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Bicycle Therapeutics PLC

BCYC
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001761612

In the last 90 days, Bicycle Therapeutics PLC insiders filed 0 open-market purchases and 5 sales; 103 institutions reported holding it in 13F filings for Q2 2026, worth $157.9M in total; no superinvestor holds it.

13F holders, Q1 2026

Institutional positions in Bicycle Therapeutics PLC as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
98
−11 vs. Q4 2025
Shares held
37.5M
−1.71M (−4.4%) vs. Q4 2025
Total value
$173.6M
−$103.3M (−37.3%) vs. Q4 2025
New holders
15
43 more added
Sold out
26
16 more reduced

Compare with Q4 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting BCYC on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ1 2026: 98 institutions
Q1 2021: 39 institutionsQ2 2021: 54 institutionsQ3 2021: 69 institutionsQ4 2021: 101 institutionsQ1 2022: 105 institutionsQ2 2022: 82 institutionsQ3 2022: 79 institutionsQ4 2022: 87 institutionsQ1 2023: 89 institutionsQ2 2023: 85 institutionsQ3 2023: 101 institutionsQ4 2023: 101 institutionsQ1 2024: 95 institutionsQ2 2024: 107 institutionsQ3 2024: 105 institutionsQ4 2024: 97 institutionsQ1 2025: 95 institutionsQ2 2025: 110 institutionsQ3 2025: 99 institutionsQ4 2025: 109 institutionsQ1 2026: 98 institutionsQ2 2026: 103 institutions
Value heldQ1 2026: $173.6M
Q1 2021: $341.2MQ2 2021: $376.9MQ3 2021: $591.1MQ4 2021: $1.31BQ1 2022: $884.5MQ2 2022: $381.1MQ3 2022: $538.0MQ4 2022: $695.9MQ1 2023: $498.9MQ2 2023: $618.5MQ3 2023: $651.3MQ4 2023: $567.4MQ1 2024: $759.1MQ2 2024: $804.0MQ3 2024: $915.3MQ4 2024: $586.5MQ1 2025: $354.4MQ2 2025: $286.3MQ3 2025: $285.6MQ4 2025: $276.9MQ1 2026: $173.6MQ2 2026: $157.9M
Institutions holding BCYC and their total value by quarter
QuarterHoldersValue
Q2 2026103$157.9M
Q1 202698$173.6M
Q4 2025109$276.9M
Q3 202599$285.6M
Q2 2025110$286.3M
Q1 202595$354.4M
Q4 202497$586.5M
Q3 2024105$915.3M
Q2 2024107$804.0M
Q1 202495$759.1M
Q4 2023101$567.4M
Q3 2023101$651.3M
Q2 202385$618.5M
Q1 202389$498.9M
Q4 202287$695.9M
Q3 202279$538.0M
Q2 202282$381.1M
Q1 2022105$884.5M
Q4 2021101$1.31B
Q3 202169$591.1M
Q2 202154$376.9M
Q1 202139$341.2M

Institutions, Q1 2026

Shares, value and share of portfolio for each institution holding Bicycle Therapeutics PLC; share changes are against Q4 2025.

