Prime Medicine, Inc.
PRME- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001894562
No open-market purchases or sales by Prime Medicine, Inc. insiders were filed in the last 90 days; 187 institutions reported holding it in 13F filings for Q2 2026, worth $393.5M in total; ARK Invest is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Prime Medicine, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 183
- +18 vs. Q3 2025
- Shares held
- 97.0M
- +6.43M (+7.1%) vs. Q3 2025
- Total value
- $336.5M
- −$165.1M (−32.9%) vs. Q3 2025
- New holders
- 44
- 66 more added
- Sold out
- 26
- 40 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PRME on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 187 | $393.5M |
| Q1 2026 | 192 | $342.6M |
| Q4 2025 | 183 | $336.5M |
| Q3 2025 | 167 | $511.5M |
| Q2 2025 | 121 | $145.0M |
| Q1 2025 | 125 | $120.4M |
| Q4 2024 | 132 | $188.0M |
| Q3 2024 | 116 | $265.9M |
| Q2 2024 | 122 | $354.0M |
| Q1 2024 | 115 | $466.6M |
| Q4 2023 | 105 | $431.4M |
| Q3 2023 | 83 | $472.3M |
| Q2 2023 | 79 | $675.7M |
| Q1 2023 | 76 | $512.1M |
| Q4 2022 | 66 | $767.8M |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Prime Medicine, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| ExodusPoint Capital Management, LP | 0 | $0 | 0.00% | −33,494−100.0% | Sold out |
| Bank of Nova Scotia | 0 | $0 | 0.00% | −25,500−100.0% | Sold out |
| Turtle Creek Wealth Advisors, LLC | 0 | $0 | 0.00% | −25,000−100.0% | Sold out |
| Owen LaRue, LLC | 0 | $0 | 0.00% | −19,032−100.0% | Sold out |
| Hudson Bay Capital Management LP | 0 | $0 | 0.00% | −13,025−100.0% | Sold out |
| SRS Capital Advisors, Inc. | 0 | $0 | 0.00% | −5,406−100.0% | Sold out |
| National Bank of Canada | 0 | $0 | 0.00% | −4,500−100.0% | Sold out |
| Principal Securities, Inc. | 0 | $0 | 0.00% | −200−100.0% | Sold out |
| Larson Financial Group LLC | 0 | $0 | 0.00% | −6−100.0% | Sold out |
| MWG Management Limited | – | – | – | – | Not filed |
| FSA Wealth Management LLC | – | – | – | – | Not filed |