Krystal Biotech, Inc.
KRYS- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001711279
In the last 90 days, Krystal Biotech, Inc. insiders filed 0 open-market purchases and 3 sales; 422 institutions reported holding it in 13F filings for Q2 2026, worth $11.1B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Krystal Biotech, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 334
- +55 vs. Q3 2025
- Shares held
- 28.4M
- +470.1K (+1.7%) vs. Q3 2025
- Total value
- $7.01B
- +$2.07B (+42.0%) vs. Q3 2025
- New holders
- 82
- 111 more added
- Sold out
- 27
- 105 more reduced
5 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KRYS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 422 | $11.1B |
| Q1 2026 | 368 | $7.32B |
| Q4 2025 | 334 | $7.01B |
| Q3 2025 | 284 | $4.94B |
| Q2 2025 | 275 | $3.80B |
| Q1 2025 | 299 | $4.98B |
| Q4 2024 | 264 | $4.35B |
| Q3 2024 | 283 | $5.15B |
| Q2 2024 | 245 | $5.24B |
| Q1 2024 | 234 | $4.49B |
| Q4 2023 | 194 | $3.03B |
| Q3 2023 | 188 | $2.76B |
| Q2 2023 | 183 | $2.71B |
| Q1 2023 | 160 | $1.68B |
| Q4 2022 | 154 | $1.66B |
| Q3 2022 | 148 | $1.45B |
| Q2 2022 | 137 | $1.36B |
| Q1 2022 | 135 | $1.37B |
| Q4 2021 | 140 | $1.35B |
| Q3 2021 | 113 | $850.7M |
| Q2 2021 | 113 | $1.12B |
| Q1 2021 | 113 | $1.27B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Krystal Biotech, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Avanza Fonder AB | 996 | $245.6K | 0.01% | −422−29.8% | Reduced |
| Prelude Capital Management, LLC | 1,032 | $254.4K | 0.02% | +1,032 | New |
| Neuberger Berman Group LLC | 1,033 | $254.7K | 0.00% | +1,033 | New |
| Oppenheimer Asset Management Inc. | 1,044 | $257.4K | 0.00% | −219−17.3% | Reduced |
| Lazard Asset Management LLC | 1,058 | $260.8K | 0.00% | +1,058 | New |
| Truist Financial Corp | 1,080 | $266.3K | 0.00% | +1,080 | New |
| Sequoia Financial Advisors, LLC | 1,083 | $267.0K | 0.00% | +1,083 | New |
| Evergreen Capital Management LLC | 1,086 | $267.7K | 0.01% | +1,086 | New |
| HighTower Advisors, LLC | 1,112 | $274.2K | 0.00% | +1,112 | New |
| LPL Financial LLC | 1,154 | $284.5K | 0.00% | +1,154 | New |
| Captrust Financial Advisors | 1,175 | $289.7K | 0.00% | +1,175 | New |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 1,175 | $290.1K | 0.00% | −623−34.6% | Reduced |
| Hohimer Wealth Management, LLC | 1,214 | $299.3K | 0.04% | −1−0.1% | Reduced |
| New Age Alpha Advisors, LLC | 1,220 | $300.8K | 0.01% | +1,220 | New |
| Covestor Ltd | 1,241 | $306.0K | 0.16% | −537−30.2% | Reduced |
| Argent Trust Co | 1,261 | $310.9K | 0.01% | −46−3.5% | Reduced |
| Gotham Asset Management, LLC | 1,303 | $321.2K | 0.00% | −4−0.3% | Reduced |
| Roman Butler Fullerton & Co | 1,125 | $325.3K | 0.09% | +1,125 | New |
| Cerity Partners LLC | 1,361 | $335.5K | 0.00% | +1,361 | New |
| Ensign Peak Advisors, Inc | 1,369 | $337.5K | 0.00% | −3,050−69.0% | Reduced |
| Tudor Investment Corp Et Al | 1,375 | $339.0K | 0.00% | +1,375 | New |
| Mirae Asset Global Investments Co., Ltd. | 1,409 | $347.4K | 0.00% | +290+25.9% | Added |
