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Prelude Therapeutics Inc

PRLD
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001678660

No open-market purchases or sales by Prelude Therapeutics Inc insiders were filed in the last 90 days; 75 institutions reported holding it in 13F filings for Q2 2026, worth $264.3M in total; no superinvestor holds it.

13F holders, Q2 2025

Institutional positions in Prelude Therapeutics Inc as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
50
−9 vs. Q1 2025
Shares held
27.2M
−3.35M (−11.0%) vs. Q1 2025
Total value
$22.0M
−$1.32M (−5.6%) vs. Q1 2025
New holders
8
12 more added
Sold out
17
23 more reduced

Compare with Q1 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting PRLD on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ2 2025: 50 institutions
Q1 2021: 60 institutionsQ2 2021: 57 institutionsQ3 2021: 61 institutionsQ4 2021: 75 institutionsQ1 2022: 68 institutionsQ2 2022: 62 institutionsQ3 2022: 53 institutionsQ4 2022: 60 institutionsQ1 2023: 55 institutionsQ2 2023: 55 institutionsQ3 2023: 60 institutionsQ4 2023: 56 institutionsQ1 2024: 58 institutionsQ2 2024: 61 institutionsQ3 2024: 70 institutionsQ4 2024: 62 institutionsQ1 2025: 59 institutionsQ2 2025: 50 institutionsQ3 2025: 47 institutionsQ4 2025: 48 institutionsQ1 2026: 55 institutionsQ2 2026: 75 institutions
Value heldQ2 2025: $22.0M
Q1 2021: $1.41BQ2 2021: $986.6MQ3 2021: $1.12BQ4 2021: $437.6MQ1 2022: $235.4MQ2 2022: $170.9MQ3 2022: $210.3MQ4 2022: $188.3MQ1 2023: $179.6MQ2 2023: $176.2MQ3 2023: $113.1MQ4 2023: $148.3MQ1 2024: $162.1MQ2 2024: $129.2MQ3 2024: $74.0MQ4 2024: $41.0MQ1 2025: $23.3MQ2 2025: $22.0MQ3 2025: $39.1MQ4 2025: $82.6MQ1 2026: $105.2MQ2 2026: $264.3M
Institutions holding PRLD and their total value by quarter
QuarterHoldersValue
Q2 202675$264.3M
Q1 202655$105.2M
Q4 202548$82.6M
Q3 202547$39.1M
Q2 202550$22.0M
Q1 202559$23.3M
Q4 202462$41.0M
Q3 202470$74.0M
Q2 202461$129.2M
Q1 202458$162.1M
Q4 202356$148.3M
Q3 202360$113.1M
Q2 202355$176.2M
Q1 202355$179.6M
Q4 202260$188.3M
Q3 202253$210.3M
Q2 202262$170.9M
Q1 202268$235.4M
Q4 202175$437.6M
Q3 202161$1.12B
Q2 202157$986.6M
Q1 202160$1.41B

Institutions, Q2 2025

Shares, value and share of portfolio for each institution holding Prelude Therapeutics Inc; share changes are against Q1 2025.

