Krystal Biotech, Inc.
KRYS- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001711279
In the last 90 days, Krystal Biotech, Inc. insiders filed 0 open-market purchases and 3 sales; 422 institutions reported holding it in 13F filings for Q2 2026, worth $11.1B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Krystal Biotech, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 334
- +55 vs. Q3 2025
- Shares held
- 28.4M
- +470.1K (+1.7%) vs. Q3 2025
- Total value
- $7.01B
- +$2.07B (+42.0%) vs. Q3 2025
- New holders
- 82
- 111 more added
- Sold out
- 27
- 105 more reduced
5 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KRYS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 422 | $11.1B |
| Q1 2026 | 368 | $7.32B |
| Q4 2025 | 334 | $7.01B |
| Q3 2025 | 284 | $4.94B |
| Q2 2025 | 275 | $3.80B |
| Q1 2025 | 299 | $4.98B |
| Q4 2024 | 264 | $4.35B |
| Q3 2024 | 283 | $5.15B |
| Q2 2024 | 245 | $5.24B |
| Q1 2024 | 234 | $4.49B |
| Q4 2023 | 194 | $3.03B |
| Q3 2023 | 188 | $2.76B |
| Q2 2023 | 183 | $2.71B |
| Q1 2023 | 160 | $1.68B |
| Q4 2022 | 154 | $1.66B |
| Q3 2022 | 148 | $1.45B |
| Q2 2022 | 137 | $1.36B |
| Q1 2022 | 135 | $1.37B |
| Q4 2021 | 140 | $1.35B |
| Q3 2021 | 113 | $850.7M |
| Q2 2021 | 113 | $1.12B |
| Q1 2021 | 113 | $1.27B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Krystal Biotech, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Teachers Retirement System of the State of Kentucky | 6,458 | $1.59M | 0.01% | −762−10.6% | Reduced |
| STRS Ohio | 6,500 | $1.60M | 0.01% | −900−12.2% | Reduced |
| Advisor Group Holdings, Inc. | 6,732 | $1.66M | 0.00% | +6,344+1,635.1% | Added |
| Police & Firemen's Retirement System of New Jersey | 6,747 | $1.66M | 0.01% | −112−1.6% | Reduced |
| Quantum Private Wealth, LLC | 7,181 | $1.77M | 0.52% | −24−0.3% | Reduced |
| Guggenheim Capital LLC | 7,252 | $1.79M | 0.01% | +3,200+79.0% | Added |
| State of New Jersey Common Pension Fund D | 7,409 | $1.83M | 0.01% | −7,190−49.2% | Reduced |
| Amalgamated Bank | 7,486 | $1.85M | 0.01% | +70+0.9% | Added |
| Tealwood Asset Management Inc | 7,713 | $1.90M | 0.85% | −189−2.4% | Reduced |
| Clough Capital Partners L P | 7,806 | $1.92M | 0.17% | +7,806 | New |
| Yousif Capital Management, LLC | 7,167 | $1.97M | 0.02% | −1,050−12.8% | Reduced |
| NFJ Investment Group, LLC | 8,249 | $2.03M | 0.07% | −363−4.2% | Reduced |
| Perigon Wealth Management, LLC | 8,970 | $2.21M | 0.04% | +41+0.5% | Added |
| Virginia Retirement Systems Et Al | 9,000 | $2.22M | 0.01% | +7,000+350.0% | Added |
| Nomura Asset Management International Inc. | 9,591 | $2.37M | 0.00% | +9,591 | New |
| Intech Investment Management LLC | 9,751 | $2.40M | 0.02% | 00.0% | Unchanged |
| Commonwealth Equity Services, LLC | 9,887 | $2.44M | 0.00% | −119−1.2% | Reduced |
| Profund Advisors LLC | 9,887 | $2.44M | 0.07% | +1,557+18.7% | Added |
| Bridgewater Associates, LP | 10,015 | $2.47M | 0.01% | +292+3.0% | Added |
| Main Management ETF Advisors, LLC | 10,179 | $2.51M | 0.09% | +104+1.0% | Added |
| Envestnet Asset Management Inc | 10,577 | $2.61M | 0.00% | −2,531−19.3% | Reduced |
| Wellington Management Group LLP | 10,651 | $2.63M | 0.00% | −230−2.1% | Reduced |
