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Bicycle Therapeutics PLC

BCYC
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001761612

In the last 90 days, Bicycle Therapeutics PLC insiders filed 0 open-market purchases and 5 sales; 103 institutions reported holding it in 13F filings for Q2 2026, worth $157.9M in total; no superinvestor holds it.

13F holders, Q1 2023

Institutional positions in Bicycle Therapeutics PLC as of Mar 31, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
89
+3 vs. Q4 2022
Shares held
23.6M
+47.8K (+0.2%) vs. Q4 2022
Total value
$498.9M
−$197.0M (−28.3%) vs. Q4 2022
New holders
18
34 more added
Sold out
15
17 more reduced

1 institution that held it in Q4 2022 haven't filed for Q1 2023 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q4 2022: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting BCYC on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ1 2023: 89 institutions
Q1 2021: 39 institutionsQ2 2021: 54 institutionsQ3 2021: 69 institutionsQ4 2021: 101 institutionsQ1 2022: 105 institutionsQ2 2022: 82 institutionsQ3 2022: 79 institutionsQ4 2022: 87 institutionsQ1 2023: 89 institutionsQ2 2023: 85 institutionsQ3 2023: 101 institutionsQ4 2023: 101 institutionsQ1 2024: 95 institutionsQ2 2024: 107 institutionsQ3 2024: 105 institutionsQ4 2024: 97 institutionsQ1 2025: 95 institutionsQ2 2025: 110 institutionsQ3 2025: 99 institutionsQ4 2025: 109 institutionsQ1 2026: 98 institutionsQ2 2026: 103 institutions
Value heldQ1 2023: $498.9M
Q1 2021: $341.2MQ2 2021: $376.9MQ3 2021: $591.1MQ4 2021: $1.31BQ1 2022: $884.5MQ2 2022: $381.1MQ3 2022: $538.0MQ4 2022: $695.9MQ1 2023: $498.9MQ2 2023: $618.5MQ3 2023: $651.3MQ4 2023: $567.4MQ1 2024: $759.1MQ2 2024: $804.0MQ3 2024: $915.3MQ4 2024: $586.5MQ1 2025: $354.4MQ2 2025: $286.3MQ3 2025: $285.6MQ4 2025: $276.9MQ1 2026: $173.6MQ2 2026: $157.9M
Institutions holding BCYC and their total value by quarter
QuarterHoldersValue
Q2 2026103$157.9M
Q1 202698$173.6M
Q4 2025109$276.9M
Q3 202599$285.6M
Q2 2025110$286.3M
Q1 202595$354.4M
Q4 202497$586.5M
Q3 2024105$915.3M
Q2 2024107$804.0M
Q1 202495$759.1M
Q4 2023101$567.4M
Q3 2023101$651.3M
Q2 202385$618.5M
Q1 202389$498.9M
Q4 202287$695.9M
Q3 202279$538.0M
Q2 202282$381.1M
Q1 2022105$884.5M
Q4 2021101$1.31B
Q3 202169$591.1M
Q2 202154$376.9M
Q1 202139$341.2M

Institutions, Q1 2023

Shares, value and share of portfolio for each institution holding Bicycle Therapeutics PLC; share changes are against Q4 2022.

