Structure Therapeutics Inc.
GPCR- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001888886
No open-market purchases or sales by Structure Therapeutics Inc. insiders were filed in the last 90 days; 191 institutions reported holding it in 13F filings for Q2 2026, worth $3.62B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Structure Therapeutics Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 199
- +44 vs. Q3 2025
- Shares held
- 65.8M
- +8.91M (+15.7%) vs. Q3 2025
- Total value
- $4.58B
- +$2.99B (+188.4%) vs. Q3 2025
- New holders
- 72
- 52 more added
- Sold out
- 28
- 63 more reduced
3 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting GPCR on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 191 | $3.62B |
| Q1 2026 | 198 | $3.23B |
| Q4 2025 | 199 | $4.58B |
| Q3 2025 | 158 | $1.59B |
| Q2 2025 | 173 | $1.14B |
| Q1 2025 | 151 | $990.0M |
| Q4 2024 | 165 | $1.65B |
| Q3 2024 | 161 | $2.69B |
| Q2 2024 | 167 | $2.33B |
| Q1 2024 | 119 | $1.86B |
| Q4 2023 | 122 | $1.74B |
| Q3 2023 | 84 | $1.64B |
| Q2 2023 | 48 | $699.4M |
| Q1 2023 | 38 | $346.2M |
| Q4 2022 | 0 | $0 |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Structure Therapeutics Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| DAFNA Capital Management LLC | 37,000 | $2.57M | 0.60% | −22,000−37.3% | Reduced |
| EAM Investors, LLC | 38,054 | $2.65M | 0.29% | +38,054 | New |
| ACT Capital Management, LLC | 38,500 | $2.68M | 2.17% | +38,500 | New |
| Sphera Funds Management Ltd. | 41,000 | $2.85M | 0.60% | −132,931−76.4% | Reduced |
| Headlands Technologies LLC | 43,729 | $3.04M | 0.25% | +16,915+63.1% | Added |
| Mariner, LLC | 44,155 | $3.07M | 0.00% | +190.0% | Added |
| Raymond James Financial Inc | 44,388 | $3.09M | 0.00% | +44,388 | New |
| Antipodes Partners Ltd | 46,291 | $3.25M | 0.07% | +42,213+1,035.1% | Added |
| State Street Corp | 48,224 | $3.35M | 0.00% | +2,207+4.8% | Added |
| Flax Pond Capital, LLC | 48,721 | $3.39M | 2.52% | +48,721 | New |
| Pier Capital, LLC | 48,757 | $3.39M | 0.54% | −148,752−75.3% | Reduced |
| Alps Advisors Inc | 49,726 | $3.46M | 0.02% | +21,768+77.9% | Added |
| Integral Health Asset Management, LLC | 50,000 | $3.48M | 0.18% | +50,000 | New |
| Seven Grand Managers, LLC | 50,000 | $3.48M | 0.26% | +50,000 | New |
| Buckland Partners Management Co LLC | 50,000 | $3.48M | 1.93% | +50,000 | New |
| Bank of Montreal | 54,341 | $3.68M | 0.00% | −6,381−10.5% | Reduced |
| Parkman Healthcare Partners LLC | 55,000 | $3.83M | 0.36% | +55,000 | New |
| Geode Capital Management, LLC | 55,148 | $3.84M | 0.00% | −2,810−4.8% | Reduced |
| Voya Investment Management LLC | 55,300 | $3.85M | 0.00% | +38,875+236.7% | Added |
| Advisor Group Holdings, Inc. | 59,238 | $4.12M | 0.01% | −3,601−5.7% | Reduced |
| Banque Pictet & Cie SA | 59,881 | $4.16M | 0.04% | −4,304−6.7% | Reduced |
| Burkehill Global Management, LP | 60,000 | $4.17M | 0.27% | +60,000 | New |
| Longaeva Partners L.P. | 60,000 | $4.17M | 0.50% | +60,000 | New |
| Susquehanna Portfolio Strategies, LLC | 68,089 | $4.74M | 0.07% | +12,147+21.7% | Added |
