Prelude Therapeutics Inc
PRLD- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001678660
No open-market purchases or sales by Prelude Therapeutics Inc insiders were filed in the last 90 days; 75 institutions reported holding it in 13F filings for Q2 2026, worth $264.3M in total; no superinvestor holds it.
13F holders, Q1 2026
Institutional positions in Prelude Therapeutics Inc as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 55
- +8 vs. Q4 2025
- Shares held
- 30.8M
- +3.71M (+13.7%) vs. Q4 2025
- Total value
- $105.2M
- +$26.8M (+34.1%) vs. Q4 2025
- New holders
- 13
- 20 more added
- Sold out
- 5
- 11 more reduced
1 institution that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PRLD on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 75 | $264.3M |
| Q1 2026 | 55 | $105.2M |
| Q4 2025 | 48 | $82.6M |
| Q3 2025 | 47 | $39.1M |
| Q2 2025 | 50 | $22.0M |
| Q1 2025 | 59 | $23.3M |
| Q4 2024 | 62 | $41.0M |
| Q3 2024 | 70 | $74.0M |
| Q2 2024 | 61 | $129.2M |
| Q1 2024 | 58 | $162.1M |
| Q4 2023 | 56 | $148.3M |
| Q3 2023 | 60 | $113.1M |
| Q2 2023 | 55 | $176.2M |
| Q1 2023 | 55 | $179.6M |
| Q4 2022 | 60 | $188.3M |
| Q3 2022 | 53 | $210.3M |
| Q2 2022 | 62 | $170.9M |
| Q1 2022 | 68 | $235.4M |
| Q4 2021 | 75 | $437.6M |
| Q3 2021 | 61 | $1.12B |
| Q2 2021 | 57 | $986.6M |
| Q1 2021 | 60 | $1.41B |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Prelude Therapeutics Inc; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| OrbiMed Advisors LLC | 10,909,256 | $37.3M | 0.85% | 00.0% | Unchanged |
| Baker Bros. Advisors LP | 10,123,824 | $34.6M | 0.20% | 00.0% | Unchanged |
| Kynam Capital Management, LP | 1,592,551 | $5.45M | 0.35% | +803,684+101.9% | Added |
| Vanguard Capital Management LLC | 1,230,406 | $4.21M | 0.00% | +1,230,406 | New |
| EcoR1 Capital, LLC | 947,049 | $3.24M | 0.14% | +947,049 | New |
| Two Sigma Investments, LP | 923,626 | $3.16M | 0.00% | +134,931+17.1% | Added |
| Sphera Funds Management Ltd. | 558,339 | $1.91M | 0.33% | +435,587+354.9% | Added |
| Acadian Asset Management LLC | 511,519 | $1.75M | 0.00% | −24,184−4.5% | Reduced |
| Millennium Management LLC | 382,737 | $1.31M | 0.00% | +231,740+153.5% | Added |
| Marshall Wace, LLP | 358,906 | $1.23M | 0.00% | +85,023+31.0% | Added |
| Morgan Stanley | 322,161 | $1.10M | 0.00% | −12,755−3.8% | Reduced |
| BlackRock, Inc. | 321,886 | $1.10M | 0.00% | +55,606+20.9% | Added |
| Geode Capital Management, LLC | 302,458 | $1.03M | 0.00% | +29,572+10.8% | Added |
| Renaissance Technologies LLC | 275,200 | $941.2K | 0.00% | +3,900+1.4% | Added |
| Susquehanna International Group, LLP | 267,788 | $915.8K | 0.00% | +131,879+97.0% | Added |
| Goldman Sachs Group Inc | 236,469 | $808.7K | 0.00% | +118,992+101.3% | Added |
| Jane Street Group, LLC | 192,963 | $659.9K | 0.00% | +81,923+73.8% | Added |
| Vanguard Fiduciary Trust Co | 157,380 | $538.2K | 0.00% | +157,380 | New |
| ADAR1 Capital Management, LLC | 152,825 | $522.7K | 0.03% | +152,825 | New |
| State Street Corp | 138,231 | $472.8K | 0.00% | +10,939+8.6% | Added |
