Structure Therapeutics Inc.
GPCR- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001888886
No open-market purchases or sales by Structure Therapeutics Inc. insiders were filed in the last 90 days; 191 institutions reported holding it in 13F filings for Q2 2026, worth $3.62B in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Structure Therapeutics Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 158
- −14 vs. Q2 2025
- Shares held
- 57.0M
- +2.18M (+4.0%) vs. Q2 2025
- Total value
- $1.59B
- +$454.7M (+40.0%) vs. Q2 2025
- New holders
- 22
- 60 more added
- Sold out
- 36
- 48 more reduced
1 institution that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting GPCR on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 191 | $3.62B |
| Q1 2026 | 198 | $3.23B |
| Q4 2025 | 199 | $4.58B |
| Q3 2025 | 158 | $1.59B |
| Q2 2025 | 173 | $1.14B |
| Q1 2025 | 151 | $990.0M |
| Q4 2024 | 165 | $1.65B |
| Q3 2024 | 161 | $2.69B |
| Q2 2024 | 167 | $2.33B |
| Q1 2024 | 119 | $1.86B |
| Q4 2023 | 122 | $1.74B |
| Q3 2023 | 84 | $1.64B |
| Q2 2023 | 48 | $699.4M |
| Q1 2023 | 38 | $346.2M |
| Q4 2022 | 0 | $0 |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Structure Therapeutics Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Wellington Management Group LLP | 5,689,187 | $159.3M | 0.03% | −1,186,582−17.3% | Reduced |
| FMR LLC | 5,250,368 | $147.0M | 0.01% | +335,403+6.8% | Added |
| Avoro Capital Advisors LLC | 5,155,555 | $144.4M | 1.87% | +5,155,555 | New |
| Janus Henderson Group PLC | 4,448,826 | $124.6M | 0.06% | −124,180−2.7% | Reduced |
| Deep Track Capital, LP | 4,215,811 | $118.0M | 3.29% | −918,106−17.9% | Reduced |
| BVF Inc | 3,203,917 | $89.7M | 3.64% | +1,432,500+80.9% | Added |
| Baker Bros. Advisors LP | 1,556,109 | $43.6M | 0.31% | −952,658−38.0% | Reduced |
| Casdin Capital, LLC | 1,555,000 | $43.5M | 3.63% | +330,000+26.9% | Added |
| Ra Capital Management, L.P. | 1,517,418 | $42.5M | 0.52% | 00.0% | Unchanged |
| Millennium Management LLC | 1,274,551 | $35.7M | 0.03% | +54,496+4.5% | Added |
| Ameriprise Financial Inc | 1,224,144 | $34.3M | 0.01% | −364,054−22.9% | Reduced |
| OrbiMed Advisors LLC | 1,139,300 | $31.9M | 0.77% | −60,000−5.0% | Reduced |
| TCG Crossover Management, LLC | 1,063,000 | $29.8M | 1.46% | 00.0% | Unchanged |
| Siren, L.L.C. | 1,026,811 | $28.8M | 1.12% | +1,026,811 | New |
| Rock Springs Capital Management LP | 951,154 | $26.6M | 1.56% | −184,725−16.3% | Reduced |
| Driehaus Capital Management LLC | 873,504 | $24.5M | 0.18% | +200,712+29.8% | Added |
| Logos Global Management LP | 850,000 | $23.8M | 2.35% | 00.0% | Unchanged |
| Principal Financial Group Inc | 787,484 | $22.0M | 0.01% | −65,718−7.7% | Reduced |
| Franklin Resources Inc | 745,734 | $20.9M | 0.01% | +3,951+0.5% | Added |
| Pacific Heights Asset Management LLC | 700,000 | $19.6M | 0.87% | +240,000+52.2% | Added |
| Catalio Capital Management, LP | 651,810 | $18.3M | 3.37% | −18,765−2.8% | Reduced |
| Standard Life Aberdeen plc | 586,869 | $16.4M | 0.03% | +185,245+46.1% | Added |
| Morgan Stanley | 577,741 | $16.2M | 0.00% | −339,605−37.0% | Reduced |
