Ionis Pharmaceuticals Inc
IONS- 交易所
- Nasdaq
- 產業
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
近 90 天，Ionis Pharmaceuticals Inc 內部人申報 1 筆公開市場買進、4 筆賣出；2026 年第 2 季末有 515 家機構在 13F 申報持有，市值合計 $142.6 億；大師中只有方舟投資持有。
2025 年第 4 季 13F 持有人
Ionis Pharmaceuticals Inc 在 2025/12/31 季末的機構持股。管理 1 億美元以上美股的機構，每季結束後 45 天內要用 13F 申報多頭部位。13F 是什麼
- 持有機構
- 494
- 較 2025 年第 3 季 +68 家
- 持有股數
- 1.70 億
- 較 2025 年第 3 季 +278.5 萬 (+1.7%)
- 總市值
- $134.6 億
- 較 2025 年第 3 季 +$25.0 億 (+22.8%)
- 新進機構
- 112
- 另有 167 家加碼
- 清倉機構
- 44
- 另有 142 家減碼
另有 11 家機構在 2025 年第 3 季持有、還沒有申報 2025 年第 4 季 13F：沒申報不算清倉，也不計入上面的變化。
歷季持有家數與市值
2021 年第 1 季起，每季在 13F 申報持有 IONS 的機構家數與合計市值。市值是各季季末的申報市值，也會跟著股價漲跌。
| 季度 | 家數 | 市值 |
|---|---|---|
| 2026 年第 2 季 | 515 | $142.6 億 |
| 2026 年第 1 季 | 497 | $129.7 億 |
| 2025 年第 4 季 | 494 | $134.6 億 |
| 2025 年第 3 季 | 437 | $110.1 億 |
| 2025 年第 2 季 | 363 | $66.7 億 |
| 2025 年第 1 季 | 344 | $50.3 億 |
| 2024 年第 4 季 | 356 | $56.1 億 |
| 2024 年第 3 季 | 354 | $63.1 億 |
| 2024 年第 2 季 | 357 | $68.3 億 |
| 2024 年第 1 季 | 361 | $61.7 億 |
| 2023 年第 4 季 | 365 | $72.1 億 |
| 2023 年第 3 季 | 312 | $63.5 億 |
| 2023 年第 2 季 | 305 | $56.0 億 |
| 2023 年第 1 季 | 315 | $46.9 億 |
| 2022 年第 4 季 | 339 | $49.3 億 |
| 2022 年第 3 季 | 350 | $55.9 億 |
| 2022 年第 2 季 | 351 | $46.1 億 |
| 2022 年第 1 季 | 333 | $46.3 億 |
| 2021 年第 4 季 | 341 | $37.5 億 |
| 2021 年第 3 季 | 326 | $40.8 億 |
| 2021 年第 2 季 | 338 | $49.6 億 |
| 2021 年第 1 季 | 365 | $55.5 億 |
2025 年第 4 季持有機構
每家機構持有 Ionis Pharmaceuticals Inc 的股數、市值與佔組合比重；股數變化跟 2025 年第 3 季比。
| 機構 | 股數 | 市值 | 佔組合 % | 股數變化 | 動作 |
|---|---|---|---|---|---|
| Natixis | 6,087 | $48.2 萬 | 0.00% | −139,199−95.8% | 減碼 |
| Regions Financial Corp | 6,089 | $48.2 萬 | 0.00% | +2,289+60.2% | 加碼 |
| Legato Capital Management LLC | 6,155 | $48.7 萬 | 0.04% | −11,145−64.4% | 減碼 |
| Jones Financial Companies LLLP | 6,483 | $51.3 萬 | 0.00% | −351−5.1% | 減碼 |
| Coldstream Capital Management Inc | 6,619 | $52.4 萬 | 0.01% | +2,140+47.8% | 加碼 |
| Significant Wealth Partners LLC | 6,764 | $53.5 萬 | 0.60% | −8,203−54.8% | 減碼 |
| Everence Capital Management Inc | 6,770 | $53.6 萬 | 0.03% | 00.0% | 不變 |
| PSP Research LLC | 6,800 | $53.8 萬 | 0.47% | +6,800 | 新進 |
| Swiss Life Asset Management Ltd | 6,903 | $54.6 萬 | 0.00% | +76+1.1% | 加碼 |
| O'Shaughnessy Asset Management, LLC | 7,032 | $55.6 萬 | 0.00% | +1,735+32.8% | 加碼 |
