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Krystal Biotech, Inc.

KRYS
Exchange
Nasdaq
Industry
Biological Products, (No Diagnostic Substances)
SEC CIK
0001711279

In the last 90 days, Krystal Biotech, Inc. insiders filed 0 open-market purchases and 3 sales; 422 institutions reported holding it in 13F filings for Q2 2026, worth $11.1B in total; no superinvestor holds it.

13F holders, Q3 2025

Institutional positions in Krystal Biotech, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
284
+15 vs. Q2 2025
Shares held
28.0M
+649.0K (+2.4%) vs. Q2 2025
Total value
$4.94B
+$1.18B (+31.5%) vs. Q2 2025
New holders
46
106 more added
Sold out
31
86 more reduced

6 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q2 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting KRYS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ3 2025: 284 institutions
Q1 2021: 113 institutionsQ2 2021: 113 institutionsQ3 2021: 113 institutionsQ4 2021: 140 institutionsQ1 2022: 135 institutionsQ2 2022: 137 institutionsQ3 2022: 148 institutionsQ4 2022: 154 institutionsQ1 2023: 160 institutionsQ2 2023: 183 institutionsQ3 2023: 188 institutionsQ4 2023: 194 institutionsQ1 2024: 234 institutionsQ2 2024: 245 institutionsQ3 2024: 283 institutionsQ4 2024: 264 institutionsQ1 2025: 299 institutionsQ2 2025: 275 institutionsQ3 2025: 284 institutionsQ4 2025: 334 institutionsQ1 2026: 368 institutionsQ2 2026: 422 institutions
Value heldQ3 2025: $4.94B
Q1 2021: $1.27BQ2 2021: $1.12BQ3 2021: $850.7MQ4 2021: $1.35BQ1 2022: $1.37BQ2 2022: $1.36BQ3 2022: $1.45BQ4 2022: $1.66BQ1 2023: $1.68BQ2 2023: $2.71BQ3 2023: $2.76BQ4 2023: $3.03BQ1 2024: $4.49BQ2 2024: $5.24BQ3 2024: $5.15BQ4 2024: $4.35BQ1 2025: $4.98BQ2 2025: $3.80BQ3 2025: $4.94BQ4 2025: $7.01BQ1 2026: $7.32BQ2 2026: $11.1B
Institutions holding KRYS and their total value by quarter
QuarterHoldersValue
Q2 2026422$11.1B
Q1 2026368$7.32B
Q4 2025334$7.01B
Q3 2025284$4.94B
Q2 2025275$3.80B
Q1 2025299$4.98B
Q4 2024264$4.35B
Q3 2024283$5.15B
Q2 2024245$5.24B
Q1 2024234$4.49B
Q4 2023194$3.03B
Q3 2023188$2.76B
Q2 2023183$2.71B
Q1 2023160$1.68B
Q4 2022154$1.66B
Q3 2022148$1.45B
Q2 2022137$1.36B
Q1 2022135$1.37B
Q4 2021140$1.35B
Q3 2021113$850.7M
Q2 2021113$1.12B
Q1 2021113$1.27B

Institutions, Q3 2025

Shares, value and share of portfolio for each institution holding Krystal Biotech, Inc.; share changes are against Q2 2025.

Institutions holding KRYS in Q3 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Aigen Investment Management, LP0$00.00%−1,944−100.0%Sold out
OmniStar Financial Group, Inc.0$00.00%−1,878−100.0%Sold out
Algert Global LLC0$00.00%−1,500−100.0%Sold out
Hilltop Holdings Inc.0$00.00%−1,468−100.0%Sold out
Mount Yale Investment Advisors, LLC0$00.00%−1,251−100.0%Sold out
Financiere des Professionnels - Fonds d,investissement inc.0$00.00%−1,182−100.0%Sold out
Asset Management One Co.,Ltd.0$00.00%−617−100.0%Sold out
Headlands Technologies LLC0$00.00%−527−100.0%Sold out
Skopos Labs, Inc.0$00.00%−202−100.0%Sold out
Lazard Asset Management LLC0$00.00%−155−100.0%Sold out
Twin Peaks Wealth Advisors, LLC0$00.00%−35−100.0%Sold out
Kestra Investment Management, LLC0$00.00%−10−100.0%Sold out
Geneos Wealth Management Inc.0$00.00%−8−100.0%Sold out
Wolff Wiese Magana LLC0$00.00%−8−100.0%Sold out
Tradewinds Capital Management, LLC0$00.00%−1−100.0%Sold out
Norges Bank––––Not filed
E Fund Management Co., Ltd.––––Not filed
CIBC World Markets Corp––––Not filed
EP Wealth Advisors, LLC––––Not filed
First Horizon Advisors, Inc.––––Not filed
Parkworth Wealth Management, Inc.––––Not filed