| Vise Technologies, Inc. | 1,424 | $351.1K | 0.01% | +1,424 | New |
| Stratos Wealth Partners, LTD. | 1,459 | $359.7K | 0.00% | +1,459 | New |
| Vident Advisory, LLC | 1,494 | $368.3K | 0.00% | +76+5.4% | Added |
| Royal Bank of Canada | 1,501 | $369.0K | 0.00% | +1,103+277.1% | Added |
| CWM, LLC | 1,508 | $372.0K | 0.00% | −28−1.8% | Reduced |
| J. Goldman & Co LP | 1,535 | $378.4K | 0.01% | +1,535 | New |
| Mackenzie Financial Corp | 1,554 | $384.4K | 0.00% | −43−2.7% | Reduced |
| Sound View Wealth Advisors Group, LLC | 1,579 | $389.3K | 0.03% | −424−21.2% | Reduced |
| City Center Advisors, LLC | 1,628 | $401.4K | 0.37% | −74−4.3% | Reduced |
| CIBC World Markets Corp | 1,640 | $404.3K | 0.00% | +1,640 | New |
| Los Angeles Capital Management LLC | 2,171 | $410.5K | 0.00% | −4,586−67.9% | Reduced |
| Parallel Advisors, LLC | 1,680 | $414.2K | 0.01% | −183−9.8% | Reduced |
| Transcend Wealth Collective, LLC | 1,680 | $414.2K | 0.03% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 1,686 | $415.7K | 0.01% | +693+69.8% | Added |
| The PNC Financial Services Group, Inc. | 1,696 | $418.1K | 0.00% | +2+0.1% | Added |
| Pacer Advisors, Inc. | 1,712 | $422.1K | 0.00% | +1,105+182.0% | Added |
| Mindset Wealth Management, LLC | 1,793 | $442.0K | 0.12% | +323+22.0% | Added |
| AlphaCentric Advisors LLC | 1,813 | $447.0K | 0.45% | +1,813 | New |
| EP Wealth Advisors, LLC | 1,846 | $455.1K | 0.00% | +1,846 | New |
| Susquehanna International Group, LLP | 1,867 | $460.3K | 0.00% | +1,867 | New |
| Allianz Asset Management GmbH | 1,900 | $468.4K | 0.00% | +1,900 | New |
| Legato Capital Management LLC | 1,913 | $471.6K | 0.04% | −1,844−49.1% | Reduced |
| Xponance, Inc. | 1,959 | $483.0K | 0.00% | +8+0.4% | Added |
| Farallon Capital Management, L.L.C. | 2,000 | $493.1K | 0.00% | 00.0% | Unchanged |
| Yorktown Management & Research Co Inc | 2,000 | $493.1K | 0.39% | 00.0% | Unchanged |
| Ameritas Investment Partners, Inc. | 2,013 | $496.3K | 0.02% | −59−2.8% | Reduced |
| D. E. Shaw & Co., Inc. | 2,108 | $519.7K | 0.00% | −4,706−69.1% | Reduced |
| Ballentine Partners, LLC | 2,108 | $519.7K | 0.01% | −7−0.3% | Reduced |
| FORA Capital, LLC | 2,112 | $520.7K | 0.06% | +2,112 | New |
| Crossmark Global Holdings, Inc. | 2,124 | $523.6K | 0.01% | +55+2.7% | Added |
| JustInvest LLC | 2,127 | $524.4K | 0.01% | +116+5.8% | Added |
| Vontobel Holding Ltd. | 2,155 | $531.3K | 0.00% | −1,023−32.2% | Reduced |
| Aviva PLC | 2,228 | $549.3K | 0.00% | −1,003−31.0% | Reduced |
| Bank of Montreal | 2,231 | $550.0K | 0.00% | −98−4.2% | Reduced |
| Allspring Global Investments Holdings, LLC | 2,234 | $551.6K | 0.00% | +185+9.0% | Added |
| Pathstone Holdings, LLC | 2,281 | $562.4K | 0.00% | −2,066−47.5% | Reduced |
| Public Employees Retirement Association of Colorado | 2,363 | $583.0K | 0.00% | 00.0% | Unchanged |
| Janney Montgomery Scott LLC | 2,398 | $591.0K | 0.00% | −182−7.1% | Reduced |
| Cynosure Management, LLC | 2,406 | $593.2K | 0.06% | −3,512−59.3% | Reduced |
| O'Shaughnessy Asset Management, LLC | 2,423 | $597.4K | 0.00% | +938+63.2% | Added |