| Callan Family Office, LLC | 7,104 | $56.2 萬 | 0.01% | +7,104 | 新進 |
| ProShare Advisors LLC | 7,154 | $56.6 萬 | 0.00% | +1,476+26.0% | 加碼 |
| Meeder Advisory Services, Inc. | 7,156 | $56.6 萬 | 0.02% | +386+5.7% | 加碼 |
| Savant Capital, LLC | 7,189 | $56.9 萬 | 0.00% | −48−0.7% | 減碼 |
| Silvercrest Asset Management Group LLC | 7,242 | $57.3 萬 | 0.00% | +124+1.7% | 加碼 |
| Fiduciary Trust Co | 7,399 | $58.5 萬 | 0.01% | +1,022+16.0% | 加碼 |
| Graham Capital Management, L.P. | 7,596 | $60.1 萬 | 0.02% | −9,567−55.7% | 減碼 |
| Stratos Wealth Partners, LTD. | 7,740 | $61.2 萬 | 0.01% | −24−0.3% | 減碼 |
| Persistent Asset Partners Ltd | 7,807 | $61.8 萬 | 0.30% | +7,807 | 新進 |
| Fifth Third Bancorp | 7,888 | $62.4 萬 | 0.00% | −56−0.7% | 減碼 |
| Commerce Bank | 8,111 | $64.2 萬 | 0.00% | +504+6.6% | 加碼 |
| M&T Bank Corp | 8,150 | $64.4 萬 | 0.00% | +2,140+35.6% | 加碼 |
| Mirae Asset Global Investments Co., Ltd. | 8,266 | $65.4 萬 | 0.00% | +2,104+34.1% | 加碼 |
| Maryland State Retirement & Pension System | 8,284 | $65.5 萬 | 0.01% | 00.0% | 不變 |
| Utah Retirement Systems | 8,300 | $65.7 萬 | 0.01% | 00.0% | 不變 |
| denkapparat Operations GmbH | 8,364 | $66.2 萬 | 0.36% | −1,604−16.1% | 減碼 |
| Sectoral Asset Management Inc | 8,365 | $66.2 萬 | 0.53% | −840−9.1% | 減碼 |
| Virtus Investment Advisers, Inc. | 8,454 | $66.9 萬 | 0.18% | −4,022−32.2% | 減碼 |
| Wealth Enhancement Advisory Services, LLC | 8,256 | $67.3 萬 | 0.00% | +817+11.0% | 加碼 |
| NEOS Investment Management LLC | 8,557 | $67.7 萬 | 0.00% | −3,749−30.5% | 減碼 |
| Tema ETFs LLC | 8,557 | $67.7 萬 | 0.05% | −3,749−30.5% | 減碼 |
| Assetmark, Inc | 8,650 | $68.4 萬 | 0.00% | +8,575+11,433.3% | 加碼 |
| Aigen Investment Management, LP | 8,861 | $70.1 萬 | 0.16% | −4,717−34.7% | 減碼 |
| KBC Group NV | 9,052 | $71.6 萬 | 0.00% | +4,353+92.6% | 加碼 |
| Intech Investment Management LLC | 9,602 | $76.0 萬 | 0.01% | +9,602 | 新進 |
| Two Sigma Securities, LLC | 9,649 | $76.3 萬 | 0.10% | +9,649 | 新進 |
| MetLife Investment Management | 9,674 | $76.5 萬 | 0.00% | +246+2.6% | 加碼 |
| Wiley Bros.-Aintree Capital, LLC | 9,723 | $76.9 萬 | 0.00% | −2,940−23.2% | 減碼 |
| Ares Systematic Credit Ltd | 9,916 | $78.4 萬 | 0.64% | +9,916 | 新進 |
| Summit Trail Advisors, LLC | 9,943 | $78.7 萬 | 0.01% | +3,738+60.2% | 加碼 |
