Prime Medicine, Inc.
PRME- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001894562
No open-market purchases or sales by Prime Medicine, Inc. insiders were filed in the last 90 days; 187 institutions reported holding it in 13F filings for Q2 2026, worth $393.5M in total; ARK Invest is the only superinvestor holding it.
13F holders, Q3 2025
Institutional positions in Prime Medicine, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 167
- +46 vs. Q2 2025
- Shares held
- 92.3M
- +33.7M (+57.4%) vs. Q2 2025
- Total value
- $511.5M
- +$366.5M (+252.7%) vs. Q2 2025
- New holders
- 53
- 63 more added
- Sold out
- 7
- 31 more reduced
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PRME on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 187 | $393.5M |
| Q1 2026 | 192 | $342.6M |
| Q4 2025 | 183 | $336.5M |
| Q3 2025 | 167 | $511.5M |
| Q2 2025 | 121 | $145.0M |
| Q1 2025 | 125 | $120.4M |
| Q4 2024 | 132 | $188.0M |
| Q3 2024 | 116 | $265.9M |
| Q2 2024 | 122 | $354.0M |
| Q1 2024 | 115 | $466.6M |
| Q4 2023 | 105 | $431.4M |
| Q3 2023 | 83 | $472.3M |
| Q2 2023 | 79 | $675.7M |
| Q1 2023 | 76 | $512.1M |
| Q4 2022 | 66 | $767.8M |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Prime Medicine, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Commonwealth Equity Services, LLC | 63,168 | $350.0K | 0.00% | +48,226+322.8% | Added |
| Keystone Financial Group | 70,855 | $392.5K | 0.03% | +70,855 | New |
| Price T Rowe Associates Inc | 74,502 | $413.0K | 0.00% | +9,182+14.1% | Added |
| Diametric Capital, LP | 81,271 | $450.2K | 0.17% | −24,259−23.0% | Reduced |
| Jane Street Group, LLC | 85,892 | $475.8K | 0.00% | +58,747+216.4% | Added |
| Redmile Group, LLC | 87,118 | $482.6K | 0.05% | −1,987,232−95.8% | Reduced |
| Palumbo Wealth Management LLC | 92,535 | $512.6K | 0.16% | −90,823−49.5% | Reduced |
| Alliancebernstein L.P. | 108,690 | $602.1K | 0.00% | −58,730−35.1% | Reduced |
| Rhumbline Advisers | 109,787 | $608.2K | 0.00% | +11,815+12.1% | Added |
| Bank of America Corp | 110,842 | $614.1K | 0.00% | −33,669−23.3% | Reduced |
| Barclays PLC | 115,900 | $642.1K | 0.00% | +1,098+1.0% | Added |
| FIL Ltd | 116,329 | $644.5K | 0.00% | −941−0.8% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 120,423 | $667.1K | 0.00% | +567+0.5% | Added |
| Davy Global Fund Management Ltd | 120,773 | $669.1K | 0.05% | +87,113+258.8% | Added |
| Fred Alger Management, LLC | 122,654 | $679.5K | 0.00% | −260,540−68.0% | Reduced |
| Steward Partners Investment Advisory, LLC | 126,387 | $700.2K | 0.00% | +126,387 | New |
| Deutsche Bank AG | 132,769 | $735.5K | 0.00% | +7,324+5.8% | Added |
| Ikarian Capital, LLC | 150,000 | $831.0K | 0.19% | +150,000 | New |
| Simplex Trading, LLC | 157,897 | $874.0K | 0.02% | −35,718−18.4% | Reduced |
| Bridgeway Capital Management, LLC | 164,800 | $913.0K | 0.02% | −50,000−23.3% | Reduced |
| Voloridge Investment Management, LLC | 170,021 | $941.9K | 0.00% | +170,021 | New |
| TD Asset Management Inc | 181,048 | $1.00M | 0.00% | +158,138+690.3% | Added |
| DnB Asset Management AS | 182,133 | $1.01M | 0.00% | +182,133 | New |
| JBF Capital, Inc. | 188,900 | $1.05M | 0.15% | +188,900 | New |
| Man Group plc | 189,588 | $1.05M | 0.00% | +189,588 | New |
| Green Alpha Advisors, LLC | 190,353 | $1.05M | 1.02% | +111,359+141.0% | Added |
| Wells Fargo & Company | 197,014 | $1.09M | 0.00% | +95,863+94.8% | Added |
| Bank of New York Mellon Corp | 197,729 | $1.10M | 0.00% | +35,677+22.0% | Added |
| Wellington Management Group LLP | 205,325 | $1.14M | 0.00% | +205,325 | New |
| Chelsea Counsel Co | 208,210 | $1.15M | 0.51% | 00.0% | Unchanged |
