Zymeworks Inc.
ZYME- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001937653
No open-market purchases or sales by Zymeworks Inc. insiders were filed in the last 90 days; 202 institutions reported holding it in 13F filings for Q2 2026, worth $1.79B in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Zymeworks Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 184
- +3 vs. Q2 2025
- Shares held
- 73.7M
- −1.71M (−2.3%) vs. Q2 2025
- Total value
- $1.26B
- +$312.6M (+33.0%) vs. Q2 2025
- New holders
- 25
- 61 more added
- Sold out
- 22
- 65 more reduced
1 institution that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting ZYME on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 202 | $1.79B |
| Q1 2026 | 212 | $1.76B |
| Q4 2025 | 210 | $1.88B |
| Q3 2025 | 184 | $1.26B |
| Q2 2025 | 182 | $949.0M |
| Q1 2025 | 186 | $840.9M |
| Q4 2024 | 174 | $973.2M |
| Q3 2024 | 163 | $834.7M |
| Q2 2024 | 164 | $580.6M |
| Q1 2024 | 171 | $713.0M |
| Q4 2023 | 157 | $674.0M |
| Q3 2023 | 140 | $395.5M |
| Q2 2023 | 137 | $547.9M |
| Q1 2023 | 116 | $512.6M |
| Q4 2022 | 96 | $449.9M |
| Q3 2022 | 91 | $293.7M |
| Q2 2022 | 114 | $253.3M |
| Q1 2022 | 120 | $327.3M |
| Q4 2021 | 114 | $693.9M |
| Q3 2021 | 123 | $1.07B |
| Q2 2021 | 109 | $1.20B |
| Q1 2021 | 125 | $1.12B |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Zymeworks Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 22,970,388 | $392.3M | 18.87% | 00.0% | Unchanged |
| Rubric Capital Management LP | 4,710,551 | $80.5M | 1.08% | 00.0% | Unchanged |
| BlackRock, Inc. | 3,989,533 | $68.1M | 0.00% | +195,261+5.1% | Added |
| Morgan Stanley | 3,984,585 | $68.1M | 0.00% | −193,029−4.6% | Reduced |
| BVF Inc | 3,938,641 | $67.3M | 2.73% | −370,294−8.6% | Reduced |
| Redmile Group, LLC | 3,705,750 | $63.3M | 6.16% | −444,877−10.7% | Reduced |
| Vanguard Group Inc | 2,154,434 | $36.8M | 0.00% | −310,259−12.6% | Reduced |
| Perceptive Advisors LLC | 2,090,663 | $35.7M | 1.03% | +815,389+63.9% | Added |
| Vestal Point Capital, LP | 1,765,000 | $30.1M | 1.37% | +615,000+53.5% | Added |
| UBS Asset Management Americas Inc | 1,710,463 | $29.2M | 0.01% | −749,050−30.5% | Reduced |
| Blackstone Group Inc. | 1,616,290 | $27.6M | 0.12% | −40,500−2.4% | Reduced |
| Deutsche Bank AG | 1,544,898 | $26.4M | 0.01% | +1350.0% | Added |
| Assenagon Asset Management S.A. | 1,326,774 | $22.7M | 0.03% | +833,994+169.2% | Added |
| Dimensional Fund Advisors LP | 1,190,838 | $20.3M | 0.00% | −1,594−0.1% | Reduced |
| Nextech Invest, Ltd. | 1,113,946 | $19.0M | 2.90% | 00.0% | Unchanged |
| Millennium Management LLC | 1,104,813 | $18.9M | 0.01% | +988,711+851.6% | Added |
| Tang Capital Management LLC | 1,100,000 | $18.8M | 0.72% | 00.0% | Unchanged |
| State Street Corp | 1,081,189 | $18.5M | 0.00% | −7,270−0.7% | Reduced |
| Prosight Management, LP | 749,611 | $12.8M | 3.07% | −560,293−42.8% | Reduced |
| Geode Capital Management, LLC | 678,636 | $11.6M | 0.00% | −26,728−3.8% | Reduced |
| Nuveen, LLC | 565,385 | $9.66M | 0.00% | −89,531−13.7% | Reduced |
| Adage Capital Partners GP, L.L.C. | 564,000 | $9.63M | 0.02% | +88,000+18.5% | Added |
