Zymeworks Inc.
ZYME- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001937653
No open-market purchases or sales by Zymeworks Inc. insiders were filed in the last 90 days; 202 institutions reported holding it in 13F filings for Q2 2026, worth $1.79B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Zymeworks Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 210
- +28 vs. Q3 2025
- Shares held
- 71.5M
- −2.08M (−2.8%) vs. Q3 2025
- Total value
- $1.88B
- +$625.5M (+49.8%) vs. Q3 2025
- New holders
- 47
- 71 more added
- Sold out
- 19
- 62 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting ZYME on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 202 | $1.79B |
| Q1 2026 | 212 | $1.76B |
| Q4 2025 | 210 | $1.88B |
| Q3 2025 | 184 | $1.26B |
| Q2 2025 | 182 | $949.0M |
| Q1 2025 | 186 | $840.9M |
| Q4 2024 | 174 | $973.2M |
| Q3 2024 | 163 | $834.7M |
| Q2 2024 | 164 | $580.6M |
| Q1 2024 | 171 | $713.0M |
| Q4 2023 | 157 | $674.0M |
| Q3 2023 | 140 | $395.5M |
| Q2 2023 | 137 | $547.9M |
| Q1 2023 | 116 | $512.6M |
| Q4 2022 | 96 | $449.9M |
| Q3 2022 | 91 | $293.7M |
| Q2 2022 | 114 | $253.3M |
| Q1 2022 | 120 | $327.3M |
| Q4 2021 | 114 | $693.9M |
| Q3 2021 | 123 | $1.07B |
| Q2 2021 | 109 | $1.20B |
| Q1 2021 | 125 | $1.12B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Zymeworks Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Price T Rowe Associates Inc | 28,784 | $758.0K | 0.00% | +1,968+7.3% | Added |
| MetLife Investment Management | 28,630 | $753.8K | 0.00% | −4,679−14.0% | Reduced |
| Creative Planning | 28,293 | $745.0K | 0.00% | +979+3.6% | Added |
| Massachusetts Financial Services Co | 28,083 | $739.4K | 0.00% | −932−3.2% | Reduced |
| Virginia Retirement Systems Et Al | 27,935 | $735.5K | 0.00% | −28,040−50.1% | Reduced |
| STRS Ohio | 26,600 | $700.4K | 0.00% | −14,300−35.0% | Reduced |
| Commonwealth Equity Services, LLC | 26,095 | $687.1K | 0.00% | −5,142−16.5% | Reduced |
| Ritholtz Wealth Management | 24,338 | $640.8K | 0.01% | −384−1.6% | Reduced |
| Aquatic Capital Management LLC | 24,103 | $634.6K | 0.02% | +24,103 | New |
| Brevan Howard Capital Management LP | 23,333 | $614.4K | 0.01% | +8,815+60.7% | Added |
| BNP Paribas Arbitrage, SA | 23,298 | $613.4K | 0.00% | +7,838+50.7% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 23,109 | $608.5K | 0.00% | +164+0.7% | Added |
| Quadrature Capital Ltd | 23,017 | $606.0K | 0.01% | +23,017 | New |
| Y-Intercept (Hong Kong) Ltd | 22,643 | $596.2K | 0.01% | +22,643 | New |
| Seven Fleet Capital Management LP | 20,600 | $542.4K | 0.37% | +20,600 | New |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 20,421 | $537.7K | 0.00% | −9,287−31.3% | Reduced |
| Intech Investment Management LLC | 20,330 | $535.3K | 0.00% | +3,348+19.7% | Added |
| PSP Research LLC | 20,312 | $534.8K | 0.47% | +20,312 | New |
| Duncan Williams Asset Management, LLC | 22,095 | $510.6K | 0.13% | 00.0% | Unchanged |
| Vinva Investment Management Ltd | 12,216 | $483.9K | 0.01% | −2,378−16.3% | Reduced |
