Bicycle Therapeutics PLC
BCYC- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001761612
In the last 90 days, Bicycle Therapeutics PLC insiders filed 0 open-market purchases and 5 sales; 103 institutions reported holding it in 13F filings for Q2 2026, worth $157.9M in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Bicycle Therapeutics PLC as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 109
- +11 vs. Q3 2025
- Shares held
- 39.2M
- +2.37M (+6.4%) vs. Q3 2025
- Total value
- $276.9M
- −$7.96M (−2.8%) vs. Q3 2025
- New holders
- 22
- 35 more added
- Sold out
- 11
- 29 more reduced
1 institution that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting BCYC on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 103 | $157.9M |
| Q1 2026 | 98 | $173.6M |
| Q4 2025 | 109 | $276.9M |
| Q3 2025 | 99 | $285.6M |
| Q2 2025 | 110 | $286.3M |
| Q1 2025 | 95 | $354.4M |
| Q4 2024 | 97 | $586.5M |
| Q3 2024 | 105 | $915.3M |
| Q2 2024 | 107 | $804.0M |
| Q1 2024 | 95 | $759.1M |
| Q4 2023 | 101 | $567.4M |
| Q3 2023 | 101 | $651.3M |
| Q2 2023 | 85 | $618.5M |
| Q1 2023 | 89 | $498.9M |
| Q4 2022 | 87 | $695.9M |
| Q3 2022 | 79 | $538.0M |
| Q2 2022 | 82 | $381.1M |
| Q1 2022 | 105 | $884.5M |
| Q4 2021 | 101 | $1.31B |
| Q3 2021 | 69 | $591.1M |
| Q2 2021 | 54 | $376.9M |
| Q1 2021 | 39 | $341.2M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Bicycle Therapeutics PLC; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Baker Bros. Advisors LP | 10,885,357 | $77.1M | 0.45% | 00.0% | Unchanged |
| FCPM III Services B.V. | 3,468,430 | $24.6M | 3.22% | +16,100+0.5% | Added |
| Armistice Capital, LLC | 3,236,000 | $22.9M | 0.56% | +258,000+8.7% | Added |
| Westfield Capital Management Co LP | 3,016,026 | $21.4M | 0.09% | +63,483+2.2% | Added |
| Siren, L.L.C. | 2,012,752 | $14.3M | 0.43% | 00.0% | Unchanged |
| Acadian Asset Management LLC | 1,671,258 | $11.8M | 0.02% | +356,702+27.1% | Added |
| Long Focus Capital Management, LLC | 1,633,091 | $11.6M | 0.58% | +214,396+15.1% | Added |
| GSK plc | 1,529,561 | $10.8M | 1.36% | +1,529,561 | New |
| Candriam Luxembourg S.C.A. | 1,192,279 | $8.44M | 0.04% | +19,892+1.7% | Added |
| Price T Rowe Associates Inc | 1,171,787 | $8.30M | 0.00% | −213,007−15.4% | Reduced |
| Principal Financial Group Inc | 1,148,272 | $8.13M | 0.00% | −1300.0% | Reduced |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 568,225 | $4.02M | 0.00% | +568,225 | New |
| Renaissance Technologies LLC | 566,600 | $4.01M | 0.01% | +47,900+9.2% | Added |
| Schroder Investment Management Group | 584,770 | $3.98M | 0.00% | +584,770 | New |
| Silvercrest Asset Management Group LLC | 476,976 | $3.38M | 0.02% | 00.0% | Unchanged |
| Morgan Stanley | 465,222 | $3.29M | 0.00% | −357,483−43.5% | Reduced |
| Birchview Capital, LP | 462,700 | $3.28M | 1.92% | +308,700+200.5% | Added |
| BlackRock, Inc. | 332,889 | $2.36M | 0.00% | +50,471+17.9% | Added |
| Millennium Management LLC | 326,626 | $2.31M | 0.00% | −728,120−69.0% | Reduced |
| Jefferies Financial Group Inc. | 297,247 | $2.10M | 0.02% | −104,679−26.0% | Reduced |
