Krystal Biotech, Inc.
KRYS- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001711279
In the last 90 days, Krystal Biotech, Inc. insiders filed 0 open-market purchases and 3 sales; 422 institutions reported holding it in 13F filings for Q2 2026, worth $11.1B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Krystal Biotech, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 334
- +55 vs. Q3 2025
- Shares held
- 28.4M
- +470.1K (+1.7%) vs. Q3 2025
- Total value
- $7.01B
- +$2.07B (+42.0%) vs. Q3 2025
- New holders
- 82
- 111 more added
- Sold out
- 27
- 105 more reduced
5 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KRYS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 422 | $11.1B |
| Q1 2026 | 368 | $7.32B |
| Q4 2025 | 334 | $7.01B |
| Q3 2025 | 284 | $4.94B |
| Q2 2025 | 275 | $3.80B |
| Q1 2025 | 299 | $4.98B |
| Q4 2024 | 264 | $4.35B |
| Q3 2024 | 283 | $5.15B |
| Q2 2024 | 245 | $5.24B |
| Q1 2024 | 234 | $4.49B |
| Q4 2023 | 194 | $3.03B |
| Q3 2023 | 188 | $2.76B |
| Q2 2023 | 183 | $2.71B |
| Q1 2023 | 160 | $1.68B |
| Q4 2022 | 154 | $1.66B |
| Q3 2022 | 148 | $1.45B |
| Q2 2022 | 137 | $1.36B |
| Q1 2022 | 135 | $1.37B |
| Q4 2021 | 140 | $1.35B |
| Q3 2021 | 113 | $850.7M |
| Q2 2021 | 113 | $1.12B |
| Q1 2021 | 113 | $1.27B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Krystal Biotech, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Franklin Resources Inc | 125,675 | $31.0M | 0.01% | +105,825+533.1% | Added |
| JPMorgan Chase & Co | 134,624 | $33.2M | 0.00% | −11,730−8.0% | Reduced |
| Woodline Partners LP | 150,616 | $37.1M | 0.14% | 00.0% | Unchanged |
| Bank of New York Mellon Corp | 151,313 | $37.3M | 0.01% | −4,240−2.7% | Reduced |
| Pictet Asset Management Holding SA | 156,568 | $38.6M | 0.04% | −40,336−20.5% | Reduced |
| UBS Group AG | 159,595 | $39.3M | 0.01% | +29,422+22.6% | Added |
| Principal Financial Group Inc | 165,074 | $40.7M | 0.02% | +22,231+15.6% | Added |
| Marshall Wace, LLP | 183,754 | $45.3M | 0.04% | +54,794+42.5% | Added |
| Nuveen, LLC | 189,094 | $46.6M | 0.01% | −8,284−4.2% | Reduced |
| Bank of America Corp | 190,807 | $47.0M | 0.00% | +52,812+38.3% | Added |
| Braidwell LP | 202,101 | $49.8M | 1.59% | −318,300−61.2% | Reduced |
| Janus Henderson Group PLC | 219,440 | $54.1M | 0.02% | +209,369+2,078.9% | Added |
| Morgan Stanley | 221,481 | $54.6M | 0.00% | −13,097−5.6% | Reduced |
| Charles Schwab Investment Management Inc | 242,774 | $59.9M | 0.01% | −890.0% | Reduced |
| First Trust Advisors LP | 245,276 | $60.5M | 0.04% | −3,116−1.3% | Reduced |
| Northern Trust Corp | 247,443 | $61.0M | 0.01% | −722−0.3% | Reduced |
| Norges Bank | 284,573 | $70.2M | 0.01% | +284,573 | New |
| Goldman Sachs Group Inc | 293,525 | $72.4M | 0.01% | −54,725−15.7% | Reduced |
| William Blair Investment Management, LLC | 376,340 | $92.8M | 0.26% | +227,038+152.1% | Added |
| Citadel Advisors LLC | 386,505 | $95.3M | 0.06% | −250,483−39.3% | Reduced |
| Bellevue Group AG | 410,323 | $101.2M | 1.92% | +409,011+31,174.6% | Added |
| Frazier Life Sciences Management, L.P. | 488,460 | $120.4M | 3.23% | −200,000−29.1% | Reduced |
| Dimensional Fund Advisors LP | 492,968 | $121.5M | 0.03% | −40,996−7.7% | Reduced |