| Goldman Sachs Group Inc | 443,525 | $7.58M | 0.00% | +14,668+3.4% | Added |
| Renaissance Technologies LLC | 431,700 | $7.37M | 0.01% | −101,600−19.1% | Reduced |
| Jupiter Asset Management Ltd | 350,660 | $5.99M | 0.05% | −18,839−5.1% | Reduced |
| Northern Trust Corp | 348,253 | $5.95M | 0.00% | −1,546−0.4% | Reduced |
| Granahan Investment Management Inc | 345,331 | $5.90M | 0.24% | −35,452−9.3% | Reduced |
| Arrowstreet Capital, Limited Partnership | 313,753 | $5.36M | 0.00% | +313,753 | New |
| Silvercrest Asset Management Group LLC | 272,797 | $4.66M | 0.03% | −7,929−2.8% | Reduced |
| Qube Research & Technologies Ltd | 255,002 | $4.36M | 0.01% | +185,128+264.9% | Added |
| Squarepoint Ops LLC | 219,948 | $3.76M | 0.01% | +64,349+41.4% | Added |
| Hillsdale Investment Management Inc. | 216,422 | $3.70M | 0.11% | +11,400+5.6% | Added |
| Algert Global LLC | 207,926 | $3.55M | 0.06% | +89,822+76.1% | Added |
| Samsara BioCapital, LLC | 207,901 | $3.55M | 0.46% | −102,399−33.0% | Reduced |
| Citadel Advisors LLC | 206,858 | $3.53M | 0.00% | −39,297−16.0% | Reduced |
| Picton Mahoney Asset Management | 206,322 | $3.52M | 0.04% | −1,280−0.6% | Reduced |
| Barclays PLC | 199,023 | $3.40M | 0.00% | +76,203+62.0% | Added |
| Charles Schwab Investment Management Inc | 193,360 | $3.30M | 0.00% | +69,156+55.7% | Added |
| Federated Hermes, Inc. | 182,847 | $3.12M | 0.01% | +577+0.3% | Added |
| Wells Fargo & Company | 176,634 | $3.02M | 0.00% | +10,206+6.1% | Added |
| Wellington Management Group LLP | 168,685 | $2.88M | 0.00% | −12,005−6.6% | Reduced |
| Schroder Investment Management Group | 161,486 | $2.78M | 0.00% | −143,180−47.0% | Reduced |
| Man Group plc | 158,616 | $2.71M | 0.01% | +123,210+348.0% | Added |
| AXA Investment Managers S.A. | 158,416 | $2.71M | 0.01% | +158,416 | New |
| Marshall Wace, LLP | 154,858 | $2.64M | 0.00% | +154,858 | New |
| AQR Capital Management LLC | 152,632 | $2.61M | 0.00% | −13,511−8.1% | Reduced |
| Kennedy Capital Management, Inc. | 146,440 | $2.50M | 0.06% | −514−0.3% | Reduced |
| Jane Street Group, LLC | 145,206 | $2.48M | 0.00% | +132,657+1,057.1% | Added |
| Bank of New York Mellon Corp | 137,552 | $2.35M | 0.00% | +4,462+3.4% | Added |
| D. E. Shaw & Co., Inc. | 126,923 | $2.17M | 0.00% | −128,368−50.3% | Reduced |
| Platinum Investment Management Ltd | 124,784 | $2.13M | 0.14% | −113,607−47.7% | Reduced |
| Raymond James Financial Inc | 122,868 | $2.10M | 0.00% | −1,567−1.3% | Reduced |
| Citigroup Inc | 117,804 | $2.01M | 0.00% | −38,194−24.5% | Reduced |
| Schonfeld Strategic Advisors LLC | 107,788 | $1.84M | 0.01% | +107,788 | New |
| Panagora Asset Management Inc | 106,072 | $1.81M | 0.01% | +72,513+216.1% | Added |
| Opaleye Management Inc. | 100,000 | $1.71M | 0.24% | −110,000−52.4% | Reduced |
| Connor, Clark & Lunn Investment Management Ltd. | 96,800 | $1.65M | 0.01% | +96,800 | New |
| Invesco Ltd. | 93,657 | $1.60M | 0.00% | +4,286+4.8% | Added |
| Rhumbline Advisers | 85,902 | $1.47M | 0.00% | −181−0.2% | Reduced |
| Tejara Capital Ltd | 85,163 | $1.45M | 0.80% | −114,987−57.5% | Reduced |
| Susquehanna Portfolio Strategies, LLC | 84,195 | $1.44M | 0.02% | −1,533−1.8% | Reduced |
