Spyre Therapeutics, Inc.
SYRE- 交易所
- Nasdaq
- 產業
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
近 90 天，Spyre Therapeutics, Inc. 內部人申報 0 筆公開市場買進、9 筆賣出；2026 年第 2 季末有 265 家機構在 13F 申報持有，市值合計 $85.2 億；沒有大師持有。
2026 年第 2 季 13F 持有人
Spyre Therapeutics, Inc. 在 2026/6/30 季末的機構持股。管理 1 億美元以上美股的機構，每季結束後 45 天內要用 13F 申報多頭部位。13F 是什麼
- 持有機構
- 265
- 較 2026 年第 1 季 +69 家
- 持有股數
- 9,583 萬
- 較 2026 年第 1 季 +1,481 萬 (+18.3%)
- 總市值
- $85.2 億
- 較 2026 年第 1 季 +$44.4 億 (+108.8%)
- 新進機構
- 91
- 另有 105 家加碼
- 清倉機構
- 22
- 另有 55 家減碼
另有 2 家機構在 2026 年第 1 季持有、還沒有申報 2026 年第 2 季 13F：沒申報不算清倉，也不計入上面的變化。
歷季持有家數與市值
2021 年第 1 季起，每季在 13F 申報持有 SYRE 的機構家數與合計市值。市值是各季季末的申報市值，也會跟著股價漲跌。
| 季度 | 家數 | 市值 |
|---|---|---|
| 2026 年第 2 季 | 265 | $85.2 億 |
| 2026 年第 1 季 | 198 | $41.6 億 |
| 2025 年第 4 季 | 153 | $26.5 億 |
| 2025 年第 3 季 | 137 | $10.8 億 |
| 2025 年第 2 季 | 129 | $9.53 億 |
| 2025 年第 1 季 | 129 | $10.0 億 |
| 2024 年第 4 季 | 131 | $13.9 億 |
| 2024 年第 3 季 | 119 | $15.1 億 |
| 2024 年第 2 季 | 107 | $11.8 億 |
| 2024 年第 1 季 | 103 | $12.1 億 |
| 2023 年第 4 季 | 54 | $6.01 億 |
| 2023 年第 3 季 | 29 | $4,387 萬 |
| 2023 年第 2 季 | 44 | $3,194 萬 |
| 2023 年第 1 季 | 45 | $1,198 萬 |
| 2022 年第 4 季 | 51 | $1,919 萬 |
| 2022 年第 3 季 | 55 | $2,352 萬 |
| 2022 年第 2 季 | 67 | $2,481 萬 |
| 2022 年第 1 季 | 84 | $9,538 萬 |
| 2021 年第 4 季 | 86 | $1.89 億 |
| 2021 年第 3 季 | 77 | $3.22 億 |
| 2021 年第 2 季 | 78 | $2.86 億 |
| 2021 年第 1 季 | 84 | $3.29 億 |
2026 年第 2 季持有機構
每家機構持有 Spyre Therapeutics, Inc. 的股數、市值與佔組合比重；股數變化跟 2026 年第 1 季比。
| 機構 | 股數 | 市值 | 佔組合 % | 股數變化 | 動作 |
|---|---|---|---|---|---|
| Glenmede Trust Co NA | 9,966 | $88.5 萬 | 0.00% | +9,966 | 新進 |
| Diametric Capital, LP | 10,000 | $88.8 萬 | 0.09% | +10,000 | 新進 |
| Virginia Retirement Systems Et Al | 11,250 | $99.9 萬 | 0.01% | −16,300−59.2% | 減碼 |
| Calamos Advisors LLC | 11,323 | $100.5 萬 | 0.00% | +11,323 | 新進 |
| STRS Ohio | 11,500 | $102.1 萬 | 0.00% | +7,000+155.6% | 加碼 |
| Global Endowment Management, LP | 12,123 | $107.6 萬 | 0.11% | −6,061−33.3% | 減碼 |
| Atom Investors LP | 12,457 | $110.6 萬 | 0.10% | +12,457 | 新進 |
| ProShare Advisors LLC | 12,599 | $111.9 萬 | 0.00% | −899−6.7% | 減碼 |
| SG Americas Securities, LLC | 12,727 | $113.0 萬 | 0.00% | −669−5.0% | 減碼 |
| Two Sigma Investments, LP | 12,771 | $113.4 萬 | 0.00% | +12,771 | 新進 |
| KLP Kapitalforvaltning AS | 12,800 | $113.6 萬 | 0.00% | +1,900+17.4% | 加碼 |
