Structure Therapeutics Inc.
GPCR- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001888886
No open-market purchases or sales by Structure Therapeutics Inc. insiders were filed in the last 90 days; 191 institutions reported holding it in 13F filings for Q2 2026, worth $3.62B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Structure Therapeutics Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 199
- +44 vs. Q3 2025
- Shares held
- 65.8M
- +8.91M (+15.7%) vs. Q3 2025
- Total value
- $4.58B
- +$2.99B (+188.4%) vs. Q3 2025
- New holders
- 72
- 52 more added
- Sold out
- 28
- 63 more reduced
3 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting GPCR on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 191 | $3.62B |
| Q1 2026 | 198 | $3.23B |
| Q4 2025 | 199 | $4.58B |
| Q3 2025 | 158 | $1.59B |
| Q2 2025 | 173 | $1.14B |
| Q1 2025 | 151 | $990.0M |
| Q4 2024 | 165 | $1.65B |
| Q3 2024 | 161 | $2.69B |
| Q2 2024 | 167 | $2.33B |
| Q1 2024 | 119 | $1.86B |
| Q4 2023 | 122 | $1.74B |
| Q3 2023 | 84 | $1.64B |
| Q2 2023 | 48 | $699.4M |
| Q1 2023 | 38 | $346.2M |
| Q4 2022 | 0 | $0 |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Structure Therapeutics Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 8,712,251 | $605.9M | 0.03% | +3,461,883+65.9% | Added |
| Wellington Management Group LLP | 7,121,984 | $495.3M | 0.09% | +1,432,797+25.2% | Added |
| Avoro Capital Advisors LLC | 6,555,555 | $455.9M | 4.48% | +1,400,000+27.2% | Added |
| Janus Henderson Group PLC | 5,090,148 | $354.0M | 0.16% | +641,322+14.4% | Added |
| Deep Track Capital, LP | 4,111,782 | $286.0M | 6.52% | −104,029−2.5% | Reduced |
| BVF Inc | 3,479,022 | $242.0M | 8.15% | +275,105+8.6% | Added |
| Morgan Stanley | 2,087,834 | $145.2M | 0.01% | +1,510,093+261.4% | Added |
| Price T Rowe Associates Inc | 1,671,138 | $116.2M | 0.01% | +1,381,745+477.5% | Added |
| Driehaus Capital Management LLC | 1,642,444 | $114.2M | 0.78% | +768,940+88.0% | Added |
| Baker Bros. Advisors LP | 1,432,529 | $99.6M | 0.58% | −123,580−7.9% | Reduced |
| Principal Financial Group Inc | 1,284,210 | $89.3M | 0.05% | +496,726+63.1% | Added |
| Casdin Capital, LLC | 1,175,000 | $81.7M | 5.08% | −380,000−24.4% | Reduced |
| OrbiMed Advisors LLC | 1,161,803 | $80.8M | 1.65% | +22,503+2.0% | Added |
| Siren, L.L.C. | 1,078,698 | $75.0M | 2.24% | +51,887+5.1% | Added |
| TCG Crossover Management, LLC | 920,857 | $64.0M | 2.12% | −142,143−13.4% | Reduced |
| Capitolis Liquid Global Markets LLC | 878,300 | $61.1M | 0.36% | +878,300 | New |
| Franklin Resources Inc | 870,582 | $60.5M | 0.01% | +124,848+16.7% | Added |
| Alliancebernstein L.P. | 848,851 | $59.0M | 0.02% | +819,292+2,771.7% | Added |
| Deutsche Bank AG | 841,162 | $58.5M | 0.02% | +841,162 | New |
| Citadel Advisors LLC | 772,518 | $53.7M | 0.04% | +328,718+74.1% | Added |
| Deerfield Management Company, L.P. (Series C) | 767,993 | $53.4M | 0.68% | +394,586+105.7% | Added |
| Rock Springs Capital Management LP | 748,236 | $52.0M | 2.67% | −202,918−21.3% | Reduced |
