Prelude Therapeutics Inc
PRLD- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001678660
No open-market purchases or sales by Prelude Therapeutics Inc insiders were filed in the last 90 days; 75 institutions reported holding it in 13F filings for Q2 2026, worth $264.3M in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Prelude Therapeutics Inc as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 48
- +1 vs. Q3 2025
- Shares held
- 28.5M
- +1.31M (+4.8%) vs. Q3 2025
- Total value
- $82.6M
- +$43.5M (+111.1%) vs. Q3 2025
- New holders
- 10
- 14 more added
- Sold out
- 9
- 15 more reduced
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PRLD on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 75 | $264.3M |
| Q1 2026 | 55 | $105.2M |
| Q4 2025 | 48 | $82.6M |
| Q3 2025 | 47 | $39.1M |
| Q2 2025 | 50 | $22.0M |
| Q1 2025 | 59 | $23.3M |
| Q4 2024 | 62 | $41.0M |
| Q3 2024 | 70 | $74.0M |
| Q2 2024 | 61 | $129.2M |
| Q1 2024 | 58 | $162.1M |
| Q4 2023 | 56 | $148.3M |
| Q3 2023 | 60 | $113.1M |
| Q2 2023 | 55 | $176.2M |
| Q1 2023 | 55 | $179.6M |
| Q4 2022 | 60 | $188.3M |
| Q3 2022 | 53 | $210.3M |
| Q2 2022 | 62 | $170.9M |
| Q1 2022 | 68 | $235.4M |
| Q4 2021 | 75 | $437.6M |
| Q3 2021 | 61 | $1.12B |
| Q2 2021 | 57 | $986.6M |
| Q1 2021 | 60 | $1.41B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Prelude Therapeutics Inc; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Citigroup Inc | 1 | $3 | 0.00% | −5,974−100.0% | Reduced |
| IFP Advisors, Inc | 1 | $3 | 0.00% | −17−94.4% | Reduced |
| Optiver Holding B.V. | 20 | $58 | 0.00% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 62 | $180 | 0.00% | −3,817−98.4% | Reduced |
| BNP Paribas Arbitrage, SA | 95 | $276 | 0.00% | +43+82.7% | Added |
| Group One Trading, L.P. | 500 | $1.45K | 0.00% | 00.0% | Unchanged |
| CWM, LLC | 692 | $2.00K | 0.00% | −527−43.2% | Reduced |
| The PNC Financial Services Group, Inc. | 1,171 | $3.40K | 0.00% | 00.0% | Unchanged |
| Nisa Investment Advisors, LLC | 1,634 | $4.74K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 1,742 | $5.00K | 0.00% | −5,970−77.4% | Reduced |
| UBS Group AG | 1,857 | $5.38K | 0.00% | −2,314−55.5% | Reduced |
| Caldwell Sutter Capital, Inc. | 2,000 | $5.80K | 0.00% | +2,000 | New |
| SBI Securities Co., Ltd. | 2,741 | $7.95K | 0.00% | 00.0% | Unchanged |
| FMR LLC | 6,152 | $17.8K | 0.00% | −2,947−32.4% | Reduced |
| Barclays PLC | 8,602 | $24.9K | 0.00% | −110−1.3% | Reduced |
| Bank of America Corp | 9,808 | $28.4K | 0.00% | +960+10.8% | Added |
| HSBC Holdings PLC | 13,652 | $39.5K | 0.00% | −95−0.7% | Reduced |
| Prudential Financial Inc | 15,520 | $45.0K | 0.00% | −10,320−39.9% | Reduced |
| Qube Research & Technologies Ltd | 21,551 | $62.5K | 0.00% | +21,551 | New |
| Cerity Partners LLC | 32,953 | $95.6K | 0.00% | −1,380−4.0% | Reduced |
