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Bicycle Therapeutics PLC

BCYC
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001761612

In the last 90 days, Bicycle Therapeutics PLC insiders filed 0 open-market purchases and 5 sales; 103 institutions reported holding it in 13F filings for Q2 2026, worth $158.8M in total; no superinvestor holds it.

13F holders, Q2 2026

Institutional positions in Bicycle Therapeutics PLC as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
103
+5 vs. Q1 2026
Shares held
37.5M
−7.74K (0.0%) vs. Q1 2026
Total value
$158.8M
−$14.8M (−8.5%) vs. Q1 2026
New holders
18
34 more added
Sold out
13
18 more reduced

Compare with Q1 2026: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting BCYC on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ2 2026: 103 institutions
Q1 2021: 39 institutionsQ2 2021: 54 institutionsQ3 2021: 69 institutionsQ4 2021: 101 institutionsQ1 2022: 105 institutionsQ2 2022: 82 institutionsQ3 2022: 79 institutionsQ4 2022: 87 institutionsQ1 2023: 89 institutionsQ2 2023: 85 institutionsQ3 2023: 101 institutionsQ4 2023: 101 institutionsQ1 2024: 95 institutionsQ2 2024: 107 institutionsQ3 2024: 105 institutionsQ4 2024: 97 institutionsQ1 2025: 95 institutionsQ2 2025: 110 institutionsQ3 2025: 99 institutionsQ4 2025: 109 institutionsQ1 2026: 98 institutionsQ2 2026: 103 institutions
Value heldQ2 2026: $158.8M
Q1 2021: $341.3MQ2 2021: $383.0MQ3 2021: $591.1MQ4 2021: $1.31BQ1 2022: $890.9MQ2 2022: $388.8MQ3 2022: $594.8MQ4 2022: $695.9MQ1 2023: $505.0MQ2 2023: $619.0MQ3 2023: $651.3MQ4 2023: $596.4MQ1 2024: $835.1MQ2 2024: $815.3MQ3 2024: $915.5MQ4 2024: $586.5MQ1 2025: $354.4MQ2 2025: $286.4MQ3 2025: $285.7MQ4 2025: $277.7MQ1 2026: $173.6MQ2 2026: $158.8M
Institutions holding BCYC and their total value by quarter
QuarterHoldersValue
Q2 2026103$158.8M
Q1 202698$173.6M
Q4 2025109$277.7M
Q3 202599$285.7M
Q2 2025110$286.4M
Q1 202595$354.4M
Q4 202497$586.5M
Q3 2024105$915.5M
Q2 2024107$815.3M
Q1 202495$835.1M
Q4 2023101$596.4M
Q3 2023101$651.3M
Q2 202385$619.0M
Q1 202389$505.0M
Q4 202287$695.9M
Q3 202279$594.8M
Q2 202282$388.8M
Q1 2022105$890.9M
Q4 2021101$1.31B
Q3 202169$591.1M
Q2 202154$383.0M
Q1 202139$341.3M

Institutions, Q2 2026

Shares, value and share of portfolio for each institution holding Bicycle Therapeutics PLC; share changes are against Q1 2026.

