Prime Medicine, Inc.
PRME- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001894562
No open-market purchases or sales by Prime Medicine, Inc. insiders were filed in the last 90 days; 187 institutions reported holding it in 13F filings for Q2 2026, worth $393.5M in total; ARK Invest is the only superinvestor holding it.
13F holders, Q1 2026
Institutional positions in Prime Medicine, Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 192
- +14 vs. Q4 2025
- Shares held
- 98.6M
- +9.86M (+11.1%) vs. Q4 2025
- Total value
- $342.6M
- +$34.8M (+11.3%) vs. Q4 2025
- New holders
- 39
- 74 more added
- Sold out
- 25
- 49 more reduced
5 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PRME on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 187 | $393.5M |
| Q1 2026 | 192 | $342.6M |
| Q4 2025 | 183 | $336.5M |
| Q3 2025 | 167 | $511.5M |
| Q2 2025 | 121 | $145.0M |
| Q1 2025 | 125 | $120.4M |
| Q4 2024 | 132 | $188.0M |
| Q3 2024 | 116 | $265.9M |
| Q2 2024 | 122 | $354.0M |
| Q1 2024 | 115 | $466.6M |
| Q4 2023 | 105 | $431.4M |
| Q3 2023 | 83 | $472.3M |
| Q2 2023 | 79 | $675.7M |
| Q1 2023 | 76 | $512.1M |
| Q4 2022 | 66 | $767.8M |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Prime Medicine, Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Millennium Management LLC | 0 | $0 | 0.00% | −51,335−100.0% | Sold out |
| Toroso Investments, LLC | 0 | $0 | 0.00% | −50,244−100.0% | Sold out |
| Walleye Capital LLC | 0 | $0 | 0.00% | −46,139−100.0% | Sold out |
| Gsa Capital Partners LLP | 0 | $0 | 0.00% | −38,510−100.0% | Sold out |
| Central Trust Co | 0 | $0 | 0.00% | −34,995−100.0% | Sold out |
| SG Americas Securities, LLC | 0 | $0 | 0.00% | −30,954−100.0% | Sold out |
| Voloridge Investment Management, LLC | 0 | $0 | 0.00% | −23,121−100.0% | Sold out |
| Integrity Advisory Solutions, LLC | 0 | $0 | 0.00% | −11,689−100.0% | Sold out |
| Callan Family Office, LLC | 0 | $0 | 0.00% | −11,292−100.0% | Sold out |
| Neuberger Berman Group LLC | 0 | $0 | 0.00% | −10,915−100.0% | Sold out |
| Lazard Asset Management LLC | 0 | $0 | 0.00% | −10,844−100.0% | Sold out |
| Rhodes Investment Advisors Inc | 0 | $0 | 0.00% | −10,750−100.0% | Sold out |
| Prelude Capital Management, LLC | 0 | $0 | 0.00% | −10,200−100.0% | Sold out |
| Amalgamated Bank | 0 | $0 | 0.00% | −3,126−100.0% | Sold out |
| Corsicana & Co. | 0 | $0 | 0.00% | −1,000−100.0% | Sold out |
| Leonteq Securities AG | 0 | $0 | 0.00% | −915−100.0% | Sold out |
| Daiwa Securities Group Inc. | 0 | $0 | 0.00% | −398−100.0% | Sold out |
| Vanguard Group Inc | – | – | – | – | Not filed |
| MWG Caph Ltd | – | – | – | – | Not filed |
| Clarius Group, LLC | – | – | – | – | Not filed |
| CIBC Private Wealth Group, LLC | – | – | – | – | Not filed |
| Global Retirement Partners, LLC | – | – | – | – | Not filed |