Taysha Gene Therapies, Inc.
TSHA- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001806310
In the last 90 days, Taysha Gene Therapies, Inc. insiders filed 0 open-market purchases and 1 sale; 208 institutions reported holding it in 13F filings for Q2 2026, worth $2.03B in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Taysha Gene Therapies, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 155
- +8 vs. Q2 2025
- Shares held
- 264.6M
- +6.95M (+2.7%) vs. Q2 2025
- Total value
- $865.6M
- +$270.3M (+45.4%) vs. Q2 2025
- New holders
- 28
- 61 more added
- Sold out
- 20
- 34 more reduced
3 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting TSHA on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 208 | $2.03B |
| Q1 2026 | 191 | $1.18B |
| Q4 2025 | 195 | $1.48B |
| Q3 2025 | 155 | $865.6M |
| Q2 2025 | 150 | $595.4M |
| Q1 2025 | 127 | $232.0M |
| Q4 2024 | 131 | $289.8M |
| Q3 2024 | 119 | $315.5M |
| Q2 2024 | 107 | $354.3M |
| Q1 2024 | 109 | $402.2M |
| Q4 2023 | 87 | $230.3M |
| Q3 2023 | 63 | $410.6M |
| Q2 2023 | 39 | $9.05M |
| Q1 2023 | 44 | $13.3M |
| Q4 2022 | 52 | $43.8M |
| Q3 2022 | 54 | $27.0M |
| Q2 2022 | 59 | $54.7M |
| Q1 2022 | 71 | $110.9M |
| Q4 2021 | 65 | $215.6M |
| Q3 2021 | 48 | $361.9M |
| Q2 2021 | 49 | $388.6M |
| Q1 2021 | 46 | $358.5M |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Taysha Gene Therapies, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Dimensional Fund Advisors LP | 345,163 | $1.13M | 0.00% | +345,163 | New |
| Citadel Advisors LLC | 367,309 | $1.20M | 0.00% | −161,684−30.6% | Reduced |
| Sphera Funds Management Ltd. | 408,146 | $1.33M | 0.32% | −11,854−2.8% | Reduced |
| Boothbay Fund Management, LLC | 415,607 | $1.36M | 0.04% | +415,607 | New |
| Acuta Capital Partners, LLC | 454,827 | $1.49M | 1.54% | −30,842−6.4% | Reduced |
| Marshall Wace, LLP | 476,865 | $1.56M | 0.00% | +397,367+499.8% | Added |
| Gsa Capital Partners LLP | 477,749 | $1.56M | 0.13% | +433,059+969.0% | Added |
| Woodline Partners LP | 500,000 | $1.64M | 0.01% | −500,254−50.0% | Reduced |
| Nuveen, LLC | 507,210 | $1.66M | 0.00% | +42,066+9.0% | Added |
| Jane Street Group, LLC | 556,785 | $1.82M | 0.00% | +419,791+306.4% | Added |
| Wellington Management Group LLP | 568,006 | $1.86M | 0.00% | −67,962−10.7% | Reduced |
| Rice Hall James & Associates, LLC | 578,118 | $1.89M | 0.10% | +578,118 | New |
| Royal Bank of Canada | 583,375 | $1.91M | 0.00% | +88,064+17.8% | Added |
| Anson Funds Management LP | 603,500 | $1.97M | 0.22% | −200,000−24.9% | Reduced |
| Bank of New York Mellon Corp | 624,839 | $2.04M | 0.00% | +166,180+36.2% | Added |
| UBS Group AG | 639,356 | $2.09M | 0.00% | +378,117+144.7% | Added |
| Alphabet Inc. | 640,882 | $2.10M | 0.09% | 00.0% | Unchanged |
| Sands Capital Ventures, LLC | 724,873 | $2.37M | 0.52% | 00.0% | Unchanged |
| Quantum Private Wealth, LLC | 822,076 | $2.69M | 0.79% | +6,100+0.7% | Added |
| StemPoint Capital LP | 839,669 | $2.75M | 0.55% | −364,272−30.3% | Reduced |
| Tang Capital Management LLC | 900,000 | $2.94M | 0.11% | 00.0% | Unchanged |
| Granahan Investment Management Inc | 1,116,629 | $3.65M | 0.15% | +158,136+16.5% | Added |
| Palo Alto Investors LP | 1,246,033 | $4.07M | 0.75% | 00.0% | Unchanged |
| Bank of America Corp | 1,307,287 | $4.27M | 0.00% | +576,559+78.9% | Added |
| Great Point Partners LLC | 1,500,000 | $4.91M | 2.05% | 00.0% | Unchanged |
| Northern Trust Corp | 1,717,178 | $5.62M | 0.00% | +388,437+29.2% | Added |
| B Group, Inc. | 1,800,556 | $5.89M | 5.63% | 00.0% | Unchanged |
| Charles Schwab Investment Management Inc | 1,846,510 | $6.04M | 0.00% | +1,354,801+275.5% | Added |
| Ally Bridge Group (NY) LLC | 1,898,112 | $6.21M | 5.20% | +1,898,112 | New |
| Toronto Dominion Bank | 1,923,962 | $6.29M | 0.01% | −2,804,844−59.3% | Reduced |