| Goldman Sachs Group Inc | 504,396 | $14.1M | 0.00% | +284,222+129.1% | Added |
| American Century Companies Inc | 486,786 | $13.6M | 0.01% | −4,407−0.9% | Reduced |
| Balyasny Asset Management LLC | 461,553 | $12.9M | 0.03% | +461,553 | New |
| Citadel Advisors LLC | 443,800 | $12.4M | 0.01% | −884,679−66.6% | Reduced |
| Invesco Ltd. | 443,737 | $12.4M | 0.00% | +19,189+4.5% | Added |
| Point72 Asset Management, L.P. | 407,700 | $11.4M | 0.02% | +77,700+23.5% | Added |
| Deerfield Management Company, L.P. (Series C) | 373,407 | $10.5M | 0.16% | 00.0% | Unchanged |
| Paradigm Biocapital Advisors LP | 372,869 | $10.4M | 0.31% | +372,869 | New |
| Nantahala Capital Management, LLC | 368,553 | $10.3M | 0.64% | +200,000+118.7% | Added |
| ArrowMark Colorado Holdings LLC | 323,166 | $9.05M | 0.17% | +24,229+8.1% | Added |
| Bellevue Group AG | 315,857 | $8.84M | 0.18% | −32,670−9.4% | Reduced |
| Price T Rowe Associates Inc | 289,393 | $8.10M | 0.00% | −63,475−18.0% | Reduced |
| Schroder Investment Management Group | 300,947 | $7.61M | 0.01% | +113,142+60.2% | Added |
| BlackRock, Inc. | 263,938 | $7.39M | 0.00% | +20,604+8.5% | Added |
| Two Sigma Advisers, LP | 249,299 | $6.98M | 0.01% | +213,199+590.6% | Added |
| Alyeska Investment Group, L.P. | 244,848 | $6.86M | 0.02% | +244,848 | New |
| Readystate Asset Management LP | 237,188 | $6.64M | 0.32% | +58,576+32.8% | Added |
| HighVista Strategies LLC | 236,236 | $6.61M | 1.62% | +149,615+172.7% | Added |
| Sectoral Asset Management Inc | 221,872 | $6.21M | 3.83% | +170,503+331.9% | Added |
| Susquehanna International Group, LLP | 213,608 | $5.98M | 0.01% | +137,806+181.8% | Added |
| UBS Group AG | 208,092 | $5.83M | 0.00% | +55,111+36.0% | Added |
| Monashee Investment Management LLC | 200,000 | $5.60M | 2.79% | −230,000−53.5% | Reduced |
| Pier Capital, LLC | 197,509 | $5.53M | 0.86% | −969−0.5% | Reduced |
| First Light Asset Management, LLC | 197,350 | $5.53M | 0.52% | +75,124+61.5% | Added |
| Two Sigma Investments, LP | 182,911 | $5.12M | 0.01% | +182,911 | New |
| Rhenman & Partners Asset Management AB | 180,100 | $5.04M | 0.56% | +45,000+33.3% | Added |
| Sphera Funds Management Ltd. | 173,931 | $4.87M | 1.16% | +78,000+81.3% | Added |
| Jefferies Financial Group Inc. | 170,345 | $4.77M | 0.04% | +170,345 | New |
| Handelsbanken Fonder AB | 168,000 | $4.70M | 0.01% | −212,000−55.8% | Reduced |
| Eversept Partners, LP | 166,391 | $4.66M | 0.36% | +67,053+67.5% | Added |
| SC China Holding Ltd | 266,062 | $4.61M | 0.24% | 00.0% | Unchanged |
| Ikarian Capital, LLC | 163,237 | $4.57M | 1.04% | −19,848−10.8% | Reduced |
| Renaissance Technologies LLC | 153,900 | $4.31M | 0.01% | +42,000+37.5% | Added |
| National Bank of Canada | 144,000 | $4.03M | 0.00% | +143,800+71,900.0% | Added |
| StemPoint Capital LP | 129,335 | $3.62M | 0.73% | +129,335 | New |
| Platinum Investment Management Ltd | 122,758 | $3.44M | 0.22% | +47,858+63.9% | Added |
| Point72 Europe (London) LLP | 116,697 | $3.27M | 0.18% | 00.0% | Unchanged |
| PFM Health Sciences, LP | 115,073 | $3.22M | 0.27% | +58,479+103.3% | Added |
