Prelude Therapeutics Inc
PRLD- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001678660
No open-market purchases or sales by Prelude Therapeutics Inc insiders were filed in the last 90 days; 75 institutions reported holding it in 13F filings for Q2 2026, worth $264.3M in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Prelude Therapeutics Inc as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 47
- −3 vs. Q2 2025
- Shares held
- 27.2M
- −26.0K (−0.1%) vs. Q2 2025
- Total value
- $39.1M
- +$17.1M (+77.8%) vs. Q2 2025
- New holders
- 5
- 8 more added
- Sold out
- 8
- 23 more reduced
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PRLD on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 75 | $264.3M |
| Q1 2026 | 55 | $105.2M |
| Q4 2025 | 48 | $82.6M |
| Q3 2025 | 47 | $39.1M |
| Q2 2025 | 50 | $22.0M |
| Q1 2025 | 59 | $23.3M |
| Q4 2024 | 62 | $41.0M |
| Q3 2024 | 70 | $74.0M |
| Q2 2024 | 61 | $129.2M |
| Q1 2024 | 58 | $162.1M |
| Q4 2023 | 56 | $148.3M |
| Q3 2023 | 60 | $113.1M |
| Q2 2023 | 55 | $176.2M |
| Q1 2023 | 55 | $179.6M |
| Q4 2022 | 60 | $188.3M |
| Q3 2022 | 53 | $210.3M |
| Q2 2022 | 62 | $170.9M |
| Q1 2022 | 68 | $235.4M |
| Q4 2021 | 75 | $437.6M |
| Q3 2021 | 61 | $1.12B |
| Q2 2021 | 57 | $986.6M |
| Q1 2021 | 60 | $1.41B |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Prelude Therapeutics Inc; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| OrbiMed Advisors LLC | 10,909,256 | $15.7M | 0.38% | 00.0% | Unchanged |
| Baker Bros. Advisors LP | 10,123,824 | $14.6M | 0.11% | 00.0% | Unchanged |
| Millennium Management LLC | 1,147,044 | $1.65M | 0.00% | +898,621+361.7% | Added |
| Vanguard Group Inc | 992,854 | $1.43M | 0.00% | +60,284+6.5% | Added |
| Price T Rowe Associates Inc | 876,338 | $1.26M | 0.00% | −51,270−5.5% | Reduced |
| Renaissance Technologies LLC | 544,000 | $783.4K | 0.00% | −37,800−6.5% | Reduced |
| Acadian Asset Management LLC | 540,565 | $777.0K | 0.00% | 00.0% | Unchanged |
| Morgan Stanley | 284,203 | $409.3K | 0.00% | −179−0.1% | Reduced |
| BlackRock, Inc. | 264,973 | $381.6K | 0.00% | −167,586−38.7% | Reduced |
| Two Sigma Advisers, LP | 222,700 | $320.7K | 0.00% | −2,300−1.0% | Reduced |
| Geode Capital Management, LLC | 217,568 | $313.4K | 0.00% | 00.0% | Unchanged |
| TD Asset Management Inc | 160,652 | $231.3K | 0.00% | 00.0% | Unchanged |
| Two Sigma Investments, LP | 152,233 | $219.2K | 0.00% | −2,744−1.8% | Reduced |
| Shay Capital LLC | 100,000 | $144.0K | 0.03% | +25,000+33.3% | Added |
| State Street Corp | 97,592 | $140.5K | 0.00% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 79,327 | $114.2K | 0.00% | −69,851−46.8% | Reduced |
| Gsa Capital Partners LLP | 75,161 | $108.0K | 0.01% | +3,783+5.3% | Added |