| Thrivent Financial for Lutherans | 9,962 | $78.8 萬 | 0.00% | 00.0% | 不變 |
| Cypress Capital, LLC | 10,000 | $79.1 萬 | 0.22% | 00.0% | 不變 |
| Vident Advisory, LLC | 10,235 | $81.0 萬 | 0.01% | −1,316−11.4% | 減碼 |
| Blueshift Asset Management, LLC | 10,443 | $82.6 萬 | 0.24% | −1,017−8.9% | 減碼 |
| Virginia Retirement Systems Et Al | 10,600 | $83.9 萬 | 0.00% | +10,600 | 新進 |
| Suvretta Capital Management, LLC | 10,800 | $85.4 萬 | 0.02% | 00.0% | 不變 |
| Cetera Investment Advisers | 10,856 | $85.9 萬 | 0.00% | +3,983+58.0% | 加碼 |
| Baader Bank INC | 11,097 | $86.6 萬 | 0.07% | +869+8.5% | 加碼 |
| Plancorp, LLC | 11,208 | $88.7 萬 | 0.03% | 00.0% | 不變 |
| Oppenheimer Asset Management Inc. | 11,264 | $89.1 萬 | 0.01% | +11,264 | 新進 |
| Advisor Group Holdings, Inc. | 11,646 | $92.1 萬 | 0.00% | +1,479+14.5% | 加碼 |
| Commonwealth Equity Services, LLC | 11,806 | $93.4 萬 | 0.00% | −1,543−11.6% | 減碼 |
| Horizon Kinetics Asset Management LLC | 11,952 | $94.6 萬 | 0.01% | −524−4.2% | 減碼 |
| Northwestern Mutual Wealth Management Co | 11,998 | $94.9 萬 | 0.00% | −784−6.1% | 減碼 |
| Amalgamated Bank | 12,455 | $98.5 萬 | 0.01% | +260+2.1% | 加碼 |
| JustInvest LLC | 12,461 | $98.6 萬 | 0.01% | +371+3.1% | 加碼 |
| Federation des caisses Desjardins du Quebec | 12,553 | $99.3 萬 | 0.00% | +12,553 | 新進 |
| Truist Financial Corp | 12,659 | $100.1 萬 | 0.00% | +7,847+163.1% | 加碼 |
| Dark Forest Capital Management LP | 12,691 | $100.4 萬 | 0.05% | −33,401−72.5% | 減碼 |
| SBI Okasan Asset Management Co.Ltd. | 12,600 | $100.8 萬 | 0.06% | +12,600 | 新進 |
| Annis Gardner Whiting Capital Advisors, LLC | 12,801 | $101.3 萬 | 0.19% | 00.0% | 不變 |
| Westmount Partners, LLC | 12,961 | $102.5 萬 | 0.26% | 00.0% | 不變 |
| Lighthouse Investment Partners, LLC | 13,082 | $103.5 萬 | 0.03% | +13,082 | 新進 |
| Friedenthal Financial | 13,115 | $103.8 萬 | 0.53% | +13,115 | 新進 |
| Cinctive Capital Management LP | 13,726 | $108.6 萬 | 0.06% | −160,093−92.1% | 減碼 |
| The PNC Financial Services Group, Inc. | 13,816 | $109.3 萬 | 0.00% | +1,703+14.1% | 加碼 |
| Bleakley Financial Group, LLC | 13,875 | $109.8 萬 | 0.02% | −30.0% | 減碼 |
| Dynasty Wealth Management, LLC | 13,990 | $110.7 萬 | 0.01% | −351−2.4% | 減碼 |
| M&G Plc | 14,423 | $113.9 萬 | 0.01% | +14,423 | 新進 |
| DnB Asset Management AS | 14,838 | $117.4 萬 | 0.00% | +5,530+59.4% | 加碼 |
