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Bicycle Therapeutics PLC

BCYC
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001761612

In the last 90 days, Bicycle Therapeutics PLC insiders filed 0 open-market purchases and 5 sales; 103 institutions reported holding it in 13F filings for Q2 2026, worth $157.9M in total; no superinvestor holds it.

13F holders, Q4 2021

Institutional positions in Bicycle Therapeutics PLC as of Dec 31, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
101
+33 vs. Q3 2021
Shares held
21.6M
+7.37M (+51.9%) vs. Q3 2021
Total value
$1.31B
+$721.6M (+122.2%) vs. Q3 2021
New holders
45
26 more added
Sold out
12
25 more reduced

1 institution that held it in Q3 2021 haven't filed for Q4 2021 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q3 2021: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting BCYC on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2021: 101 institutions
Q1 2021: 39 institutionsQ2 2021: 54 institutionsQ3 2021: 69 institutionsQ4 2021: 101 institutionsQ1 2022: 105 institutionsQ2 2022: 82 institutionsQ3 2022: 79 institutionsQ4 2022: 87 institutionsQ1 2023: 89 institutionsQ2 2023: 85 institutionsQ3 2023: 101 institutionsQ4 2023: 101 institutionsQ1 2024: 95 institutionsQ2 2024: 107 institutionsQ3 2024: 105 institutionsQ4 2024: 97 institutionsQ1 2025: 95 institutionsQ2 2025: 110 institutionsQ3 2025: 99 institutionsQ4 2025: 109 institutionsQ1 2026: 98 institutionsQ2 2026: 103 institutions
Value heldQ4 2021: $1.31B
Q1 2021: $341.2MQ2 2021: $376.9MQ3 2021: $591.1MQ4 2021: $1.31BQ1 2022: $884.5MQ2 2022: $381.1MQ3 2022: $538.0MQ4 2022: $695.9MQ1 2023: $498.9MQ2 2023: $618.5MQ3 2023: $651.3MQ4 2023: $567.4MQ1 2024: $759.1MQ2 2024: $804.0MQ3 2024: $915.3MQ4 2024: $586.5MQ1 2025: $354.4MQ2 2025: $286.3MQ3 2025: $285.6MQ4 2025: $276.9MQ1 2026: $173.6MQ2 2026: $157.9M
Institutions holding BCYC and their total value by quarter
QuarterHoldersValue
Q2 2026103$157.9M
Q1 202698$173.6M
Q4 2025109$276.9M
Q3 202599$285.6M
Q2 2025110$286.3M
Q1 202595$354.4M
Q4 202497$586.5M
Q3 2024105$915.3M
Q2 2024107$804.0M
Q1 202495$759.1M
Q4 2023101$567.4M
Q3 2023101$651.3M
Q2 202385$618.5M
Q1 202389$498.9M
Q4 202287$695.9M
Q3 202279$538.0M
Q2 202282$381.1M
Q1 2022105$884.5M
Q4 2021101$1.31B
Q3 202169$591.1M
Q2 202154$376.9M
Q1 202139$341.2M

Institutions, Q4 2021

Shares, value and share of portfolio for each institution holding Bicycle Therapeutics PLC; share changes are against Q3 2021.

