Krystal Biotech, Inc.
KRYS- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001711279
In the last 90 days, Krystal Biotech, Inc. insiders filed 0 open-market purchases and 3 sales; 422 institutions reported holding it in 13F filings for Q2 2026, worth $11.1B in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Krystal Biotech, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 284
- +15 vs. Q2 2025
- Shares held
- 28.0M
- +649.0K (+2.4%) vs. Q2 2025
- Total value
- $4.94B
- +$1.18B (+31.5%) vs. Q2 2025
- New holders
- 46
- 106 more added
- Sold out
- 31
- 86 more reduced
6 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KRYS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 422 | $11.1B |
| Q1 2026 | 368 | $7.32B |
| Q4 2025 | 334 | $7.01B |
| Q3 2025 | 284 | $4.94B |
| Q2 2025 | 275 | $3.80B |
| Q1 2025 | 299 | $4.98B |
| Q4 2024 | 264 | $4.35B |
| Q3 2024 | 283 | $5.15B |
| Q2 2024 | 245 | $5.24B |
| Q1 2024 | 234 | $4.49B |
| Q4 2023 | 194 | $3.03B |
| Q3 2023 | 188 | $2.76B |
| Q2 2023 | 183 | $2.71B |
| Q1 2023 | 160 | $1.68B |
| Q4 2022 | 154 | $1.66B |
| Q3 2022 | 148 | $1.45B |
| Q2 2022 | 137 | $1.36B |
| Q1 2022 | 135 | $1.37B |
| Q4 2021 | 140 | $1.35B |
| Q3 2021 | 113 | $850.7M |
| Q2 2021 | 113 | $1.12B |
| Q1 2021 | 113 | $1.27B |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Krystal Biotech, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| DekaBank Deutsche Girozentrale | 15,503 | $2.72M | 0.00% | 00.0% | Unchanged |
| New York State Teachers Retirement System | 15,550 | $2.75M | 0.01% | −100−0.6% | Reduced |
| Erste Asset Management GmbH | 18,200 | $3.22M | 0.03% | 00.0% | Unchanged |
| ADAR1 Capital Management, LLC | 18,523 | $3.27M | 0.32% | +18,523 | New |
| Thrivent Financial for Lutherans | 18,584 | $3.28M | 0.01% | −116−0.6% | Reduced |
| Wells Fargo & Company | 19,653 | $3.47M | 0.00% | +3,106+18.8% | Added |
| Franklin Resources Inc | 19,850 | $3.50M | 0.00% | +1,425+7.7% | Added |
| AQR Capital Management LLC | 20,133 | $3.55M | 0.00% | +8,165+68.2% | Added |
| Synovus Financial Corp | 20,516 | $3.62M | 0.04% | −127−0.6% | Reduced |
| California State Teachers Retirement System | 20,882 | $3.69M | 0.00% | +756+3.8% | Added |
| Deutsche Bank AG | 21,379 | $3.77M | 0.00% | +2,244+11.7% | Added |
| Great West Life Assurance Co | 21,398 | $3.78M | 0.01% | +551+2.6% | Added |
| SEI Investments Co | 23,393 | $4.13M | 0.00% | +4,093+21.2% | Added |
| Federated Hermes, Inc. | 23,981 | $4.23M | 0.01% | −18,762−43.9% | Reduced |
| Ikarian Capital, LLC | 24,421 | $4.31M | 0.98% | +24,421 | New |
| Prudential Financial Inc | 25,496 | $4.50M | 0.01% | −655−2.5% | Reduced |
| Russell Investments Group, Ltd. | 26,549 | $4.69M | 0.01% | +16,191+156.3% | Added |
| New York State Common Retirement Fund | 26,994 | $4.77M | 0.01% | +3,612+15.4% | Added |
| EFG Asset Management (North America) Corp. | 27,095 | $4.78M | 0.62% | +4,217+18.4% | Added |
| State of Wisconsin Investment Board | 29,340 | $5.18M | 0.01% | −6,749−18.7% | Reduced |
| Alliancebernstein L.P. | 29,920 | $5.28M | 0.00% | −1,200−3.9% | Reduced |
