Zymeworks Inc.
ZYME- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001937653
No open-market purchases or sales by Zymeworks Inc. insiders were filed in the last 90 days; 202 institutions reported holding it in 13F filings for Q2 2026, worth $1.79B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Zymeworks Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 210
- +28 vs. Q3 2025
- Shares held
- 71.5M
- −2.08M (−2.8%) vs. Q3 2025
- Total value
- $1.88B
- +$625.5M (+49.8%) vs. Q3 2025
- New holders
- 47
- 71 more added
- Sold out
- 19
- 62 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting ZYME on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 202 | $1.79B |
| Q1 2026 | 212 | $1.76B |
| Q4 2025 | 210 | $1.88B |
| Q3 2025 | 184 | $1.26B |
| Q2 2025 | 182 | $949.0M |
| Q1 2025 | 186 | $840.9M |
| Q4 2024 | 174 | $973.2M |
| Q3 2024 | 163 | $834.7M |
| Q2 2024 | 164 | $580.6M |
| Q1 2024 | 171 | $713.0M |
| Q4 2023 | 157 | $674.0M |
| Q3 2023 | 140 | $395.5M |
| Q2 2023 | 137 | $547.9M |
| Q1 2023 | 116 | $512.6M |
| Q4 2022 | 96 | $449.9M |
| Q3 2022 | 91 | $293.7M |
| Q2 2022 | 114 | $253.3M |
| Q1 2022 | 120 | $327.3M |
| Q4 2021 | 114 | $693.9M |
| Q3 2021 | 123 | $1.07B |
| Q2 2021 | 109 | $1.20B |
| Q1 2021 | 125 | $1.12B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Zymeworks Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Brevan Howard Capital Management LP | 23,333 | $614.4K | 0.01% | +8,815+60.7% | Added |
| Aquatic Capital Management LLC | 24,103 | $634.6K | 0.02% | +24,103 | New |
| Ritholtz Wealth Management | 24,338 | $640.8K | 0.01% | −384−1.6% | Reduced |
| Commonwealth Equity Services, LLC | 26,095 | $687.1K | 0.00% | −5,142−16.5% | Reduced |
| STRS Ohio | 26,600 | $700.4K | 0.00% | −14,300−35.0% | Reduced |
| Virginia Retirement Systems Et Al | 27,935 | $735.5K | 0.00% | −28,040−50.1% | Reduced |
| Massachusetts Financial Services Co | 28,083 | $739.4K | 0.00% | −932−3.2% | Reduced |
| Creative Planning | 28,293 | $745.0K | 0.00% | +979+3.6% | Added |
| MetLife Investment Management | 28,630 | $753.8K | 0.00% | −4,679−14.0% | Reduced |
| Price T Rowe Associates Inc | 28,784 | $758.0K | 0.00% | +1,968+7.3% | Added |
| Quantinno Capital Management LP | 28,883 | $760.5K | 0.00% | +28,883 | New |
| Journey Strategic Wealth LLC | 29,050 | $764.9K | 0.02% | 00.0% | Unchanged |
| Tudor Investment Corp Et Al | 30,324 | $798.4K | 0.00% | −7,259−19.3% | Reduced |
| Two Sigma Advisers, LP | 31,415 | $827.2K | 0.00% | +31,415 | New |
| Legal & General Group Plc | 32,149 | $846.5K | 0.00% | +3,780+13.3% | Added |
| SBI Okasan Asset Management Co.Ltd. | 32,000 | $855.7K | 0.05% | +32,000 | New |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 32,815 | $864.0K | 0.00% | +2,383+7.8% | Added |
| Campbell & CO Investment Adviser LLC | 33,588 | $884.4K | 0.04% | +1,095+3.4% | Added |
| Tang Capital Management LLC | 34,631 | $911.8K | 0.05% | −1,065,369−96.9% | Reduced |
| JPMorgan Chase & Co | 35,008 | $921.8K | 0.00% | +1,124+3.3% | Added |
| California State Teachers Retirement System | 37,761 | $994.2K | 0.00% | +2,530+7.2% | Added |
| Envestnet Asset Management Inc | 40,812 | $1.07M | 0.00% | +26,238+180.0% | Added |
