Edgewise Therapeutics, Inc.
EWTX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001710072
In the last 90 days, Edgewise Therapeutics, Inc. insiders filed 0 open-market purchases and 6 sales; 226 institutions reported holding it in 13F filings for Q2 2026, worth $4.82B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Edgewise Therapeutics, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 199
- +28 vs. Q3 2025
- Shares held
- 121.8M
- +10.9M (+9.8%) vs. Q3 2025
- Total value
- $3.02B
- +$1.22B (+68.0%) vs. Q3 2025
- New holders
- 48
- 69 more added
- Sold out
- 20
- 54 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting EWTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 226 | $4.82B |
| Q1 2026 | 214 | $3.72B |
| Q4 2025 | 199 | $3.02B |
| Q3 2025 | 173 | $1.82B |
| Q2 2025 | 179 | $1.56B |
| Q1 2025 | 193 | $2.32B |
| Q4 2024 | 201 | $2.64B |
| Q3 2024 | 177 | $2.71B |
| Q2 2024 | 140 | $1.83B |
| Q1 2024 | 129 | $1.67B |
| Q4 2023 | 116 | $871.4M |
| Q3 2023 | 85 | $392.2M |
| Q2 2023 | 95 | $538.8M |
| Q1 2023 | 85 | $443.1M |
| Q4 2022 | 90 | $594.1M |
| Q3 2022 | 94 | $633.5M |
| Q2 2022 | 78 | $405.7M |
| Q1 2022 | 72 | $523.5M |
| Q4 2021 | 58 | $769.4M |
| Q3 2021 | 48 | $795.8M |
| Q2 2021 | 46 | $1.03B |
| Q1 2021 | 31 | $1.48B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Edgewise Therapeutics, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| OrbiMed Advisors LLC | 15,518,492 | $385.1M | 7.88% | 00.0% | Unchanged |
| Ra Capital Management, L.P. | 10,428,437 | $258.8M | 2.65% | 00.0% | Unchanged |
| BlackRock, Inc. | 6,630,576 | $164.5M | 0.00% | +279,089+4.4% | Added |
| Baker Bros. Advisors LP | 6,575,940 | $163.2M | 0.96% | −730,000−10.0% | Reduced |
| Paradigm Biocapital Advisors LP | 6,541,210 | $162.3M | 4.35% | +371,079+6.0% | Added |
| Novo Holdings A/S | 5,350,000 | $132.8M | 10.31% | 00.0% | Unchanged |
| Braidwell LP | 5,210,831 | $129.3M | 4.14% | 00.0% | Unchanged |
| Vanguard Group Inc | 4,871,624 | $120.9M | 0.00% | +67,683+1.4% | Added |
| Janus Henderson Group PLC | 4,566,850 | $113.3M | 0.05% | −412,481−8.3% | Reduced |
| Siren, L.L.C. | 4,529,990 | $112.4M | 3.35% | +632,891+16.2% | Added |
| Perceptive Advisors LLC | 4,457,974 | $110.6M | 2.03% | +662,080+17.4% | Added |
| Driehaus Capital Management LLC | 4,191,193 | $104.0M | 0.71% | +1,962,908+88.1% | Added |
| Cormorant Asset Management, LP | 3,285,000 | $81.5M | 4.62% | −725,000−18.1% | Reduced |
| Morgan Stanley | 2,910,881 | $72.2M | 0.00% | +2,041,203+234.7% | Added |
| UBS Group AG | 2,117,073 | $52.5M | 0.01% | +2,002,945+1,755.0% | Added |
| Geode Capital Management, LLC | 1,746,222 | $43.3M | 0.00% | +28,581+1.7% | Added |
| State Street Corp | 1,717,343 | $42.6M | 0.00% | +17,434+1.0% | Added |
| MPM Oncology Impact Management LP | 1,655,256 | $41.1M | 4.70% | −65,485−3.8% | Reduced |
| First Light Asset Management, LLC | 1,573,701 | $39.1M | 2.99% | +158,707+11.2% | Added |
| Bellevue Group AG | 1,528,518 | $37.9M | 0.72% | −1,247,479−44.9% | Reduced |
| Integral Health Asset Management, LLC | 1,500,000 | $37.2M | 1.89% | 00.0% | Unchanged |
| Bank of America Corp | 1,474,797 | $36.6M | 0.00% | +1,153,665+359.2% | Added |