| Verition Fund Management LLC | 31,333 | $5.53M | 0.03% | +4,819+18.2% | Added |
| Decheng Capital LLC | 32,300 | $5.70M | 0.99% | −33,700−51.1% | Reduced |
| Manufacturers Life Insurance Company, The | 34,455 | $6.08M | 0.01% | +9,775+39.6% | Added |
| Rafferty Asset Management, LLC | 34,640 | $6.11M | 0.02% | −25−0.1% | Reduced |
| Perceptive Advisors LLC | 35,000 | $6.18M | 0.18% | +35,000 | New |
| Mutual of America Capital Management LLC | 37,934 | $6.70M | 0.07% | −423−1.1% | Reduced |
| CI Private Wealth, LLC | 39,130 | $6.92M | 0.01% | −1,408−3.5% | Reduced |
| Kennedy Capital Management, Inc. | 39,291 | $6.94M | 0.15% | +1,145+3.0% | Added |
| Palisades Investment Partners, LLC | 41,389 | $7.31M | 2.87% | +1,186+3.0% | Added |
| Swiss National Bank | 42,000 | $7.41M | 0.00% | +600+1.4% | Added |
| HealthInvest Partners AB | 42,191 | $7.91M | 2.93% | +22,033+109.3% | Added |
| TD Asset Management Inc | 45,080 | $7.96M | 0.01% | +25,000+124.5% | Added |
| Biondo Investment Advisors, LLC | 51,885 | $9.16M | 1.15% | +30,645+144.3% | Added |
| Victory Capital Management Inc | 54,816 | $9.68M | 0.01% | −25,307−31.6% | Reduced |
| Ameriprise Financial Inc | 55,792 | $9.85M | 0.00% | −7,043−11.2% | Reduced |
| Standard Life Aberdeen plc | 59,372 | $10.5M | 0.02% | −49,146−45.3% | Reduced |
| Skandinaviska Enskilda Banken AB (publ) | 59,978 | $10.6M | 0.04% | 00.0% | Unchanged |
| Raymond James Financial Inc | 64,363 | $11.4M | 0.00% | −4,372−6.4% | Reduced |
| Legal & General Group Plc | 65,815 | $11.6M | 0.00% | −2,578−3.8% | Reduced |
| Handelsbanken Fonder AB | 66,800 | $11.8M | 0.04% | 00.0% | Unchanged |
| Invesco Ltd. | 66,880 | $11.8M | 0.00% | −4,008−5.7% | Reduced |
| Readystate Asset Management LP | 70,349 | $12.4M | 0.60% | −77,631−52.5% | Reduced |
| Rhumbline Advisers | 70,552 | $12.5M | 0.01% | −201−0.3% | Reduced |
| Barclays PLC | 75,896 | $13.4M | 0.00% | −16,975−18.3% | Reduced |
| Segall Bryant & Hamill, LLC | 85,263 | $15.1M | 0.20% | −63,351−42.6% | Reduced |
| C WorldWide Group Holding A/S | 85,809 | $15.1M | 0.23% | 00.0% | Unchanged |
| Voya Investment Management LLC | 93,908 | $16.6M | 0.02% | +29,915+46.7% | Added |
| Public Sector Pension Investment Board | 100,431 | $17.7M | 0.07% | +13,743+15.9% | Added |
| OrbiMed Advisors LLC | 102,745 | $18.1M | 0.43% | +93,545+1,016.8% | Added |
| S Squared Technology, LLC | 109,215 | $19.3M | 7.33% | 00.0% | Unchanged |
| TimesSquare Capital Management, LLC | 118,514 | $20.9M | 0.30% | +4,310+3.8% | Added |
| Marshall Wace, LLP | 128,960 | $22.8M | 0.03% | +16,578+14.8% | Added |
| UBS Group AG | 130,173 | $23.0M | 0.00% | +32,933+33.9% | Added |
| Bank of America Corp | 137,995 | $24.4M | 0.00% | +16,183+13.3% | Added |
| Principal Financial Group Inc | 142,843 | $25.2M | 0.01% | +1,960+1.4% | Added |
| JPMorgan Chase & Co | 146,354 | $25.8M | 0.00% | +55,201+60.6% | Added |
| Millennium Management LLC | 148,713 | $26.3M | 0.02% | +136,151+1,083.8% | Added |
| William Blair Investment Management, LLC | 149,302 | $26.4M | 0.07% | +58,203+63.9% | Added |
| Woodline Partners LP | 150,616 | $26.6M | 0.13% | 00.0% | Unchanged |