Institutions holding BCYC in Q1 2023
InstitutionSharesValue% of portfolioChange in sharesAction
Deep Track Capital, LP2,819,045$60.0M2.55%00.0%Unchanged
Jefferies Financial Group Inc.1,948,000$41.4M0.88%+1,948,000New
Paradigm Biocapital Advisors LP1,816,781$38.6M3.66%+583,501+47.3%Added
Morgan Stanley1,507,749$32.1M0.00%+786,190+109.0%Added
Janus Henderson Group PLC1,474,378$31.4M0.02%−29,069−1.9%Reduced
Tybourne Capital Management (HK) Ltd1,408,831$30.0M3.02%+503,109+55.5%Added
Candriam Luxembourg S.C.A.1,303,211$25.5M0.18%+128,000+10.9%Added
Polar Capital Holdings Plc1,009,500$21.5M0.16%+259,500+34.6%Added
Sio Capital Management, LLC967,347$20.6M10.17%+283,922+41.5%Added
Baker Bros. Advisors LP843,814$17.9M0.10%00.0%Unchanged
Point72 Asset Management, L.P.802,400$17.1M0.06%−205,578−20.4%Reduced
Logos Global Management LP750,000$16.0M2.28%−685,000−47.7%Reduced
Armistice Capital, LLC736,000$15.7M0.36%+736,000New
First Light Asset Management, LLC699,328$14.9M1.34%+2,896+0.4%Added
Verition Fund Management LLC582,558$12.4M0.20%+201,709+53.0%Added
BNP PARIBAS ASSET MANAGEMENT Holding S.A.519,573$11.1M0.04%+218,605+72.6%Added
AXA S.A.460,125$9.79M0.03%+79,570+20.9%Added
Soleus Capital Management, L.P.411,800$8.76M1.09%+153,400+59.4%Added
Price T Rowe Associates Inc318,076$6.77M0.00%−20,657−6.1%Reduced
FMR LLC287,147$6.11M0.00%−90,500−24.0%Reduced
Ikarian Capital, LLC207,112$4.41M1.83%+207,112New
Rubric Capital Management LP205,423$4.37M0.17%+205,423New
Two Sigma Advisers, LP187,900$4.00M0.01%+26,100+16.1%Added
BlackRock Inc.178,932$3.81M0.00%−10,886−5.7%Reduced
Two Sigma Investments, LP160,576$3.42M0.01%+160,576New
Parkman Healthcare Partners LLC147,799$3.14M0.68%+56,467+61.8%Added
Handelsbanken Fonder AB131,800$2.80M0.02%00.0%Unchanged
ExodusPoint Capital Management, LP122,781$2.61M0.03%+17,915+17.1%Added
DAFNA Capital Management LLC122,200$2.60M0.78%00.0%Unchanged
HighVista Strategies LLC92,434$1.97M1.60%00.0%Unchanged
Tekla Capital Management LLC88,676$1.89M0.07%00.0%Unchanged
JPMorgan Chase & Co87,138$1.85M0.00%+3,932+4.7%Added
UBS Oconnor LLC80,719$1.72M0.04%+80,719New
Voya Investment Management LLC80,595$1.71M0.00%+14,555+22.0%Added
Marshall Wace, LLP76,649$1.63M0.00%+67,378+726.8%Added
Citadel Advisors LLC67,200$1.43M0.00%+34,210+103.7%Added
Renaissance Technologies LLC61,900$1.32M0.00%+61,900New
Schonfeld Strategic Advisors LLC60,100$1.28M0.01%−19,646−24.6%Reduced
Bellevue Group AG53,200$1.13M0.02%−17,000−24.2%Reduced
J. Goldman & Co LP49,944$1.06M0.06%+49,944New
Group One Trading, L.P.48,439$1.03M0.05%+9,655+24.9%Added
Susquehanna International Group, LLP44,573$948.1K0.00%+7,518+20.3%Added
Cubist Systematic Strategies, LLC43,807$931.8K0.01%+30,617+232.1%Added
Boothbay Fund Management, LLC42,979$914.2K0.03%+42,979New
Jump Financial, LLC37,737$802.7K0.03%+30,337+410.0%Added
Caption Management, LLC26,000$553.0K0.12%+26,000New
Simplex Trading, LLC25,888$550.0K0.02%+11,554+80.6%Added