| Connor, Clark & Lunn Investment Management Ltd. | 46,090 | $133.7K | 0.00% | +46,090 | New |
| Colony Group, LLC | 50,007 | $145.0K | 0.00% | +50,007 | New |
| Northern Trust Corp | 50,120 | $145.3K | 0.00% | +13,699+37.6% | Added |
| XTX Topco Ltd | 50,159 | $145.5K | 0.00% | +34,581+222.0% | Added |
| Bridgeway Capital Management, LLC | 53,500 | $155.2K | 0.00% | 00.0% | Unchanged |
| Point72 Asset Management, L.P. | 59,168 | $171.6K | 0.00% | +59,168 | New |
| Manufacturers Life Insurance Company, The | 70,546 | $200.4K | 0.00% | +1,294+1.9% | Added |
| Omers Administration Corp | 73,000 | $211.7K | 0.00% | +73,000 | New |
| Jane Street Group, LLC | 111,040 | $322.0K | 0.00% | +76,218+218.9% | Added |
| Goldman Sachs Group Inc | 117,477 | $340.7K | 0.00% | +38,150+48.1% | Added |
| Sphera Funds Management Ltd. | 122,752 | $356.0K | 0.07% | +122,752 | New |
| State Street Corp | 127,292 | $369.1K | 0.00% | +29,700+30.4% | Added |
| Susquehanna International Group, LLP | 135,909 | $394.1K | 0.00% | +135,909 | New |
| Millennium Management LLC | 150,997 | $437.9K | 0.00% | −996,047−86.8% | Reduced |
| TD Asset Management Inc | 160,652 | $465.9K | 0.00% | 00.0% | Unchanged |
| Two Sigma Advisers, LP | 237,300 | $688.2K | 0.00% | +14,600+6.6% | Added |
| BlackRock, Inc. | 266,280 | $772.2K | 0.00% | +1,307+0.5% | Added |
| Renaissance Technologies LLC | 271,300 | $786.8K | 0.00% | −272,700−50.1% | Reduced |
| Geode Capital Management, LLC | 272,886 | $791.5K | 0.00% | +55,318+25.4% | Added |
| Marshall Wace, LLP | 273,883 | $794.3K | 0.00% | +273,883 | New |
| Morgan Stanley | 334,916 | $971.3K | 0.00% | +50,713+17.8% | Added |
| Acadian Asset Management LLC | 535,703 | $1.55M | 0.00% | −4,862−0.9% | Reduced |
| Price T Rowe Associates Inc | 755,956 | $2.19M | 0.00% | −120,382−13.7% | Reduced |
| Two Sigma Investments, LP | 788,695 | $2.29M | 0.00% | +636,462+418.1% | Added |
| Kynam Capital Management, LP | 788,867 | $2.29M | 0.15% | +788,867 | New |
| Vanguard Group Inc | 1,413,986 | $4.10M | 0.00% | +421,132+42.4% | Added |
| Baker Bros. Advisors LP | 10,123,824 | $29.4M | 0.17% | 00.0% | Unchanged |
| OrbiMed Advisors LLC | 10,909,256 | $31.6M | 0.65% | 00.0% | Unchanged |
| Shay Capital LLC | 0 | $0 | 0.00% | −100,000−100.0% | Sold out |
| Gsa Capital Partners LLP | 0 | $0 | 0.00% | −75,161−100.0% | Sold out |
| HRT Financial LP | 0 | $0 | 0.00% | −16,901−100.0% | Sold out |
| AQR Capital Management LLC | 0 | $0 | 0.00% | −10,500−100.0% | Sold out |
| Tower Research Capital LLC (TRC) | 0 | $0 | 0.00% | −6,927−100.0% | Sold out |
| EverSource Wealth Advisors, LLC | 0 | $0 | 0.00% | −89−100.0% | Sold out |
| Essential Partners LLC | 0 | $0 | 0.00% | −17−100.0% | Sold out |
| SRS Capital Advisors, Inc. | 0 | $0 | 0.00% | −15−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −153−100.0% | Sold out |