Zymeworks Inc.
ZYME- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001937653
No open-market purchases or sales by Zymeworks Inc. insiders were filed in the last 90 days; 202 institutions reported holding it in 13F filings for Q2 2026, worth $1.79B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Zymeworks Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 210
- +28 vs. Q3 2025
- Shares held
- 71.5M
- −2.08M (−2.8%) vs. Q3 2025
- Total value
- $1.88B
- +$625.5M (+49.8%) vs. Q3 2025
- New holders
- 47
- 71 more added
- Sold out
- 19
- 62 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting ZYME on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 202 | $1.79B |
| Q1 2026 | 212 | $1.76B |
| Q4 2025 | 210 | $1.88B |
| Q3 2025 | 184 | $1.26B |
| Q2 2025 | 182 | $949.0M |
| Q1 2025 | 186 | $840.9M |
| Q4 2024 | 174 | $973.2M |
| Q3 2024 | 163 | $834.7M |
| Q2 2024 | 164 | $580.6M |
| Q1 2024 | 171 | $713.0M |
| Q4 2023 | 157 | $674.0M |
| Q3 2023 | 140 | $395.5M |
| Q2 2023 | 137 | $547.9M |
| Q1 2023 | 116 | $512.6M |
| Q4 2022 | 96 | $449.9M |
| Q3 2022 | 91 | $293.7M |
| Q2 2022 | 114 | $253.3M |
| Q1 2022 | 120 | $327.3M |
| Q4 2021 | 114 | $693.9M |
| Q3 2021 | 123 | $1.07B |
| Q2 2021 | 109 | $1.20B |
| Q1 2021 | 125 | $1.12B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Zymeworks Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 22,970,388 | $604.8M | 27.72% | 00.0% | Unchanged |
| Rubric Capital Management LP | 5,750,000 | $151.4M | 1.81% | +1,039,449+22.1% | Added |
| BlackRock, Inc. | 4,595,548 | $121.0M | 0.00% | +606,015+15.2% | Added |
| BVF Inc | 3,938,641 | $103.7M | 3.49% | 00.0% | Unchanged |
| Perceptive Advisors LLC | 3,261,850 | $85.9M | 1.57% | +1,171,187+56.0% | Added |
| Morgan Stanley | 2,593,080 | $68.3M | 0.00% | −1,391,505−34.9% | Reduced |
| Vanguard Group Inc | 2,328,727 | $61.3M | 0.00% | +174,293+8.1% | Added |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,822,048 | $48.0M | 0.06% | +1,822,048 | New |
| Siren, L.L.C. | 1,680,121 | $44.2M | 1.32% | +1,680,121 | New |
| Deutsche Bank AG | 1,595,833 | $42.0M | 0.01% | +50,935+3.3% | Added |
| Dimensional Fund Advisors LP | 1,159,215 | $30.5M | 0.01% | −31,623−2.7% | Reduced |
| Nextech Invest, Ltd. | 1,113,946 | $29.3M | 2.84% | 00.0% | Unchanged |
| State Street Corp | 1,037,642 | $27.3M | 0.00% | −43,547−4.0% | Reduced |
| Capricorn Fund Managers Ltd | 1,022,840 | $26.9M | 6.49% | +1,022,840 | New |
| Vestal Point Capital, LP | 865,000 | $22.8M | 0.84% | −900,000−51.0% | Reduced |
| Arrowstreet Capital, Limited Partnership | 700,002 | $18.4M | 0.01% | +386,249+123.1% | Added |
| Adage Capital Partners GP, L.L.C. | 663,546 | $17.5M | 0.03% | +99,546+17.7% | Added |
| Nuveen, LLC | 648,326 | $17.1M | 0.00% | +82,941+14.7% | Added |
| Geode Capital Management, LLC | 647,970 | $17.1M | 0.00% | −30,666−4.5% | Reduced |
| Assenagon Asset Management S.A. | 647,374 | $17.0M | 0.03% | −679,400−51.2% | Reduced |
| FMR LLC | 560,086 | $14.7M | 0.00% | +556,572+15,838.7% | Added |
| Prosight Management, LP | 530,393 | $14.0M | 2.89% | −219,218−29.2% | Reduced |
