Crescent Biopharma, Inc.
CBIO- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001253689
In the last 90 days, Crescent Biopharma, Inc. insiders filed 1 open-market purchase and 7 sales; 82 institutions reported holding it in 13F filings for Q2 2026, worth $532.6M in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Crescent Biopharma, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 58
- +17 vs. Q3 2025
- Shares held
- 24.1M
- +12.8M (+113.1%) vs. Q3 2025
- Total value
- $285.9M
- +$151.3M (+112.4%) vs. Q3 2025
- New holders
- 23
- 17 more added
- Sold out
- 6
- 9 more reduced
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting CBIO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 82 | $532.6M |
| Q1 2026 | 63 | $476.6M |
| Q4 2025 | 58 | $285.9M |
| Q3 2025 | 41 | $134.6M |
| Q2 2025 | 30 | $173.5M |
| Q1 2025 | 35 | $6.46M |
| Q4 2024 | 41 | $7.56M |
| Q3 2024 | 36 | $3.00M |
| Q2 2024 | 35 | $7.20M |
| Q1 2024 | 69 | $110.5M |
| Q4 2023 | 58 | $82.8M |
| Q3 2023 | 49 | $52.1M |
| Q2 2023 | 55 | $61.9M |
| Q1 2023 | 54 | $46.6M |
| Q4 2022 | 48 | $83.3M |
| Q3 2022 | 35 | $14.3M |
| Q2 2022 | 37 | $15.8M |
| Q1 2022 | 44 | $31.2M |
| Q4 2021 | 47 | $42.7M |
| Q3 2021 | 48 | $64.9M |
| Q2 2021 | 58 | $72.5M |
| Q1 2021 | 78 | $110.4M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Crescent Biopharma, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Royal Bank of Canada | 20 | $0 | 0.00% | 00.0% | Unchanged |
| Avion Wealth | 40 | $0 | 0.00% | +40 | New |
| Group One Trading, L.P. | 4 | $47 | 0.00% | −78−95.1% | Reduced |
| Advisor Group Holdings, Inc. | 26 | $308 | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 68 | $806 | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 409 | $4.85K | 0.00% | +209+104.5% | Added |
| Citigroup Inc | 623 | $7.39K | 0.00% | −175−21.9% | Reduced |
| BNP Paribas Arbitrage, SA | 3,585 | $42.5K | 0.00% | +3,581+89,525.0% | Added |
| Bank of America Corp | 5,573 | $66.1K | 0.00% | +1,710+44.3% | Added |
| UBS Group AG | 7,125 | $84.5K | 0.00% | −5,536−43.7% | Reduced |
| Omers Administration Corp | 11,600 | $137.6K | 0.00% | +11,600 | New |
| HRT Financial LP | 13,083 | $155.0K | 0.00% | +13,083 | New |
| Quadrature Capital Ltd | 13,246 | $157.1K | 0.00% | +13,246 | New |
| Northern Trust Corp | 17,229 | $204.3K | 0.00% | +413+2.5% | Added |
| Marshall Wace, LLP | 21,826 | $258.9K | 0.00% | −21,868−50.0% | Reduced |
| Jane Street Group, LLC | 22,965 | $272.4K | 0.00% | +22,965 | New |
| JPMorgan Chase & Co | 23,339 | $276.8K | 0.00% | +23,322+137,188.2% | Added |
| Manufacturers Life Insurance Company, The | 24,903 | $288.9K | 0.00% | −20−0.1% | Reduced |
| Moore Capital Management, LP | 25,000 | $296.5K | 0.01% | +25,000 | New |
| Goldman Sachs Group Inc | 25,245 | $299.4K | 0.00% | −11,730−31.7% | Reduced |
| State Street Corp | 26,217 | $310.9K | 0.00% | +7,600+40.8% | Added |
| Morgan Stanley | 27,521 | $326.4K | 0.00% | +27,376+18,880.0% | Added |
| Two Sigma Advisers, LP | 32,500 | $385.4K | 0.00% | +32,500 | New |
| Renaissance Technologies LLC | 46,700 | $553.9K | 0.00% | +19,800+73.6% | Added |
