Amylyx Pharmaceuticals, Inc.
AMLX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001658551
In the last 90 days, Amylyx Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 206 institutions reported holding it in 13F filings for Q2 2026, worth $2.07B in total; no superinvestor holds it.
13F holders, Q2 2026
Institutional positions in Amylyx Pharmaceuticals, Inc. as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 206
- +37 vs. Q1 2026
- Shares held
- 115.0M
- +5.82M (+5.3%) vs. Q1 2026
- Total value
- $2.07B
- +$549.0M (+36.2%) vs. Q1 2026
- New holders
- 50
- 71 more added
- Sold out
- 13
- 60 more reduced
2 institutions that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2026: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting AMLX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 206 | $2.07B |
| Q1 2026 | 171 | $1.59B |
| Q4 2025 | 180 | $1.36B |
| Q3 2025 | 169 | $1.49B |
| Q2 2025 | 131 | $523.6M |
| Q1 2025 | 136 | $261.6M |
| Q4 2024 | 122 | $188.3M |
| Q3 2024 | 110 | $140.8M |
| Q2 2024 | 119 | $82.9M |
| Q1 2024 | 143 | $141.5M |
| Q4 2023 | 178 | $887.4M |
| Q3 2023 | 170 | $1.08B |
| Q2 2023 | 154 | $1.18B |
| Q1 2023 | 147 | $1.51B |
| Q4 2022 | 133 | $1.79B |
| Q3 2022 | 95 | $1.05B |
| Q2 2022 | 78 | $512.9M |
| Q1 2022 | 72 | $299.9M |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q2 2026
Shares, value and share of portfolio for each institution holding Amylyx Pharmaceuticals, Inc.; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Jennison Associates LLC | 35,841 | $643.7K | 0.00% | +35,841 | New |
| Boothbay Fund Management, LLC | 36,060 | $647.6K | 0.01% | +36,060 | New |
| Manufacturers Life Insurance Company, The | 37,828 | $679.4K | 0.00% | −953−2.5% | Reduced |
| Gsa Capital Partners LLP | 39,241 | $705.0K | 0.04% | +39,241 | New |
| Aquatic Capital Management LLC | 39,425 | $708.1K | 0.02% | +39,425 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 42,351 | $760.6K | 0.00% | −202−0.5% | Reduced |
| Fox Run Management, L.L.C. | 44,817 | $804.9K | 0.13% | +44,817 | New |
| Vanguard Global Advisers, LLC | 47,851 | $859.4K | 0.00% | 00.0% | Unchanged |
| Hudson Bay Capital Management LP | 50,000 | $898.0K | 0.00% | +50,000 | New |
| SG Americas Securities, LLC | 55,321 | $994.0K | 0.00% | +55,321 | New |
| MetLife Investment Management | 55,700 | $1.00M | 0.00% | +4,113+8.0% | Added |
| Barclays PLC | 56,258 | $1.01M | 0.00% | −915,596−94.2% | Reduced |
| Legal & General Group Plc | 56,477 | $1.01M | 0.00% | +704+1.3% | Added |
| Vanguard Asset Management, Ltd | 56,948 | $1.02M | 0.00% | +13,665+31.6% | Added |
| Moody Aldrich Partners LLC | 57,802 | $1.04M | 0.19% | +57,802 | New |
| CI Private Wealth, LLC | 59,322 | $1.07M | 0.00% | +59,322 | New |
| State of Wisconsin Investment Board | 61,278 | $1.10M | 0.00% | −10,783−15.0% | Reduced |
| Schonfeld Strategic Advisors LLC | 66,804 | $1.20M | 0.01% | −10,990−14.1% | Reduced |
| Citigroup Inc | 68,684 | $1.23M | 0.00% | +36,902+116.1% | Added |
| 1492 Capital Management LLC | 79,751 | $1.43M | 0.42% | +79,751 | New |
| California State Teachers Retirement System | 79,872 | $1.43M | 0.00% | +14,870+22.9% | Added |