Institutions holding BCYC in Q1 2026
InstitutionSharesValue% of portfolioChange in sharesAction
Caitong International Asset Management Co., Ltd1$50.00%+1New
Caitlin John, LLC2$90.00%00.0%Unchanged
Rockefeller Capital Management L.P.5$230.00%00.0%Unchanged
SBI Securities Co., Ltd.6$280.00%00.0%Unchanged
Fideuram - Intesa Sanpaolo Private Banking S.P.A.9$420.00%−134,680−100.0%Reduced
Advisor Group Holdings, Inc.10$460.00%+10New
Basecamp Wealth Advisors LLC167$7750.00%00.0%Unchanged
Winch Advisory Services, LLC172$7980.00%00.0%Unchanged
Wells Fargo & Company200$9280.00%00.0%Unchanged
HighMark Wealth Management LLC435$2.02K0.00%00.0%Unchanged
Jones Financial Companies LLLP500$2.15K0.00%+250+100.0%Added
BNP Paribas Arbitrage, SA1,016$4.71K0.00%−100−9.0%Reduced
GF Fund Management Co. Ltd.1,032$4.79K0.00%+123+13.5%Added
GAMMA Investing LLC1,257$5.83K0.00%−129−9.3%Reduced
Citigroup Inc1,295$6.01K0.00%+4+0.3%Added
Tower Research Capital LLC (TRC)1,966$9.12K0.00%+298+17.9%Added
Barclays PLC2,357$10.9K0.00%+1,795+319.4%Added
Mirae Asset Global Investments Co., Ltd.2,417$11.2K0.00%+169+7.5%Added
Assetmark, Inc4,218$19.6K0.00%+590+16.3%Added
Natixis4,645$21.2K0.00%00.0%Unchanged
FNY Investment Advisers, LLC7,557$35.0K0.02%+71+0.9%Added
China Universal Asset Management Co., Ltd.8,222$38.1K0.00%+682+9.0%Added
Legal & General Group Plc9,054$39.2K0.00%00.0%Unchanged
JPMorgan Chase & Co9,873$42.8K0.00%−8,482−46.2%Reduced
Commonwealth of Pennsylvania Public School Empls Retrmt Sys10,116$46.9K0.00%00.0%Unchanged
Two Sigma Securities, LLC10,879$50.5K0.01%+10,879New
Pinnacle Wealth Management Advisory Group, LLC10,985$51.0K0.00%+985+9.9%Added
Crossmark Global Holdings, Inc.11,408$52.9K0.00%+9+0.1%Added
Rhumbline Advisers12,571$58.3K0.00%+1,400+12.5%Added
Erste Asset Management GmbH14,000$60.8K0.00%00.0%Unchanged
Horizon Kinetics Asset Management LLC13,188$61.2K0.00%−604−4.4%Reduced
Cerity Partners LLC13,570$63.0K0.00%+220+1.6%Added
49 Wealth Management, LLC14,317$66.4K0.00%+14,317New
Federation des caisses Desjardins du Quebec14,302$66.5K0.00%00.0%Unchanged
Forefront Analytics, LLC14,394$66.8K0.06%+1,023+7.7%Added
Royal Bank of Canada14,470$67.0K0.00%+3,788+35.5%Added
Stifel Financial Corp14,687$68.1K0.00%+14,687New
Portland Investment Counsel Inc.15,000$69.6K0.02%00.0%Unchanged
Invesco Ltd.15,067$69.9K0.00%+4,975+49.3%Added
Vontobel Holding Ltd.20,000$92.8K0.00%+10,000+100.0%Added
State of New Jersey Common Pension Fund D20,105$93.3K0.00%00.0%Unchanged
R Squared Ltd21,057$97.7K0.05%+21,057New
Geode Capital Management, LLC25,129$116.6K0.00%00.0%Unchanged
Aquatic Capital Management LLC26,160$121.4K0.00%+7,343+39.0%Added
Gsa Capital Partners LLP26,842$125.0K0.01%+26,842New
Woodstock Corp29,146$135.2K0.01%00.0%Unchanged
State Street Corp30,512$141.6K0.00%−39,666−56.5%Reduced
UBS Group AG32,159$149.2K0.00%+6,483+25.2%Added
Engineers Gate Manager LP35,400$164.3K0.00%+11,353+47.2%Added
Virtus Investment Advisers, Inc.36,601$169.8K0.05%+892+2.5%Added
