| Jan 13, 2026 (view filing) | Jan 12 | 1 day | Hollywood MarkEVP & Chief Operating Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −6.12K | $22.67 | −$138.7K | −4.4%132.9K after | |
| Jan 12, 2026 (view filing) | Jan 12 | Same day | Smith Jeffrey T LEVP & Chief Medical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −9.31K | $22.67 | −$211.1K | −25.8%26.7K after | |
| Jan 12, 2026 (view filing) | Jan 12 | Same day | Moore Paul AndrewChief Scientific Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −9.56K | $22.67 | −$216.7K | −16.5%48.5K after | |
| Jan 12, 2026 (view filing) | Jan 12 | Same day | Galbraith KennethChair & CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −30.4K | $22.67 | −$689.7K | −11.8%226.8K after | |
| Jan 5, 2026 (view filing) | Jan 5 | Same day | Smith Jeffrey T LEVP & Chief Medical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −10.5K | $25.10 | −$264.5K | −36.5%18.4K after | |
| Jan 5, 2026 (view filing) | Jan 5 | Same day | Galbraith KennethChair & CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −54.3K | $25.10 | −$1.36M | −21.9%193.3K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Jan 5, 2026 (view filing) | Jan 5 | Same day | Moore Paul AndrewChief Scientific Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −20.1K | $25.10 | −$504.8K | −33.2%40.4K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Dec 22, 2025 (view filing) | Dec 22 | Same day | Galbraith KennethChair & CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −47.5K | $27.02 | −$1.28M | −26.3%133.3K after | |
| May 19, 2025 (view filing)6:35 PM ET | May 15-19 | 4 days | Nodelman Oleg and 1 otherDirector, 10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +55.4K | $11.47 | +$635.6K | +0.3%17.9M after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Apr 18, 2025 (view filing)3:17 PM ET | Apr 16-17 | 2 days | Nodelman Oleg and 1 otherDirector, 10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +128.7K | $11.32 | +$1.46M | +0.7%17.8M after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Apr 7, 2025 (view filing)6:34 PM ET | Apr 3-4 | 4 days | Nodelman Oleg and 1 otherDirector, 10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +317.2K | $11.42 | +$3.62M | +1.8%17.7M after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Apr 2, 2025 (view filing)7:02 PM ET | Mar 31-Apr 2 | 2 days | Nodelman Oleg and 1 otherDirector, 10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +127.4K | $11.75 | +$1.50M | +0.7%17.4M after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Mar 27, 2025 (view filing)6:53 PM ET | Mar 25-26 | 2 days | Nodelman Oleg and 1 otherDirector, 10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +97.3K | $12.61 | +$1.23M | +0.6%17.3M after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Mar 24, 2025 (view filing)5:45 PM ET | Mar 20-24 | 4 days | Nodelman Oleg and 1 otherDirector, 10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +127.2K | $12.92 | +$1.64M | +0.7%17.2M after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Mar 19, 2025 (view filing)6:32 PM ET | Mar 17-19 | 2 days | Nodelman Oleg and 1 otherDirector, 10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +228.5K | $12.55 | +$2.87M | +1.4%17.0M after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Mar 13, 2025 (view filing)7:35 PM ET | Mar 11-13 | 2 days | Nodelman Oleg and 1 otherDirector, 10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +1.08M | $12.13 | +$13.1M | +6.9%16.8M after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Jan 21, 2025 (view filing) | Jan 16-17 | 5 days | EcoR1 Capital, LLCDirector, 10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +141.4K | $13.89 | +$1.96M | +0.9%15.7M after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Jan 15, 2025 (view filing) | Jan 13-15 | 2 days | EcoR1 Capital, LLCDirector, 10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +167.7K | $13.59 | +$2.28M | +1.1%15.6M after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Jan 10, 2025 (view filing) | Jan 8-10 | 2 days | EcoR1 Capital, LLCDirector, 10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +225.1K | $13.22 | +$2.98M | +1.5%15.4M after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Jan 6, 2025 (view filing) | Jan 6 | Same day | Moore Paul AndrewChief Scientific Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −21.2K | $14.92 | −$316.3K | −47.6%23.3K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Jan 6, 2025 (view filing) | Jan 6 | Same day | Galbraith KennethChair & CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −57.3K | $14.92 | −$854.8K | −41.5%80.8K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Jan 6, 2025 (view filing) | Jan 6 | Same day | Smith Jeffrey T LEVP & Chief Medical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −11.1K | $14.92 | −$165.8K | −55.6%8.89K after | |