| DekaBank Deutsche Girozentrale | 15,503 | $2.63M | 0.00% | 00.0% | Unchanged |
| State of Tennessee, Treasury Department | 10,193 | $2.85M | 0.01% | −925−8.3% | Reduced |
| Natixis Advisors, L.P. | 11,682 | $2.88M | 0.00% | +11,682 | New |
| Louisiana State Employees Retirement System | 11,800 | $2.91M | 0.05% | 00.0% | Unchanged |
| Polygon Management Ltd. | 11,814 | $2.91M | 0.61% | +6,944+142.6% | Added |
| Torray LLC | 11,985 | $2.95M | 0.42% | +84+0.7% | Added |
| Bridge City Capital, LLC | 12,135 | $2.99M | 0.88% | −2,019−14.3% | Reduced |
| Privium Fund Management B.V. | 12,170 | $3.00M | 0.55% | 00.0% | Unchanged |
| Illinois Municipal Retirement Fund | 12,699 | $3.13M | 0.04% | −1,546−10.9% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 12,954 | $3.20M | 0.00% | −336−2.5% | Reduced |
| Credit Agricole S A | 12,976 | $3.20M | 0.01% | +12,976 | New |
| MetLife Investment Management | 13,844 | $3.41M | 0.02% | −586−4.1% | Reduced |
| Creative Planning | 13,881 | $3.42M | 0.00% | +2,272+19.6% | Added |
| AQR Capital Management LLC | 14,157 | $3.49M | 0.00% | −5,976−29.7% | Reduced |
| State of Wisconsin Investment Board | 14,466 | $3.57M | 0.01% | −14,874−50.7% | Reduced |
| Millennium Management LLC | 14,658 | $3.61M | 0.00% | −134,055−90.1% | Reduced |
| Ikarian Capital, LLC | 14,814 | $3.65M | 0.47% | −9,607−39.3% | Reduced |
| New York State Teachers Retirement System | 15,650 | $3.86M | 0.01% | +100+0.6% | Added |
| State Board of Administration of Florida Retirement System | 15,756 | $3.88M | 0.01% | +9,971+172.4% | Added |
| Evolutionary Tree Capital Management, LLC | 16,811 | $4.14M | 4.81% | +4,350+34.9% | Added |
| Verition Fund Management LLC | 16,969 | $4.18M | 0.02% | −14,364−45.8% | Reduced |
| Pinnacle Financial Partners, Inc. | 16,983 | $4.19M | 0.03% | +16,983 | New |
| Decheng Capital LLC | 17,300 | $4.27M | 0.57% | −15,000−46.4% | Reduced |
| Perceptive Advisors LLC | 17,500 | $4.31M | 0.08% | −17,500−50.0% | Reduced |
| 1832 Asset Management L.P. | 17,600 | $4.34M | 0.01% | +17,600 | New |
| Thrivent Financial for Lutherans | 17,734 | $4.37M | 0.01% | −850−4.6% | Reduced |
| State of Alaska, Department of Revenue | 17,902 | $4.41M | 0.05% | +3,628+25.4% | Added |
| Fiera Capital Corp | 18,857 | $4.65M | 0.01% | +3,794+25.2% | Added |
| SG Americas Securities, LLC | 18,909 | $4.66M | 0.01% | +15,591+469.9% | Added |
| GW&K Investment Management, LLC | 19,581 | $4.83M | 0.04% | +9,089+86.6% | Added |
| ADAR1 Capital Management, LLC | 20,014 | $4.93M | 0.37% | +1,491+8.0% | Added |
| Bessemer Group Inc | 20,260 | $5.00M | 0.01% | +20,111+13,497.3% | Added |
| California State Teachers Retirement System | 20,583 | $5.07M | 0.01% | −299−1.4% | Reduced |
| Elmind Capital, LP | 22,000 | $5.42M | 1.60% | +22,000 | New |
| Great West Life Assurance Co | 22,087 | $5.45M | 0.01% | +689+3.2% | Added |
| Deutsche Bank AG | 22,450 | $5.53M | 0.00% | +1,071+5.0% | Added |
| EFG International AG | 23,569 | $5.82M | 0.11% | +23,569 | New |
| Rafferty Asset Management, LLC | 24,268 | $5.98M | 0.02% | −10,372−29.9% | Reduced |
| EAM Investors, LLC | 24,667 | $6.08M | 0.68% | +24,667 | New |