Susquehanna International Group, LLP37,888$175.8K0.00%−70,535−65.1%Reduced
Alps Advisors Inc40,651$188.6K0.00%−344−0.8%Reduced
HRT Financial LP45,915$213.0K0.00%+45,915New
Jump Financial, LLC52,544$243.8K0.00%+21,544+69.5%Added
SEI Investments Co52,784$244.9K0.00%+3,728+7.6%Added
State of Tennessee, Treasury Department61,153$283.8K0.00%00.0%Unchanged
Axq Capital, LP63,134$292.9K0.04%+63,134New
Man Group plc63,305$293.7K0.00%+20,445+47.7%Added
EntryPoint Capital, LLC63,906$296.5K0.09%+63,906New
DAFNA Capital Management LLC64,492$299.2K0.07%00.0%Unchanged
ADAR1 Capital Management, LLC71,298$330.8K0.02%+71,298New
TD Asset Management Inc91,992$426.8K0.00%−56,000−37.8%Reduced
XTX Topco Ltd106,392$493.7K0.01%+58,718+123.2%Added
Goldman Sachs Group Inc110,147$511.1K0.00%+85,415+345.4%Added
Marex Group plc115,000$533.6K0.01%+36,594+46.7%Added
Peapod Lane Capital LLC121,106$550.2K0.45%+121,106New
Persistent Asset Partners Ltd120,437$558.8K0.22%+120,437New
Manufacturers Life Insurance Company, The127,863$593.3K0.00%00.0%Unchanged
Point72 Asset Management, L.P.130,422$605.2K0.00%+53,643+69.9%Added
Two Sigma Investments, LP164,800$764.7K0.00%+32,768+24.8%Added
Flax Pond Capital, LLC176,136$817.3K0.66%+2,503+1.4%Added
Platinum Investment Management Ltd184,603$856.6K0.22%00.0%Unchanged
Pinnacle Associates Ltd185,410$860.3K0.01%−5,070−2.7%Reduced
Eversept Partners, LP190,715$884.9K0.06%+11,800+6.6%Added
Palo Alto Investors LP201,890$936.8K0.14%−19,181−8.7%Reduced
Jane Street Group, LLC218,115$1.01M0.00%+154,925+245.2%Added
Rangeley Capital, LLC232,260$1.08M1.17%+100,260+76.0%Added
Moore Capital Management, LP275,000$1.28M0.05%00.0%Unchanged
BlackRock, Inc.278,992$1.29M0.00%−53,897−16.2%Reduced
Millennium Management LLC283,986$1.32M0.00%−42,640−13.1%Reduced
Qube Research & Technologies Ltd308,617$1.43M0.00%+308,617New
Citadel Advisors LLC377,085$1.75M0.00%+105,702+38.9%Added
Marshall Wace, LLP377,335$1.75M0.00%+338,540+872.6%Added
Silvercrest Asset Management Group LLC428,684$1.99M0.01%−48,292−10.1%Reduced
Birchview Capital, LP463,599$2.15M1.22%+899+0.2%Added
Diadema Partners LP476,424$2.21M0.91%+476,424New
Schroder Investment Management Group615,833$2.67M0.00%+31,063+5.3%Added
Morgan Stanley618,327$2.87M0.00%+153,105+32.9%Added
Renaissance Technologies LLC979,300$4.54M0.01%+412,700+72.8%Added
Price T Rowe Associates Inc1,028,243$4.77M0.00%−143,544−12.3%Reduced
Principal Financial Group Inc1,174,625$5.45M0.00%+26,353+2.3%Added
GSK plc1,529,561$7.10M1.18%00.0%Unchanged
Siren, L.L.C.1,560,882$7.24M0.20%−451,870−22.5%Reduced
Acadian Asset Management LLC1,968,025$9.11M0.01%+296,767+17.8%Added
Long Focus Capital Management, LLC3,310,687$15.4M0.67%+1,677,596+102.7%Added
Armistice Capital, LLC3,398,000$15.8M0.52%+162,000+5.0%Added
FCPM III Services B.V.3,468,430$16.1M2.23%00.0%Unchanged
Baker Bros. Advisors LP10,885,357$50.5M0.29%00.0%Unchanged
Westfield Capital Management Co LP0$00.00%−3,016,026−100.0%Sold out
Candriam Luxembourg S.C.A.0$00.00%−1,192,279−100.0%Sold out