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Definium Therapeutics, Inc.

DFTX
Exchange
Nasdaq
Industry
Medicinal Chemicals & Botanical Products
SEC CIK
0001813814

In the last 90 days, Definium Therapeutics, Inc. insiders filed 0 open-market purchases and 1 sale; 362 institutions reported holding it in 13F filings for Q2 2026, worth $5.35B in total; Duquesne Family Office is the only superinvestor holding it.

13F holders, Q4 2022

Institutional positions in Definium Therapeutics, Inc. as of Dec 31, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
104
+7 vs. Q3 2022
Shares held
5.06M
−640.9K (−11.2%) vs. Q3 2022
Total value
$11.1M
−$8.73M (−44.0%) vs. Q3 2022
New holders
29
19 more added
Sold out
22
24 more reduced

4 institutions that held it in Q3 2022 haven't filed for Q4 2022 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q3 2022: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting DFTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2022: 104 institutions
Q1 2021: 8 institutionsQ2 2021: 156 institutionsQ3 2021: 175 institutionsQ4 2021: 176 institutionsQ1 2022: 159 institutionsQ2 2022: 156 institutionsQ3 2022: 101 institutionsQ4 2022: 104 institutionsQ1 2023: 89 institutionsQ2 2023: 84 institutionsQ3 2023: 93 institutionsQ4 2023: 104 institutionsQ1 2024: 135 institutionsQ2 2024: 152 institutionsQ3 2024: 158 institutionsQ4 2024: 174 institutionsQ1 2025: 191 institutionsQ2 2025: 183 institutionsQ3 2025: 196 institutionsQ4 2025: 209 institutionsQ1 2026: 248 institutionsQ2 2026: 362 institutions
Value heldQ4 2022: $11.1M
Q1 2021: $932.0KQ2 2021: $131.0MQ3 2021: $104.8MQ4 2021: $72.0MQ1 2022: $53.6MQ2 2022: $15.1MQ3 2022: $20.5MQ4 2022: $11.1MQ1 2023: $12.6MQ2 2023: $13.9MQ3 2023: $12.1MQ4 2023: $17.9MQ1 2024: $327.2MQ2 2024: $299.3MQ3 2024: $281.6MQ4 2024: $288.9MQ1 2025: $240.5MQ2 2025: $271.0MQ3 2025: $468.6MQ4 2025: $908.7MQ1 2026: $1.47BQ2 2026: $5.35B
Institutions holding DFTX and their total value by quarter
QuarterHoldersValue
Q2 2026362$5.35B
Q1 2026248$1.47B
Q4 2025209$908.7M
Q3 2025196$468.6M
Q2 2025183$271.0M
Q1 2025191$240.5M
Q4 2024174$288.9M
Q3 2024158$281.6M
Q2 2024152$299.3M
Q1 2024135$327.2M
Q4 2023104$17.9M
Q3 202393$12.1M
Q2 202384$13.9M
Q1 202389$12.6M
Q4 2022104$11.1M
Q3 2022101$20.5M
Q2 2022156$15.1M
Q1 2022159$53.6M
Q4 2021176$72.0M
Q3 2021175$104.8M
Q2 2021156$131.0M
Q1 20218$932.0K

Institutions, Q4 2022

Shares, value and share of portfolio for each institution holding Definium Therapeutics, Inc.; share changes are against Q3 2022.

Institutions holding DFTX in Q4 2022
InstitutionSharesValue% of portfolioChange in sharesAction
Merit Financial Group, LLC540,287$1.19M0.04%−540,287−50.0%Reduced
Vanguard Group Inc594,394$1.31M0.00%+581,486+4,504.8%Added
Alyeska Investment Group, L.P.1,100,000$2.42M0.03%+100,000+10.0%Added
IFP Advisors, Inc233––−15,261−98.5%Reduced
CVI Holdings, LLC0$00.00%−652,374−100.0%Sold out
Group One Trading, L.P.0$00.00%−62,534−100.0%Sold out
Swiss National Bank0$00.00%−56,560−100.0%Sold out
Jane Street Group, LLC0$00.00%−41,563−100.0%Sold out
Wolverine Trading, LLC0$00.00%−29,939−100.0%Sold out
Credit Suisse AG0$00.00%−22,306−100.0%Sold out
XTX Topco Ltd0$00.00%−20,831−100.0%Sold out
The PNC Financial Services Group, Inc.0$00.00%−13,535−100.0%Sold out
Commonwealth Equity Services, LLC0$00.00%−12,491−100.0%Sold out
LMR Partners LLP0$00.00%−10,211−100.0%Sold out
Equitec Proprietary Markets, LLC0$00.00%−4,400−100.0%Sold out
Public Employees Retirement Association of Colorado0$00.00%−1,880−100.0%Sold out
Toronto Dominion Bank0$00.00%−1,960−100.0%Sold out
Shell Asset Management Co0$00.00%−1,982−100.0%Sold out
Sandy Spring Bank0$00.00%−810−100.0%Sold out
Glassman Wealth Services0$00.00%−833−100.0%Sold out
Almanack Investment Partners, LLC.0$00.00%−894−100.0%Sold out
Laffer Tengler Investments0$00.00%−6−100.0%Sold out
Montag A & Associates Inc0$00.00%−3−100.0%Sold out
Clearstead Advisors, LLC0$00.00%−10−100.0%Sold out
Bogart Wealth, LLC0$00.00%−100−100.0%Sold out
Professional Financial Advisors, LLC0$00.00%−5−100.0%Sold out
Empery Asset Management, LP––––Not filed
American Portfolios Advisors––––Not filed
Covington Capital Management––––Not filed
Wipfli Financial Advisors LLC,––––Not filed