Prelude Therapeutics Inc
PRLD- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001678660
No open-market purchases or sales by Prelude Therapeutics Inc insiders were filed in the last 90 days; 75 institutions reported holding it in 13F filings for Q2 2026, worth $264.3M in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Prelude Therapeutics Inc as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 48
- +1 vs. Q3 2025
- Shares held
- 28.5M
- +1.31M (+4.8%) vs. Q3 2025
- Total value
- $82.6M
- +$43.5M (+111.1%) vs. Q3 2025
- New holders
- 10
- 14 more added
- Sold out
- 9
- 15 more reduced
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PRLD on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 75 | $264.3M |
| Q1 2026 | 55 | $105.2M |
| Q4 2025 | 48 | $82.6M |
| Q3 2025 | 47 | $39.1M |
| Q2 2025 | 50 | $22.0M |
| Q1 2025 | 59 | $23.3M |
| Q4 2024 | 62 | $41.0M |
| Q3 2024 | 70 | $74.0M |
| Q2 2024 | 61 | $129.2M |
| Q1 2024 | 58 | $162.1M |
| Q4 2023 | 56 | $148.3M |
| Q3 2023 | 60 | $113.1M |
| Q2 2023 | 55 | $176.2M |
| Q1 2023 | 55 | $179.6M |
| Q4 2022 | 60 | $188.3M |
| Q3 2022 | 53 | $210.3M |
| Q2 2022 | 62 | $170.9M |
| Q1 2022 | 68 | $235.4M |
| Q4 2021 | 75 | $437.6M |
| Q3 2021 | 61 | $1.12B |
| Q2 2021 | 57 | $986.6M |
| Q1 2021 | 60 | $1.41B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Prelude Therapeutics Inc; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| OrbiMed Advisors LLC | 10,909,256 | $31.6M | 0.65% | 00.0% | Unchanged |
| Baker Bros. Advisors LP | 10,123,824 | $29.4M | 0.17% | 00.0% | Unchanged |
| Vanguard Group Inc | 1,413,986 | $4.10M | 0.00% | +421,132+42.4% | Added |
| Kynam Capital Management, LP | 788,867 | $2.29M | 0.15% | +788,867 | New |
| Two Sigma Investments, LP | 788,695 | $2.29M | 0.00% | +636,462+418.1% | Added |
| Price T Rowe Associates Inc | 755,956 | $2.19M | 0.00% | −120,382−13.7% | Reduced |
| Acadian Asset Management LLC | 535,703 | $1.55M | 0.00% | −4,862−0.9% | Reduced |
| Morgan Stanley | 334,916 | $971.3K | 0.00% | +50,713+17.8% | Added |
| Marshall Wace, LLP | 273,883 | $794.3K | 0.00% | +273,883 | New |
| Geode Capital Management, LLC | 272,886 | $791.5K | 0.00% | +55,318+25.4% | Added |
| Renaissance Technologies LLC | 271,300 | $786.8K | 0.00% | −272,700−50.1% | Reduced |
| BlackRock, Inc. | 266,280 | $772.2K | 0.00% | +1,307+0.5% | Added |
| Two Sigma Advisers, LP | 237,300 | $688.2K | 0.00% | +14,600+6.6% | Added |
| TD Asset Management Inc | 160,652 | $465.9K | 0.00% | 00.0% | Unchanged |
| Millennium Management LLC | 150,997 | $437.9K | 0.00% | −996,047−86.8% | Reduced |
| Susquehanna International Group, LLP | 135,909 | $394.1K | 0.00% | +135,909 | New |
| State Street Corp | 127,292 | $369.1K | 0.00% | +29,700+30.4% | Added |
| Sphera Funds Management Ltd. | 122,752 | $356.0K | 0.07% | +122,752 | New |