| Brown Advisory Inc | 14,965 | $118.4 萬 | 0.00% | +939+6.7% | 加碼 |
| LMR Partners LLP | 15,000 | $118.7 萬 | 0.01% | −22,600−60.1% | 減碼 |
| Davy Global Fund Management Ltd | 15,168 | $120.0 萬 | 0.08% | −116−0.8% | 減碼 |
| Public Employees Retirement Association of Colorado | 15,589 | $123.3 萬 | 0.00% | 00.0% | 不變 |
| North Star Asset Management Inc | 16,610 | $131.4 萬 | 0.05% | 00.0% | 不變 |
| Allianz Asset Management GmbH | 16,716 | $132.2 萬 | 0.00% | +5,216+45.4% | 加碼 |
| XTX Topco Ltd | 16,917 | $133.8 萬 | 0.04% | +16,917 | 新進 |
| J. Safra Sarasin Holding AG | 17,404 | $137.7 萬 | 0.02% | +17,404 | 新進 |
| Worldquant Millennium Advisors LLC | 17,410 | $137.7 萬 | 0.01% | +17,410 | 新進 |
| Inceptionr LLC | 17,850 | $141.2 萬 | 0.39% | +10,229+134.2% | 加碼 |
| Toroso Investments, LLC | 17,908 | $141.7 萬 | 0.01% | +17,908 | 新進 |
| Dana Investment Advisors, Inc. | 18,026 | $142.6 萬 | 0.04% | −792−4.2% | 減碼 |
| Elo Mutual Pension Insurance Co | 18,417 | $145.7 萬 | 0.02% | +18,417 | 新進 |
| Quantedge Capital Pte Ltd | 18,500 | $146.4 萬 | 0.70% | +18,500 | 新進 |
| AlphaCentric Advisors LLC | 18,523 | $146.5 萬 | 1.46% | +18,523 | 新進 |
| AQR Capital Management LLC | 18,762 | $147.7 萬 | 0.00% | +11,947+175.3% | 加碼 |
| Gilder Gagnon Howe & Co LLC | 19,275 | $152.5 萬 | 0.02% | +19,275 | 新進 |
| Nicollet Investment Management, Inc. | 20,523 | $162.4 萬 | 0.51% | +115+0.6% | 加碼 |
| Great West Life Assurance Co | 20,894 | $165.4 萬 | 0.00% | −25,234−54.7% | 減碼 |
| Exchange Traded Concepts, LLC | 21,094 | $166.9 萬 | 0.01% | +3,024+16.7% | 加碼 |
| Natixis Advisors, L.P. | 21,891 | $173.2 萬 | 0.00% | +21,891 | 新進 |
| Engineers Gate Manager LP | 22,191 | $175.6 萬 | 0.02% | −3,588−13.9% | 減碼 |
| Verition Fund Management LLC | 22,685 | $179.5 萬 | 0.01% | −14,511−39.0% | 減碼 |
| HRT Financial LP | 22,928 | $181.3 萬 | 0.01% | +22,928 | 新進 |
| Xponance, Inc. | 22,941 | $181.5 萬 | 0.01% | +1,491+7.0% | 加碼 |
| Brinker Capital Investments, LLC | 23,574 | $186.5 萬 | 0.01% | +13,612+136.6% | 加碼 |
| Cerity Partners LLC | 23,927 | $189.3 萬 | 0.00% | +23,927 | 新進 |
| Prudential Financial Inc | 24,008 | $189.9 萬 | 0.00% | +14,664+156.9% | 加碼 |
| Teachers Retirement System of the State of Kentucky | 24,083 | $190.5 萬 | 0.01% | 00.0% | 不變 |
| Landscape Capital Management, L.L.C. | 24,155 | $191.1 萬 | 0.13% | −2,407−9.1% | 減碼 |