| Bank of New York Mellon Corp | 155,553 | $27.5M | 0.00% | −4,964−3.1% | Reduced |
| Pictet Asset Management Holding SA | 196,904 | $34.8M | 0.03% | +66,367+50.8% | Added |
| Nuveen, LLC | 197,378 | $34.8M | 0.01% | +9,359+5.0% | Added |
| UBS Asset Management Americas Inc | 202,589 | $35.8M | 0.01% | −31,731−13.5% | Reduced |
| Morgan Stanley | 234,578 | $41.4M | 0.00% | +157+0.1% | Added |
| Charles Schwab Investment Management Inc | 242,863 | $42.9M | 0.01% | −3,317−1.3% | Reduced |
| Northern Trust Corp | 248,165 | $43.8M | 0.01% | −3,243−1.3% | Reduced |
| First Trust Advisors LP | 248,392 | $43.8M | 0.03% | +26,022+11.7% | Added |
| Goldman Sachs Group Inc | 348,250 | $61.5M | 0.01% | −182,111−34.3% | Reduced |
| Price T Rowe Associates Inc | 467,058 | $82.5M | 0.01% | +205,675+78.7% | Added |
| Braidwell LP | 520,401 | $91.9M | 2.73% | −207,410−28.5% | Reduced |
| Dimensional Fund Advisors LP | 533,964 | $94.3M | 0.02% | +28,075+5.5% | Added |
| Hood River Capital Management LLC | 606,946 | $107.1M | 1.27% | +73,923+13.9% | Added |
| Geode Capital Management, LLC | 611,244 | $107.9M | 0.01% | −8,303−1.3% | Reduced |
| Citadel Advisors LLC | 636,988 | $112.4M | 0.09% | +602,428+1,743.1% | Added |
| Redmile Group, LLC | 661,388 | $116.8M | 11.36% | −2,083−0.3% | Reduced |
| Frazier Life Sciences Management, L.P. | 688,460 | $121.5M | 3.64% | 00.0% | Unchanged |
| Capital World Investors | 809,240 | $142.9M | 0.02% | −133,009−14.1% | Reduced |
| Soleus Capital Management, L.P. | 1,018,831 | $179.9M | 9.61% | +95,873+10.4% | Added |
| State Street Corp | 1,395,967 | $246.4M | 0.01% | +40,621+3.0% | Added |
| Avoro Capital Advisors LLC | 2,777,777 | $490.4M | 6.34% | +117,777+4.4% | Added |
| Vanguard Group Inc | 2,792,208 | $492.9M | 0.01% | −30,680−1.1% | Reduced |
| BlackRock, Inc. | 3,834,128 | $676.8M | 0.01% | −11,027−0.3% | Reduced |
| FMR LLC | 4,341,447 | $766.4M | 0.04% | +6,686+0.2% | Added |
| Logos Global Management LP | 0 | $0 | 0.00% | −100,000−100.0% | Sold out |
| Renaissance Technologies LLC | 0 | $0 | 0.00% | −89,800−100.0% | Sold out |
| Alyeska Investment Group, L.P. | 0 | $0 | 0.00% | −53,934−100.0% | Sold out |
| Susquehanna International Group, LLP | 0 | $0 | 0.00% | −30,252−100.0% | Sold out |
| Edgestream Partners, L.P. | 0 | $0 | 0.00% | −19,678−100.0% | Sold out |
| Sphera Funds Management Ltd. | 0 | $0 | 0.00% | −7,335−100.0% | Sold out |
| M&G Plc | 0 | $0 | 0.00% | −6,748−100.0% | Sold out |
| Shay Capital LLC | 0 | $0 | 0.00% | −6,500−100.0% | Sold out |
| Summit Global Investments | 0 | $0 | 0.00% | −4,547−100.0% | Sold out |
| Bryce Point Capital, LLC | 0 | $0 | 0.00% | −4,323−100.0% | Sold out |
| M&T Bank Corp | 0 | $0 | 0.00% | −3,785−100.0% | Sold out |
| Hennion & Walsh Asset Management, Inc. | 0 | $0 | 0.00% | −3,253−100.0% | Sold out |
| Graham Capital Management, L.P. | 0 | $0 | 0.00% | −2,435−100.0% | Sold out |
| Tempus Wealth Planning, LLC | 0 | $0 | 0.00% | −2,379−100.0% | Sold out |
| Nebula Research & Development LLC | 0 | $0 | 0.00% | −2,355−100.0% | Sold out |
| Capstone Investment Advisors, LLC | 0 | $0 | 0.00% | −2,196−100.0% | Sold out |