| North Growth Management Ltd. | 82,000 | $1.41M | 0.25% | −15,000−15.5% | Reduced |
| Acuta Capital Partners, LLC | 80,143 | $1.37M | 1.41% | −3,512−4.2% | Reduced |
| Ameriprise Financial Inc | 75,928 | $1.30M | 0.00% | +75,928 | New |
| Bank of America Corp | 75,327 | $1.29M | 0.00% | −15,051−16.7% | Reduced |
| Swiss National Bank | 73,100 | $1.25M | 0.00% | 00.0% | Unchanged |
| Ikarian Capital, LLC | 72,787 | $1.24M | 0.28% | +47,787+191.1% | Added |
| Stifel Financial Corp | 72,530 | $1.24M | 0.00% | +2,800+4.0% | Added |
| Fisher Asset Management, LLC | 71,974 | $1.23M | 0.00% | −50.0% | Reduced |
| HRT Financial LP | 68,461 | $1.17M | 0.00% | +35,703+109.0% | Added |
| NEOS Investment Management LLC | 63,663 | $1.09M | 0.01% | +11,808+22.8% | Added |
| Tema ETFs LLC | 63,663 | $1.09M | 0.09% | +11,808+22.8% | Added |
| Royal Bank of Canada | 57,925 | $989.0K | 0.00% | −15,058−20.6% | Reduced |
| Russell Investments Group, Ltd. | 57,448 | $981.2K | 0.00% | +29,136+102.9% | Added |
| Mackenzie Financial Corp | 56,377 | $962.9K | 0.00% | +35,022+164.0% | Added |
| Engineers Gate Manager LP | 56,318 | $961.9K | 0.01% | +37,377+197.3% | Added |
| State of Wisconsin Investment Board | 56,274 | $961.2K | 0.00% | +34,239+155.4% | Added |
| Virginia Retirement Systems Et Al | 55,975 | $956.1K | 0.01% | +1,900+3.5% | Added |
| Susquehanna International Group, LLP | 52,054 | $889.1K | 0.00% | −207,083−79.9% | Reduced |
| UBS Group AG | 51,841 | $885.4K | 0.00% | −199,669−79.4% | Reduced |
| American Century Companies Inc | 51,016 | $871.4K | 0.00% | +19,869+63.8% | Added |
| Alliancebernstein L.P. | 50,030 | $854.5K | 0.00% | 00.0% | Unchanged |
| O'Shaughnessy Asset Management, LLC | 41,768 | $713.4K | 0.00% | +544+1.3% | Added |
| STRS Ohio | 40,900 | $698.6K | 0.00% | −5,400−11.7% | Reduced |
| Tudor Investment Corp Et Al | 37,583 | $641.9K | 0.00% | +3,290+9.6% | Added |
| HSBC Holdings PLC | 37,600 | $639.6K | 0.00% | +1,103+3.0% | Added |
| Dark Forest Capital Management LP | 37,167 | $634.8K | 0.02% | −59,822−61.7% | Reduced |
| Oxford Asset Management LLP | 36,359 | $621.0K | 0.20% | +36,359 | New |
| California State Teachers Retirement System | 35,231 | $601.7K | 0.00% | −7,642−17.8% | Reduced |
| Victory Capital Management Inc | 34,510 | $589.4K | 0.00% | −100−0.3% | Reduced |
| JPMorgan Chase & Co | 33,884 | $578.7K | 0.00% | −407,806−92.3% | Reduced |
| Franklin Resources Inc | 33,821 | $577.7K | 0.00% | +33,821 | New |
| Prudential Financial Inc | 33,390 | $570.3K | 0.00% | −11,575−25.7% | Reduced |
| MetLife Investment Management | 33,309 | $568.9K | 0.00% | 00.0% | Unchanged |
| Boothbay Fund Management, LLC | 32,757 | $559.5K | 0.01% | +32,757 | New |
| Campbell & CO Investment Adviser LLC | 32,493 | $555.0K | 0.04% | +17,508+116.8% | Added |
| Commonwealth Equity Services, LLC | 31,237 | $534.0K | 0.00% | −933−2.9% | Reduced |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 30,432 | $519.8K | 0.00% | +16,132+112.8% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 29,708 | $507.4K | 0.00% | −226−0.8% | Reduced |
| Journey Strategic Wealth LLC | 29,050 | $496.2K | 0.01% | +100.0% | Added |