| Seven Fleet Capital Management LP | 13,300 | $118.1 萬 | 0.19% | −6,390−32.5% | 減碼 |
| Brown Advisory Inc | 13,550 | $120.3 萬 | 0.00% | +1,150+9.3% | 加碼 |
| China Universal Asset Management Co., Ltd. | 13,821 | $122.7 萬 | 0.07% | −117−0.8% | 減碼 |
| SEI Investments Co | 13,941 | $123.8 萬 | 0.00% | +4,966+55.3% | 加碼 |
| Allianz Asset Management GmbH | 14,100 | $125.2 萬 | 0.00% | +14,100 | 新進 |
| Neo Ivy Capital Management | 14,551 | $129.2 萬 | 0.30% | +13,953+2,333.3% | 加碼 |
| Vanguard Investments Australia, Ltd. | 14,752 | $131.0 萬 | 0.00% | +1,939+15.1% | 加碼 |
| Diadema Partners LP | 15,000 | $133.2 萬 | 0.47% | +15,000 | 新進 |
| Arizona State Retirement System | 15,471 | $137.4 萬 | 0.01% | +2,033+15.1% | 加碼 |
| Fifth Third Bancorp | 15,638 | $138.8 萬 | 0.00% | +15,633+312,660.0% | 加碼 |
| Algert Global LLC | 16,460 | $146.1 萬 | 0.02% | +16,460 | 新進 |
| Kennedy Capital Management, Inc. | 17,310 | $153.7 萬 | 0.03% | +437+2.6% | 加碼 |
| Intech Investment Management LLC | 17,628 | $156.5 萬 | 0.01% | +1,185+7.2% | 加碼 |
| State Board of Administration of Florida Retirement System | 18,076 | $160.5 萬 | 0.00% | +4,171+30.0% | 加碼 |
| State of New Jersey Common Pension Fund D | 18,129 | $160.9 萬 | 0.01% | +1,409+8.4% | 加碼 |
| Advisor Group Holdings, Inc. | 18,146 | $161.1 萬 | 0.00% | +17,648+3,543.8% | 加碼 |
| Ellsworth Advisors, LLC | 16,553 | $169.0 萬 | 0.28% | −5,410−24.6% | 減碼 |
| Schonfeld Strategic Advisors LLC | 19,089 | $169.5 萬 | 0.01% | +19,089 | 新進 |
| Profund Advisors LLC | 19,419 | $172.4 萬 | 0.05% | −6,624−25.4% | 減碼 |
| Police & Firemen's Retirement System of New Jersey | 21,968 | $195.0 萬 | 0.01% | +3,608+19.7% | 加碼 |
| Freestone Grove Partners LP | 22,777 | $202.2 萬 | 0.01% | +22,777 | 新進 |
| AQR Capital Management LLC | 22,937 | $203.6 萬 | 0.00% | +2,063+9.9% | 加碼 |
| Aquatic Capital Management LLC | 25,222 | $223.9 萬 | 0.08% | +25,222 | 新進 |
| Warren Averett Asset Management, LLC | 25,512 | $226.5 萬 | 0.01% | −454−1.7% | 減碼 |
| Creative Planning | 25,713 | $228.3 萬 | 0.00% | +10,227+66.0% | 加碼 |
| Teachers Retirement System of the State of Kentucky | 25,799 | $229.0 萬 | 0.02% | 00.0% | 不變 |
| Handelsbanken Fonder AB | 26,000 | $230.8 萬 | 0.01% | +26,000 | 新進 |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 26,143 | $232.1 萬 | 0.00% | +12,188+87.3% | 加碼 |
| New York State Common Retirement Fund | 26,165 | $232.3 萬 | 0.00% | +3,900+17.5% | 加碼 |