| Jan 2, 2025 (view filing) | Dec 30, 2024-Jan 2, 2025 | 3 days | EcoR1 Capital, LLCDirector, 10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +363.4K | $14.65 | +$5.32M | +2.5%15.2M after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Dec 27, 2024 (view filing) | Dec 24-27 | 3 days | EcoR1 Capital, LLCDirector, 10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +130.3K | $14.44 | +$1.88M | +0.9%14.8M after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Dec 26, 2024 (view filing) | Dec 19-23 | 7 days | EcoR1 Capital, LLCDirector, 10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +1.25M | $13.98 | +$17.5M | +9.3%14.7M after | AmendedAn amended filing (for example Form 4/A or 13F-HR/A) that corrects or adds to an earlier filing.3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Jan 8, 2024 (view filing) | Jan 5-8 | 3 days | Galbraith KennethChair & CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −23.9K | $10.79 | −$257.8K | −50.1%23.8K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Jan 8, 2024 (view filing) | Jan 5-8 | 3 days | Astle ChristopherSVP & Chief Financial Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −5.99K | $10.79 | −$64.7K | −48.0%6.50K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Jan 8, 2024 (view filing) | Jan 5-8 | 3 days | Moore Paul AndrewChief Scientific Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −9.80K | $10.79 | −$105.7K | −57.1%7.37K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Dec 28, 2023 (view filing) | Dec 26 | 2 days | EcoR1 Capital, LLC10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +5.09M | $9.83 | +$50.0M | –5.09M after | DerivativeA trade in a derivative security (option, warrant, restricted stock unit and so on). The value is the derivative's own price times the quantity. |
| Dec 11, 2023 (view filing) | Dec 11 | Same day | Astle ChristopherSVP & Chief Financial Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −886 | $9.13 | −$8.09K | −30.7%2.00K after | |
| Jun 21, 2023 (view filing) | Jun 16 | 5 days | EcoR1 Capital, LLC10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +3.35M | $8.12 | +$27.2M | +33.2%13.4M after | |
| Mar 30, 2023 (view filing) | Mar 28 | 2 days | EcoR1 Capital, LLC10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +200.0K | $8.00 | +$1.60M | +2.0%10.1M after | |
| Mar 14, 2023 (view filing) | Mar 10 | 4 days | Klompas Neil APresident & COO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −2.98K | $7.83 | −$23.3K | −14.9%17.0K after | |
| Jan 23, 2023 (view filing) | Jan 19-20 | 4 days | EcoR1 Capital, LLC10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +307.5K | $9.70 | +$2.98M | +3.2%9.89M after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Jan 18, 2023 (view filing) | Jan 13-18 | 5 days | EcoR1 Capital, LLC10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +985.1K | $9.84 | +$9.70M | +11.5%9.58M after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Jan 12, 2023 (view filing) | Jan 10-11 | 2 days | EcoR1 Capital, LLC10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +1.03M | $7.67 | +$7.87M | +13.6%8.59M after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Dec 23, 2022 (view filing) | Dec 12 | 11 days | Astle ChristopherSVP & Chief Financial Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −887 | $6.01 | −$5.33K | −40.0%1.33K after | AmendedAn amended filing (for example Form 4/A or 13F-HR/A) that corrects or adds to an earlier filing. |
| Dec 23, 2022 (view filing) | Nov 10 | 43 days | Josephson NeilChief Medical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −2.48K | $8.10 | −$20.0K | −14.6%14.4K after | AmendedAn amended filing (for example Form 4/A or 13F-HR/A) that corrects or adds to an earlier filing. |
| Oct 18, 2022 (view filing)6:07 AM ET | Oct 13 | 5 days | Redmile Group, LLC and 1 other10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in.Common Stock, par value $0.00001 per share | +30.5K | $5.03 | +$153.4K | +0.5%6.08M after | AmendedAn amended filing (for example Form 4/A or 13F-HR/A) that corrects or adds to an earlier filing. |