Manufacturers Life Insurance Company, The25,136$534.6K0.00%00.0%Unchanged
Vident Investment Advisory, LLC24,287$516.6K0.02%+330+1.4%Added
TD Asset Management Inc23,586$501.7K0.00%00.0%Unchanged
Eagle Health Investments LP23,500$499.8K0.10%00.0%Unchanged
Allianz Asset Management GmbH21,100$448.8K0.00%+5,900+38.8%Added
Harbor Capital Advisors, Inc.19,132$406.9K0.12%−5,015−20.8%Reduced
Woodstock Corp18,630$396.3K0.05%+3,790+25.5%Added
Geode Capital Management, LLC17,144$364.7K0.00%00.0%Unchanged
Millennium Management LLC16,836$358.0K0.00%−151,887−90.0%Reduced
AtonRa Partners15,169$322.6K0.47%−1,898−11.1%Reduced
Horizon Kinetics Asset Management LLC15,000$319.1K0.01%+15,000New
Erste Asset Management GmbH14,000$304.8K0.01%00.0%Unchanged
UBS Group AG13,892$295.5K0.00%+950+7.3%Added
Legal & General Group Plc13,159$280.1K0.00%+2,626+24.9%Added
DekaBank Deutsche Girozentrale13,200$275.0K0.00%00.0%Unchanged
Prelude Capital Management, LLC12,634$268.7K0.02%+12,634New
Goldman Sachs Group Inc10,548$224.4K0.00%−70,005−86.9%Reduced
Fishman Jay A Ltd10,500$223.3K0.03%00.0%Unchanged
Jane Street Group, LLC9,800$208.4K0.00%+9,800New
Deutsche Bank AG8,370$178.0K0.00%00.0%Unchanged
BNP Paribas Arbitrage, SA7,279$154.8K0.00%+7,117+4,393.2%Added
Bank of America Corp5,919$125.9K0.00%+406+7.4%Added
HighMark Wealth Management LLC4,235$90.1K0.07%00.0%Unchanged
Natixis3,400$73.7K0.00%−213−5.9%Reduced
Virtus ETF Advisers LLC3,145$66.9K0.04%−1,216−27.9%Reduced
Cutler Group LP2,942$62.0K0.01%+902+44.2%Added
Values First Advisors, Inc.2,392$50.9K0.03%+2,392New
Tower Research Capital LLC (TRC)1,263$27.0K0.00%+99+8.5%Added
Advisor Group Holdings, Inc.1,060$22.5K0.00%−250−19.1%Reduced
Zurcher Kantonalbank (Zurich Cantonalbank)853$18.1K0.00%+458+115.9%Added
Aquatic Capital Management LLC800$17.0K0.00%+800New
Citigroup Inc455$9.68K0.00%−56−11.0%Reduced
China Universal Asset Management Co., Ltd.349$7.42K0.00%+90+34.7%Added
Quantbot Technologies LP300$6.38K0.00%+300New
Royal Bank of Canada193$4.00K0.00%−18−8.5%Reduced
Advisory Services Network, LLC115$2.45K0.00%00.0%Unchanged
Daiwa Securities Group Inc.103$2.00K0.00%00.0%Unchanged
Barclays PLC84$1.79K0.00%+84New
Crewe Advisors LLC83$1.77K0.00%00.0%Unchanged
Newbridge Financial Services Group, Inc.40$8510.00%00.0%Unchanged
Wells Fargo & Company19$4040.00%+19New
Parallel Advisors, LLC5$1060.00%00.0%Unchanged
Ridgeback Capital Investments L.P.0$00.00%−2,264,801−100.0%Sold out
RTW Investments, LP0$00.00%−1,258,587−100.0%Sold out
Samlyn Capital, LLC0$00.00%−987,888−100.0%Sold out
Eventide Asset Management, LLC0$00.00%−853,800−100.0%Sold out
Pura Vida Investments, LLC0$00.00%−239,015−100.0%Sold out
Alliancebernstein L.P.0$00.00%−72,549−100.0%Sold out
L & S Advisors Inc0$00.00%−34,950−100.0%Sold out
State Street Corp0$00.00%−8,861−100.0%Sold out
Victory Capital Management Inc0$00.00%−8,037−100.0%Sold out
Twelve Points Wealth Management LLC0$00.00%−7,200−100.0%Sold out
US Bancorp0$00.00%−234−100.0%Sold out