| PFM Health Sciences, LP | 68,248 | $4.75M | 0.48% | −46,825−40.7% | Reduced |
| Boxer Capital Management, LLC | 75,000 | $5.22M | 1.14% | +75,000 | New |
| Verition Fund Management LLC | 78,149 | $5.44M | 0.03% | +38,800+98.6% | Added |
| Nomura Asset Management International Inc. | 82,645 | $5.75M | 0.01% | +82,645 | New |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 83,052 | $5.78M | 0.01% | +67,338+428.5% | Added |
| Peregrine Capital Management LLC | 84,324 | $5.86M | 0.18% | +84,324 | New |
| Brevan Howard Capital Management LP | 86,310 | $5.96M | 0.11% | +86,310 | New |
| Platinum Investment Management Ltd | 87,874 | $6.11M | 1.41% | −34,884−28.4% | Reduced |
| Trexquant Investment LP | 89,945 | $6.26M | 0.06% | +69,753+345.4% | Added |
| Birchview Capital, LP | 90,000 | $6.26M | 3.66% | +12,000+15.4% | Added |
| Soleus Capital Management, L.P. | 90,000 | $6.26M | 0.27% | +90,000 | New |
| B Group, Inc. | 90,000 | $6.26M | 4.64% | +90,000 | New |
| Simplex Trading, LLC | 92,668 | $6.45M | 0.18% | +67,507+268.3% | Added |
| Manufacturers Life Insurance Company, The | 96,387 | $6.53M | 0.01% | +67,855+237.8% | Added |
| NEXTBio Capital Management LP | 94,443 | $6.57M | 3.85% | +94,443 | New |
| SummitTX Capital, L.P. | 94,671 | $6.58M | 0.20% | +94,671 | New |
| Two Sigma Investments, LP | 95,543 | $6.65M | 0.01% | −87,368−47.8% | Reduced |
| Susquehanna Fundamental Investments, LLC | 99,617 | $6.93M | 0.24% | 00.0% | Unchanged |
| Jain Global LLC | 99,996 | $6.95M | 0.07% | +99,996 | New |
| RTW Investments, LP | 100,000 | $6.96M | 0.07% | +100,000 | New |
| Jefferies Financial Group Inc. | 102,993 | $7.16M | 0.06% | −67,352−39.5% | Reduced |
| Alyeska Investment Group, L.P. | 115,000 | $8.00M | 0.02% | −129,848−53.0% | Reduced |
| Renaissance Technologies LLC | 115,200 | $8.01M | 0.01% | −38,700−25.1% | Reduced |
| Woodline Partners LP | 123,902 | $8.62M | 0.03% | +58,462+89.3% | Added |
| Eversept Partners, LP | 127,561 | $8.87M | 0.50% | −38,830−23.3% | Reduced |
| Bellevue Group AG | 145,167 | $10.1M | 0.19% | −170,690−54.0% | Reduced |
| Jane Street Group, LLC | 147,217 | $10.2M | 0.01% | +147,217 | New |
| Rhenman & Partners Asset Management AB | 147,600 | $10.3M | 0.96% | −32,500−18.0% | Reduced |
| Millennium Management LLC | 152,560 | $10.6M | 0.01% | −1,121,991−88.0% | Reduced |
| Marshall Wace, LLP | 168,584 | $11.7M | 0.01% | +168,584 | New |
| TD Asset Management Inc | 174,674 | $12.1M | 0.01% | +138,588+384.0% | Added |
| HighVista Strategies LLC | 193,001 | $13.4M | 3.46% | −43,235−18.3% | Reduced |
| Sio Capital Management, LLC | 201,500 | $14.0M | 2.32% | +201,500 | New |
| UBS Group AG | 202,477 | $14.1M | 0.00% | −5,615−2.7% | Reduced |
| Balyasny Asset Management LLC | 216,199 | $15.0M | 0.03% | −245,354−53.2% | Reduced |
| Goldman Sachs Group Inc | 224,332 | $15.6M | 0.00% | −280,064−55.5% | Reduced |
| Monashee Investment Management LLC | 225,000 | $15.6M | 8.82% | +25,000+12.5% | Added |
| Voloridge Investment Management, LLC | 250,000 | $17.4M | 0.06% | +250,000 | New |
