Zymeworks Inc.
ZYME- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001937653
No open-market purchases or sales by Zymeworks Inc. insiders were filed in the last 90 days; 202 institutions reported holding it in 13F filings for Q2 2026, worth $1.79B in total; no superinvestor holds it.
13F holders, Q1 2026
Institutional positions in Zymeworks Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 212
- +4 vs. Q4 2025
- Shares held
- 70.3M
- +1.16M (+1.7%) vs. Q4 2025
- Total value
- $1.76B
- −$60.1M (−3.3%) vs. Q4 2025
- New holders
- 40
- 77 more added
- Sold out
- 36
- 58 more reduced
2 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting ZYME on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 202 | $1.79B |
| Q1 2026 | 212 | $1.76B |
| Q4 2025 | 210 | $1.88B |
| Q3 2025 | 184 | $1.26B |
| Q2 2025 | 182 | $949.0M |
| Q1 2025 | 186 | $840.9M |
| Q4 2024 | 174 | $973.2M |
| Q3 2024 | 163 | $834.7M |
| Q2 2024 | 164 | $580.6M |
| Q1 2024 | 171 | $713.0M |
| Q4 2023 | 157 | $674.0M |
| Q3 2023 | 140 | $395.5M |
| Q2 2023 | 137 | $547.9M |
| Q1 2023 | 116 | $512.6M |
| Q4 2022 | 96 | $449.9M |
| Q3 2022 | 91 | $293.7M |
| Q2 2022 | 114 | $253.3M |
| Q1 2022 | 120 | $327.3M |
| Q4 2021 | 114 | $693.9M |
| Q3 2021 | 123 | $1.07B |
| Q2 2021 | 109 | $1.20B |
| Q1 2021 | 125 | $1.12B |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Zymeworks Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 22,970,388 | $575.2M | 24.58% | 00.0% | Unchanged |
| Rubric Capital Management LP | 7,000,000 | $175.3M | 2.15% | +1,250,000+21.7% | Added |
| BlackRock, Inc. | 4,553,888 | $114.0M | 0.00% | −41,660−0.9% | Reduced |
| BVF Inc | 3,734,142 | $93.5M | 2.98% | −204,499−5.2% | Reduced |
| Perceptive Advisors LLC | 3,510,078 | $87.9M | 1.74% | +248,228+7.6% | Added |
| Morgan Stanley | 2,480,568 | $62.1M | 0.00% | −112,512−4.3% | Reduced |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,908,039 | $47.8M | 0.06% | +85,991+4.7% | Added |
| Vanguard Capital Management LLC | 1,705,580 | $42.7M | 0.00% | +1,705,580 | New |
| Citadel Advisors LLC | 1,150,018 | $28.8M | 0.02% | +894,667+350.4% | Added |
| Dimensional Fund Advisors LP | 1,139,135 | $28.5M | 0.01% | −20,080−1.7% | Reduced |
| Nextech Invest, Ltd. | 1,113,946 | $27.9M | 1.96% | 00.0% | Unchanged |
| State Street Corp | 1,011,777 | $25.3M | 0.00% | −25,865−2.5% | Reduced |
| Capricorn Fund Managers Ltd | 1,007,210 | $25.2M | 3.93% | −15,630−1.5% | Reduced |
| Deutsche Bank AG | 921,250 | $23.1M | 0.01% | −674,583−42.3% | Reduced |
| Arrowstreet Capital, Limited Partnership | 743,898 | $18.6M | 0.01% | +43,896+6.3% | Added |
| Assenagon Asset Management S.A. | 727,986 | $18.2M | 0.03% | +80,612+12.5% | Added |
| FMR LLC | 667,153 | $16.7M | 0.00% | +107,067+19.1% | Added |
| Geode Capital Management, LLC | 659,940 | $16.5M | 0.00% | +11,970+1.8% | Added |
| Nuveen, LLC | 651,662 | $16.3M | 0.00% | +3,336+0.5% | Added |
| Goldman Sachs Group Inc | 599,486 | $15.0M | 0.00% | +179,279+42.7% | Added |
| MPM Oncology Impact Management LP | 565,249 | $14.2M | 1.09% | +565,249 | New |
| Prosight Management, LP | 539,049 | $13.5M | 2.21% | +8,656+1.6% | Added |