| Manufacturers Life Insurance Company, The | 69,252 | $99.7K | 0.00% | 00.0% | Unchanged |
| Bridgeway Capital Management, LLC | 53,500 | $77.0K | 0.00% | −35,000−39.5% | Reduced |
| Northern Trust Corp | 36,421 | $52.4K | 0.00% | −1,706−4.5% | Reduced |
| Jane Street Group, LLC | 34,822 | $50.1K | 0.00% | −56,931−62.0% | Reduced |
| Cerity Partners LLC | 34,333 | $49.4K | 0.00% | −2,060−5.7% | Reduced |
| Prudential Financial Inc | 25,840 | $37.2K | 0.00% | +25,840 | New |
| HRT Financial LP | 16,901 | $24.0K | 0.00% | +16,901 | New |
| XTX Topco Ltd | 15,578 | $22.4K | 0.00% | −26,995−63.4% | Reduced |
| HSBC Holdings PLC | 13,747 | $20.2K | 0.00% | −3,664−21.0% | Reduced |
| AQR Capital Management LLC | 10,500 | $15.1K | 0.00% | −33,147−75.9% | Reduced |
| FMR LLC | 9,099 | $13.1K | 0.00% | −2,068−18.5% | Reduced |
| Bank of America Corp | 8,848 | $12.7K | 0.00% | −2,445−21.7% | Reduced |
| Barclays PLC | 8,712 | $12.5K | 0.00% | +110+1.3% | Added |
| Royal Bank of Canada | 7,712 | $11.0K | 0.00% | +4,885+172.8% | Added |
| Tower Research Capital LLC (TRC) | 6,927 | $9.97K | 0.00% | −9,872−58.8% | Reduced |
| Citigroup Inc | 5,975 | $8.60K | 0.00% | +1,257+26.6% | Added |
| UBS Group AG | 4,171 | $6.01K | 0.00% | −100,033−96.0% | Reduced |
| JPMorgan Chase & Co | 3,879 | $5.58K | 0.00% | +1,930+99.0% | Added |
| SBI Securities Co., Ltd. | 2,741 | $3.95K | 0.00% | 00.0% | Unchanged |
| Nisa Investment Advisors, LLC | 1,634 | $2.35K | 0.00% | 00.0% | Unchanged |
| CWM, LLC | 1,219 | $2.00K | 0.00% | −2,795−69.6% | Reduced |
| The PNC Financial Services Group, Inc. | 1,171 | $1.69K | 0.00% | −9−0.8% | Reduced |
| Group One Trading, L.P. | 500 | $720 | 0.00% | 00.0% | Unchanged |
| EverSource Wealth Advisors, LLC | 89 | $128 | 0.00% | −59−39.9% | Reduced |
| BNP Paribas Arbitrage, SA | 52 | $75 | 0.00% | 00.0% | Unchanged |
| Optiver Holding B.V. | 20 | $29 | 0.00% | +20 | New |
| IFP Advisors, Inc | 18 | $26 | 0.00% | −16−47.1% | Reduced |
| Essential Partners LLC | 17 | $24 | 0.00% | −70−80.5% | Reduced |
| SRS Capital Advisors, Inc. | 15 | $22 | 0.00% | +15 | New |
| Simplex Trading, LLC | 153 | $0 | 0.00% | +153 | New |
| Cantor Fitzgerald, L. P. | 0 | $0 | 0.00% | −211,859−100.0% | Sold out |
| Charles Schwab Investment Management Inc | 0 | $0 | 0.00% | −80,845−100.0% | Sold out |
| Y-Intercept (Hong Kong) Ltd | 0 | $0 | 0.00% | −47,788−100.0% | Sold out |
| Marshall Wace, LLP | 0 | $0 | 0.00% | −41,747−100.0% | Sold out |
| Susquehanna International Group, LLP | 0 | $0 | 0.00% | −39,977−100.0% | Sold out |
| Citadel Advisors LLC | 0 | $0 | 0.00% | −33,625−100.0% | Sold out |
| Wells Fargo & Company | 0 | $0 | 0.00% | −297−100.0% | Sold out |
| True Wealth Design, LLC | 0 | $0 | 0.00% | −13−100.0% | Sold out |