| Capricorn Fund Managers Ltd | 252,600 | $17.6M | 4.23% | +252,600 | New |
| Catalio Capital Management, LP | 252,901 | $17.6M | 3.11% | −398,909−61.2% | Reduced |
| Standard Life Aberdeen plc | 264,869 | $18.4M | 0.03% | −322,000−54.9% | Reduced |
| National Bank of Canada | 265,400 | $18.5M | 0.02% | +121,400+84.3% | Added |
| ArrowMark Colorado Holdings LLC | 271,213 | $18.9M | 0.42% | −51,953−16.1% | Reduced |
| Ameriprise Financial Inc | 285,518 | $19.9M | 0.00% | −938,626−76.7% | Reduced |
| EcoR1 Capital, LLC | 334,380 | $23.3M | 1.07% | +334,380 | New |
| StemPoint Capital LP | 351,073 | $24.4M | 4.19% | +221,738+171.4% | Added |
| SC China Holding Ltd | 266,062 | $24.4M | 1.43% | 00.0% | Unchanged |
| BlackRock, Inc. | 430,082 | $29.9M | 0.00% | +166,144+62.9% | Added |
| Farallon Capital Management, L.L.C. | 454,000 | $31.6M | 0.16% | +454,000 | New |
| Healthcare of Ontario Pension Plan Trust Fund | 467,800 | $32.5M | 0.06% | +467,800 | New |
| American Century Companies Inc | 506,959 | $35.3M | 0.02% | +20,173+4.1% | Added |
| Logos Global Management LP | 600,000 | $41.7M | 2.78% | −250,000−29.4% | Reduced |
| Pacific Heights Asset Management LLC | 700,000 | $48.7M | 1.82% | 00.0% | Unchanged |
| Rock Springs Capital Management LP | 748,236 | $52.0M | 2.67% | −202,918−21.3% | Reduced |
| Deerfield Management Company, L.P. (Series C) | 767,993 | $53.4M | 0.68% | +394,586+105.7% | Added |
| Citadel Advisors LLC | 772,518 | $53.7M | 0.04% | +328,718+74.1% | Added |
| Deutsche Bank AG | 841,162 | $58.5M | 0.02% | +841,162 | New |
| Alliancebernstein L.P. | 848,851 | $59.0M | 0.02% | +819,292+2,771.7% | Added |
| Franklin Resources Inc | 870,582 | $60.5M | 0.01% | +124,848+16.7% | Added |
| Capitolis Liquid Global Markets LLC | 878,300 | $61.1M | 0.36% | +878,300 | New |
| TCG Crossover Management, LLC | 920,857 | $64.0M | 2.12% | −142,143−13.4% | Reduced |
| Siren, L.L.C. | 1,078,698 | $75.0M | 2.24% | +51,887+5.1% | Added |
| OrbiMed Advisors LLC | 1,161,803 | $80.8M | 1.65% | +22,503+2.0% | Added |
| Casdin Capital, LLC | 1,175,000 | $81.7M | 5.08% | −380,000−24.4% | Reduced |
| Principal Financial Group Inc | 1,284,210 | $89.3M | 0.05% | +496,726+63.1% | Added |
| Baker Bros. Advisors LP | 1,432,529 | $99.6M | 0.58% | −123,580−7.9% | Reduced |
| Driehaus Capital Management LLC | 1,642,444 | $114.2M | 0.78% | +768,940+88.0% | Added |
| Price T Rowe Associates Inc | 1,671,138 | $116.2M | 0.01% | +1,381,745+477.5% | Added |
| Morgan Stanley | 2,087,834 | $145.2M | 0.01% | +1,510,093+261.4% | Added |
| BVF Inc | 3,479,022 | $242.0M | 8.15% | +275,105+8.6% | Added |
| Deep Track Capital, LP | 4,111,782 | $286.0M | 6.52% | −104,029−2.5% | Reduced |
| Janus Henderson Group PLC | 5,090,148 | $354.0M | 0.16% | +641,322+14.4% | Added |
| Avoro Capital Advisors LLC | 6,555,555 | $455.9M | 4.48% | +1,400,000+27.2% | Added |
| Wellington Management Group LLP | 7,121,984 | $495.3M | 0.09% | +1,432,797+25.2% | Added |
| FMR LLC | 8,712,251 | $605.9M | 0.03% | +3,461,883+65.9% | Added |
| Ra Capital Management, L.P. | 0 | $0 | 0.00% | −1,517,418−100.0% | Sold out |