| HRT Financial LP | 221,464 | $1.23M | 0.00% | +157,297+245.1% | Added |
| Nuveen, LLC | 225,843 | $1.25M | 0.00% | +17,949+8.6% | Added |
| UBS Group AG | 304,773 | $1.69M | 0.00% | +109,446+56.0% | Added |
| HighTower Advisors, LLC | 333,755 | $1.85M | 0.00% | +312,401+1,463.0% | Added |
| Bollard Group LLC | 361,136 | $2.00M | 0.05% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 410,736 | $2.28M | 0.00% | +203,728+98.4% | Added |
| AQR Capital Management LLC | 414,211 | $2.29M | 0.00% | −10,144−2.4% | Reduced |
| Two Sigma Investments, LP | 447,667 | $2.48M | 0.00% | +189,244+73.2% | Added |
| Moore Capital Management, LP | 500,000 | $2.77M | 0.06% | 00.0% | Unchanged |
| Charles Schwab Investment Management Inc | 573,158 | $3.18M | 0.00% | +54,530+10.5% | Added |
| Susquehanna International Group, LLP | 584,424 | $3.24M | 0.00% | +101,696+21.1% | Added |
| Schonfeld Strategic Advisors LLC | 593,039 | $3.29M | 0.02% | −225,479−27.5% | Reduced |
| Northern Trust Corp | 607,989 | $3.37M | 0.00% | +95,755+18.7% | Added |
| Greenwich Wealth Management LLC | 720,001 | $3.99M | 0.20% | −126,200−14.9% | Reduced |
| Morgan Stanley | 731,004 | $4.05M | 0.00% | +143,328+24.4% | Added |
| Invesco Ltd. | 762,078 | $4.22M | 0.00% | +748,416+5,478.1% | Added |
| Adage Capital Partners GP, L.L.C. | 771,361 | $4.27M | 0.01% | +771,361 | New |
| Citadel Advisors LLC | 900,142 | $4.99M | 0.00% | +378,634+72.6% | Added |
| Renaissance Technologies LLC | 1,134,670 | $6.29M | 0.01% | +911,270+407.9% | Added |
| State Street Corp | 1,296,626 | $7.18M | 0.00% | +57,289+4.6% | Added |
| Millennium Management LLC | 1,418,463 | $7.86M | 0.01% | +1,270,467+858.4% | Added |
| EcoR1 Capital, LLC | 1,543,326 | $8.55M | 0.41% | +1,543,326 | New |
| Geode Capital Management, LLC | 1,766,896 | $9.79M | 0.00% | +256,147+17.0% | Added |
| MWG Management Limited | 1,792,210 | $9.93M | 12.21% | 00.0% | Unchanged |
| D. E. Shaw & Co., Inc. | 2,215,852 | $12.3M | 0.01% | +2,215,852 | New |
| FMR LLC | 2,813,075 | $15.6M | 0.00% | −931,352−24.9% | Reduced |
| Ra Capital Management, L.P. | 3,000,000 | $16.6M | 0.20% | +3,000,000 | New |
| Woodline Partners LP | 3,002,482 | $16.6M | 0.08% | +3,002,482 | New |
| Casdin Capital, LLC | 3,167,175 | $17.5M | 1.46% | +1,600,000+102.1% | Added |
| Nikko Asset Management Americas, Inc. | 3,629,924 | $20.0M | 0.19% | +2,040,807+128.4% | Added |
| Sumitomo Mitsui Trust Holdings, Inc. | 3,629,924 | $20.1M | 0.01% | +2,035,406+127.7% | Added |
| Farallon Capital Management, L.L.C. | 4,750,000 | $26.3M | 0.15% | +4,000,000+533.3% | Added |
| Vanguard Group Inc | 4,921,865 | $27.3M | 0.00% | +1,294,355+35.7% | Added |
| ARK Investment Management LLCSuperinvestorARK Invest | 5,477,851 | $30.3M | 0.18% | +3,155,182+135.8% | Added |
| BlackRock, Inc. | 5,650,859 | $31.3M | 0.00% | +1,165,031+26.0% | Added |
| T. Rowe Price Investment Management, Inc. | 9,217,097 | $51.1M | 0.03% | +2,732,310+42.1% | Added |
| Alphabet Inc. | 16,562,498 | $91.8M | 3.81% | +1,500,000+10.0% | Added |
| Jaffetilchin Investment Partners, LLC | 0 | $0 | 0.00% | −37,744−100.0% | Sold out |
| SG Americas Securities, LLC | 0 | $0 | 0.00% | −27,919−100.0% | Sold out |
| CIBC World Markets Inc. | 0 | $0 | 0.00% | −14,326−100.0% | Sold out |
| R Squared Ltd | 0 | $0 | 0.00% | −12,519−100.0% | Sold out |
| State Board of Administration of Florida Retirement System | 0 | $0 | 0.00% | −11,420−100.0% | Sold out |
| Eqis Capital Management, Inc. | 0 | $0 | 0.00% | −10,432−100.0% | Sold out |
| Fogel Capital Management, Inc. | 0 | $0 | 0.00% | −10,000−100.0% | Sold out |