| Redmile Group, LLC | 491,654 | $12.9M | 0.95% | −3,214,096−86.7% | Reduced |
| Qube Research & Technologies Ltd | 474,290 | $12.5M | 0.02% | +219,288+86.0% | Added |
| Algert Global LLC | 423,646 | $11.2M | 0.17% | +215,720+103.7% | Added |
| Goldman Sachs Group Inc | 420,207 | $11.1M | 0.00% | −23,318−5.3% | Reduced |
| Millennium Management LLC | 381,621 | $10.0M | 0.01% | −723,192−65.5% | Reduced |
| UBS Asset Management Americas Inc | 320,261 | $8.43M | 0.00% | −1,390,202−81.3% | Reduced |
| Northern Trust Corp | 307,979 | $8.11M | 0.00% | −40,274−11.6% | Reduced |
| Schonfeld Strategic Advisors LLC | 288,571 | $7.60M | 0.04% | +180,783+167.7% | Added |
| UBS Group AG | 278,854 | $7.34M | 0.00% | +227,013+437.9% | Added |
| Invesco Ltd. | 257,580 | $6.78M | 0.00% | +163,923+175.0% | Added |
| Citadel Advisors LLC | 255,351 | $6.72M | 0.00% | +48,493+23.4% | Added |
| Picton Mahoney Asset Management | 244,798 | $6.45M | 0.07% | +38,476+18.6% | Added |
| Hillsdale Investment Management Inc. | 237,922 | $6.26M | 0.17% | +21,500+9.9% | Added |
| Granahan Investment Management Inc | 224,408 | $5.91M | 0.25% | −120,923−35.0% | Reduced |
| SummitTX Capital, L.P. | 224,268 | $5.90M | 0.18% | +224,268 | New |
| D. E. Shaw & Co., Inc. | 223,786 | $5.89M | 0.00% | +96,863+76.3% | Added |
| Charles Schwab Investment Management Inc | 220,909 | $5.82M | 0.00% | +27,549+14.2% | Added |
| Renaissance Technologies LLC | 220,877 | $5.82M | 0.01% | −210,823−48.8% | Reduced |
| Wells Fargo & Company | 208,313 | $5.48M | 0.00% | +31,679+17.9% | Added |
| Raymond James Financial Inc | 187,685 | $4.94M | 0.00% | +64,817+52.8% | Added |
| Silvercrest Asset Management Group LLC | 181,790 | $4.79M | 0.03% | −91,007−33.4% | Reduced |
| Wellington Management Group LLP | 181,705 | $4.78M | 0.00% | +13,020+7.7% | Added |
| Susquehanna International Group, LLP | 176,088 | $4.64M | 0.01% | +124,034+238.3% | Added |
| Federated Hermes, Inc. | 152,689 | $4.02M | 0.01% | −30,158−16.5% | Reduced |
| Kennedy Capital Management, Inc. | 145,534 | $3.83M | 0.08% | −906−0.6% | Reduced |
| Bank of New York Mellon Corp | 128,131 | $3.37M | 0.00% | −9,421−6.8% | Reduced |
| Jupiter Asset Management Ltd | 125,506 | $3.30M | 0.03% | −225,154−64.2% | Reduced |
| HRT Financial LP | 121,064 | $3.19M | 0.01% | +52,603+76.8% | Added |
| Ameriprise Financial Inc | 113,141 | $2.98M | 0.00% | +37,213+49.0% | Added |
| Citigroup Inc | 111,207 | $2.93M | 0.00% | −6,597−5.6% | Reduced |
| Opaleye Management Inc. | 108,929 | $2.87M | 0.38% | +8,929+8.9% | Added |
| Platinum Investment Management Ltd | 105,184 | $2.77M | 0.64% | −19,600−15.7% | Reduced |
| Trexquant Investment LP | 101,274 | $2.67M | 0.02% | +101,274 | New |
| Soleus Capital Management, L.P. | 100,000 | $2.63M | 0.11% | +100,000 | New |
| Susquehanna Portfolio Strategies, LLC | 99,795 | $2.63M | 0.04% | +15,600+18.5% | Added |
| Schroder Investment Management Group | 97,907 | $2.60M | 0.00% | −63,579−39.4% | Reduced |
| XTX Topco Ltd | 93,469 | $2.46M | 0.06% | +93,469 | New |
| AQR Capital Management LLC | 91,075 | $2.40M | 0.00% | −61,557−40.3% | Reduced |
| Bank of America Corp | 89,524 | $2.36M | 0.00% | +14,197+18.8% | Added |