| Octagon Capital Advisors LP | 115,000 | $3.22M | 0.50% | +115,000 | New |
| Jump Financial, LLC | 106,400 | $2.98M | 0.04% | +43,166+68.3% | Added |
| Susquehanna Fundamental Investments, LLC | 99,617 | $2.79M | 0.11% | −40,100−28.7% | Reduced |
| BNP Paribas Arbitrage, SA | 90,431 | $2.53M | 0.00% | +24,595+37.4% | Added |
| Birchview Capital, LP | 78,000 | $2.18M | 1.65% | +42,000+116.7% | Added |
| Woodline Partners LP | 65,440 | $1.83M | 0.01% | −111,013−62.9% | Reduced |
| DCF Advisers, LLC | 64,250 | $1.80M | 0.68% | +39,500+159.6% | Added |
| Banque Pictet & Cie SA | 64,185 | $1.80M | 0.02% | −6,216−8.8% | Reduced |
| Bank of Montreal | 60,722 | $1.70M | 0.00% | +2,649+4.6% | Added |
| DAFNA Capital Management LLC | 59,000 | $1.65M | 0.41% | 00.0% | Unchanged |
| Exchange Traded Concepts, LLC | 58,222 | $1.63M | 0.02% | −3,510−5.7% | Reduced |
| JPMorgan Chase & Co | 58,148 | $1.63M | 0.00% | +15,706+37.0% | Added |
| Macquarie Group Ltd | 58,000 | $1.62M | 0.00% | 00.0% | Unchanged |
| Geode Capital Management, LLC | 57,958 | $1.62M | 0.00% | +3,777+7.0% | Added |
| Caption Management, LLC | 56,682 | $1.59M | 0.09% | +28,508+101.2% | Added |
| Susquehanna Portfolio Strategies, LLC | 55,942 | $1.57M | 0.02% | +15,982+40.0% | Added |
| Private Capital Advisors, Inc. | 55,185 | $1.55M | 0.17% | +55,185 | New |
| State Street Corp | 46,017 | $1.29M | 0.00% | +12,558+37.5% | Added |
| Mariner, LLC | 44,136 | $1.24M | 0.00% | +4,635+11.7% | Added |
| Advisor Group Holdings, Inc. | 62,839 | $1.23M | 0.00% | −523−0.8% | Reduced |
| Boothbay Fund Management, LLC | 43,674 | $1.22M | 0.03% | −13,948−24.2% | Reduced |
| Quinn Opportunity Partners LLC | 42,000 | $1.18M | 0.09% | 00.0% | Unchanged |
| SG Americas Securities, LLC | 39,700 | $1.11M | 0.00% | +20,461+106.4% | Added |
| Verition Fund Management LLC | 39,349 | $1.10M | 0.01% | −33,635−46.1% | Reduced |
| D. E. Shaw & Co., Inc. | 36,346 | $1.02M | 0.00% | +24,181+198.8% | Added |
| TD Asset Management Inc | 36,086 | $1.01M | 0.00% | −7,600−17.4% | Reduced |
| TrueMark Investments, LLC | 34,861 | $976.1K | 0.17% | −2,904−7.7% | Reduced |
| Alliancebernstein L.P. | 29,559 | $827.7K | 0.00% | +7,060+31.4% | Added |
| Manufacturers Life Insurance Company, The | 28,532 | $798.9K | 0.00% | −12,257−30.0% | Reduced |
| Alps Advisors Inc | 27,958 | $782.8K | 0.00% | −3,115−10.0% | Reduced |
| Headlands Technologies LLC | 26,814 | $750.8K | 0.06% | +4,476+20.0% | Added |
| Nomura Asset Management Co Ltd | 25,856 | $724.0K | 0.00% | +982+3.9% | Added |
| Simplex Trading, LLC | 25,161 | $704.0K | 0.02% | +2,067+9.0% | Added |
| LPL Financial LLC | 23,003 | $644.1K | 0.00% | +11,404+98.3% | Added |
| Trexquant Investment LP | 20,192 | $565.4K | 0.01% | −61,396−75.3% | Reduced |
| Bleichroeder LP | 20,000 | $560.0K | 0.11% | +10,000+100.0% | Added |
| Voya Investment Management LLC | 16,425 | $459.9K | 0.00% | −14,230−46.4% | Reduced |
| Cubist Systematic Strategies, LLC | 16,312 | $456.7K | 0.01% | −55,378−77.2% | Reduced |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 15,714 | $440.0K | 0.00% | +3,800+31.9% | Added |