Institutions holding BCYC in Q2 2026
InstitutionSharesValue% of portfolioChange in sharesAction
Baker Bros. Advisors LP10,885,357$46.2M0.23%00.0%Unchanged
FCPM III Services B.V.3,468,430$14.7M1.96%00.0%Unchanged
Armistice Capital, LLC3,398,000$14.4M0.40%00.0%Unchanged
Long Focus Capital Management, LLC3,310,687$14.0M0.57%00.0%Unchanged
Acadian Asset Management LLC1,968,025$8.32M0.01%00.0%Unchanged
Renaissance Technologies LLC1,533,400$6.50M0.01%+554,100+56.6%Added
GSK plc1,529,561$6.49M1.08%00.0%Unchanged
Price T Rowe Associates Inc902,150$3.83M0.00%−126,093−12.3%Reduced
Marshall Wace, LLP797,940$3.38M0.00%+420,605+111.5%Added
Qube Research & Technologies Ltd775,567$3.29M0.00%+466,950+151.3%Added
Morgan Stanley667,269$2.83M0.00%+48,942+7.9%Added
Schroder Investment Management Group615,833$2.56M0.00%00.0%Unchanged
Citadel Advisors LLC554,225$2.35M0.00%+177,140+47.0%Added
Millennium Management LLC553,967$2.35M0.00%+269,981+95.1%Added
Peapod Lane Capital LLC537,978$2.28M1.54%+416,872+344.2%Added
Diadema Partners LP462,724$1.96M0.69%−13,700−2.9%Reduced
Two Sigma Investments, LP434,577$1.84M0.00%+269,777+163.7%Added
Flax Pond Capital, LLC376,222$1.67M0.62%+200,086+113.6%Added
Jane Street Group, LLC392,163$1.66M0.00%+174,048+79.8%Added
Birchview Capital, LP313,616$1.33M0.62%−149,983−32.4%Reduced
BlackRock, Inc.280,386$1.19M0.00%+1,394+0.5%Added
Moore Capital Management, LP275,000$1.17M0.03%00.0%Unchanged
Rangeley Capital, LLC253,500$1.07M1.00%+21,240+9.1%Added
Palo Alto Investors LP201,890$856.0K0.12%00.0%Unchanged
Sculptor Capital LP197,904$839.1K0.01%+197,904New
Eversept Partners, LP190,715$808.6K0.04%00.0%Unchanged
Pinnacle Associates Ltd189,990$805.6K0.01%+4,580+2.5%Added
Jump Financial, LLC167,100$708.5K0.01%+114,556+218.0%Added
Point72 Asset Management, L.P.149,936$635.7K0.00%+19,514+15.0%Added
Manufacturers Life Insurance Company, The127,863$542.1K0.00%00.0%Unchanged
Goldman Sachs Group Inc121,281$514.2K0.00%+11,134+10.1%Added
Persistent Asset Partners Ltd117,254$497.2K0.16%−3,183−2.6%Reduced
XTX Topco Ltd109,801$465.6K0.01%+3,409+3.2%Added
Quadrature Capital Ltd104,092$441.4K0.00%+104,092New
TD Asset Management Inc91,992$390.0K0.00%00.0%Unchanged
Virtus Investment Advisers, Inc.80,789$342.5K0.08%+44,188+120.7%Added
Nano Cap New Millennium Growth Fund L P80,000$339.2K0.26%+80,000New
EntryPoint Capital, LLC77,743$329.6K0.08%+13,837+21.7%Added
Marquette Asset Management, LLC72,854$308.9K0.04%+72,854New
HRT Financial LP66,237$280.0K0.00%+20,322+44.3%Added
DAFNA Capital Management LLC64,492$273.4K0.05%00.0%Unchanged
State of Tennessee, Treasury Department61,153$259.3K0.00%00.0%Unchanged
SEI Investments Co52,784$223.8K0.00%00.0%Unchanged
Alps Advisors Inc51,122$216.8K0.00%+10,471+25.8%Added
Verdad Advisers, LP51,100$216.7K0.21%+51,100New
ADAR1 Capital Management, LLC50,638$214.7K0.01%−20,660−29.0%Reduced
Simplex Trading, LLC35,232$149.4K0.00%+35,232New
Susquehanna International Group, LLP31,957$135.5K0.00%−5,931−15.7%Reduced