| Rhenman & Partners Asset Management AB | 25,000 | $6.16M | 0.58% | +13,250+112.8% | Added |
| Granite Investment Partners, LLC | 25,760 | $6.35M | 0.38% | +25,760 | New |
| Victory Capital Management Inc | 26,461 | $6.52M | 0.00% | −28,355−51.7% | Reduced |
| Prudential Financial Inc | 27,015 | $6.66M | 0.01% | +1,519+6.0% | Added |
| Russell Investments Group, Ltd. | 28,954 | $7.14M | 0.01% | +2,405+9.1% | Added |
| Castleark Management LLC | 29,260 | $7.21M | 0.21% | +29,260 | New |
| Citigroup Inc | 29,943 | $7.38M | 0.01% | +20,293+210.3% | Added |
| New York State Common Retirement Fund | 31,342 | $7.73M | 0.01% | +4,348+16.1% | Added |
| Alliancebernstein L.P. | 31,529 | $7.77M | 0.00% | +1,609+5.4% | Added |
| Wells Fargo & Company | 31,572 | $7.78M | 0.00% | +11,919+60.6% | Added |
| SEI Investments Co | 32,310 | $7.97M | 0.01% | +8,917+38.1% | Added |
| UBS Asset Management Americas Inc | 33,617 | $8.29M | 0.00% | −168,972−83.4% | Reduced |
| HealthInvest Partners AB | 33,853 | $8.35M | 2.66% | −8,338−19.8% | Reduced |
| Federated Hermes, Inc. | 34,541 | $8.52M | 0.01% | +10,560+44.0% | Added |
| Mutual of America Capital Management LLC | 37,269 | $9.19M | 0.10% | −665−1.8% | Reduced |
| CI Private Wealth, LLC | 38,346 | $9.50M | 0.01% | −784−2.0% | Reduced |
| Standard Life Aberdeen plc | 39,360 | $9.70M | 0.02% | −20,012−33.7% | Reduced |
| Manufacturers Life Insurance Company, The | 40,629 | $10.1M | 0.01% | +6,174+17.9% | Added |
| Palisades Investment Partners, LLC | 42,765 | $10.5M | 3.98% | +1,376+3.3% | Added |
| Swiss National Bank | 42,900 | $10.6M | 0.01% | +900+2.1% | Added |
| Skandinaviska Enskilda Banken AB (publ) | 46,732 | $11.5M | 0.05% | −13,246−22.1% | Reduced |
| Ameriprise Financial Inc | 52,345 | $12.9M | 0.00% | −3,447−6.2% | Reduced |
| BNP Paribas Arbitrage, SA | 53,911 | $13.3M | 0.01% | +44,732+487.3% | Added |
| TD Asset Management Inc | 54,142 | $13.3M | 0.01% | +9,062+20.1% | Added |
| Invesco Ltd. | 60,008 | $14.8M | 0.00% | −6,872−10.3% | Reduced |
| Barclays PLC | 60,062 | $14.8M | 0.01% | −15,834−20.9% | Reduced |
| ACT Capital Management, LLC | 60,500 | $14.9M | 12.06% | +60,500 | New |
| Legal & General Group Plc | 63,361 | $15.6M | 0.00% | −2,454−3.7% | Reduced |
| Rhumbline Advisers | 66,436 | $16.4M | 0.01% | −4,116−5.8% | Reduced |
| Biondo Investment Advisors, LLC | 68,130 | $16.8M | 2.03% | +16,245+31.3% | Added |
| Raymond James Financial Inc | 76,538 | $19.0M | 0.01% | +12,175+18.9% | Added |
| Segall Bryant & Hamill, LLC | 83,246 | $20.5M | 0.28% | −2,017−2.4% | Reduced |
| C WorldWide Group Holding A/S | 85,809 | $21.2M | 0.37% | 00.0% | Unchanged |
| Public Sector Pension Investment Board | 89,362 | $22.0M | 0.07% | −11,069−11.0% | Reduced |
| S Squared Technology, LLC | 96,215 | $23.7M | 9.19% | −13,000−11.9% | Reduced |
| TimesSquare Capital Management, LLC | 97,400 | $24.0M | 0.36% | −21,114−17.8% | Reduced |
| Voya Investment Management LLC | 103,261 | $25.5M | 0.03% | +9,353+10.0% | Added |
| Handelsbanken Fonder AB | 105,800 | $26.1M | 0.08% | +39,000+58.4% | Added |
| OrbiMed Advisors LLC | 119,800 | $29.5M | 0.60% | +17,055+16.6% | Added |