| Susquehanna International Group, LLP | 57,048 | $676.6K | 0.00% | +57,048 | New |
| Millennium Management LLC | 61,882 | $733.9K | 0.00% | +61,882 | New |
| Jefferies Financial Group Inc. | 64,244 | $761.9K | 0.01% | −38,470−37.5% | Reduced |
| Burkehill Global Management, LP | 74,000 | $844.3K | 0.06% | +74,000 | New |
| Woodline Partners LP | 74,000 | $877.6K | 0.00% | +74,000 | New |
| Blackstone Group Inc. | 75,614 | $896.8K | 0.00% | 00.0% | Unchanged |
| Stonepine Capital Management, LLC | 87,682 | $1.04M | 0.82% | +87,682 | New |
| Geode Capital Management, LLC | 91,079 | $1.08M | 0.00% | +21,945+31.7% | Added |
| BlackRock, Inc. | 109,230 | $1.30M | 0.00% | +115+0.1% | Added |
| Balyasny Asset Management LLC | 111,715 | $1.32M | 0.00% | +111,715 | New |
| Two Sigma Investments, LP | 125,224 | $1.49M | 0.00% | +96,906+342.2% | Added |
| Wellington Management Group LLP | 143,412 | $1.63M | 0.00% | +125,714+710.3% | Added |
| Alyeska Investment Group, L.P. | 264,000 | $3.11M | 0.01% | +264,000 | New |
| Heights Capital Management, Inc | 264,000 | $3.13M | 1.18% | +264,000 | New |
| Point72 Asset Management, L.P. | 300,000 | $3.56M | 0.01% | +300,000 | New |
| Driehaus Capital Management LLC | 302,457 | $3.59M | 0.02% | 00.0% | Unchanged |
| Price T Rowe Associates Inc | 338,125 | $4.01M | 0.00% | −45,470−11.9% | Reduced |
| Remedium Capital Partners, LLC | 361,250 | $4.28M | 2.52% | +361,250 | New |
| RTW Investments, LP | 372,856 | $4.42M | 0.04% | +372,856 | New |
| NEXTBio Capital Management LP | 372,856 | $4.42M | 2.59% | +372,856 | New |
| Perceptive Advisors LLC | 453,686 | $5.38M | 0.10% | 00.0% | Unchanged |
| Deep Track Capital, LP | 453,686 | $5.38M | 0.12% | 00.0% | Unchanged |
| Boxer Capital Management, LLC | 453,686 | $5.38M | 1.18% | 00.0% | Unchanged |
| Vanguard Group Inc | 557,506 | $6.61M | 0.00% | −100,394−15.3% | Reduced |
| Logos Global Management LP | 600,000 | $7.12M | 0.47% | 00.0% | Unchanged |
| ADAR1 Capital Management, LLC | 606,000 | $7.19M | 0.54% | +606,000 | New |
| Tang Capital Management LLC | 872,398 | $10.3M | 0.51% | +192,574+28.3% | Added |
| Opaleye Management Inc. | 1,178,300 | $14.0M | 1.84% | +1,178,300 | New |
| Vestal Point Capital, LP | 1,500,000 | $17.8M | 0.65% | +1,500,000 | New |
| FCPM III Services B.V. | 1,677,852 | $19.9M | 2.61% | +1,677,852 | New |
| VR Adviser, LLC | 2,133,576 | $25.3M | 1.25% | +745,712+53.7% | Added |
| Fairmount Funds Management LLC | 2,747,866 | $32.6M | 2.48% | +1,360,000+98.0% | Added |
| BVF Inc | 2,748,763 | $32.6M | 1.10% | +1,360,900+98.1% | Added |
| FMR LLC | 4,133,514 | $49.0M | 0.00% | +2,718,834+192.2% | Added |
| Commodore Capital LP | 0 | $0 | 0.00% | −450,829−100.0% | Sold out |
| Frazier Life Sciences Management, L.P. | 0 | $0 | 0.00% | −272,951−100.0% | Sold out |
| Adage Capital Partners GP, L.L.C. | 0 | $0 | 0.00% | −200,005−100.0% | Sold out |
| Soleus Capital Management, L.P. | 0 | $0 | 0.00% | −200,000−100.0% | Sold out |
| Citadel Advisors LLC | 0 | $0 | 0.00% | −25,593−100.0% | Sold out |
| Affinity Asset Advisors, LLC | 0 | $0 | 0.00% | −17,998−100.0% | Sold out |