Institutions holding BCYC in Q4 2021
InstitutionSharesValue% of portfolioChange in sharesAction
Parallel Advisors, LLC5$00.00%+5New
Newbridge Financial Services Group, Inc.40$2.00K0.00%00.0%Unchanged
Zullo Investment Group, Inc.50$3.00K0.00%+50New
Daiwa Securities Group Inc.58$4.00K0.00%+58New
McDonald Partners LLC70$4.26K0.00%+70New
Absolute Capital Management, LLC70$4.26K0.00%+70New
American Portfolios Advisors114$6.94K0.00%00.0%Unchanged
Royal Bank of Canada151$9.00K0.00%+47+45.2%Added
Rockefeller Capital Management L.P.165$10.0K0.00%−181−52.3%Reduced
Leonteq Securities AG270$16.4K0.00%+270New
US Bancorp371$23.0K0.00%−9,618−96.3%Reduced
High Net Worth Advisory Group LLC500$30.0K0.01%+500New
Quantbot Technologies LP559$34.0K0.00%+559New
Signet Financial Management, LLC665$40.0K0.01%+665New
Citigroup Inc802$49.0K0.00%+649+424.2%Added
UBS Group AG892$54.0K0.00%+46+5.4%Added
Cutler Group LP1,250$76.0K0.01%−13,376−91.5%Reduced
Simplex Trading, LLC1,557$94.0K0.00%+1,557New
Captrust Financial Advisors2,260$138.0K0.00%00.0%Unchanged
Bank of America Corp2,524$153.0K0.00%+368+17.1%Added
JPMorgan Chase & Co2,828$172.0K0.00%+1,463+107.2%Added
Northern Trust Corp2,905$177.0K0.00%+2,905New
Virtus ETF Advisers LLC3,166$193.0K0.07%−3,964−55.6%Reduced
Commonwealth of Pennsylvania Public School Empls Retrmt Sys3,373$205.0K0.00%+3,373New
Difesa Capital Management, LP3,500$213.0K0.15%+3,500New
Barclays PLC3,600$219.0K0.00%−2,522−41.2%Reduced
Claro Advisors LLC3,637$221.0K0.08%+3,637New
Tower Research Capital LLC (TRC)3,727$227.0K0.00%+3,727New
SEI Investments Co3,760$229.0K0.00%+3,760New
Susquehanna Fundamental Investments, LLC4,200$256.0K0.01%+4,200New
Castleview Partners, LLC15,704$258.0K0.00%+15,704New
HighMark Wealth Management LLC4,325$263.0K0.17%+3,699+590.9%Added
Advisor Group Holdings, Inc.4,334$264.0K0.00%−730−14.4%Reduced
Trexquant Investment LP4,370$266.0K0.02%+4,370New
Shilanski & Associates, Inc.5,156$314.0K0.13%+5,156New
Wells Fargo & Company6,001$365.0K0.00%−103−1.7%Reduced
Truist Financial Corp6,905$420.0K0.00%−476−6.4%Reduced
Twelve Points Wealth Management LLC7,100$432.0K0.35%+7,100New
TownSquare Capital, LLC7,182$437.0K0.01%−605−7.8%Reduced
Personal Cfo Solutions, LLC7,467$455.0K0.09%−91−1.2%Reduced
Squarepoint Ops LLC8,200$499.0K0.00%+8,200New
State Street Corp8,354$509.0K0.00%+1,654+24.7%Added
Wrapmanager Inc9,066$552.0K0.14%−554−5.8%Reduced
Vestmark Advisory Solutions, Inc.9,749$593.0K0.03%−128−1.3%Reduced
Geode Capital Management, LLC9,880$601.0K0.00%00.0%Unchanged
Legal & General Group Plc10,060$612.0K0.00%−148−1.4%Reduced
Soleus Capital Management, L.P.10,250$624.0K0.08%+10,250New
Woodstock Corp10,682$650.0K0.07%00.0%Unchanged
DekaBank Deutsche Girozentrale12,000$675.0K0.00%+12,000New
Jane Street Group, LLC13,386$814.0K0.00%+13,386New
Erste Asset Management GmbH14,000$821.5K0.01%+14,000New
Vident Investment Advisory, LLC17,933$1.09M0.03%+17,933New
Ensign Peak Advisors, Inc18,260$1.11M0.00%+18,260New
Goldman Sachs Group Inc20,687$1.26M0.00%+5,824+39.2%Added
Jump Financial, LLC31,207$1.90M0.12%+14,007+81.4%Added
Laurion Capital Management LP31,410$1.91M0.03%−3,734−10.6%Reduced
TD Asset Management Inc31,586$1.92M0.00%+31,586New
Harbor Capital Advisors, Inc.34,600$2.11M0.77%+34,600New
Stifel Financial Corp34,959$2.13M0.00%−2,928−7.7%Reduced
Pentwater Capital Management LP39,500$2.40M0.04%+27,500+229.2%Added
LMR Partners LLP40,000$2.44M0.03%+40,000New
Envestnet Asset Management Inc41,292$2.51M0.00%−2,004−4.6%Reduced
Goldstream Capital Management Ltd48,257$2.94M0.72%+48,257New
Marshall Wace, LLP50,398$3.07M0.01%+42,704+555.0%Added
Voloridge Investment Management, LLC52,575$3.20M0.02%+52,575New
Bellevue Group AG53,700$3.27M0.03%−12,000−18.3%Reduced
Sio Capital Management, LLC54,000$3.29M1.00%+54,000New
Citadel Advisors LLC58,187$3.54M0.00%+32,840+129.6%Added
Boothbay Fund Management, LLC63,416$3.86M0.13%+8,510+15.5%Added
Parkman Healthcare Partners LLC64,800$3.94M0.89%−4,749−6.8%Reduced
Renaissance Technologies LLC73,179$4.45M0.01%+73,179New
Handelsbanken Fonder AB80,000$4.87M0.02%+80,000New
Two Sigma Advisers, LP97,200$5.92M0.01%+50,500+108.1%Added
Dorsey Wright & Associates130,726$7.96M1.64%+2,938+2.3%Added
AXA S.A.145,252$8.84M0.02%−53,421−26.9%Reduced
Morgan Stanley150,012$9.13M0.00%+5,399+3.7%Added
Two Sigma Investments, LP151,361$9.21M0.02%+59,169+64.2%Added
Millennium Management LLC152,732$9.30M0.01%+152,732New
Verition Fund Management LLC164,715$10.0M0.13%−14,546−8.1%Reduced
Altium Capital Management LP172,000$10.5M2.94%+80,000+87.0%Added
Acadian Asset Management LLC178,539$10.9M0.04%+157,365+743.2%Added
Great Point Partners LLC200,000$12.2M2.72%+200,000New
BlackRock Inc.203,995$12.4M0.00%+203,995New
Driehaus Capital Management LLC267,032$16.3M0.17%+267,032New
Samlyn Capital, LLC309,115$18.8M0.29%−145,766−32.0%Reduced
Frazier Management LLC555,240$33.8M2.60%+112,360+25.4%Added
Victory Capital Management Inc568,568$34.6M0.03%+414,845+269.9%Added
Loomis Sayles & Co L P570,047$34.7M0.04%+570,047New
Ikarian Capital, LLC613,126$37.3M10.68%+86,626+16.5%Added
Price T Rowe Associates Inc796,014$48.5M0.00%+796,014New
RTW Investments, LP869,271$52.9M0.77%+869,271New
Logos Global Management LP870,000$53.0M5.46%−605,000−41.0%Reduced
SV Health Investors, LLC918,154$55.9M36.13%−518,302−36.1%Reduced
First Light Asset Management, LLC1,000,783$60.9M4.36%+268,052+36.6%Added
Deep Track Capital, LP1,100,000$67.0M4.95%+1,100,000New
Eventide Asset Management, LLC1,263,471$76.9M0.98%+100,000+8.6%Added
FMR LLC1,460,882$88.9M0.01%+999,253+216.5%Added
Point72 Asset Management, L.P.1,572,823$95.7M0.42%−42,269−2.6%Reduced
Janus Henderson Group PLC1,695,409$103.2M0.04%−47,596−2.7%Reduced
Tybourne Capital Management (HK) Ltd2,053,804$125.0M3.71%+95,843+4.9%Added