| Change Path, LLC | 18,264 | $480.9K | 0.01% | +18,264 | New |
| Janus Henderson Group PLC | 18,200 | $479.1K | 0.00% | 00.0% | Unchanged |
| HSBC Holdings PLC | 17,868 | $476.2K | 0.00% | −19,732−52.5% | Reduced |
| SG Americas Securities, LLC | 17,557 | $462.0K | 0.00% | +3,933+28.9% | Added |
| Bank of Montreal | 17,468 | $459.9K | 0.00% | −10,174−36.8% | Reduced |
| Manufacturers Life Insurance Company, The | 17,433 | $459.0K | 0.00% | −141−0.8% | Reduced |
| New York State Common Retirement Fund | 17,371 | $457.4K | 0.00% | +4,000+29.9% | Added |
| State Board of Administration of Florida Retirement System | 15,340 | $403.9K | 0.00% | 00.0% | Unchanged |
| Agf Management Ltd | 15,000 | $394.9K | 0.00% | +15,000 | New |
| Lazard Asset Management LLC | 13,776 | $362.7K | 0.00% | −1,532−10.0% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 13,702 | $360.8K | 0.00% | −503−3.5% | Reduced |
| Walleye Capital LLC | 13,667 | $359.9K | 0.00% | +13,591+17,882.9% | Added |
| Walleye Trading LLC | 13,252 | $348.9K | 0.01% | +13,252 | New |
| Prudential Financial Inc | 12,755 | $335.8K | 0.00% | −20,635−61.8% | Reduced |
| ProShare Advisors LLC | 12,387 | $326.2K | 0.00% | +1,186+10.6% | Added |
| China Universal Asset Management Co., Ltd. | 12,195 | $321.1K | 0.02% | −981−7.4% | Reduced |
| Northwest & Ethical Investments L.P. | 12,044 | $319.6K | 0.01% | +2,014+20.1% | Added |
| Winton Group Ltd | 11,180 | $294.4K | 0.01% | +11,180 | New |
| Janney Montgomery Scott LLC | 11,067 | $291.0K | 0.00% | 00.0% | Unchanged |
| Ewing Morris & Co. Investment Partners Ltd. | 10,850 | $289.2K | 0.13% | 00.0% | Unchanged |
| James Investment Research Inc | 10,925 | $287.7K | 0.03% | +347+3.3% | Added |
| State of Wyoming | 10,875 | $286.3K | 0.03% | +10,875 | New |
| Virtus Investment Advisers, Inc. | 10,441 | $274.9K | 0.07% | +1,755+20.2% | Added |
| Arizona State Retirement System | 10,395 | $273.7K | 0.00% | −664−6.0% | Reduced |
| Abacus Wealth Partners, LLC | 10,222 | $269.1K | 0.03% | +10,222 | New |
| Baader Bank INC | 10,013 | $263.5K | 0.02% | +10,013 | New |
| VARCOV Co. | 9,818 | $258.5K | 0.10% | +9,818 | New |
| Voya Investment Management LLC | 9,234 | $243.1K | 0.00% | +9,234 | New |
| Group One Trading, L.P. | 8,841 | $232.8K | 0.01% | +1,973+28.7% | Added |
| Quest Partners LLC | 8,313 | $218.9K | 0.01% | −158−1.9% | Reduced |
| Skopos Labs, Inc. | 8,020 | $214.5K | 0.01% | +8,020 | New |
| Cresset Asset Management, LLC | 8,120 | $213.8K | 0.00% | +8,120 | New |
| KLP Kapitalforvaltning AS | 8,000 | $210.6K | 0.00% | +700+9.6% | Added |
| Apollon Wealth Management, LLC | 7,875 | $207.3K | 0.00% | +7,875 | New |
| Allspring Global Investments Holdings, LLC | 7,707 | $205.2K | 0.00% | +7,707 | New |
| Persistent Asset Partners Ltd | 7,346 | $193.4K | 0.09% | +7,346 | New |
| CWM, LLC | 6,975 | $184.0K | 0.00% | +7+0.1% | Added |
| Cygnus Capital Advisors, LLC | 5,997 | $158.0K | 0.12% | +5,997 | New |
| Ameritas Investment Partners, Inc. | 4,164 | $109.6K | 0.00% | 00.0% | Unchanged |
