Design Therapeutics, Inc.
DSGN- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001807120
No open-market purchases or sales by Design Therapeutics, Inc. insiders were filed in the last 90 days; 136 institutions reported holding it in 13F filings for Q2 2026, worth $626.4M in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Design Therapeutics, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 117
- +23 vs. Q3 2025
- Shares held
- 38.1M
- +3.63M (+10.5%) vs. Q3 2025
- Total value
- $357.6M
- +$97.9M (+37.7%) vs. Q3 2025
- New holders
- 31
- 39 more added
- Sold out
- 8
- 28 more reduced
1 institution that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DSGN on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 136 | $626.4M |
| Q1 2026 | 125 | $404.1M |
| Q4 2025 | 117 | $357.6M |
| Q3 2025 | 95 | $259.7M |
| Q2 2025 | 93 | $116.4M |
| Q1 2025 | 98 | $133.0M |
| Q4 2024 | 95 | $206.5M |
| Q3 2024 | 100 | $172.3M |
| Q2 2024 | 95 | $107.5M |
| Q1 2024 | 93 | $123.9M |
| Q4 2023 | 88 | $84.0M |
| Q3 2023 | 87 | $77.6M |
| Q2 2023 | 97 | $244.4M |
| Q1 2023 | 96 | $223.3M |
| Q4 2022 | 83 | $414.2M |
| Q3 2022 | 79 | $667.2M |
| Q2 2022 | 74 | $541.7M |
| Q1 2022 | 63 | $613.7M |
| Q4 2021 | 60 | $773.1M |
| Q3 2021 | 52 | $414.8M |
| Q2 2021 | 50 | $546.2M |
| Q1 2021 | 43 | $755.2M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Design Therapeutics, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Acadian Asset Management LLC | 612,768 | $5.74M | 0.01% | −4,721−0.8% | Reduced |
| State Street Corp | 647,636 | $6.07M | 0.00% | +13,239+2.1% | Added |
| Geode Capital Management, LLC | 679,590 | $6.38M | 0.00% | −16,023−2.3% | Reduced |
| Morgan Stanley | 702,306 | $6.59M | 0.00% | +526,315+299.1% | Added |
| FMR LLC | 771,268 | $7.23M | 0.00% | +30,419+4.1% | Added |
| Kynam Capital Management, LP | 784,606 | $7.36M | 0.48% | −244,973−23.8% | Reduced |
| Woodline Partners LP | 944,039 | $8.86M | 0.03% | +331,327+54.1% | Added |
| Driehaus Capital Management LLC | 1,179,817 | $11.1M | 0.08% | +103,581+9.6% | Added |
| Ra Capital Management, L.P. | 1,461,381 | $13.7M | 0.14% | +985,682+207.2% | Added |
| Almitas Capital LLC | 1,530,435 | $14.4M | 3.16% | 00.0% | Unchanged |
| Vivo Capital, LLC | 1,612,903 | $15.1M | 0.98% | +1,612,903 | New |
| Vanguard Group Inc | 1,630,910 | $15.3M | 0.00% | +187,209+13.0% | Added |
| BlackRock, Inc. | 2,117,156 | $19.9M | 0.00% | +72,768+3.6% | Added |
| Baker Bros. Advisors LP | 2,233,099 | $20.9M | 0.12% | +520,217+30.4% | Added |
| Logos Global Management LP | 2,500,000 | $23.4M | 1.56% | −1,155,000−31.6% | Reduced |
| Point72 Asset Management, L.P. | 5,372,004 | $50.4M | 0.08% | +2,031,452+60.8% | Added |
| Sr One Capital Management, LP | 6,526,476 | $61.2M | 8.67% | 00.0% | Unchanged |
| Tang Capital Management LLC | 0 | $0 | 0.00% | −1,780,975−100.0% | Sold out |
| MPM Oncology Impact Management LP | 0 | $0 | 0.00% | −555,187−100.0% | Sold out |
| DLD Asset Management, LP | 0 | $0 | 0.00% | −50,000−100.0% | Sold out |
| HRT Financial LP | 0 | $0 | 0.00% | −31,903−100.0% | Sold out |
| Sphera Funds Management Ltd. | 0 | $0 | 0.00% | −21,918−100.0% | Sold out |
| Intech Investment Management LLC | 0 | $0 | 0.00% | −14,155−100.0% | Sold out |
| Rise Advisors, LLC | 0 | $0 | 0.00% | −130−100.0% | Sold out |
| Versant Capital Management, Inc | 0 | $0 | 0.00% | −71−100.0% | Sold out |
| Point72 Asia (Singapore) Pte. Ltd. | – | – | – | – | Not filed |