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Prime Medicine, Inc.

PRME
Exchange
Nasdaq
Industry
Biological Products, (No Diagnostic Substances)
SEC CIK
0001894562

No open-market purchases or sales by Prime Medicine, Inc. insiders were filed in the last 90 days; 187 institutions reported holding it in 13F filings for Q2 2026, worth $393.5M in total; ARK Invest is the only superinvestor holding it.

13F holders, Q3 2023

Institutional positions in Prime Medicine, Inc. as of Sep 30, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
83
+5 vs. Q2 2023
Shares held
49.5M
+3.39M (+7.3%) vs. Q2 2023
Total value
$472.3M
−$203.4M (−30.1%) vs. Q2 2023
New holders
11
35 more added
Sold out
6
15 more reduced

1 institution that held it in Q2 2023 haven't filed for Q3 2023 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q2 2023: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting PRME on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ3 2023: 83 institutions
Q1 2021: 0 institutionsQ2 2021: 0 institutionsQ3 2021: 0 institutionsQ4 2021: 0 institutionsQ1 2022: 0 institutionsQ2 2022: 0 institutionsQ3 2022: 0 institutionsQ4 2022: 66 institutionsQ1 2023: 76 institutionsQ2 2023: 79 institutionsQ3 2023: 83 institutionsQ4 2023: 105 institutionsQ1 2024: 115 institutionsQ2 2024: 122 institutionsQ3 2024: 116 institutionsQ4 2024: 132 institutionsQ1 2025: 125 institutionsQ2 2025: 121 institutionsQ3 2025: 167 institutionsQ4 2025: 183 institutionsQ1 2026: 192 institutionsQ2 2026: 187 institutions
Value heldQ3 2023: $472.3M
Q1 2021: $0Q2 2021: $0Q3 2021: $0Q4 2021: $0Q1 2022: $0Q2 2022: $0Q3 2022: $0Q4 2022: $767.8MQ1 2023: $512.1MQ2 2023: $675.7MQ3 2023: $472.3MQ4 2023: $431.4MQ1 2024: $466.6MQ2 2024: $354.0MQ3 2024: $265.9MQ4 2024: $188.0MQ1 2025: $120.4MQ2 2025: $145.0MQ3 2025: $511.5MQ4 2025: $336.5MQ1 2026: $342.6MQ2 2026: $393.5M
Institutions holding PRME and their total value by quarter
QuarterHoldersValue
Q2 2026187$393.5M
Q1 2026192$342.6M
Q4 2025183$336.5M
Q3 2025167$511.5M
Q2 2025121$145.0M
Q1 2025125$120.4M
Q4 2024132$188.0M
Q3 2024116$265.9M
Q2 2024122$354.0M
Q1 2024115$466.6M
Q4 2023105$431.4M
Q3 202383$472.3M
Q2 202379$675.7M
Q1 202376$512.1M
Q4 202266$767.8M
Q3 20220$0
Q2 20220$0
Q1 20220$0
Q4 20210$0
Q3 20210$0
Q2 20210$0
Q1 20210$0

Institutions, Q3 2023

Shares, value and share of portfolio for each institution holding Prime Medicine, Inc.; share changes are against Q2 2023.