| Entropy Technologies, LP | 2,503 | $617.1K | 0.03% | +2,503 | New |
| Virtus Investment Advisers, Inc. | 2,792 | $688.3K | 0.19% | −375−11.8% | Reduced |
| Optimize Financial Inc | 2,855 | $703.9K | 0.35% | +40+1.4% | Added |
| Brevan Howard Capital Management LP | 2,902 | $715.5K | 0.01% | +2,902 | New |
| Quantinno Capital Management LP | 2,904 | $716.0K | 0.00% | +742+34.3% | Added |
| Natixis | 2,920 | $719.9K | 0.00% | +2,798+2,293.4% | Added |
| Confluence Wealth Services, Inc. | 2,922 | $720.4K | 0.03% | 00.0% | Unchanged |
| Odyssean, LLC | 3,014 | $743.1K | 0.53% | +3,014 | New |
| Resona Asset Management Co.,Ltd. | 3,057 | $753.7K | 0.00% | 00.0% | Unchanged |
| DnB Asset Management AS | 3,093 | $762.5K | 0.00% | +737+31.3% | Added |
| Baader Bank INC | 3,163 | $769.1K | 0.06% | +3,163 | New |
| Blair William & Co | 3,177 | $783.3K | 0.00% | −1,575−33.1% | Reduced |
| Teacher Retirement System of Texas | 3,222 | $794.4K | 0.00% | −2,109−39.6% | Reduced |
| Renaissance Technologies LLC | 3,300 | $813.6K | 0.00% | +3,300 | New |
| Boothbay Fund Management, LLC | 3,527 | $869.5K | 0.02% | −5,362−60.3% | Reduced |
| Amundi | 3,754 | $925.5K | 0.00% | −807−17.7% | Reduced |
| Maryland State Retirement & Pension System | 3,774 | $930.4K | 0.02% | +69+1.9% | Added |
| Fisher Asset Management, LLC | 3,786 | $933.4K | 0.00% | +3,786 | New |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 3,864 | $952.6K | 0.00% | 00.0% | Unchanged |
| Pier 88 Investment Partners LLC | 3,970 | $978.8K | 0.22% | +150+3.9% | Added |
| Seven Fleet Capital Management LP | 4,000 | $986.2K | 0.67% | +4,000 | New |
| Susquehanna Portfolio Strategies, LLC | 4,104 | $1.01M | 0.02% | +325+8.6% | Added |
| Mariner, LLC | 4,320 | $1.07M | 0.00% | −285−6.2% | Reduced |
| Regal Investment Advisors LLC | 4,360 | $1.07M | 0.06% | +44+1.0% | Added |
| Kennedy Capital Management, Inc. | 4,501 | $1.11M | 0.02% | −34,790−88.5% | Reduced |
| Martingale Asset Management L P | 4,506 | $1.11M | 0.03% | +10.0% | Added |
| Cetera Investment Advisers | 4,616 | $1.14M | 0.00% | +118+2.6% | Added |
| KLP Kapitalforvaltning AS | 4,700 | $1.16M | 0.00% | 00.0% | Unchanged |
| China Universal Asset Management Co., Ltd. | 4,725 | $1.16M | 0.09% | −348−6.9% | Reduced |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 5,086 | $1.25M | 0.00% | +61+1.2% | Added |
| Comerica Bank | 5,692 | $1.40M | 0.01% | −1,459−20.4% | Reduced |
| Erste Asset Management GmbH | 5,700 | $1.45M | 0.01% | −12,500−68.7% | Reduced |
| Winton Group Ltd | 5,874 | $1.45M | 0.05% | −2,338−28.5% | Reduced |
| Oregon Public Employees Retirement Fund | 5,896 | $1.45M | 0.02% | +57+1.0% | Added |
| Cookson Peirce & Co Inc | 5,954 | $1.47M | 0.06% | +300+5.3% | Added |
| Arizona State Retirement System | 6,038 | $1.49M | 0.01% | −359−5.6% | Reduced |
| ProShare Advisors LLC | 6,116 | $1.51M | 0.00% | +399+7.0% | Added |
| Commonwealth of Pennsylvania Public School Empls Retrmt Sys | 6,389 | $1.58M | 0.01% | −171−2.6% | Reduced |