| Goldman Sachs Group Inc | 117,477 | $340.7K | 0.00% | +38,150+48.1% | Added |
| Jane Street Group, LLC | 111,040 | $322.0K | 0.00% | +76,218+218.9% | Added |
| Omers Administration Corp | 73,000 | $211.7K | 0.00% | +73,000 | New |
| Manufacturers Life Insurance Company, The | 70,546 | $200.4K | 0.00% | +1,294+1.9% | Added |
| Point72 Asset Management, L.P. | 59,168 | $171.6K | 0.00% | +59,168 | New |
| Bridgeway Capital Management, LLC | 53,500 | $155.2K | 0.00% | 00.0% | Unchanged |
| XTX Topco Ltd | 50,159 | $145.5K | 0.00% | +34,581+222.0% | Added |
| Northern Trust Corp | 50,120 | $145.3K | 0.00% | +13,699+37.6% | Added |
| Colony Group, LLC | 50,007 | $145.0K | 0.00% | +50,007 | New |
| Connor, Clark & Lunn Investment Management Ltd. | 46,090 | $133.7K | 0.00% | +46,090 | New |
| Cerity Partners LLC | 32,953 | $95.6K | 0.00% | −1,380−4.0% | Reduced |
| Qube Research & Technologies Ltd | 21,551 | $62.5K | 0.00% | +21,551 | New |
| Prudential Financial Inc | 15,520 | $45.0K | 0.00% | −10,320−39.9% | Reduced |
| HSBC Holdings PLC | 13,652 | $39.5K | 0.00% | −95−0.7% | Reduced |
| Bank of America Corp | 9,808 | $28.4K | 0.00% | +960+10.8% | Added |
| Barclays PLC | 8,602 | $24.9K | 0.00% | −110−1.3% | Reduced |
| FMR LLC | 6,152 | $17.8K | 0.00% | −2,947−32.4% | Reduced |
| SBI Securities Co., Ltd. | 2,741 | $7.95K | 0.00% | 00.0% | Unchanged |
| Caldwell Sutter Capital, Inc. | 2,000 | $5.80K | 0.00% | +2,000 | New |
| UBS Group AG | 1,857 | $5.38K | 0.00% | −2,314−55.5% | Reduced |
| Royal Bank of Canada | 1,742 | $5.00K | 0.00% | −5,970−77.4% | Reduced |
| Nisa Investment Advisors, LLC | 1,634 | $4.74K | 0.00% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 1,171 | $3.40K | 0.00% | 00.0% | Unchanged |
| CWM, LLC | 692 | $2.00K | 0.00% | −527−43.2% | Reduced |
| Group One Trading, L.P. | 500 | $1.45K | 0.00% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 95 | $276 | 0.00% | +43+82.7% | Added |
| JPMorgan Chase & Co | 62 | $180 | 0.00% | −3,817−98.4% | Reduced |
| Optiver Holding B.V. | 20 | $58 | 0.00% | 00.0% | Unchanged |
| Citigroup Inc | 1 | $3 | 0.00% | −5,974−100.0% | Reduced |
| IFP Advisors, Inc | 1 | $3 | 0.00% | −17−94.4% | Reduced |
| Shay Capital LLC | 0 | $0 | 0.00% | −100,000−100.0% | Sold out |
| Gsa Capital Partners LLP | 0 | $0 | 0.00% | −75,161−100.0% | Sold out |
| HRT Financial LP | 0 | $0 | 0.00% | −16,901−100.0% | Sold out |
| AQR Capital Management LLC | 0 | $0 | 0.00% | −10,500−100.0% | Sold out |
| Tower Research Capital LLC (TRC) | 0 | $0 | 0.00% | −6,927−100.0% | Sold out |
| EverSource Wealth Advisors, LLC | 0 | $0 | 0.00% | −89−100.0% | Sold out |
| Essential Partners LLC | 0 | $0 | 0.00% | −17−100.0% | Sold out |
| SRS Capital Advisors, Inc. | 0 | $0 | 0.00% | −15−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −153−100.0% | Sold out |