| Qube Research & Technologies Ltd | 511,937 | $12.8M | 0.02% | +37,647+7.9% | Added |
| Vanguard Portfolio Management LLC | 499,875 | $12.5M | 0.00% | +499,875 | New |
| Redmile Group, LLC | 491,654 | $12.3M | 0.82% | 00.0% | Unchanged |
| Hillsdale Investment Management Inc. | 345,622 | $8.65M | 0.24% | +107,700+45.3% | Added |
| SummitTX Capital, L.P. | 321,427 | $8.05M | 0.26% | +97,159+43.3% | Added |
| Northern Trust Corp | 320,210 | $8.02M | 0.00% | +12,231+4.0% | Added |
| UBS Asset Management Americas Inc | 319,385 | $8.00M | 0.00% | −876−0.3% | Reduced |
| Royce & Associates LP | 299,202 | $7.49M | 0.07% | +299,202 | New |
| Picton Mahoney Asset Management | 256,690 | $6.43M | 0.07% | +11,892+4.9% | Added |
| Granahan Investment Management Inc | 250,773 | $6.28M | 0.30% | +26,365+11.7% | Added |
| HRT Financial LP | 237,889 | $5.96M | 0.01% | +116,825+96.5% | Added |
| Bank of America Corp | 236,754 | $5.93M | 0.00% | +147,230+164.5% | Added |
| D. E. Shaw & Co., Inc. | 235,621 | $5.90M | 0.00% | +11,835+5.3% | Added |
| Jane Street Group, LLC | 226,967 | $5.68M | 0.01% | +156,522+222.2% | Added |
| Panagora Asset Management Inc | 206,854 | $5.18M | 0.02% | +128,518+164.1% | Added |
| Man Group plc | 189,890 | $4.75M | 0.01% | +114,572+152.1% | Added |
| Wells Fargo & Company | 189,636 | $4.75M | 0.00% | −18,677−9.0% | Reduced |
| Charles Schwab Investment Management Inc | 185,124 | $4.64M | 0.00% | −35,785−16.2% | Reduced |
| Federated Hermes, Inc. | 182,410 | $4.57M | 0.01% | +29,721+19.5% | Added |
| Raymond James Financial Inc | 176,411 | $4.42M | 0.00% | −11,274−6.0% | Reduced |
| UBS Group AG | 171,779 | $4.30M | 0.00% | −107,075−38.4% | Reduced |
| Silvercrest Asset Management Group LLC | 163,649 | $4.10M | 0.03% | −18,141−10.0% | Reduced |
| Kennedy Capital Management, Inc. | 148,226 | $3.71M | 0.08% | +2,692+1.8% | Added |
| XTX Topco Ltd | 143,882 | $3.60M | 0.06% | +50,413+53.9% | Added |
| Diadema Partners LP | 142,132 | $3.56M | 1.47% | +142,132 | New |
| Wellington Management Group LLP | 138,690 | $3.47M | 0.00% | −43,015−23.7% | Reduced |
| Invesco Ltd. | 125,630 | $3.15M | 0.00% | −131,950−51.2% | Reduced |
| Bank of New York Mellon Corp | 124,105 | $3.11M | 0.00% | −4,026−3.1% | Reduced |
| Citigroup Inc | 114,327 | $2.86M | 0.00% | +3,120+2.8% | Added |
| JPMorgan Chase & Co | 114,072 | $2.76M | 0.00% | +79,064+225.8% | Added |
| Platinum Investment Management Ltd | 105,184 | $2.63M | 0.66% | 00.0% | Unchanged |
| Tema ETFs LLC | 104,931 | $2.63M | 0.18% | +28,956+38.1% | Added |
| Toroso Investments, LLC | 104,931 | $2.63M | 0.01% | +104,931 | New |
| Fisher Asset Management, LLC | 101,439 | $2.54M | 0.00% | +33,242+48.7% | Added |
| Susquehanna Portfolio Strategies, LLC | 99,795 | $2.50M | 0.04% | 00.0% | Unchanged |
| AQR Capital Management LLC | 90,669 | $2.27M | 0.00% | −406−0.4% | Reduced |
| Kornitzer Capital Management Inc | 88,800 | $2.22M | 0.05% | 00.0% | Unchanged |
| Vanguard Fiduciary Trust Co | 84,403 | $2.11M | 0.00% | +84,403 | New |
| Squarepoint Ops LLC | 83,146 | $2.08M | 0.00% | +83,146 | New |
