Crescent Biopharma, Inc.
CBIO- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001253689
In the last 90 days, Crescent Biopharma, Inc. insiders filed 1 open-market purchase and 7 sales; 82 institutions reported holding it in 13F filings for Q2 2026, worth $532.6M in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Crescent Biopharma, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 58
- +17 vs. Q3 2025
- Shares held
- 24.1M
- +12.8M (+113.1%) vs. Q3 2025
- Total value
- $285.9M
- +$151.3M (+112.4%) vs. Q3 2025
- New holders
- 23
- 17 more added
- Sold out
- 6
- 9 more reduced
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting CBIO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 82 | $532.6M |
| Q1 2026 | 63 | $476.6M |
| Q4 2025 | 58 | $285.9M |
| Q3 2025 | 41 | $134.6M |
| Q2 2025 | 30 | $173.5M |
| Q1 2025 | 35 | $6.46M |
| Q4 2024 | 41 | $7.56M |
| Q3 2024 | 36 | $3.00M |
| Q2 2024 | 35 | $7.20M |
| Q1 2024 | 69 | $110.5M |
| Q4 2023 | 58 | $82.8M |
| Q3 2023 | 49 | $52.1M |
| Q2 2023 | 55 | $61.9M |
| Q1 2023 | 54 | $46.6M |
| Q4 2022 | 48 | $83.3M |
| Q3 2022 | 35 | $14.3M |
| Q2 2022 | 37 | $15.8M |
| Q1 2022 | 44 | $31.2M |
| Q4 2021 | 47 | $42.7M |
| Q3 2021 | 48 | $64.9M |
| Q2 2021 | 58 | $72.5M |
| Q1 2021 | 78 | $110.4M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Crescent Biopharma, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 4,133,514 | $49.0M | 0.00% | +2,718,834+192.2% | Added |
| BVF Inc | 2,748,763 | $32.6M | 1.10% | +1,360,900+98.1% | Added |
| Fairmount Funds Management LLC | 2,747,866 | $32.6M | 2.48% | +1,360,000+98.0% | Added |
| VR Adviser, LLC | 2,133,576 | $25.3M | 1.25% | +745,712+53.7% | Added |
| FCPM III Services B.V. | 1,677,852 | $19.9M | 2.61% | +1,677,852 | New |
| Vestal Point Capital, LP | 1,500,000 | $17.8M | 0.65% | +1,500,000 | New |
| Opaleye Management Inc. | 1,178,300 | $14.0M | 1.84% | +1,178,300 | New |
| Tang Capital Management LLC | 872,398 | $10.3M | 0.51% | +192,574+28.3% | Added |
| ADAR1 Capital Management, LLC | 606,000 | $7.19M | 0.54% | +606,000 | New |
| Logos Global Management LP | 600,000 | $7.12M | 0.47% | 00.0% | Unchanged |
| Vanguard Group Inc | 557,506 | $6.61M | 0.00% | −100,394−15.3% | Reduced |
| Perceptive Advisors LLC | 453,686 | $5.38M | 0.10% | 00.0% | Unchanged |
| Deep Track Capital, LP | 453,686 | $5.38M | 0.12% | 00.0% | Unchanged |
| Boxer Capital Management, LLC | 453,686 | $5.38M | 1.18% | 00.0% | Unchanged |
| RTW Investments, LP | 372,856 | $4.42M | 0.04% | +372,856 | New |
| NEXTBio Capital Management LP | 372,856 | $4.42M | 2.59% | +372,856 | New |
| Remedium Capital Partners, LLC | 361,250 | $4.28M | 2.52% | +361,250 | New |
| Price T Rowe Associates Inc | 338,125 | $4.01M | 0.00% | −45,470−11.9% | Reduced |
| Driehaus Capital Management LLC | 302,457 | $3.59M | 0.02% | 00.0% | Unchanged |
| Point72 Asset Management, L.P. | 300,000 | $3.56M | 0.01% | +300,000 | New |
| Heights Capital Management, Inc | 264,000 | $3.13M | 1.18% | +264,000 | New |
| Alyeska Investment Group, L.P. | 264,000 | $3.11M | 0.01% | +264,000 | New |