| Alliancebernstein L.P. | 104,400 | $1.45M | 0.00% | +23,600+29.2% | Added |
| Quantinno Capital Management LP | 80,850 | $1.45M | 0.00% | +80,850 | New |
| Russell Investments Group, Ltd. | 87,574 | $1.57M | 0.00% | +28,228+47.6% | Added |
| Affinity Asset Advisors, LLC | 98,999 | $1.78M | 0.09% | +98,999 | New |
| Campbell & CO Investment Adviser LLC | 100,963 | $1.81M | 0.10% | +46,541+85.5% | Added |
| Elmind Capital, LP | 112,000 | $2.01M | 0.51% | 00.0% | Unchanged |
| Alps Advisors Inc | 112,447 | $2.02M | 0.01% | +22,464+25.0% | Added |
| Rhumbline Advisers | 112,920 | $2.03M | 0.00% | +4,453+4.1% | Added |
| Ikarian Capital, LLC | 117,500 | $2.11M | 0.35% | +117,500 | New |
| Lighthouse Investment Partners, LLC | 122,909 | $2.21M | 0.07% | +122,909 | New |
| Ameriprise Financial Inc | 125,484 | $2.25M | 0.00% | +125,484 | New |
| Wells Fargo & Company | 128,164 | $2.30M | 0.00% | +53,081+70.7% | Added |
| Invesco Ltd. | 139,942 | $2.51M | 0.00% | −31,678−18.5% | Reduced |
| PFM Health Sciences, LP | 143,700 | $2.58M | 0.22% | −1,575−1.1% | Reduced |
| Swiss National Bank | 144,200 | $2.59M | 0.00% | +13,900+10.7% | Added |
| Price T Rowe Associates Inc | 145,133 | $2.61M | 0.00% | +23,694+19.5% | Added |
| Falcon Edge Capital, LP | 155,422 | $2.79M | 0.04% | +13,086+9.2% | Added |
| Norges Bank | 159,900 | $2.87M | 0.00% | +159,900 | New |
| Acuta Capital Partners, LLC | 168,115 | $3.02M | 2.10% | +17,048+11.3% | Added |
| UBS Asset Management Americas Inc | 173,407 | $3.11M | 0.00% | +16,318+10.4% | Added |
| D. E. Shaw & Co., Inc. | 174,285 | $3.13M | 0.00% | +100,055+134.8% | Added |
| Citadel Advisors LLC | 178,686 | $3.21M | 0.00% | −232,846−56.6% | Reduced |
| OrbiMed Advisors LLC | 183,400 | $3.29M | 0.06% | +183,400 | New |
| Walleye Capital LLC | 186,588 | $3.35M | 0.02% | +124,877+202.4% | Added |
| Aldebaran Capital, LLC | 195,892 | $3.52M | 2.64% | −2,000−1.0% | Reduced |
| Cormorant Asset Management, LP | 200,000 | $3.59M | 0.18% | −150,000−42.9% | Reduced |
| Wellington Management Group LLP | 212,842 | $3.82M | 0.00% | −28,710−11.9% | Reduced |
| SummitTX Capital, L.P. | 227,690 | $4.09M | 0.11% | +680+0.3% | Added |
| First Trust Advisors LP | 254,587 | $4.57M | 0.00% | +254,587 | New |
| UBS Group AG | 271,881 | $4.88M | 0.00% | −52,438−16.2% | Reduced |
| Bank of New York Mellon Corp | 274,435 | $4.93M | 0.00% | +23,331+9.3% | Added |
| Jupiter Asset Management Ltd | 274,944 | $4.94M | 0.02% | −317,710−53.6% | Reduced |
| Polygon Management Ltd. | 297,926 | $5.35M | 0.87% | −19,951−6.3% | Reduced |
| Jane Street Group, LLC | 299,565 | $5.38M | 0.00% | +299,565 | New |
| iA Global Asset Management Inc. | 303,786 | $5.46M | 0.06% | −1,000−0.3% | Reduced |
| Ensign Peak Advisors, Inc | 305,441 | $5.49M | 0.01% | +305,441 | New |
| Nuveen, LLC | 330,521 | $5.94M | 0.00% | +65,624+24.8% | Added |
| Trexquant Investment LP | 349,439 | $6.28M | 0.04% | +349,439 | New |
| Logos Global Management LP | 350,000 | $6.29M | 0.27% | −350,000−50.0% | Reduced |
| StemPoint Capital LP | 384,304 | $6.90M | 1.19% | −285,381−42.6% | Reduced |
| HighVista Strategies LLC | 386,080 | $6.93M | 1.58% | +33,995+9.7% | Added |