| Jefferies Financial Group Inc. | 2,156,642 | $7.05M | 0.06% | −8,157,091−79.1% | Reduced |
| D. E. Shaw & Co., Inc. | 2,706,434 | $8.85M | 0.01% | +2,304,925+574.1% | Added |
| ADAR1 Capital Management, LLC | 2,835,680 | $9.27M | 0.92% | −174,190−5.8% | Reduced |
| Affinity Asset Advisors, LLC | 3,000,000 | $9.81M | 0.91% | +2,800,000+1,400.0% | Added |
| Adage Capital Partners GP, L.L.C. | 3,328,000 | $10.9M | 0.02% | −1,511,000−31.2% | Reduced |
| Tybourne Capital Management (HK) Ltd | 3,700,000 | $12.1M | 39.11% | −395,000−9.6% | Reduced |
| Baker Bros. Advisors LP | 4,004,756 | $13.1M | 0.09% | 00.0% | Unchanged |
| Millennium Management LLC | 4,026,122 | $13.2M | 0.01% | +1,090,394+37.1% | Added |
| Barclays PLC | 5,148,112 | $16.8M | 0.01% | +4,697,611+1,042.8% | Added |
| Geode Capital Management, LLC | 5,174,516 | $16.9M | 0.00% | +1,380,944+36.4% | Added |
| Polar Capital Holdings Plc | 5,293,879 | $17.3M | 0.08% | +293,879+5.9% | Added |
| Deerfield Management Company, L.P. (Series C) | 5,386,000 | $17.6M | 0.27% | 00.0% | Unchanged |
| Vestal Point Capital, LP | 5,500,000 | $18.0M | 0.82% | +2,500,000+83.3% | Added |
| State Street Corp | 7,236,465 | $23.7M | 0.00% | +2,098,155+40.8% | Added |
| Point72 Asset Management, L.P. | 7,331,470 | $24.0M | 0.05% | +13,856+0.2% | Added |
| Octagon Capital Advisors LP | 9,067,500 | $29.7M | 4.63% | −3,525,000−28.0% | Reduced |
| Siren, L.L.C. | 11,014,737 | $36.0M | 1.41% | 00.0% | Unchanged |
| Vanguard Group Inc | 12,849,613 | $42.0M | 0.00% | +1,955,486+17.9% | Added |
| Goldman Sachs Group Inc | 13,383,708 | $43.8M | 0.01% | +796,008+6.3% | Added |
| FMR LLC | 14,593,412 | $47.7M | 0.00% | −1,034,410−6.6% | Reduced |
| BlackRock, Inc. | 16,364,861 | $53.5M | 0.00% | +3,061,086+23.0% | Added |
| Morgan Stanley | 19,307,603 | $63.1M | 0.00% | +2,442,521+14.5% | Added |
| Avoro Capital Advisors LLC | 21,700,000 | $71.0M | 0.92% | 00.0% | Unchanged |
| Ra Capital Management, L.P. | 23,555,648 | $77.0M | 0.95% | 00.0% | Unchanged |
| RTW Investments, LP | 24,354,291 | $79.6M | 0.98% | −667,293−2.7% | Reduced |
| Suvretta Capital Management, LLC | 0 | $0 | 0.00% | −3,217,449−100.0% | Sold out |
| MPM Oncology Impact Management LP | 0 | $0 | 0.00% | −2,953,562−100.0% | Sold out |
| XTX Topco Ltd | 0 | $0 | 0.00% | −320,737−100.0% | Sold out |
| ExodusPoint Capital Management, LP | 0 | $0 | 0.00% | −148,357−100.0% | Sold out |
| Los Angeles Capital Management LLC | 0 | $0 | 0.00% | −117,740−100.0% | Sold out |
| Omers Administration Corp | 0 | $0 | 0.00% | −72,900−100.0% | Sold out |
| EntryPoint Capital, LLC | 0 | $0 | 0.00% | −69,109−100.0% | Sold out |
| Renaissance Technologies LLC | 0 | $0 | 0.00% | −54,900−100.0% | Sold out |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | $0 | 0.00% | −25,252−100.0% | Sold out |
| State Board of Administration of Florida Retirement System | 0 | $0 | 0.00% | −22,700−100.0% | Sold out |
| May Hill Capital, LLC | 0 | $0 | 0.00% | −16,051−100.0% | Sold out |
| Howard Capital Management Inc. | 0 | $0 | 0.00% | −14,165−100.0% | Sold out |
| Marex Group plc | 0 | $0 | 0.00% | −12,500−100.0% | Sold out |
| Ieq Capital, LLC | 0 | $0 | 0.00% | −10,063−100.0% | Sold out |
| Atticus Wealth Management, LLC | 0 | $0 | 0.00% | −7,425−100.0% | Sold out |
| Point72 (DIFC) Ltd | 0 | $0 | 0.00% | −4,441−100.0% | Sold out |
| Raymond James Financial Inc | 0 | $0 | 0.00% | −3,605−100.0% | Sold out |
| Headlands Technologies LLC | 0 | $0 | 0.00% | −3,037−100.0% | Sold out |
| Rothschild Investment LLC | 0 | $0 | 0.00% | −105−100.0% | Sold out |
| National Bank of Canada | 0 | $0 | 0.00% | −48−100.0% | Sold out |
| CIBC World Markets Corp | – | – | – | – | Not filed |
| E Fund Management Co., Ltd. | – | – | – | – | Not filed |
| Bordeaux Wealth Advisors LLC | – | – | – | – | Not filed |