| Dimensional Fund Advisors LP | 1,213,657 | $30.1M | 0.01% | +30,521+2.6% | Added |
| American Century Companies Inc | 1,186,467 | $29.4M | 0.01% | +90,994+8.3% | Added |
| Alliancebernstein L.P. | 1,036,170 | $25.7M | 0.01% | +958,910+1,241.1% | Added |
| Soleus Capital Management, L.P. | 910,000 | $22.6M | 0.96% | +910,000 | New |
| Standard Life Aberdeen plc | 821,940 | $20.4M | 0.03% | +202,062+32.6% | Added |
| Deerfield Management Company, L.P. (Series C) | 765,694 | $19.0M | 0.24% | 00.0% | Unchanged |
| Norges Bank | 751,355 | $18.6M | 0.00% | +751,355 | New |
| Victory Capital Management Inc | 746,562 | $18.5M | 0.01% | +247,916+49.7% | Added |
| Goldman Sachs Group Inc | 718,372 | $17.8M | 0.00% | +190,545+36.1% | Added |
| Artisan Partners Limited Partnership | 704,077 | $17.5M | 0.03% | −14,098−2.0% | Reduced |
| FMR LLC | 692,955 | $17.2M | 0.00% | +439,630+173.5% | Added |
| Marshall Wace, LLP | 681,921 | $16.9M | 0.02% | +681,921 | New |
| Healthcare of Ontario Pension Plan Trust Fund | 640,400 | $15.9M | 0.03% | +640,400 | New |
| Charles Schwab Investment Management Inc | 611,384 | $15.2M | 0.00% | +13,781+2.3% | Added |
| Eventide Asset Management, LLC | 568,310 | $14.1M | 0.22% | 00.0% | Unchanged |
| Northern Trust Corp | 559,649 | $13.9M | 0.00% | −28,233−4.8% | Reduced |
| Candriam Luxembourg S.C.A. | 501,214 | $12.4M | 0.06% | +280,055+126.6% | Added |
| Opaleye Management Inc. | 500,000 | $12.4M | 1.64% | 00.0% | Unchanged |
| Sofinnova Investments, Inc. | 437,819 | $10.9M | 0.47% | −82,421−15.8% | Reduced |
| Parkman Healthcare Partners LLC | 427,690 | $10.6M | 1.01% | −122,483−22.3% | Reduced |
| D. E. Shaw & Co., Inc. | 394,695 | $9.79M | 0.01% | −282,866−41.7% | Reduced |
| Barclays PLC | 372,738 | $9.25M | 0.00% | +138,088+58.8% | Added |
| StemPoint Capital LP | 360,876 | $8.96M | 1.54% | +360,876 | New |
| Squadron Capital Management LLC | 350,000 | $8.69M | 3.88% | +350,000 | New |
| Eversept Partners, LP | 337,340 | $8.37M | 0.47% | −164,894−32.8% | Reduced |
| Qube Research & Technologies Ltd | 296,208 | $7.35M | 0.01% | −259,505−46.7% | Reduced |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 271,385 | $6.73M | 0.01% | +138,882+104.8% | Added |
| Kennedy Capital Management, Inc. | 241,509 | $5.99M | 0.13% | −9,113−3.6% | Reduced |
| Sio Capital Management, LLC | 237,481 | $5.89M | 0.98% | −69,700−22.7% | Reduced |
| Granahan Investment Management Inc | 232,295 | $5.76M | 0.25% | −107,322−31.6% | Reduced |
| Woodline Partners LP | 224,192 | $5.56M | 0.02% | +20.0% | Added |
| Citigroup Inc | 223,294 | $5.54M | 0.00% | −315,159−58.5% | Reduced |
| Deutsche Bank AG | 214,769 | $5.33M | 0.00% | +59,873+38.7% | Added |
| Ameriprise Financial Inc | 202,297 | $5.02M | 0.00% | +202,297 | New |
| Bank of New York Mellon Corp | 198,614 | $4.93M | 0.00% | −5,628−2.8% | Reduced |
| Ally Bridge Group (NY) LLC | 195,000 | $4.84M | 7.68% | +195,000 | New |
| HighVista Strategies LLC | 171,137 | $4.25M | 1.09% | −36,964−17.8% | Reduced |
| Nuveen, LLC | 169,466 | $4.21M | 0.00% | −3,241−1.9% | Reduced |
| DAFNA Capital Management LLC | 159,736 | $3.96M | 0.92% | −54,000−25.3% | Reduced |
