Taysha Gene Therapies, Inc.
TSHA- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001806310
In the last 90 days, Taysha Gene Therapies, Inc. insiders filed 0 open-market purchases and 1 sale; 208 institutions reported holding it in 13F filings for Q2 2026, worth $2.03B in total; no superinvestor holds it.
13F holders, Q2 2025
Institutional positions in Taysha Gene Therapies, Inc. as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 150
- +24 vs. Q1 2025
- Shares held
- 257.7M
- +90.9M (+54.5%) vs. Q1 2025
- Total value
- $595.4M
- +$363.4M (+156.7%) vs. Q1 2025
- New holders
- 44
- 48 more added
- Sold out
- 20
- 34 more reduced
1 institution that held it in Q1 2025 haven't filed for Q2 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting TSHA on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 208 | $2.03B |
| Q1 2026 | 191 | $1.18B |
| Q4 2025 | 195 | $1.48B |
| Q3 2025 | 155 | $865.6M |
| Q2 2025 | 150 | $595.4M |
| Q1 2025 | 127 | $232.0M |
| Q4 2024 | 131 | $289.8M |
| Q3 2024 | 119 | $315.5M |
| Q2 2024 | 107 | $354.3M |
| Q1 2024 | 109 | $402.2M |
| Q4 2023 | 87 | $230.3M |
| Q3 2023 | 63 | $410.6M |
| Q2 2023 | 39 | $9.05M |
| Q1 2023 | 44 | $13.3M |
| Q4 2022 | 52 | $43.8M |
| Q3 2022 | 54 | $27.0M |
| Q2 2022 | 59 | $54.7M |
| Q1 2022 | 71 | $110.9M |
| Q4 2021 | 65 | $215.6M |
| Q3 2021 | 48 | $361.9M |
| Q2 2021 | 49 | $388.6M |
| Q1 2021 | 46 | $358.5M |
Institutions, Q2 2025
Shares, value and share of portfolio for each institution holding Taysha Gene Therapies, Inc.; share changes are against Q1 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| XTX Topco Ltd | 320,737 | $740.9K | 0.03% | +117,608+57.9% | Added |
| D. E. Shaw & Co., Inc. | 401,509 | $927.5K | 0.00% | +401,509 | New |
| Sphera Funds Management Ltd. | 420,000 | $970.2K | 0.25% | +420,000 | New |
| Barclays PLC | 450,501 | $1.04M | 0.00% | −258,465−36.5% | Reduced |
| Bank of New York Mellon Corp | 458,659 | $1.06M | 0.00% | +5,239+1.2% | Added |
| Nuveen, LLC | 465,144 | $1.07M | 0.00% | −81,270−14.9% | Reduced |
| Acuta Capital Partners, LLC | 485,669 | $1.12M | 1.57% | +485,669 | New |
| Charles Schwab Investment Management Inc | 491,709 | $1.14M | 0.00% | −55,419−10.1% | Reduced |
| SG Americas Securities, LLC | 493,301 | $1.14M | 0.01% | +493,301 | New |
| Royal Bank of Canada | 495,311 | $1.15M | 0.00% | +493,849+33,779.0% | Added |
| Citadel Advisors LLC | 528,993 | $1.22M | 0.00% | +312,382+144.2% | Added |
| Wellington Management Group LLP | 635,968 | $1.47M | 0.00% | +10,770+1.7% | Added |
| Alphabet Inc. | 640,882 | $1.48M | 0.07% | 00.0% | Unchanged |
| Sands Capital Ventures, LLC | 724,873 | $1.67M | 0.33% | 00.0% | Unchanged |
| Bank of America Corp | 730,728 | $1.69M | 0.00% | +93,886+14.7% | Added |
| Anson Funds Management LP | 803,500 | $1.86M | 0.34% | +803,500 | New |
| Quantum Private Wealth, LLC | 815,976 | $1.88M | 0.61% | +24,500+3.1% | Added |
| Tang Capital Management LLC | 900,000 | $2.08M | 0.11% | +900,000 | New |
| Granahan Investment Management Inc | 958,493 | $2.21M | 0.09% | −682,300−41.6% | Reduced |
| Woodline Partners LP | 1,000,254 | $2.31M | 0.01% | +142,000+16.5% | Added |
| StemPoint Capital LP | 1,203,941 | $2.78M | 0.90% | +1,203,941 | New |
| Palo Alto Investors LP | 1,246,033 | $2.88M | 0.61% | −173,435−12.2% | Reduced |
| Northern Trust Corp | 1,328,741 | $3.07M | 0.00% | −102,925−7.2% | Reduced |
| Great Point Partners LLC | 1,500,000 | $3.46M | 2.25% | +1,500,000 | New |
| B Group, Inc. | 1,800,556 | $4.16M | 3.59% | +545,000+43.4% | Added |