| Mirae Asset Global Investments Co., Ltd. | 3,637 | $95.8K | 0.00% | +731+25.2% | Added |
| CFG Wealth Management Services, Inc. | 3,080 | $81.1K | 0.07% | +3,080 | New |
| Advisor Group Holdings, Inc. | 2,510 | $66.1K | 0.00% | +1,735+223.9% | Added |
| Amalgamated Bank | 1,566 | $41.0K | 0.00% | −314−16.7% | Reduced |
| GF Fund Management Co. Ltd. | 1,470 | $38.7K | 0.00% | −147−9.1% | Reduced |
| Caitong International Asset Management Co., Ltd | 1,399 | $36.8K | 0.01% | +1,399 | New |
| Tower Research Capital LLC (TRC) | 1,353 | $35.6K | 0.00% | −9,948−88.0% | Reduced |
| DekaBank Deutsche Girozentrale | 3,843 | $35.0K | 0.00% | 00.0% | Unchanged |
| Optiver Holding B.V. | 1,148 | $30.3K | 0.00% | −362−24.0% | Reduced |
| GAMMA Investing LLC | 985 | $25.9K | 0.00% | +180+22.4% | Added |
| Nisa Investment Advisors, LLC | 968 | $25.5K | 0.00% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 781 | $20.6K | 0.00% | +468+149.5% | Added |
| NBC Securities, Inc. | 623 | $16.4K | 0.00% | +623 | New |
| Thurston, Springer, Miller, Herd & Titak, Inc. | 610 | $16.1K | 0.01% | +610 | New |
| Federation des caisses Desjardins du Quebec | 570 | $15.0K | 0.00% | −300−34.5% | Reduced |
| National Bank of Canada | 545 | $14.3K | 0.00% | −4−0.7% | Reduced |
| Umb Bank N A | 466 | $12.3K | 0.00% | +466 | New |
| Huntington National Bank | 364 | $9.58K | 0.00% | +364 | New |
| Sterling Capital Management LLC | 331 | $8.71K | 0.00% | +210+173.6% | Added |
| Parallel Advisors, LLC | 329 | $8.66K | 0.00% | 00.0% | Unchanged |
| TD Waterhouse Canada Inc. | 311 | $8.19K | 0.00% | 00.0% | Unchanged |
| US Bancorp | 287 | $7.56K | 0.00% | +39+15.7% | Added |
| Los Angeles Capital Management LLC | 387 | $7.40K | 0.00% | +387 | New |
| Farther Finance Advisors, LLC | 279 | $7.35K | 0.00% | +217+350.0% | Added |
| Truvestments Capital LLC | 231 | $6.08K | 0.00% | 00.0% | Unchanged |
| HighMark Wealth Management LLC | 230 | $6.05K | 0.00% | −50−17.9% | Reduced |
| Comerica Bank | 211 | $5.56K | 0.00% | 00.0% | Unchanged |
| Daiwa Securities Group Inc. | 186 | $5.00K | 0.00% | −100−35.0% | Reduced |
| EverSource Wealth Advisors, LLC | 182 | $4.79K | 0.00% | 00.0% | Unchanged |
| SRS Capital Advisors, Inc. | 169 | $4.45K | 0.00% | −2,812−94.3% | Reduced |
| Allworth Financial LP | 146 | $3.85K | 0.00% | +6+4.3% | Added |
| IFP Advisors, Inc | 96 | $2.53K | 0.00% | 00.0% | Unchanged |
| Quarry LP | 90 | $2.37K | 0.00% | −2,852−96.9% | Reduced |
| Kilter Group LLC | 66 | $1.74K | 0.00% | 00.0% | Unchanged |
| Bare Financial Services, Inc | 64 | $1.69K | 0.00% | 00.0% | Unchanged |
| True Wealth Design, LLC | 58 | $1.53K | 0.00% | 00.0% | Unchanged |
| Rothschild Investment LLC | 56 | $1.47K | 0.00% | +1+1.8% | Added |
| Steward Partners Investment Advisory, LLC | 53 | $1.40K | 0.00% | 00.0% | Unchanged |
| UMA Financial Services, Inc. | 51 | $1.34K | 0.00% | 00.0% | Unchanged |
| Signaturefd, LLC | 42 | $1.11K | 0.00% | +42 | New |
| Covestor Ltd | 54 | $1.00K | 0.00% | +1+1.9% | Added |