Institutions holding PRME in Q3 2023
InstitutionSharesValue% of portfolioChange in sharesAction
Covestor Ltd8$00.00%−1−11.1%Reduced
Nisa Investment Advisors, LLC20$1910.00%−13−39.4%Reduced
Massmutual Trust Co FSB25$2390.00%−9−26.5%Reduced
Grove Bank & Trust77$7350.00%+77New
Benjamin Edwards Inc321$3.00K0.00%00.0%Unchanged
US Bancorp346$3.30K0.00%00.0%Unchanged
Chelsea Counsel Co600$5.72K0.00%00.0%Unchanged
Comerica Bank779$7.43K0.00%+779New
First Horizon Advisors, Inc.1,031$9.84K0.00%−524−33.7%Reduced
Lazard Asset Management LLC1,670$15.0K0.00%+66+4.1%Added
Metropolitan Life Insurance Co2,203$21.0K0.00%00.0%Unchanged
Allspring Global Investments Holdings, LLC3,067$29.3K0.00%−8,374−73.2%Reduced
Tower Research Capital LLC (TRC)3,528$33.7K0.00%+385+12.2%Added
Ameritas Investment Partners, Inc.3,901$37.2K0.00%+634+19.4%Added
Legal & General Group Plc4,524$43.1K0.00%−267−5.6%Reduced
Royal Bank of Canada4,953$47.0K0.00%+1,374+38.4%Added
ORG Partners LLC5,270$50.3K0.01%00.0%Unchanged
Amalgamated Bank6,014$57.0K0.00%+1,262+26.6%Added
Citadel Advisors LLC6,524$62.2K0.00%+6,524New
Advisor Group Holdings, Inc.7,962$75.9K0.00%+1,559+24.3%Added
California State Teachers Retirement System8,729$83.3K0.00%−4,430−33.7%Reduced
Sandia Investment Management LP10,000$95.4K0.03%00.0%Unchanged
Brown Brothers Harriman & Co10,065$96.0K0.00%00.0%Unchanged
Walleye Capital LLC10,700$102.1K0.00%+10,700New
State Board of Administration of Florida Retirement System11,420$108.9K0.00%+190+1.7%Added
Virtu Financial LLC12,466$119.0K0.01%+12,466New
Red Lighthouse Investment Management, LLC14,950$142.6K0.07%00.0%Unchanged
Squarepoint Ops LLC15,490$147.8K0.00%+15,490New
Clarius Group, LLC16,080$153.4K0.01%00.0%Unchanged
Voya Investment Management LLC16,160$154.2K0.00%+417+2.6%Added
New York State Common Retirement Fund16,316$155.7K0.00%+332+2.1%Added
Envestnet Asset Management Inc16,616$158.5K0.00%+16,616New
Principal Financial Group Inc18,041$172.1K0.00%+12+0.1%Added
Penserra Capital Management LLC18,468$176.0K0.00%+10,361+127.8%Added
American International Group, Inc.19,743$188.3K0.00%+703+3.7%Added
Deutsche Bank AG20,555$196.1K0.00%+2,743+15.4%Added
HighTower Advisors, LLC21,299$201.0K0.00%−23−0.1%Reduced
MetLife Investment Management21,262$202.8K0.00%00.0%Unchanged
Oppenheimer & Co Inc21,537$205.5K0.00%+6,152+40.0%Added
Profund Advisors LLC21,995$209.8K0.01%+21,995New
Mirae Asset Global Investments Co., Ltd.23,016$219.6K0.00%+4,145+22.0%Added
JPMorgan Chase & Co27,014$257.7K0.00%−3,658−11.9%Reduced
Wells Fargo & Company31,317$298.8K0.00%+15,020+92.2%Added
Alliancebernstein L.P.31,840$303.8K0.00%+5,300+20.0%Added
Brandywine Managers, LLC32,977$314.6K0.53%00.0%Unchanged
Green Alpha Advisors, LLC37,815$360.8K0.28%+25,429+205.3%Added
Morgan Stanley42,791$408.2K0.00%−15,138−26.1%Reduced
UBS Group AG43,772$417.6K0.00%−55,267−55.8%Reduced
Rhumbline Advisers50,959$486.1K0.00%+3,896+8.3%Added
Citigroup Inc56,193$536.1K0.00%+42,032+296.8%Added
Goldman Sachs Group Inc58,911$562.0K0.00%+58,911New
Manufacturers Life Insurance Company, The64,660$616.9K0.00%+6,259+10.7%Added
Barclays PLC65,140$621.4K0.00%+57,261+726.8%Added
Two Sigma Investments, LP92,993$887.2K0.00%+92,993New
TD Asset Management Inc104,542$997.3K0.00%+37,471+55.9%Added
Nuveen Asset Management, LLC106,922$1.02M0.00%−16,273−13.2%Reduced
Bank of New York Mellon Corp115,389$1.10M0.00%+12,176+11.8%Added
Janus Henderson Group PLC120,946$1.15M0.00%−443,908−78.6%Reduced
Rafferty Asset Management, LLC128,876$1.23M0.01%+128,876New
Ensign Peak Advisors, Inc150,000$1.43M0.00%00.0%Unchanged
Charles Schwab Investment Management Inc292,570$2.79M0.00%+151,426+107.3%Added
Bank of America Corp302,642$2.89M0.00%+155,127+105.2%Added
Northern Trust Corp332,958$3.18M0.00%+50,527+17.9%Added
Casdin Capital, LLC367,175$3.50M0.39%00.0%Unchanged
Greenwich Wealth Management LLC439,021$4.19M0.44%+231,021+111.1%Added
Moore Capital Management, LP446,733$4.26M0.12%00.0%Unchanged
Samsara BioCapital, LLC470,304$4.49M1.37%00.0%Unchanged
EcoR1 Capital, LLC600,000$5.72M0.20%00.0%Unchanged
Geode Capital Management, LLC846,637$8.08M0.00%+306,329+56.7%Added
Deerfield Management Company, L.P. (Series C)885,314$8.45M0.19%00.0%Unchanged
Baker Bros. Advisors LP1,028,466$9.81M0.06%00.0%Unchanged
Redmile Group, LLC1,324,350$12.6M0.60%00.0%Unchanged
State Street Corp1,686,001$16.1M0.00%+1,080,802+178.6%Added
MWG Management Limited1,792,210$17.1M16.57%00.0%Unchanged
FIL Ltd1,805,558$17.2M0.02%00.0%Unchanged
Price T Rowe Associates Inc2,173,371$20.7M0.00%−160,460−6.9%Reduced
ARK Investment Management LLCSuperinvestorARK Invest2,622,429$25.0M0.19%+173,230+7.1%Added
BlackRock Inc.3,334,525$31.8M0.00%+445,309+15.4%Added
Nikko Asset Management Americas, Inc.3,634,848$34.6M0.41%+570,232+18.6%Added
Sumitomo Mitsui Trust Holdings, Inc.3,634,848$34.7M0.03%+571,097+18.6%Added
FMR LLC3,922,416$37.4M0.00%−116,803−2.9%Reduced
Vanguard Group Inc3,951,793$37.7M0.00%+617,310+18.5%Added
Alphabet Inc.11,862,498$113.2M7.27%00.0%Unchanged
Jane Street Group, LLC0$00.00%−397,004−100.0%Sold out
Millennium Management LLC0$00.00%−256,560−100.0%Sold out
Laurion Capital Management LP0$00.00%−55,888−100.0%Sold out
Levin Capital Strategies, L.P.0$00.00%−20,000−100.0%Sold out
Susquehanna International Group, LLP0$00.00%−12,254−100.0%Sold out
CWM, LLC0$00.00%−15−100.0%Sold out
Endurance Wealth Management, Inc.––––Not filed