| Millennium Management LLC | 2,935,728 | $6.78M | 0.01% | +1,163,074+65.6% | Added |
| MPM Oncology Impact Management LP | 2,953,562 | $6.82M | 1.18% | +2,953,562 | New |
| Vestal Point Capital, LP | 3,000,000 | $6.93M | 0.36% | +3,000,000 | New |
| ADAR1 Capital Management, LLC | 3,009,870 | $6.95M | 1.13% | +1,943,561+182.3% | Added |
| Suvretta Capital Management, LLC | 3,217,449 | $7.43M | 0.28% | +3,217,449 | New |
| Geode Capital Management, LLC | 3,793,572 | $8.77M | 0.00% | +128,840+3.5% | Added |
| Baker Bros. Advisors LP | 4,004,756 | $9.25M | 0.09% | 00.0% | Unchanged |
| Tybourne Capital Management (HK) Ltd | 4,095,000 | $9.46M | 27.39% | +395,000+10.7% | Added |
| Toronto Dominion Bank | 4,728,806 | $10.9M | 0.02% | +4,728,806 | New |
| Adage Capital Partners GP, L.L.C. | 4,839,000 | $11.2M | 0.02% | +4,839,000 | New |
| Polar Capital Holdings Plc | 5,000,000 | $11.6M | 0.06% | +2,000,000+66.7% | Added |
| State Street Corp | 5,138,310 | $11.9M | 0.00% | +1,904,798+58.9% | Added |
| Deerfield Management Company, L.P. (Series C) | 5,386,000 | $12.4M | 0.23% | +5,386,000 | New |
| Point72 Asset Management, L.P. | 7,317,614 | $16.9M | 0.04% | +2,747,936+60.1% | Added |
| Jefferies Financial Group Inc. | 10,313,733 | $23.8M | 0.39% | +10,068,479+4,105.3% | Added |
| Vanguard Group Inc | 10,894,127 | $25.2M | 0.00% | +2,123,206+24.2% | Added |
| Siren, L.L.C. | 11,014,737 | $25.4M | 1.32% | +4,500,000+69.1% | Added |
| Goldman Sachs Group Inc | 12,587,700 | $29.1M | 0.00% | +12,228,693+3,406.3% | Added |
| Octagon Capital Advisors LP | 12,592,500 | $29.1M | 6.39% | +1,892,500+17.7% | Added |
| BlackRock, Inc. | 13,303,775 | $30.7M | 0.00% | −285,403−2.1% | Reduced |
| FMR LLC | 15,627,822 | $36.1M | 0.00% | −4,1320.0% | Reduced |
| Morgan Stanley | 16,865,082 | $39.0M | 0.00% | +18,708+0.1% | Added |
| Avoro Capital Advisors LLC | 21,700,000 | $50.1M | 0.88% | +1,700,001+8.5% | Added |
| Ra Capital Management, L.P. | 23,555,648 | $54.4M | 0.92% | +12,683,145+116.7% | Added |
| RTW Investments, LP | 25,021,584 | $57.8M | 0.82% | +6,233,718+33.2% | Added |
| Superstring Capital Management LP | 0 | $0 | 0.00% | −755,599−100.0% | Sold out |
| DAFNA Capital Management LLC | 0 | $0 | 0.00% | −522,500−100.0% | Sold out |
| HRT Financial LP | 0 | $0 | 0.00% | −139,692−100.0% | Sold out |
| BIT Capital GmbH | 0 | $0 | 0.00% | −117,062−100.0% | Sold out |
| Corebridge Financial, Inc. | 0 | $0 | 0.00% | −85,878−100.0% | Sold out |
| Y-Intercept (Hong Kong) Ltd | 0 | $0 | 0.00% | −83,864−100.0% | Sold out |
| Mariner, LLC | 0 | $0 | 0.00% | −58,490−100.0% | Sold out |
| Jain Global LLC | 0 | $0 | 0.00% | −45,200−100.0% | Sold out |
| Ameriprise Financial Inc | 0 | $0 | 0.00% | −22,844−100.0% | Sold out |
| HSBC Holdings PLC | 0 | $0 | 0.00% | −20,257−100.0% | Sold out |
| Two Sigma Securities, LLC | 0 | $0 | 0.00% | −13,071−100.0% | Sold out |
| SIH Partners, LLLP | 0 | $0 | 0.00% | −12,173−100.0% | Sold out |
| Catalyst Funds Management Pty Ltd | 0 | $0 | 0.00% | −11,900−100.0% | Sold out |
| Camelot Portfolios, LLC | 0 | $0 | 0.00% | −11,000−100.0% | Sold out |
| CIBC Private Wealth Group, LLC | 0 | $0 | 0.00% | −6,833−100.0% | Sold out |
| Allworth Financial LP | 0 | $0 | 0.00% | −1,000−100.0% | Sold out |
| Signaturefd, LLC | 0 | $0 | 0.00% | −553−100.0% | Sold out |
| CoreCap Advisors, LLC | 0 | $0 | 0.00% | −290−100.0% | Sold out |
| Coldstream Capital Management Inc | 0 | $0 | 0.00% | −207−100.0% | Sold out |
| Quadrant Capital Group LLC | 0 | $0 | 0.00% | −2−100.0% | Sold out |
| Lindbrook Capital, LLC | – | – | – | – | Not filed |