| Price T Rowe Associates Inc | 529,955 | $130.7M | 0.01% | +62,897+13.5% | Added |
| Geode Capital Management, LLC | 611,878 | $150.9M | 0.01% | +634+0.1% | Added |
| Hood River Capital Management LLC | 613,302 | $151.2M | 1.66% | +6,356+1.0% | Added |
| Redmile Group, LLC | 677,705 | $167.1M | 12.30% | +16,317+2.5% | Added |
| Capital World Investors | 809,500 | $199.6M | 0.03% | +2600.0% | Added |
| Soleus Capital Management, L.P. | 941,059 | $232.0M | 9.84% | −77,772−7.6% | Reduced |
| State Street Corp | 1,342,303 | $330.9M | 0.01% | −53,664−3.8% | Reduced |
| Vanguard Group Inc | 2,778,845 | $685.1M | 0.01% | −13,363−0.5% | Reduced |
| Avoro Capital Advisors LLC | 2,888,888 | $712.2M | 7.00% | +111,111+4.0% | Added |
| BlackRock, Inc. | 3,937,817 | $970.8M | 0.02% | +103,689+2.7% | Added |
| FMR LLC | 4,349,628 | $1.07B | 0.05% | +8,181+0.2% | Added |
| Readystate Asset Management LP | 0 | $0 | 0.00% | −70,349−100.0% | Sold out |
| Fieldview Capital Management, LLC | 0 | $0 | 0.00% | −14,705−100.0% | Sold out |
| Alps Advisors Inc | 0 | $0 | 0.00% | −13,367−100.0% | Sold out |
| Acuta Capital Partners, LLC | 0 | $0 | 0.00% | −10,573−100.0% | Sold out |
| Schroder Investment Management Group | 0 | $0 | 0.00% | −10,170−100.0% | Sold out |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | $0 | 0.00% | −9,778−100.0% | Sold out |
| Summit Trail Advisors, LLC | 0 | $0 | 0.00% | −6,464−100.0% | Sold out |
| Dark Forest Capital Management LP | 0 | $0 | 0.00% | −5,903−100.0% | Sold out |
| Omers Administration Corp | 0 | $0 | 0.00% | −4,000−100.0% | Sold out |
| CenterBook Partners LP | 0 | $0 | 0.00% | −3,429−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −3,381−100.0% | Sold out |
| Sig Brokerage, LP | 0 | $0 | 0.00% | −2,849−100.0% | Sold out |
| Advantage Alpha Capital Partners LP | 0 | $0 | 0.00% | −2,387−100.0% | Sold out |
| Man Group plc | 0 | $0 | 0.00% | −2,088−100.0% | Sold out |
| Freestone Grove Partners LP | 0 | $0 | 0.00% | −2,031−100.0% | Sold out |
| Altfest L J & Co Inc | 0 | $0 | 0.00% | −1,870−100.0% | Sold out |
| Campbell & CO Investment Adviser LLC | 0 | $0 | 0.00% | −1,721−100.0% | Sold out |
| Advisory Services Network, LLC | 0 | $0 | 0.00% | −854−100.0% | Sold out |
| Pilgrim Partners Asia Pte Ltd | 0 | $0 | 0.00% | −330−100.0% | Sold out |
| Group One Trading, L.P. | 0 | $0 | 0.00% | −160−100.0% | Sold out |
| Rise Advisors, LLC | 0 | $0 | 0.00% | −66−100.0% | Sold out |
| Principal Securities, Inc. | 0 | $0 | 0.00% | −17−100.0% | Sold out |
| Wealthspire Advisors, LLC | 0 | $0 | 0.00% | −15−100.0% | Sold out |
| JPL Wealth Management, LLC | 0 | $0 | 0.00% | −10−100.0% | Sold out |
| Salem Investment Counselors Inc | 0 | $0 | 0.00% | −8−100.0% | Sold out |
| Atlantic Trust, LLC | 0 | $0 | 0.00% | −5−100.0% | Sold out |
| Tortoise Investment Management, LLC | 0 | $0 | 0.00% | −1−100.0% | Sold out |
| EFG Asset Management (North America) Corp. | – | – | – | – | Not filed |
| Synovus Financial Corp | – | – | – | – | Not filed |
| CIBC Bancorp USA Inc. | – | – | – | – | Not filed |
| Wolverine Trading, LLC | – | – | – | – | Not filed |
| Abich Financial Wealth Management LLC | – | – | – | – | Not filed |