| Citadel Advisors LLC | 124,378 | $425.4K | 0.00% | +124,378 | New |
| Connor, Clark & Lunn Investment Management Ltd. | 109,085 | $373.1K | 0.00% | +62,995+136.7% | Added |
| UBS Group AG | 64,505 | $220.6K | 0.00% | +62,648+3,373.6% | Added |
| HRT Financial LP | 58,699 | $200.0K | 0.00% | +58,699 | New |
| XTX Topco Ltd | 57,190 | $195.6K | 0.00% | +7,031+14.0% | Added |
| Bank of America Corp | 56,525 | $193.3K | 0.00% | +46,717+476.3% | Added |
| Bridgeway Capital Management, LLC | 53,500 | $183.0K | 0.00% | 00.0% | Unchanged |
| Northern Trust Corp | 50,120 | $171.4K | 0.00% | 00.0% | Unchanged |
| Colony Group, LLC | 50,007 | $171.0K | 0.00% | 00.0% | Unchanged |
| Dimensional Fund Advisors LP | 35,210 | $119.7K | 0.00% | +35,210 | New |
| Cerity Partners LLC | 32,875 | $112.4K | 0.00% | −78−0.2% | Reduced |
| Omers Administration Corp | 32,700 | $111.8K | 0.00% | −40,300−55.2% | Reduced |
| Prudential Financial Inc | 17,420 | $59.6K | 0.00% | +1,900+12.2% | Added |
| Qube Research & Technologies Ltd | 16,417 | $56.1K | 0.00% | −5,134−23.8% | Reduced |
| Point72 Asset Management, L.P. | 16,329 | $55.8K | 0.00% | −42,839−72.4% | Reduced |
| HSBC Holdings PLC | 13,652 | $47.9K | 0.00% | 00.0% | Unchanged |
| Diametric Capital, LP | 11,980 | $41.0K | 0.01% | +11,980 | New |
| Nine Masts Capital Ltd | 11,699 | $40.0K | 0.01% | +11,699 | New |
| Graham Capital Management, L.P. | 11,343 | $38.8K | 0.00% | +11,343 | New |
| American Century Companies Inc | 10,294 | $35.2K | 0.00% | +10,294 | New |
| Barclays PLC | 8,600 | $29.4K | 0.00% | −20.0% | Reduced |
| FMR LLC | 6,009 | $20.6K | 0.00% | −143−2.3% | Reduced |
| Vanguard Global Advisers, LLC | 4,636 | $15.9K | 0.00% | +4,636 | New |
| Group One Trading, L.P. | 3,907 | $13.4K | 0.00% | +3,407+681.4% | Added |
| SBI Securities Co., Ltd. | 2,641 | $9.03K | 0.00% | −100−3.6% | Reduced |
| Royal Bank of Canada | 2,331 | $8.00K | 0.00% | +589+33.8% | Added |
| Nisa Investment Advisors, LLC | 1,634 | $5.59K | 0.00% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 1,171 | $4.00K | 0.00% | 00.0% | Unchanged |
| Caldwell Sutter Capital, Inc. | 1,000 | $3.42K | 0.00% | −1,000−50.0% | Reduced |
| CWM, LLC | 573 | $1.96K | 0.00% | −119−17.2% | Reduced |
| Fortitude Family Office, LLC | 230 | $787 | 0.00% | +230 | New |
| BNP Paribas Arbitrage, SA | 95 | $325 | 0.00% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 62 | $190 | 0.00% | 00.0% | Unchanged |
| Optiver Holding B.V. | 20 | $68 | 0.00% | 00.0% | Unchanged |
| Citigroup Inc | 5 | $17 | 0.00% | +4+400.0% | Added |
| Price T Rowe Associates Inc | 0 | $0 | 0.00% | −755,956−100.0% | Sold out |
| Two Sigma Advisers, LP | 0 | $0 | 0.00% | −237,300−100.0% | Sold out |
| TD Asset Management Inc | 0 | $0 | 0.00% | −160,652−100.0% | Sold out |
| Manufacturers Life Insurance Company, The | 0 | $0 | 0.00% | −70,546−100.0% | Sold out |
| IFP Advisors, Inc | 0 | $0 | 0.00% | −1−100.0% | Sold out |
| Vanguard Group Inc | – | – | – | – | Not filed |