Institutions holding PRLD in Q2 2025
InstitutionSharesValue% of portfolioChange in sharesAction
OrbiMed Advisors LLC10,909,256$8.83M0.22%00.0%Unchanged
Baker Bros. Advisors LP10,123,824$8.19M0.08%00.0%Unchanged
Vanguard Group Inc932,570$754.5K0.00%−76,634−7.6%Reduced
Price T Rowe Associates Inc927,608$743.0K0.00%−48,539−5.0%Reduced
Renaissance Technologies LLC581,800$470.9K0.00%−74,900−11.4%Reduced
Acadian Asset Management LLC540,565$436.0K0.00%+11,238+2.1%Added
BlackRock, Inc.432,559$350.1K0.00%−615,166−58.7%Reduced
Morgan Stanley284,382$230.2K0.00%−18,397−6.1%Reduced
Millennium Management LLC248,423$201.1K0.00%+101,653+69.3%Added
Two Sigma Advisers, LP225,000$182.1K0.00%−35,400−13.6%Reduced
Geode Capital Management, LLC217,568$176.1K0.00%−187,387−46.3%Reduced
Cantor Fitzgerald, L. P.211,859$171.5K0.00%+211,859New
TD Asset Management Inc160,652$130.0K0.00%00.0%Unchanged
Two Sigma Investments, LP154,977$125.4K0.00%−28,690−15.6%Reduced
Goldman Sachs Group Inc149,178$120.7K0.00%−6,037−3.9%Reduced
UBS Group AG104,204$84.3K0.00%+8,048+8.4%Added
State Street Corp97,592$79.0K0.00%−188,454−65.9%Reduced
Jane Street Group, LLC91,753$74.3K0.00%+91,753New
Bridgeway Capital Management, LLC88,500$71.6K0.00%00.0%Unchanged
Charles Schwab Investment Management Inc80,845$65.4K0.00%−33,205−29.1%Reduced
Shay Capital LLC75,000$60.7K0.01%+75,000New
Gsa Capital Partners LLP71,378$58.0K0.00%+71,378New
Manufacturers Life Insurance Company, The69,252$56.1K0.00%00.0%Unchanged
Y-Intercept (Hong Kong) Ltd47,788$38.7K0.00%+47,788New
AQR Capital Management LLC43,647$35.3K0.00%+9,824+29.0%Added
XTX Topco Ltd42,573$34.5K0.00%+17,873+72.4%Added
Marshall Wace, LLP41,747$33.8K0.00%+41,747New
Susquehanna International Group, LLP39,977$32.4K0.00%−37,893−48.7%Reduced
Northern Trust Corp38,127$30.9K0.00%−78,780−67.4%Reduced
Cerity Partners LLC36,393$29.5K0.00%+1,828+5.3%Added
Citadel Advisors LLC33,625$27.2K0.00%+33,591+98,797.1%Added
HSBC Holdings PLC17,411$13.9K0.00%−3,219−15.6%Reduced
Tower Research Capital LLC (TRC)16,799$13.6K0.00%+3,213+23.6%Added
Bank of America Corp11,293$9.14K0.00%−4,153−26.9%Reduced
FMR LLC11,167$9.04K0.00%−9,071−44.8%Reduced
Barclays PLC8,602$6.96K0.00%−14,543−62.8%Reduced
Citigroup Inc4,718$3.82K0.00%−4,582−49.3%Reduced
CWM, LLC4,014$3.00K0.00%+668+20.0%Added
SBI Securities Co., Ltd.2,741$2.22K0.00%00.0%Unchanged
Royal Bank of Canada2,827$2.00K0.00%−517−15.5%Reduced
JPMorgan Chase & Co1,949$1.58K0.00%−21,831−91.8%Reduced
Nisa Investment Advisors, LLC1,634$1.32K0.00%+1,234+308.5%Added
The PNC Financial Services Group, Inc.1,180$9560.00%−12−1.0%Reduced
Group One Trading, L.P.500$4050.00%00.0%Unchanged
Wells Fargo & Company297$2400.00%−7,615−96.2%Reduced
EverSource Wealth Advisors, LLC148$1200.00%+139+1,544.4%Added
Essential Partners LLC87$700.00%+87New
BNP Paribas Arbitrage, SA52$420.00%−19,616−99.7%Reduced
IFP Advisors, Inc34$280.00%+34New
True Wealth Design, LLC13$110.00%+3+30.0%Added
Boxer Capital Management, LLC0$00.00%−2,108,014−100.0%Sold out
Deutsche Bank AG0$00.00%−80,723−100.0%Sold out
Marex Group plc0$00.00%−56,270−100.0%Sold out
Simplex Trading, LLC0$00.00%−41,846−100.0%Sold out
Bank of New York Mellon Corp0$00.00%−28,613−100.0%Sold out
SG Americas Securities, LLC0$00.00%−17,251−100.0%Sold out
Rhumbline Advisers0$00.00%−15,499−100.0%Sold out
Mirae Asset Global ETFs Holdings Ltd.0$00.00%−7,887−100.0%Sold out
Corebridge Financial, Inc.0$00.00%−6,458−100.0%Sold out
Militia Capital Partners, LP0$00.00%−4,300−100.0%Sold out
New York State Common Retirement Fund0$00.00%−3,622−100.0%Sold out
Legal & General Group Plc0$00.00%−962−100.0%Sold out
California State Teachers Retirement System0$00.00%−955−100.0%Sold out
Ameritas Investment Partners, Inc.0$00.00%−819−100.0%Sold out
Sterling Capital Management LLC0$00.00%−227−100.0%Sold out
Amalgamated Bank0$00.00%−334−100.0%Sold out
Nuveen, LLC0$00.00%−187,613−100.0%Sold out