| Kornitzer Capital Management Inc | 88,800 | $2.34M | 0.05% | +88,800 | New |
| Acuta Capital Partners, LLC | 80,143 | $2.11M | 1.43% | 00.0% | Unchanged |
| Barclays PLC | 79,966 | $2.11M | 0.00% | −119,057−59.8% | Reduced |
| Panagora Asset Management Inc | 78,336 | $2.06M | 0.01% | −27,736−26.1% | Reduced |
| NEOS Investment Management LLC | 77,115 | $2.03M | 0.01% | +13,452+21.1% | Added |
| Tema ETFs LLC | 75,975 | $2.00M | 0.16% | +12,312+19.3% | Added |
| Stifel Financial Corp | 75,847 | $2.00M | 0.00% | +3,317+4.6% | Added |
| State of Wisconsin Investment Board | 75,566 | $1.99M | 0.00% | +19,292+34.3% | Added |
| Rhumbline Advisers | 75,498 | $1.99M | 0.00% | −10,404−12.1% | Reduced |
| Man Group plc | 75,318 | $1.98M | 0.00% | −83,298−52.5% | Reduced |
| Credit Agricole S A | 75,000 | $1.97M | 0.01% | +75,000 | New |
| Pictet Asset Management Holding SA | 73,627 | $1.97M | 0.00% | +73,627 | New |
| Swiss National Bank | 74,200 | $1.95M | 0.00% | +1,100+1.5% | Added |
| Jane Street Group, LLC | 70,445 | $1.85M | 0.00% | −74,761−51.5% | Reduced |
| Fisher Asset Management, LLC | 68,197 | $1.80M | 0.00% | −3,777−5.2% | Reduced |
| Penserra Capital Management LLC | 60,146 | $1.58M | 0.02% | +60,146 | New |
| Franklin Resources Inc | 58,987 | $1.55M | 0.00% | +25,166+74.4% | Added |
| American Century Companies Inc | 58,832 | $1.55M | 0.00% | +7,816+15.3% | Added |
| Russell Investments Group, Ltd. | 58,350 | $1.54M | 0.00% | +902+1.6% | Added |
| Royal Bank of Canada | 55,055 | $1.45M | 0.00% | −2,870−5.0% | Reduced |
| Alliancebernstein L.P. | 50,030 | $1.32M | 0.00% | 00.0% | Unchanged |
| Dana Investment Advisors, Inc. | 48,318 | $1.27M | 0.04% | +48,318 | New |
| Simplex Trading, LLC | 48,040 | $1.26M | 0.04% | +19,279+67.0% | Added |
| Mackenzie Financial Corp | 45,460 | $1.20M | 0.00% | −10,917−19.4% | Reduced |
| North Growth Management Ltd. | 45,000 | $1.18M | 0.19% | −37,000−45.1% | Reduced |
| O'Shaughnessy Asset Management, LLC | 43,052 | $1.13M | 0.01% | +1,284+3.1% | Added |
| Victory Capital Management Inc | 42,905 | $1.13M | 0.00% | +8,395+24.3% | Added |
| Envestnet Asset Management Inc | 40,812 | $1.07M | 0.00% | +26,238+180.0% | Added |
| California State Teachers Retirement System | 37,761 | $994.2K | 0.00% | +2,530+7.2% | Added |
| JPMorgan Chase & Co | 35,008 | $921.8K | 0.00% | +1,124+3.3% | Added |
| Tang Capital Management LLC | 34,631 | $911.8K | 0.05% | −1,065,369−96.9% | Reduced |
| Campbell & CO Investment Adviser LLC | 33,588 | $884.4K | 0.04% | +1,095+3.4% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 32,815 | $864.0K | 0.00% | +2,383+7.8% | Added |
| SBI Okasan Asset Management Co.Ltd. | 32,000 | $855.7K | 0.05% | +32,000 | New |
| Legal & General Group Plc | 32,149 | $846.5K | 0.00% | +3,780+13.3% | Added |
| Two Sigma Advisers, LP | 31,415 | $827.2K | 0.00% | +31,415 | New |
| Tudor Investment Corp Et Al | 30,324 | $798.4K | 0.00% | −7,259−19.3% | Reduced |
| Journey Strategic Wealth LLC | 29,050 | $764.9K | 0.02% | 00.0% | Unchanged |
| Quantinno Capital Management LP | 28,883 | $760.5K | 0.00% | +28,883 | New |