| Moore Capital Management, LP | 275,000 | $1.95M | 0.04% | +150,000+120.0% | Added |
| Citadel Advisors LLC | 271,383 | $1.92M | 0.00% | +82,356+43.6% | Added |
| Palo Alto Investors LP | 221,071 | $1.57M | 0.22% | 00.0% | Unchanged |
| Pinnacle Associates Ltd | 190,480 | $1.35M | 0.02% | −6,138−3.1% | Reduced |
| Platinum Investment Management Ltd | 184,603 | $1.31M | 0.30% | 00.0% | Unchanged |
| Eversept Partners, LP | 178,915 | $1.27M | 0.07% | −15,525−8.0% | Reduced |
| Flax Pond Capital, LLC | 173,633 | $1.23M | 0.91% | +173,633 | New |
| TD Asset Management Inc | 147,992 | $1.05M | 0.00% | −30,100−16.9% | Reduced |
| Two Sigma Advisers, LP | 146,100 | $1.03M | 0.00% | −10,600−6.8% | Reduced |
| Fideuram - Intesa Sanpaolo Private Banking S.P.A. | 134,689 | $953.6K | 0.03% | +134,689 | New |
| Two Sigma Investments, LP | 132,032 | $934.8K | 0.00% | −52,505−28.5% | Reduced |
| Rangeley Capital, LLC | 132,000 | $934.6K | 0.81% | +2,000+1.5% | Added |
| Manufacturers Life Insurance Company, The | 127,863 | $869.5K | 0.00% | −12,629−9.0% | Reduced |
| Walleye Capital LLC | 111,659 | $790.5K | 0.00% | +111,659 | New |
| Susquehanna International Group, LLP | 108,423 | $767.6K | 0.00% | +81,794+307.2% | Added |
| Bank of America Corp | 96,401 | $682.5K | 0.00% | −495,134−83.7% | Reduced |
| Monimus Capital Management, LP | 93,840 | $664.4K | 0.44% | +8,616+10.1% | Added |
| Marex Group plc | 78,406 | $555.1K | 0.01% | +78,406 | New |
| Point72 Asset Management, L.P. | 76,779 | $543.6K | 0.00% | −354,121−82.2% | Reduced |
| State Street Corp | 70,178 | $496.9K | 0.00% | −4,227−5.7% | Reduced |
| Nan Fung Group Holdings Ltd | 68,943 | $488.1K | 0.44% | 00.0% | Unchanged |
| DAFNA Capital Management LLC | 64,492 | $456.6K | 0.11% | 00.0% | Unchanged |
| Jane Street Group, LLC | 63,190 | $447.4K | 0.00% | −39,269−38.3% | Reduced |
| State of Tennessee, Treasury Department | 61,153 | $392.6K | 0.00% | +16,311+36.4% | Added |
| SEI Investments Co | 49,056 | $347.3K | 0.00% | 00.0% | Unchanged |
| XTX Topco Ltd | 47,674 | $337.5K | 0.01% | +36,026+309.3% | Added |
| Quadrature Capital Ltd | 46,728 | $330.8K | 0.00% | +18,834+67.5% | Added |
| Man Group plc | 42,860 | $303.4K | 0.00% | +1,969+4.8% | Added |
| Alps Advisors Inc | 40,995 | $290.2K | 0.00% | +16,872+69.9% | Added |
| Harbor Capital Advisors, Inc. | 40,486 | $287.0K | 0.02% | −882−2.1% | Reduced |
| Marshall Wace, LLP | 38,795 | $274.7K | 0.00% | +38,795 | New |
| Virtus Investment Advisers, Inc. | 35,709 | $252.8K | 0.07% | +22,615+172.7% | Added |
| Jump Financial, LLC | 31,000 | $219.5K | 0.00% | +9,579+44.7% | Added |
| Woodstock Corp | 29,146 | $206.4K | 0.02% | +5,219+21.8% | Added |
| UBS Group AG | 25,676 | $181.8K | 0.00% | +14,303+125.8% | Added |
| Geode Capital Management, LLC | 25,129 | $177.9K | 0.00% | −14,796−37.1% | Reduced |
| Goldman Sachs Group Inc | 24,732 | $175.1K | 0.00% | +24,732 | New |
| Engineers Gate Manager LP | 24,047 | $170.3K | 0.00% | +10,626+79.2% | Added |
| D. E. Shaw & Co., Inc. | 21,548 | $152.6K | 0.00% | +21,548 | New |
