Rhythm Pharmaceuticals, Inc.
RYTM- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001649904
In the last 90 days, Rhythm Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 304 institutions reported holding it in 13F filings for Q2 2026, worth $8.55B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Rhythm Pharmaceuticals, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 281
- +19 vs. Q3 2025
- Shares held
- 72.9M
- +2.01M (+2.8%) vs. Q3 2025
- Total value
- $7.80B
- +$602.5M (+8.4%) vs. Q3 2025
- New holders
- 58
- 107 more added
- Sold out
- 39
- 89 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting RYTM on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 304 | $8.55B |
| Q1 2026 | 285 | $6.42B |
| Q4 2025 | 281 | $7.80B |
| Q3 2025 | 264 | $7.20B |
| Q2 2025 | 227 | $4.20B |
| Q1 2025 | 228 | $3.44B |
| Q4 2024 | 203 | $3.63B |
| Q3 2024 | 176 | $3.55B |
| Q2 2024 | 165 | $2.85B |
| Q1 2024 | 167 | $2.95B |
| Q4 2023 | 169 | $3.07B |
| Q3 2023 | 144 | $1.56B |
| Q2 2023 | 116 | $1.09B |
| Q1 2023 | 126 | $1.08B |
| Q4 2022 | 115 | $1.81B |
| Q3 2022 | 101 | $1.45B |
| Q2 2022 | 90 | $190.8M |
| Q1 2022 | 111 | $562.7M |
| Q4 2021 | 98 | $483.6M |
| Q3 2021 | 97 | $626.3M |
| Q2 2021 | 105 | $905.6M |
| Q1 2021 | 124 | $1.01B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Rhythm Pharmaceuticals, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Inceptionr LLC | 0 | $0 | 0.00% | −7,482−100.0% | Sold out |
| Arrowstreet Capital, Limited Partnership | 0 | $0 | 0.00% | −6,307−100.0% | Sold out |
| Oxford Asset Management LLP | 0 | $0 | 0.00% | −5,538−100.0% | Sold out |
| Quantbot Technologies LP | 0 | $0 | 0.00% | −4,981−100.0% | Sold out |
| Gsa Capital Partners LLP | 0 | $0 | 0.00% | −3,897−100.0% | Sold out |
| FORA Capital, LLC | 0 | $0 | 0.00% | −3,599−100.0% | Sold out |
| Mariner, LLC | 0 | $0 | 0.00% | −3,597−100.0% | Sold out |
| Capstone Investment Advisors, LLC | 0 | $0 | 0.00% | −3,497−100.0% | Sold out |
| National Asset Management, Inc. | 0 | $0 | 0.00% | −2,675−100.0% | Sold out |
| Fox Run Management, L.L.C. | 0 | $0 | 0.00% | −2,517−100.0% | Sold out |
| Integrated Wealth Concepts LLC | 0 | $0 | 0.00% | −2,491−100.0% | Sold out |
| American Century Companies Inc | 0 | $0 | 0.00% | −2,077−100.0% | Sold out |
| EntryPoint Capital, LLC | 0 | $0 | 0.00% | −1,993−100.0% | Sold out |
| RWC Asset Management LLP | 0 | $0 | 0.00% | −1,988−100.0% | Sold out |
| Bank of Montreal | 0 | $0 | 0.00% | −715−100.0% | Sold out |
| Quadrant Capital Group LLC | 0 | $0 | 0.00% | −42−100.0% | Sold out |
| Aster Capital Management (DIFC) Ltd | 0 | $0 | 0.00% | −40−100.0% | Sold out |
| J.Safra Asset Management Corp | 0 | $0 | 0.00% | −20−100.0% | Sold out |
| Advisory Services Network, LLC | 0 | $0 | 0.00% | −19−100.0% | Sold out |
| Wealthspire Advisors, LLC | 0 | $0 | 0.00% | −1−100.0% | Sold out |
| EFG Asset Management (North America) Corp. | – | – | – | – | Not filed |
| CIBC Bancorp USA Inc. | – | – | – | – | Not filed |