Trexquant Investment LP31,044$131.6K0.00%+31,044New
Gsa Capital Partners LLP30,785$131.0K0.01%+3,943+14.7%Added
State Street Corp30,829$130.7K0.00%+317+1.0%Added
Woodstock Corp29,146$123.6K0.01%00.0%Unchanged
Axq Capital, LP27,368$116.0K0.01%−35,766−56.7%Reduced
FNY Investment Advisers, LLC26,250$111.0K0.04%+18,693+247.4%Added
D. E. Shaw & Co., Inc.25,457$107.9K0.00%+25,457New
Invesco Ltd.24,802$105.2K0.00%+9,735+64.6%Added
National Philanthropic Trust24,723$104.8K0.00%+24,723New
Forefront Analytics, LLC21,822$92.5K0.10%+7,428+51.6%Added
Stifel Financial Corp20,479$86.8K0.00%+5,792+39.4%Added
State of New Jersey Common Pension Fund D20,105$85.2K0.00%00.0%Unchanged
Vontobel Holding Ltd.20,000$84.8K0.00%00.0%Unchanged
Aigen Investment Management, LP19,319$81.9K0.02%+19,319New
Geode Capital Management, LLC19,035$80.7K0.00%−6,094−24.3%Reduced
Rhumbline Advisers15,967$67.7K0.00%+3,396+27.0%Added
UBS Group AG15,459$65.5K0.00%−16,700−51.9%Reduced
Portland Investment Counsel Inc.15,000$63.6K0.02%00.0%Unchanged
Federation des caisses Desjardins du Quebec14,302$60.6K0.00%00.0%Unchanged
Erste Asset Management GmbH14,000$58.1K0.00%00.0%Unchanged
Cerity Partners LLC13,570$57.5K0.00%00.0%Unchanged
Schonfeld Strategic Advisors LLC13,399$56.8K0.00%+13,399New
Walleye Capital LLC13,000$55.1K0.00%+13,000New
JPMorgan Chase & Co13,056$54.2K0.00%+3,183+32.2%Added
Horizon Kinetics Asset Management LLC12,584$53.4K0.00%−604−4.6%Reduced
Aquatic Capital Management LLC12,343$52.3K0.00%−13,817−52.8%Reduced
Jain Global LLC12,000$50.9K0.00%+12,000New
Crossmark Global Holdings, Inc.11,402$48.3K0.00%−6−0.1%Reduced
Pinnacle Wealth Management Advisory Group, LLC10,985$46.6K0.00%00.0%Unchanged
State of Wyoming10,760$45.6K0.00%+10,760New
Commonwealth of Pennsylvania Public School Empls Retrmt Sys10,116$42.9K0.00%00.0%Unchanged
GAMMA Investing LLC7,704$32.7K0.00%+6,447+512.9%Added
China Universal Asset Management Co., Ltd.7,420$31.5K0.00%−802−9.8%Reduced
Natixis4,645$20.0K0.00%00.0%Unchanged
Tower Research Capital LLC (TRC)3,669$15.6K0.00%+1,703+86.6%Added
Barclays PLC3,149$13.4K0.00%+792+33.6%Added
Royal Bank of Canada2,500$11.0K0.00%−11,970−82.7%Reduced
Mirae Asset Global Investments Co., Ltd.2,085$8.84K0.00%−332−13.7%Reduced
Group One Trading, L.P.1,938$8.22K0.00%+1,938New
Assetmark, Inc1,588$6.73K0.00%−2,630−62.4%Reduced
Citigroup Inc1,175$4.98K0.00%−120−9.3%Reduced
BNP Paribas Arbitrage, SA1,016$4.31K0.00%00.0%Unchanged
GF Fund Management Co. Ltd.962$4.08K0.00%−70−6.8%Reduced
Jones Financial Companies LLLP700$2.87K0.00%+200+40.0%Added
Quarry LP537$2.28K0.00%+537New
HighMark Wealth Management LLC435$1.84K0.00%00.0%Unchanged
SRS Capital Advisors, Inc.304$1.29K0.00%+304New
Wells Fargo & Company200$8480.00%00.0%Unchanged
Winch Advisory Services, LLC172$7290.00%00.0%Unchanged
EverSource Wealth Advisors, LLC147$6230.00%+147New
Caitong International Asset Management Co., Ltd117$4960.00%+116+11,600.0%Added
Advisor Group Holdings, Inc.10$420.00%00.0%Unchanged