| State of New Jersey Common Pension Fund D | 20,105 | $142.3K | 0.00% | 00.0% | Unchanged |
| Simplex Trading, LLC | 19,986 | $141.5K | 0.00% | +19,986 | New |
| Fox Run Management, L.L.C. | 19,771 | $140.0K | 0.02% | +19,771 | New |
| Aquatic Capital Management LLC | 18,817 | $133.2K | 0.00% | +18,817 | New |
| JPMorgan Chase & Co | 18,355 | $130.0K | 0.00% | +10,228+125.9% | Added |
| Portland Investment Counsel Inc. | 15,000 | $106.2K | 0.03% | 00.0% | Unchanged |
| Federation des caisses Desjardins du Quebec | 14,302 | $101.1K | 0.00% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 14,138 | $100.1K | 0.00% | +1,058+8.1% | Added |
| Horizon Kinetics Asset Management LLC | 13,792 | $97.6K | 0.00% | −604−4.2% | Reduced |
| Erste Asset Management GmbH | 14,000 | $94.9K | 0.00% | 00.0% | Unchanged |
| Forefront Analytics, LLC | 13,371 | $94.7K | 0.08% | +13,371 | New |
| Cerity Partners LLC | 13,350 | $94.5K | 0.00% | −1,000−7.0% | Reduced |
| JustInvest LLC | 12,776 | $90.5K | 0.00% | −177−1.4% | Reduced |
| Tocqueville Asset Management L.P. | 12,600 | $89.2K | 0.00% | +300+2.4% | Added |
| Raymond James Financial Inc | 12,336 | $87.3K | 0.00% | +12,336 | New |
| Crossmark Global Holdings, Inc. | 11,399 | $80.7K | 0.00% | +9+0.1% | Added |
| Rhumbline Advisers | 11,171 | $79.1K | 0.00% | +7,896+241.1% | Added |
| Royal Bank of Canada | 10,682 | $76.0K | 0.00% | −2,051−16.1% | Reduced |
| Commonwealth of Pennsylvania Public School Empls Retrmt Sys | 10,116 | $71.6K | 0.00% | 00.0% | Unchanged |
| Invesco Ltd. | 10,092 | $71.5K | 0.00% | +10,092 | New |
| Vontobel Holding Ltd. | 10,000 | $70.8K | 0.00% | +10,000 | New |
| Pinnacle Wealth Management Advisory Group, LLC | 10,000 | $70.8K | 0.00% | +10,000 | New |
| Skopos Labs, Inc. | 10,216 | $69.3K | 0.00% | +10,216 | New |
| Legal & General Group Plc | 9,054 | $64.1K | 0.00% | −188,863−95.4% | Reduced |
| China Universal Asset Management Co., Ltd. | 7,540 | $53.4K | 0.00% | −564−7.0% | Reduced |
| FNY Investment Advisers, LLC | 7,486 | $53.0K | 0.02% | −3,014−28.7% | Reduced |
| Clearstead Advisors, LLC | 4,655 | $33.0K | 0.00% | +3,262+234.2% | Added |
| Natixis | 4,645 | $31.6K | 0.00% | +2,698+138.6% | Added |
| Assetmark, Inc | 3,628 | $25.7K | 0.00% | +3+0.1% | Added |
| Mirae Asset Global Investments Co., Ltd. | 2,248 | $15.9K | 0.00% | +461+25.8% | Added |
| Tower Research Capital LLC (TRC) | 1,668 | $11.8K | 0.00% | +3+0.2% | Added |
| GAMMA Investing LLC | 1,386 | $9.81K | 0.00% | −730−34.5% | Reduced |
| Citigroup Inc | 1,291 | $9.14K | 0.00% | −1,310−50.4% | Reduced |
| BNP Paribas Arbitrage, SA | 1,116 | $7.90K | 0.00% | +305+37.6% | Added |
| GF Fund Management Co. Ltd. | 909 | $6.44K | 0.00% | −86−8.6% | Reduced |
| Barclays PLC | 562 | $3.98K | 0.00% | −1,710−75.3% | Reduced |
| HighMark Wealth Management LLC | 435 | $3.08K | 0.00% | 00.0% | Unchanged |
| FMR LLC | 316 | $2.24K | 0.00% | 00.0% | Unchanged |
| Jones Financial Companies LLLP | 250 | $1.77K | 0.00% | 00.0% | Unchanged |
| Farther Finance Advisors, LLC | 218 | $1.54K | 0.00% | +218 | New |
| Wells Fargo & Company | 200 | $1.42K | 0.00% | 00.0% | Unchanged |