| Castleark Management LLC | 26,420 | $234.6 萬 | 0.06% | +26,420 | 新進 |
| D. E. Shaw & Co., Inc. | 26,452 | $234.8 萬 | 0.00% | +26,452 | 新進 |
| Fred Alger Management, LLC | 28,834 | $256.0 萬 | 0.01% | −30,619−51.5% | 減碼 |
| Ghisallo Capital Management LLC | 30,000 | $266.3 萬 | 0.05% | +30,000 | 新進 |
| Vanguard Global Advisers, LLC | 34,500 | $306.3 萬 | 0.00% | +3,359+10.8% | 加碼 |
| Caption Management, LLC | 36,000 | $319.6 萬 | 0.11% | +36,000 | 新進 |
| Rafferty Asset Management, LLC | 36,767 | $326.4 萬 | 0.01% | −20,153−35.4% | 減碼 |
| Engineers Gate Manager LP | 38,474 | $341.6 萬 | 0.04% | +38,474 | 新進 |
| Mirae Asset Global ETFs Holdings Ltd. | 38,439 | $341.9 萬 | 0.00% | +2,116+5.8% | 加碼 |
| Vanguard Asset Management, Ltd | 39,220 | $348.2 萬 | 0.00% | +5,988+18.0% | 加碼 |
| Susquehanna International Group, LLP | 39,311 | $349.0 萬 | 0.00% | +10,349+35.7% | 加碼 |
| Maven Securities LTD | 40,000 | $355.1 萬 | 0.24% | +40,000 | 新進 |
| Rock Springs Capital Management LP | 42,254 | $375.1 萬 | 0.18% | +42,254 | 新進 |
| Moody Aldrich Partners LLC | 42,458 | $376.9 萬 | 0.68% | +42,458 | 新進 |
| Nomura Asset Management International Inc. | 43,071 | $382.4 萬 | 0.01% | +43,071 | 新進 |
| MetLife Investment Management | 43,316 | $384.6 萬 | 0.02% | +4,909+12.8% | 加碼 |
| State of Wisconsin Investment Board | 45,030 | $399.8 萬 | 0.01% | +18,507+69.8% | 加碼 |
| Schroder Investment Management Group | 44,586 | $402.0 萬 | 0.00% | −19,098−30.0% | 減碼 |
| PFM Health Sciences, LP | 46,217 | $410.3 萬 | 0.36% | +46,217 | 新進 |
| Rockefeller Capital Management L.P. | 47,466 | $421.4 萬 | 0.01% | −16,536−25.8% | 減碼 |
| Dimensional Fund Advisors LP | 47,698 | $423.5 萬 | 0.00% | +10.0% | 加碼 |
| Cinctive Capital Management LP | 48,978 | $434.8 萬 | 0.17% | +21,548+78.6% | 加碼 |
| Legal & General Group Plc | 49,141 | $436.3 萬 | 0.00% | +4,349+9.7% | 加碼 |
| Monashee Investment Management LLC | 50,000 | $443.9 萬 | 7.45% | +50,000 | 新進 |
| XTX Topco Ltd | 50,483 | $448.2 萬 | 0.06% | +26,048+106.6% | 加碼 |
| Royce & Associates LP | 51,789 | $459.8 萬 | 0.04% | +51,789 | 新進 |
| Alliancebernstein L.P. | 92,540 | $466.8 萬 | 0.00% | +21,640+30.5% | 加碼 |
| Susquehanna Portfolio Strategies, LLC | 53,101 | $471.4 萬 | 0.08% | 00.0% | 不變 |
| Raymond James Financial Inc | 53,627 | $476.1 萬 | 0.00% | +33,872+171.5% | 加碼 |