| Victory Capital Management Inc | 42,905 | $1.13M | 0.00% | +8,395+24.3% | Added |
| O'Shaughnessy Asset Management, LLC | 43,052 | $1.13M | 0.01% | +1,284+3.1% | Added |
| North Growth Management Ltd. | 45,000 | $1.18M | 0.19% | −37,000−45.1% | Reduced |
| Mackenzie Financial Corp | 45,460 | $1.20M | 0.00% | −10,917−19.4% | Reduced |
| Simplex Trading, LLC | 48,040 | $1.26M | 0.04% | +19,279+67.0% | Added |
| Dana Investment Advisors, Inc. | 48,318 | $1.27M | 0.04% | +48,318 | New |
| Alliancebernstein L.P. | 50,030 | $1.32M | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 55,055 | $1.45M | 0.00% | −2,870−5.0% | Reduced |
| Russell Investments Group, Ltd. | 58,350 | $1.54M | 0.00% | +902+1.6% | Added |
| American Century Companies Inc | 58,832 | $1.55M | 0.00% | +7,816+15.3% | Added |
| Franklin Resources Inc | 58,987 | $1.55M | 0.00% | +25,166+74.4% | Added |
| Penserra Capital Management LLC | 60,146 | $1.58M | 0.02% | +60,146 | New |
| Fisher Asset Management, LLC | 68,197 | $1.80M | 0.00% | −3,777−5.2% | Reduced |
| Jane Street Group, LLC | 70,445 | $1.85M | 0.00% | −74,761−51.5% | Reduced |
| Swiss National Bank | 74,200 | $1.95M | 0.00% | +1,100+1.5% | Added |
| Pictet Asset Management Holding SA | 73,627 | $1.97M | 0.00% | +73,627 | New |
| Credit Agricole S A | 75,000 | $1.97M | 0.01% | +75,000 | New |
| Man Group plc | 75,318 | $1.98M | 0.00% | −83,298−52.5% | Reduced |
| Rhumbline Advisers | 75,498 | $1.99M | 0.00% | −10,404−12.1% | Reduced |
| State of Wisconsin Investment Board | 75,566 | $1.99M | 0.00% | +19,292+34.3% | Added |
| Stifel Financial Corp | 75,847 | $2.00M | 0.00% | +3,317+4.6% | Added |
| Tema ETFs LLC | 75,975 | $2.00M | 0.16% | +12,312+19.3% | Added |
| NEOS Investment Management LLC | 77,115 | $2.03M | 0.01% | +13,452+21.1% | Added |
| Panagora Asset Management Inc | 78,336 | $2.06M | 0.01% | −27,736−26.1% | Reduced |
| Barclays PLC | 79,966 | $2.11M | 0.00% | −119,057−59.8% | Reduced |
| Acuta Capital Partners, LLC | 80,143 | $2.11M | 1.43% | 00.0% | Unchanged |
| Kornitzer Capital Management Inc | 88,800 | $2.34M | 0.05% | +88,800 | New |
| Bank of America Corp | 89,524 | $2.36M | 0.00% | +14,197+18.8% | Added |
| AQR Capital Management LLC | 91,075 | $2.40M | 0.00% | −61,557−40.3% | Reduced |
| XTX Topco Ltd | 93,469 | $2.46M | 0.06% | +93,469 | New |
| Schroder Investment Management Group | 97,907 | $2.60M | 0.00% | −63,579−39.4% | Reduced |
| Susquehanna Portfolio Strategies, LLC | 99,795 | $2.63M | 0.04% | +15,600+18.5% | Added |
| Soleus Capital Management, L.P. | 100,000 | $2.63M | 0.11% | +100,000 | New |
| Trexquant Investment LP | 101,274 | $2.67M | 0.02% | +101,274 | New |
| Platinum Investment Management Ltd | 105,184 | $2.77M | 0.64% | −19,600−15.7% | Reduced |
| Opaleye Management Inc. | 108,929 | $2.87M | 0.38% | +8,929+8.9% | Added |
| Citigroup Inc | 111,207 | $2.93M | 0.00% | −6,597−5.6% | Reduced |
| Ameriprise Financial Inc | 113,141 | $2.98M | 0.00% | +37,213+49.0% | Added |
| HRT Financial LP | 121,064 | $3.19M | 0.01% | +52,603+76.8% | Added |
| Jupiter Asset Management Ltd | 125,506 | $3.30M | 0.03% | −225,154−64.2% | Reduced |
