. | 1,393,621 | $4.85M | 0.00% | −157,748−10.2% | Reduced |
| Two Sigma Investments, LP | 1,572,811 | $5.47M | 0.00% | −56,513−3.5% | Reduced |
| Redmile Group, LLC | 1,590,832 | $5.54M | 0.37% | +1,590,832 | New |
| FMR LLC | 1,769,476 | $6.16M | 0.00% | −407,170−18.7% | Reduced |
| ADAR1 Capital Management, LLC | 1,973,282 | $6.87M | 0.41% | +1,973,282 | New |
| Geode Capital Management, LLC | 2,743,700 | $9.55M | 0.00% | +115,271+4.4% | Added |
| UBS Group AG | 2,888,418 | $10.1M | 0.00% | +447,835+18.3% | Added |
| Nikko Asset Management Americas, Inc. | 2,940,793 | $10.2M | 0.14% | −304,713−9.4% | Reduced |
| Sumitomo Mitsui Trust Holdings, Inc. | 2,940,793 | $10.2M | 0.01% | −304,713−9.4% | Reduced |
| Woodline Partners LP | 3,003,313 | $10.5M | 0.04% | +4690.0% | Added |
| Casdin Capital, LLC | 3,167,175 | $11.0M | 0.83% | 00.0% | Unchanged |
| Balyasny Asset Management LLC | 4,123,365 | $14.3M | 0.03% | +999,003+32.0% | Added |
| Vanguard Capital Management LLC | 4,474,162 | $15.6M | 0.00% | +4,474,162 | New |
| T. Rowe Price Investment Management, Inc. | 5,481,893 | $19.1M | 0.01% | −513,290−8.6% | Reduced |
| ARK Investment Management LLCSuperinvestorARK Invest | 6,246,827 | $21.7M | 0.17% | +878,301+16.4% | Added |
| State Street Corp | 6,345,125 | $22.1M | 0.00% | +1,249,615+24.5% | Added |
| BlackRock, Inc. | 8,501,708 | $29.6M | 0.00% | +232,865+2.8% | Added |
| Alphabet Inc. | 16,562,498 | $57.6M | 1.44% | 00.0% | Unchanged |
| Point72 Asset Management, L.P. | 0 | $0 | 0.00% | −551,030−100.0% | Sold out |
| Two Sigma Advisers, LP | 0 | $0 | 0.00% | −383,500−100.0% | Sold out |
| Verition Fund Management LLC | 0 | $0 | 0.00% | −290,983−100.0% | Sold out |
| Dark Forest Capital Management LP | 0 | $0 | 0.00% | −225,859−100.0% | Sold out |
| Jump Financial, LLC | 0 | $0 | 0.00% | −171,931−100.0% | Sold out |
| Virtu Financial LLC | 0 | $0 | 0.00% | −94,778−100.0% | Sold out |
| Qube Research & Technologies Ltd | 0 | $0 | 0.00% | −94,670−100.0% | Sold out |
| Brevan Howard Capital Management LP | 0 | $0 | 0.00% | −56,088−100.0% | Sold out |