| Balyasny Asset Management LLC | 151,905 | $3.77M | 0.01% | +151,905 | New |
| JPMorgan Chase & Co | 146,038 | $3.62M | 0.00% | +77,318+112.5% | Added |
| Schroder Investment Management Group | 145,286 | $3.57M | 0.00% | −5,776−3.8% | Reduced |
| KVP Capital Advisors, LP | 133,000 | $3.30M | 3.41% | +133,000 | New |
| Neuberger Berman Group LLC | 127,136 | $3.15M | 0.00% | −92,510−42.1% | Reduced |
| Millennium Management LLC | 126,436 | $3.14M | 0.00% | −598,989−82.6% | Reduced |
| Citadel Advisors LLC | 123,097 | $3.05M | 0.00% | +100,780+451.6% | Added |
| Jain Global LLC | 113,856 | $2.83M | 0.03% | +113,856 | New |
| Wellington Management Group LLP | 111,387 | $2.76M | 0.00% | −3,144−2.7% | Reduced |
| Quantum Private Wealth, LLC | 106,024 | $2.63M | 0.77% | +150+0.1% | Added |
| Swiss National Bank | 103,900 | $2.58M | 0.00% | +2,000+2.0% | Added |
| Exome Asset Management LLC | 100,046 | $2.48M | 1.23% | −73,393−42.3% | Reduced |
| UBS Asset Management Americas Inc | 98,063 | $2.43M | 0.00% | −41,049−29.5% | Reduced |
| ADAR1 Capital Management, LLC | 90,999 | $2.26M | 0.17% | +50,999+127.5% | Added |
| New York State Common Retirement Fund | 88,937 | $2.21M | 0.00% | +5,500+6.6% | Added |
| SG Americas Securities, LLC | 88,723 | $2.20M | 0.00% | +78,842+797.9% | Added |
| Alps Advisors Inc | 86,929 | $2.16M | 0.01% | +35,817+70.1% | Added |
| Rhumbline Advisers | 85,075 | $2.11M | 0.00% | −19,754−18.8% | Reduced |
| Federated Hermes, Inc. | 82,096 | $2.04M | 0.00% | +22,840+38.5% | Added |
| Jump Financial, LLC | 79,915 | $1.98M | 0.02% | −910−1.1% | Reduced |
| Wells Fargo & Company | 75,442 | $1.87M | 0.00% | +33,246+78.8% | Added |
| Invesco Ltd. | 75,438 | $1.87M | 0.00% | +9,382+14.2% | Added |
| Susquehanna International Group, LLP | 70,196 | $1.74M | 0.00% | +24,561+53.8% | Added |
| DekaBank Deutsche Girozentrale | 80,000 | $1.56M | 0.00% | 00.0% | Unchanged |
| Schonfeld Strategic Advisors LLC | 59,326 | $1.47M | 0.01% | +7,337+14.1% | Added |
| Ishara Investments LP | 58,000 | $1.44M | 1.68% | +58,000 | New |
| Price T Rowe Associates Inc | 57,315 | $1.42M | 0.00% | +5,929+11.5% | Added |
| XTX Topco Ltd | 55,620 | $1.38M | 0.04% | +55,620 | New |
| HighMark Wealth Management LLC | 53,179 | $1.32M | 0.54% | 00.0% | Unchanged |
| Legal & General Group Plc | 52,747 | $1.31M | 0.00% | −3,194−5.7% | Reduced |
| Two Sigma Investments, LP | 50,848 | $1.26M | 0.00% | +24,582+93.6% | Added |
| California State Teachers Retirement System | 50,392 | $1.25M | 0.00% | −401−0.8% | Reduced |
| Franklin Resources Inc | 43,145 | $1.07M | 0.00% | −5,075−10.5% | Reduced |
| Moody Aldrich Partners LLC | 43,134 | $1.07M | 0.20% | −39,807−48.0% | Reduced |
| Silverarc Capital Management, LLC | 42,052 | $1.04M | 0.15% | +42,052 | New |
| Prelude Capital Management, LLC | 41,584 | $1.03M | 0.08% | −7,621−15.5% | Reduced |
| State of Wisconsin Investment Board | 39,997 | $992.5K | 0.00% | +3,378+9.2% | Added |
| Voya Investment Management LLC | 39,648 | $983.9K | 0.00% | +27,231+219.3% | Added |
| Knights of Columbus Asset Advisors LLC | 38,676 | $959.7K | 0.05% | +38,676 | New |