| Pacific Heights Asset Management LLC | 700,000 | $48.7M | 1.82% | 00.0% | Unchanged |
| Logos Global Management LP | 600,000 | $41.7M | 2.78% | −250,000−29.4% | Reduced |
| American Century Companies Inc | 506,959 | $35.3M | 0.02% | +20,173+4.1% | Added |
| Healthcare of Ontario Pension Plan Trust Fund | 467,800 | $32.5M | 0.06% | +467,800 | New |
| Farallon Capital Management, L.L.C. | 454,000 | $31.6M | 0.16% | +454,000 | New |
| BlackRock, Inc. | 430,082 | $29.9M | 0.00% | +166,144+62.9% | Added |
| SC China Holding Ltd | 266,062 | $24.4M | 1.43% | 00.0% | Unchanged |
| StemPoint Capital LP | 351,073 | $24.4M | 4.19% | +221,738+171.4% | Added |
| EcoR1 Capital, LLC | 334,380 | $23.3M | 1.07% | +334,380 | New |
| Ameriprise Financial Inc | 285,518 | $19.9M | 0.00% | −938,626−76.7% | Reduced |
| ArrowMark Colorado Holdings LLC | 271,213 | $18.9M | 0.42% | −51,953−16.1% | Reduced |
| National Bank of Canada | 265,400 | $18.5M | 0.02% | +121,400+84.3% | Added |
| Standard Life Aberdeen plc | 264,869 | $18.4M | 0.03% | −322,000−54.9% | Reduced |
| Catalio Capital Management, LP | 252,901 | $17.6M | 3.11% | −398,909−61.2% | Reduced |
| Capricorn Fund Managers Ltd | 252,600 | $17.6M | 4.23% | +252,600 | New |
| Voloridge Investment Management, LLC | 250,000 | $17.4M | 0.06% | +250,000 | New |
| Monashee Investment Management LLC | 225,000 | $15.6M | 8.82% | +25,000+12.5% | Added |
| Goldman Sachs Group Inc | 224,332 | $15.6M | 0.00% | −280,064−55.5% | Reduced |
| Balyasny Asset Management LLC | 216,199 | $15.0M | 0.03% | −245,354−53.2% | Reduced |
| UBS Group AG | 202,477 | $14.1M | 0.00% | −5,615−2.7% | Reduced |
| Sio Capital Management, LLC | 201,500 | $14.0M | 2.32% | +201,500 | New |
| HighVista Strategies LLC | 193,001 | $13.4M | 3.46% | −43,235−18.3% | Reduced |
| TD Asset Management Inc | 174,674 | $12.1M | 0.01% | +138,588+384.0% | Added |
| Marshall Wace, LLP | 168,584 | $11.7M | 0.01% | +168,584 | New |
| Millennium Management LLC | 152,560 | $10.6M | 0.01% | −1,121,991−88.0% | Reduced |
| Rhenman & Partners Asset Management AB | 147,600 | $10.3M | 0.96% | −32,500−18.0% | Reduced |
| Jane Street Group, LLC | 147,217 | $10.2M | 0.01% | +147,217 | New |
| Bellevue Group AG | 145,167 | $10.1M | 0.19% | −170,690−54.0% | Reduced |
| Eversept Partners, LP | 127,561 | $8.87M | 0.50% | −38,830−23.3% | Reduced |
| Woodline Partners LP | 123,902 | $8.62M | 0.03% | +58,462+89.3% | Added |
| Renaissance Technologies LLC | 115,200 | $8.01M | 0.01% | −38,700−25.1% | Reduced |
| Alyeska Investment Group, L.P. | 115,000 | $8.00M | 0.02% | −129,848−53.0% | Reduced |
| Jefferies Financial Group Inc. | 102,993 | $7.16M | 0.06% | −67,352−39.5% | Reduced |
| RTW Investments, LP | 100,000 | $6.96M | 0.07% | +100,000 | New |
| Jain Global LLC | 99,996 | $6.95M | 0.07% | +99,996 | New |
| Susquehanna Fundamental Investments, LLC | 99,617 | $6.93M | 0.24% | 00.0% | Unchanged |
| Two Sigma Investments, LP | 95,543 | $6.65M | 0.01% | −87,368−47.8% | Reduced |
| SummitTX Capital, L.P. | 94,671 | $6.58M | 0.20% | +94,671 | New |
| NEXTBio Capital Management LP | 94,443 | $6.57M | 3.85% | +94,443 | New |