| Bank of New York Mellon Corp | 128,131 | $3.37M | 0.00% | −9,421−6.8% | Reduced |
| Kennedy Capital Management, Inc. | 145,534 | $3.83M | 0.08% | −906−0.6% | Reduced |
| Federated Hermes, Inc. | 152,689 | $4.02M | 0.01% | −30,158−16.5% | Reduced |
| Susquehanna International Group, LLP | 176,088 | $4.64M | 0.01% | +124,034+238.3% | Added |
| Wellington Management Group LLP | 181,705 | $4.78M | 0.00% | +13,020+7.7% | Added |
| Silvercrest Asset Management Group LLC | 181,790 | $4.79M | 0.03% | −91,007−33.4% | Reduced |
| Raymond James Financial Inc | 187,685 | $4.94M | 0.00% | +64,817+52.8% | Added |
| Wells Fargo & Company | 208,313 | $5.48M | 0.00% | +31,679+17.9% | Added |
| Renaissance Technologies LLC | 220,877 | $5.82M | 0.01% | −210,823−48.8% | Reduced |
| Charles Schwab Investment Management Inc | 220,909 | $5.82M | 0.00% | +27,549+14.2% | Added |
| D. E. Shaw & Co., Inc. | 223,786 | $5.89M | 0.00% | +96,863+76.3% | Added |
| SummitTX Capital, L.P. | 224,268 | $5.90M | 0.18% | +224,268 | New |
| Granahan Investment Management Inc | 224,408 | $5.91M | 0.25% | −120,923−35.0% | Reduced |
| Hillsdale Investment Management Inc. | 237,922 | $6.26M | 0.17% | +21,500+9.9% | Added |
| Picton Mahoney Asset Management | 244,798 | $6.45M | 0.07% | +38,476+18.6% | Added |
| Citadel Advisors LLC | 255,351 | $6.72M | 0.00% | +48,493+23.4% | Added |
| Invesco Ltd. | 257,580 | $6.78M | 0.00% | +163,923+175.0% | Added |
| UBS Group AG | 278,854 | $7.34M | 0.00% | +227,013+437.9% | Added |
| Schonfeld Strategic Advisors LLC | 288,571 | $7.60M | 0.04% | +180,783+167.7% | Added |
| Northern Trust Corp | 307,979 | $8.11M | 0.00% | −40,274−11.6% | Reduced |
| UBS Asset Management Americas Inc | 320,261 | $8.43M | 0.00% | −1,390,202−81.3% | Reduced |
| Millennium Management LLC | 381,621 | $10.0M | 0.01% | −723,192−65.5% | Reduced |
| Goldman Sachs Group Inc | 420,207 | $11.1M | 0.00% | −23,318−5.3% | Reduced |
| Algert Global LLC | 423,646 | $11.2M | 0.17% | +215,720+103.7% | Added |
| Qube Research & Technologies Ltd | 474,290 | $12.5M | 0.02% | +219,288+86.0% | Added |
| Redmile Group, LLC | 491,654 | $12.9M | 0.95% | −3,214,096−86.7% | Reduced |
| Prosight Management, LP | 530,393 | $14.0M | 2.89% | −219,218−29.2% | Reduced |
| FMR LLC | 560,086 | $14.7M | 0.00% | +556,572+15,838.7% | Added |
| Assenagon Asset Management S.A. | 647,374 | $17.0M | 0.03% | −679,400−51.2% | Reduced |
| Geode Capital Management, LLC | 647,970 | $17.1M | 0.00% | −30,666−4.5% | Reduced |
| Nuveen, LLC | 648,326 | $17.1M | 0.00% | +82,941+14.7% | Added |
| Adage Capital Partners GP, L.L.C. | 663,546 | $17.5M | 0.03% | +99,546+17.7% | Added |
| Arrowstreet Capital, Limited Partnership | 700,002 | $18.4M | 0.01% | +386,249+123.1% | Added |
| Vestal Point Capital, LP | 865,000 | $22.8M | 0.84% | −900,000−51.0% | Reduced |
| Capricorn Fund Managers Ltd | 1,022,840 | $26.9M | 6.49% | +1,022,840 | New |
| State Street Corp | 1,037,642 | $27.3M | 0.00% | −43,547−4.0% | Reduced |
| Nextech Invest, Ltd. | 1,113,946 | $29.3M | 2.84% | 00.0% | Unchanged |
| Dimensional Fund Advisors LP | 1,159,215 | $30.5M | 0.01% | −31,623−2.7% | Reduced |