| Parkman Healthcare Partners LLC | 398,782 | $7.16M | 0.74% | −222,676−35.8% | Reduced |
| Nearwater Capital Markets, Ltd | 425,000 | $7.63M | 0.13% | +425,000 | New |
| Federated Hermes, Inc. | 462,205 | $8.30M | 0.01% | +98,659+27.1% | Added |
| Nantahala Capital Management, LLC | 486,684 | $8.74M | 0.53% | −49,000−9.1% | Reduced |
| ADAR1 Capital Management, LLC | 494,378 | $8.88M | 0.42% | −506,226−50.6% | Reduced |
| Rock Springs Capital Management LP | 499,764 | $8.98M | 0.44% | 00.0% | Unchanged |
| Deutsche Bank AG | 557,937 | $10.0M | 0.00% | −709,848−56.0% | Reduced |
| Two Sigma Investments, LP | 593,435 | $10.7M | 0.01% | +431,490+266.4% | Added |
| Vanguard Fiduciary Trust Co | 623,078 | $11.2M | 0.00% | +36,926+6.3% | Added |
| Qube Research & Technologies Ltd | 681,389 | $12.2M | 0.01% | −20,847−3.0% | Reduced |
| Balyasny Asset Management LLC | 684,974 | $12.3M | 0.02% | −422,297−38.1% | Reduced |
| Great Point Partners LLC | 700,000 | $12.6M | 2.96% | −1,050,000−60.0% | Reduced |
| Connor, Clark & Lunn Investment Management Ltd. | 721,002 | $12.9M | 0.02% | −147,323−17.0% | Reduced |
| Charles Schwab Investment Management Inc | 725,030 | $13.0M | 0.00% | +8,805+1.2% | Added |
| Standard Life Aberdeen plc | 737,670 | $13.2M | 0.02% | +737,670 | New |
| Boxer Capital Management, LLC | 800,000 | $14.4M | 1.08% | 00.0% | Unchanged |
| Bank of America Corp | 821,841 | $14.8M | 0.00% | −508,848−38.2% | Reduced |
| Northern Trust Corp | 831,740 | $14.9M | 0.00% | +51,832+6.6% | Added |
| Woodline Partners LP | 846,387 | $15.2M | 0.05% | +587+0.1% | Added |
| Jones Hill Capital LP | 894,058 | $16.1M | 3.41% | −704,736−44.1% | Reduced |
| Dimensional Fund Advisors LP | 902,463 | $16.2M | 0.00% | −729−0.1% | Reduced |
| Almitas Capital LLC | 974,881 | $17.5M | 4.20% | −1,147,716−54.1% | Reduced |
| Alyeska Investment Group, L.P. | 1,053,015 | $18.9M | 0.05% | +1,053,015 | New |
| Vanguard Portfolio Management LLC | 1,061,534 | $19.1M | 0.00% | +116,753+12.4% | Added |
| 683 Capital Management, LLC | 1,279,512 | $23.0M | 2.11% | −250,488−16.4% | Reduced |
| Eventide Asset Management, LLC | 1,327,536 | $23.8M | 0.32% | −186,422−12.3% | Reduced |
| Siren, L.L.C. | 1,480,586 | $26.6M | 0.54% | +250,586+20.4% | Added |
| Adage Capital Partners GP, L.L.C. | 1,900,000 | $34.1M | 0.05% | −1,660,764−46.6% | Reduced |
| JPMorgan Chase & Co | 1,863,650 | $34.9M | 0.00% | +1,703,987+1,067.2% | Added |
| Geode Capital Management, LLC | 2,335,315 | $41.9M | 0.00% | +124,383+5.6% | Added |
| State Street Corp | 2,603,337 | $46.8M | 0.00% | +240,176+10.2% | Added |
| Goldman Sachs Group Inc | 2,858,239 | $51.3M | 0.01% | +232,248+8.8% | Added |
| Franklin Resources Inc | 2,950,225 | $53.0M | 0.01% | +688,656+30.5% | Added |
| First Light Asset Management, LLC | 3,023,256 | $54.3M | 3.30% | −167,389−5.2% | Reduced |
| Driehaus Capital Management LLC | 3,036,970 | $54.5M | 0.32% | +49,823+1.7% | Added |
| Morgan Stanley | 3,130,808 | $56.2M | 0.00% | +955,261+43.9% | Added |
| Vanguard Capital Management LLC | 4,224,224 | $75.9M | 0.00% | +82,649+2.0% | Added |
| Saturn V Capital Management LLC | 4,624,101 | $83.0M | 11.91% | +274,216+6.3% | Added |