| Wellington Management Group LLP | 143,412 | $1.63M | 0.00% | +125,714+710.3% | Added |
| Two Sigma Investments, LP | 125,224 | $1.49M | 0.00% | +96,906+342.2% | Added |
| Balyasny Asset Management LLC | 111,715 | $1.32M | 0.00% | +111,715 | New |
| BlackRock, Inc. | 109,230 | $1.30M | 0.00% | +115+0.1% | Added |
| Geode Capital Management, LLC | 91,079 | $1.08M | 0.00% | +21,945+31.7% | Added |
| Stonepine Capital Management, LLC | 87,682 | $1.04M | 0.82% | +87,682 | New |
| Blackstone Group Inc. | 75,614 | $896.8K | 0.00% | 00.0% | Unchanged |
| Woodline Partners LP | 74,000 | $877.6K | 0.00% | +74,000 | New |
| Burkehill Global Management, LP | 74,000 | $844.3K | 0.06% | +74,000 | New |
| Jefferies Financial Group Inc. | 64,244 | $761.9K | 0.01% | −38,470−37.5% | Reduced |
| Millennium Management LLC | 61,882 | $733.9K | 0.00% | +61,882 | New |
| Susquehanna International Group, LLP | 57,048 | $676.6K | 0.00% | +57,048 | New |
| Renaissance Technologies LLC | 46,700 | $553.9K | 0.00% | +19,800+73.6% | Added |
| Two Sigma Advisers, LP | 32,500 | $385.4K | 0.00% | +32,500 | New |
| Morgan Stanley | 27,521 | $326.4K | 0.00% | +27,376+18,880.0% | Added |
| State Street Corp | 26,217 | $310.9K | 0.00% | +7,600+40.8% | Added |
| Goldman Sachs Group Inc | 25,245 | $299.4K | 0.00% | −11,730−31.7% | Reduced |
| Moore Capital Management, LP | 25,000 | $296.5K | 0.01% | +25,000 | New |
| Manufacturers Life Insurance Company, The | 24,903 | $288.9K | 0.00% | −20−0.1% | Reduced |
| JPMorgan Chase & Co | 23,339 | $276.8K | 0.00% | +23,322+137,188.2% | Added |
| Jane Street Group, LLC | 22,965 | $272.4K | 0.00% | +22,965 | New |
| Marshall Wace, LLP | 21,826 | $258.9K | 0.00% | −21,868−50.0% | Reduced |
| Northern Trust Corp | 17,229 | $204.3K | 0.00% | +413+2.5% | Added |
| Quadrature Capital Ltd | 13,246 | $157.1K | 0.00% | +13,246 | New |
| HRT Financial LP | 13,083 | $155.0K | 0.00% | +13,083 | New |
| Omers Administration Corp | 11,600 | $137.6K | 0.00% | +11,600 | New |
| UBS Group AG | 7,125 | $84.5K | 0.00% | −5,536−43.7% | Reduced |
| Bank of America Corp | 5,573 | $66.1K | 0.00% | +1,710+44.3% | Added |
| BNP Paribas Arbitrage, SA | 3,585 | $42.5K | 0.00% | +3,581+89,525.0% | Added |
| Citigroup Inc | 623 | $7.39K | 0.00% | −175−21.9% | Reduced |
| Tower Research Capital LLC (TRC) | 409 | $4.85K | 0.00% | +209+104.5% | Added |
| SBI Securities Co., Ltd. | 68 | $806 | 0.00% | 00.0% | Unchanged |
| Advisor Group Holdings, Inc. | 26 | $308 | 0.00% | 00.0% | Unchanged |
| Group One Trading, L.P. | 4 | $47 | 0.00% | −78−95.1% | Reduced |
| Royal Bank of Canada | 20 | $0 | 0.00% | 00.0% | Unchanged |
| Avion Wealth | 40 | $0 | 0.00% | +40 | New |
| Commodore Capital LP | 0 | $0 | 0.00% | −450,829−100.0% | Sold out |
| Frazier Life Sciences Management, L.P. | 0 | $0 | 0.00% | −272,951−100.0% | Sold out |
| Adage Capital Partners GP, L.L.C. | 0 | $0 | 0.00% | −200,005−100.0% | Sold out |
| Soleus Capital Management, L.P. | 0 | $0 | 0.00% | −200,000−100.0% | Sold out |
| Citadel Advisors LLC | 0 | $0 | 0.00% | −25,593−100.0% | Sold out |
| Affinity Asset Advisors, LLC | 0 | $0 | 0.00% | −17,998−100.0% | Sold out |