| HealthInvest Partners AB | 57,030 | $506.3 萬 | 1.36% | −5,705−9.1% | 減碼 |
| Hudson Bay Capital Management LP | 58,387 | $518.4 萬 | 0.02% | +58,387 | 新進 |
| Principal Financial Group Inc | 59,747 | $530.4 萬 | 0.00% | +55,448+1,289.8% | 加碼 |
| Silverarc Capital Management, LLC | 59,959 | $532.3 萬 | 0.59% | −126,659−67.9% | 減碼 |
| EAM Investors, LLC | 60,393 | $536.2 萬 | 0.48% | +60,393 | 新進 |
| California State Teachers Retirement System | 64,687 | $574.3 萬 | 0.01% | +5,445+9.2% | 加碼 |
| Trexquant Investment LP | 67,007 | $594.9 萬 | 0.04% | +67,007 | 新進 |
| B Group, Inc. | 70,000 | $621.5 萬 | 3.53% | −30,000−30.0% | 減碼 |
| Mercer Global Advisors Inc | 71,145 | $631.6 萬 | 0.01% | +54+0.1% | 加碼 |
| HighVista Strategies LLC | 77,807 | $690.8 萬 | 1.57% | −68,457−46.8% | 減碼 |
| Wells Fargo & Company | 82,506 | $732.5 萬 | 0.00% | +49,298+148.5% | 加碼 |
| Citigroup Inc | 82,593 | $733.3 萬 | 0.00% | +70,587+587.9% | 加碼 |
| Granahan Investment Management Inc | 82,991 | $736.8 萬 | 0.26% | +82,991 | 新進 |
| Federated Hermes, Inc. | 85,950 | $763.1 萬 | 0.01% | +85,950 | 新進 |
| Prudential Financial Inc | 87,370 | $775.7 萬 | 0.01% | +27,815+46.7% | 加碼 |
| F/M Investments LLC | 92,618 | $822.3 萬 | 0.42% | −6,842−6.9% | 減碼 |
| Barclays PLC | 94,069 | $835.1 萬 | 0.00% | +48,283+105.5% | 加碼 |
| Rhumbline Advisers | 94,763 | $841.3 萬 | 0.01% | +9,642+11.3% | 加碼 |
| Boxer Capital Management, LLC | 100,000 | $887.8 萬 | 0.67% | +100,000 | 新進 |
| Citadel Advisors LLC | 103,100 | $915.3 萬 | 0.01% | −5,035−4.7% | 減碼 |
| Manufacturers Life Insurance Company, The | 104,516 | $927.9 萬 | 0.01% | −8,325−7.4% | 減碼 |
| StemPoint Capital LP | 106,926 | $949.3 萬 | 1.64% | −60,680−36.2% | 減碼 |
| Swiss National Bank | 112,500 | $998.8 萬 | 0.01% | +16,000+16.6% | 加碼 |
| TD Asset Management Inc | 115,990 | $1,030 萬 | 0.01% | −21,400−15.6% | 減碼 |
| Rhenman & Partners Asset Management AB | 119,300 | $1,059 萬 | 1.00% | +119,300 | 新進 |
| Blackstone Group Inc. | 120,177 | $1,067 萬 | 0.03% | −172,670−59.0% | 減碼 |
| Invesco Ltd. | 120,541 | $1,070 萬 | 0.00% | −11,849−9.0% | 減碼 |
| Ensign Peak Advisors, Inc | 126,620 | $1,124 萬 | 0.02% | −21,917−14.8% | 減碼 |
| Russell Investments Group, Ltd. | 134,757 | $1,196 萬 | 0.01% | +124,826+1,256.9% | 加碼 |
| Armistice Capital, LLC | 137,588 | $1,222 萬 | 0.34% | +16,657+13.8% | 加碼 |
| Squarepoint Ops LLC | 139,605 | $1,239 萬 | 0.02% | +139,605 | 新進 |