| Manufacturers Life Insurance Company, The | 96,387 | $6.53M | 0.01% | +67,855+237.8% | Added |
| Simplex Trading, LLC | 92,668 | $6.45M | 0.18% | +67,507+268.3% | Added |
| Birchview Capital, LP | 90,000 | $6.26M | 3.66% | +12,000+15.4% | Added |
| Soleus Capital Management, L.P. | 90,000 | $6.26M | 0.27% | +90,000 | New |
| B Group, Inc. | 90,000 | $6.26M | 4.64% | +90,000 | New |
| Trexquant Investment LP | 89,945 | $6.26M | 0.06% | +69,753+345.4% | Added |
| Platinum Investment Management Ltd | 87,874 | $6.11M | 1.41% | −34,884−28.4% | Reduced |
| Brevan Howard Capital Management LP | 86,310 | $5.96M | 0.11% | +86,310 | New |
| Peregrine Capital Management LLC | 84,324 | $5.86M | 0.18% | +84,324 | New |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 83,052 | $5.78M | 0.01% | +67,338+428.5% | Added |
| Nomura Asset Management International Inc. | 82,645 | $5.75M | 0.01% | +82,645 | New |
| Verition Fund Management LLC | 78,149 | $5.44M | 0.03% | +38,800+98.6% | Added |
| Boxer Capital Management, LLC | 75,000 | $5.22M | 1.14% | +75,000 | New |
| PFM Health Sciences, LP | 68,248 | $4.75M | 0.48% | −46,825−40.7% | Reduced |
| Susquehanna Portfolio Strategies, LLC | 68,089 | $4.74M | 0.07% | +12,147+21.7% | Added |
| Burkehill Global Management, LP | 60,000 | $4.17M | 0.27% | +60,000 | New |
| Longaeva Partners L.P. | 60,000 | $4.17M | 0.50% | +60,000 | New |
| Banque Pictet & Cie SA | 59,881 | $4.16M | 0.04% | −4,304−6.7% | Reduced |
| Advisor Group Holdings, Inc. | 59,238 | $4.12M | 0.01% | −3,601−5.7% | Reduced |
| Voya Investment Management LLC | 55,300 | $3.85M | 0.00% | +38,875+236.7% | Added |
| Geode Capital Management, LLC | 55,148 | $3.84M | 0.00% | −2,810−4.8% | Reduced |
| Parkman Healthcare Partners LLC | 55,000 | $3.83M | 0.36% | +55,000 | New |
| Bank of Montreal | 54,341 | $3.68M | 0.00% | −6,381−10.5% | Reduced |
| Integral Health Asset Management, LLC | 50,000 | $3.48M | 0.18% | +50,000 | New |
| Seven Grand Managers, LLC | 50,000 | $3.48M | 0.26% | +50,000 | New |
| Buckland Partners Management Co LLC | 50,000 | $3.48M | 1.93% | +50,000 | New |
| Alps Advisors Inc | 49,726 | $3.46M | 0.02% | +21,768+77.9% | Added |
| Pier Capital, LLC | 48,757 | $3.39M | 0.54% | −148,752−75.3% | Reduced |
| Flax Pond Capital, LLC | 48,721 | $3.39M | 2.52% | +48,721 | New |
| State Street Corp | 48,224 | $3.35M | 0.00% | +2,207+4.8% | Added |
| Antipodes Partners Ltd | 46,291 | $3.25M | 0.07% | +42,213+1,035.1% | Added |
| Raymond James Financial Inc | 44,388 | $3.09M | 0.00% | +44,388 | New |
| Mariner, LLC | 44,155 | $3.07M | 0.00% | +190.0% | Added |
| Headlands Technologies LLC | 43,729 | $3.04M | 0.25% | +16,915+63.1% | Added |
| Sphera Funds Management Ltd. | 41,000 | $2.85M | 0.60% | −132,931−76.4% | Reduced |
| ACT Capital Management, LLC | 38,500 | $2.68M | 2.17% | +38,500 | New |
| EAM Investors, LLC | 38,054 | $2.65M | 0.29% | +38,054 | New |
| DAFNA Capital Management LLC | 37,000 | $2.57M | 0.60% | −22,000−37.3% | Reduced |
| Tudor Investment Corp Et Al | 35,053 | $2.44M | 0.01% | +35,053 | New |