| Mackenzie Financial Corp | 82,726 | $2.07M | 0.00% | +37,266+82.0% | Added |
| Verdad Advisers, LP | 82,698 | $2.07M | 2.33% | +82,698 | New |
| Principal Financial Group Inc | 78,547 | $1.97M | 0.00% | +78,547 | New |
| Franklin Resources Inc | 77,659 | $1.94M | 0.00% | +18,672+31.7% | Added |
| Stifel Financial Corp | 76,756 | $1.92M | 0.00% | +909+1.2% | Added |
| Rhumbline Advisers | 75,399 | $1.89M | 0.00% | −99−0.1% | Reduced |
| Credit Agricole S A | 75,000 | $1.88M | 0.01% | 00.0% | Unchanged |
| Ameriprise Financial Inc | 74,222 | $1.86M | 0.00% | −38,919−34.4% | Reduced |
| Swiss National Bank | 74,200 | $1.86M | 0.00% | 00.0% | Unchanged |
| American Century Companies Inc | 70,851 | $1.77M | 0.00% | +12,019+20.4% | Added |
| State of Wisconsin Investment Board | 66,106 | $1.66M | 0.00% | −9,460−12.5% | Reduced |
| Alliancebernstein L.P. | 55,896 | $1.47M | 0.00% | +5,866+11.7% | Added |
| Dana Investment Advisors, Inc. | 56,107 | $1.40M | 0.04% | +7,789+16.1% | Added |
| Campbell & CO Investment Adviser LLC | 54,883 | $1.37M | 0.08% | +21,295+63.4% | Added |
| Russell Investments Group, Ltd. | 47,450 | $1.19M | 0.00% | −10,900−18.7% | Reduced |
| Royal Bank of Canada | 47,360 | $1.19M | 0.00% | −7,695−14.0% | Reduced |
| Segall Bryant & Hamill, LLC | 45,726 | $1.14M | 0.02% | +45,726 | New |
| North Growth Management Ltd. | 46,000 | $1.14M | 0.17% | +1,000+2.2% | Added |
| Jacobs Levy Equity Management, Inc | 42,786 | $1.07M | 0.00% | +42,786 | New |
| Victory Capital Management Inc | 42,404 | $1.06M | 0.00% | −501−1.2% | Reduced |
| Envestnet Asset Management Inc | 40,419 | $1.01M | 0.00% | −393−1.0% | Reduced |
| Manatuck Hill Partners, LLC | 40,000 | $1.00M | 0.33% | +40,000 | New |
| Los Angeles Capital Management LLC | 39,750 | $995.3K | 0.00% | +39,363+10,171.3% | Added |
| Quantinno Capital Management LP | 39,640 | $992.6K | 0.00% | +10,757+37.2% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 39,355 | $985.4K | 0.00% | +18,934+92.7% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 37,919 | $949.5K | 0.00% | +37,919 | New |
| HSBC Holdings PLC | 37,777 | $940.1K | 0.00% | +19,909+111.4% | Added |
| California State Teachers Retirement System | 37,389 | $936.2K | 0.00% | −372−1.0% | Reduced |
| O'Shaughnessy Asset Management, LLC | 37,129 | $929.7K | 0.00% | −5,923−13.8% | Reduced |
| Tudor Investment Corp Et Al | 36,875 | $923.4K | 0.00% | +6,551+21.6% | Added |
| HighTower Advisors, LLC | 36,262 | $908.0K | 0.00% | +36,262 | New |
| Persistent Asset Partners Ltd | 35,935 | $899.8K | 0.35% | +28,589+389.2% | Added |
| Price T Rowe Associates Inc | 35,487 | $889.0K | 0.00% | +6,703+23.3% | Added |
| HighVista Strategies LLC | 34,085 | $853.5K | 0.24% | +34,085 | New |
| Vinva Investment Management Ltd | 24,090 | $850.8K | 0.01% | +11,874+97.2% | Added |
| Martingale Asset Management L P | 32,764 | $820.4K | 0.02% | +32,764 | New |
| Creative Planning | 32,394 | $811.1K | 0.00% | +4,101+14.5% | Added |
| Marshall Wace, LLP | 32,223 | $806.9K | 0.00% | +32,223 | New |
| Manufacturers Life Insurance Company, The | 31,592 | $791.1K | 0.00% | +14,159+81.2% | Added |