Zymeworks Inc.
ZYME- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001937653
No open-market purchases or sales by Zymeworks Inc. insiders were filed in the last 90 days; 202 institutions reported holding it in 13F filings for Q2 2026, worth $1.79B in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Zymeworks Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 184
- +3 vs. Q2 2025
- Shares held
- 73.7M
- −1.71M (−2.3%) vs. Q2 2025
- Total value
- $1.26B
- +$312.6M (+33.0%) vs. Q2 2025
- New holders
- 25
- 61 more added
- Sold out
- 22
- 65 more reduced
1 institution that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting ZYME on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 202 | $1.79B |
| Q1 2026 | 212 | $1.76B |
| Q4 2025 | 210 | $1.88B |
| Q3 2025 | 184 | $1.26B |
| Q2 2025 | 182 | $949.0M |
| Q1 2025 | 186 | $840.9M |
| Q4 2024 | 174 | $973.2M |
| Q3 2024 | 163 | $834.7M |
| Q2 2024 | 164 | $580.6M |
| Q1 2024 | 171 | $713.0M |
| Q4 2023 | 157 | $674.0M |
| Q3 2023 | 140 | $395.5M |
| Q2 2023 | 137 | $547.9M |
| Q1 2023 | 116 | $512.6M |
| Q4 2022 | 96 | $449.9M |
| Q3 2022 | 91 | $293.7M |
| Q2 2022 | 114 | $253.3M |
| Q1 2022 | 120 | $327.3M |
| Q4 2021 | 114 | $693.9M |
| Q3 2021 | 123 | $1.07B |
| Q2 2021 | 109 | $1.20B |
| Q1 2021 | 125 | $1.12B |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Zymeworks Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| STRS Ohio | 40,900 | $698.6K | 0.00% | −5,400−11.7% | Reduced |
| O'Shaughnessy Asset Management, LLC | 41,768 | $713.4K | 0.00% | +544+1.3% | Added |
| Alliancebernstein L.P. | 50,030 | $854.5K | 0.00% | 00.0% | Unchanged |
| American Century Companies Inc | 51,016 | $871.4K | 0.00% | +19,869+63.8% | Added |
| UBS Group AG | 51,841 | $885.4K | 0.00% | −199,669−79.4% | Reduced |
| Susquehanna International Group, LLP | 52,054 | $889.1K | 0.00% | −207,083−79.9% | Reduced |
| Virginia Retirement Systems Et Al | 55,975 | $956.1K | 0.01% | +1,900+3.5% | Added |
| State of Wisconsin Investment Board | 56,274 | $961.2K | 0.00% | +34,239+155.4% | Added |
| Engineers Gate Manager LP | 56,318 | $961.9K | 0.01% | +37,377+197.3% | Added |
| Mackenzie Financial Corp | 56,377 | $962.9K | 0.00% | +35,022+164.0% | Added |
| Russell Investments Group, Ltd. | 57,448 | $981.2K | 0.00% | +29,136+102.9% | Added |
| Royal Bank of Canada | 57,925 | $989.0K | 0.00% | −15,058−20.6% | Reduced |
| NEOS Investment Management LLC | 63,663 | $1.09M | 0.01% | +11,808+22.8% | Added |
| Tema ETFs LLC | 63,663 | $1.09M | 0.09% | +11,808+22.8% | Added |
| HRT Financial LP | 68,461 | $1.17M | 0.00% | +35,703+109.0% | Added |
| Fisher Asset Management, LLC | 71,974 | $1.23M | 0.00% | −50.0% | Reduced |
| Stifel Financial Corp | 72,530 | $1.24M | 0.00% | +2,800+4.0% | Added |
| Ikarian Capital, LLC | 72,787 | $1.24M | 0.28% | +47,787+191.1% | Added |
| Swiss National Bank | 73,100 | $1.25M | 0.00% | 00.0% | Unchanged |
| Bank of America Corp | 75,327 | $1.29M | 0.00% | −15,051−16.7% | Reduced |
| Ameriprise Financial Inc | 75,928 | $1.30M | 0.00% | +75,928 | New |
| Acuta Capital Partners, LLC | 80,143 | $1.37M | 1.41% | −3,512−4.2% | Reduced |
| North Growth Management Ltd. | 82,000 | $1.41M | 0.25% | −15,000−15.5% | Reduced |
| Susquehanna Portfolio Strategies, LLC | 84,195 | $1.44M | 0.02% | −1,533−1.8% | Reduced |
| Tejara Capital Ltd | 85,163 | $1.45M | 0.80% | −114,987−57.5% | Reduced |
| Rhumbline Advisers | 85,902 | $1.47M | 0.00% | −181−0.2% | Reduced |
| Invesco Ltd. | 93,657 | $1.60M | 0.00% | +4,286+4.8% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 96,800 | $1.65M | 0.01% | +96,800 | New |
| Opaleye Management Inc. | 100,000 | $1.71M | 0.24% | −110,000−52.4% | Reduced |
| Panagora Asset Management Inc | 106,072 | $1.81M | 0.01% | +72,513+216.1% | Added |
| Schonfeld Strategic Advisors LLC | 107,788 | $1.84M | 0.01% | +107,788 | New |
| Citigroup Inc | 117,804 | $2.01M | 0.00% | −38,194−24.5% | Reduced |
| Raymond James Financial Inc | 122,868 | $2.10M | 0.00% | −1,567−1.3% | Reduced |
| Platinum Investment Management Ltd | 124,784 | $2.13M | 0.14% | −113,607−47.7% | Reduced |
| D. E. Shaw & Co., Inc. | 126,923 | $2.17M | 0.00% | −128,368−50.3% | Reduced |
| Bank of New York Mellon Corp | 137,552 | $2.35M | 0.00% | +4,462+3.4% | Added |
| Jane Street Group, LLC | 145,206 | $2.48M | 0.00% | +132,657+1,057.1% | Added |
| Kennedy Capital Management, Inc. | 146,440 | $2.50M | 0.06% | −514−0.3% | Reduced |
| AQR Capital Management LLC | 152,632 | $2.61M | 0.00% | −13,511−8.1% | Reduced |
| Marshall Wace, LLP | 154,858 | $2.64M | 0.00% | +154,858 | New |
| AXA Investment Managers S.A. | 158,416 | $2.71M | 0.01% | +158,416 | New |
| Man Group plc | 158,616 | $2.71M | 0.01% | +123,210+348.0% | Added |
| Schroder Investment Management Group | 161,486 | $2.78M | 0.00% | −143,180−47.0% | Reduced |
| Wellington Management Group LLP | 168,685 | $2.88M | 0.00% | −12,005−6.6% | Reduced |
| Wells Fargo & Company | 176,634 | $3.02M | 0.00% | +10,206+6.1% | Added |
| Federated Hermes, Inc. | 182,847 | $3.12M | 0.01% | +577+0.3% | Added |
| Charles Schwab Investment Management Inc | 193,360 | $3.30M | 0.00% | +69,156+55.7% | Added |
| Barclays PLC | 199,023 | $3.40M | 0.00% | +76,203+62.0% | Added |
| Picton Mahoney Asset Management | 206,322 | $3.52M | 0.04% | −1,280−0.6% | Reduced |
| Citadel Advisors LLC | 206,858 | $3.53M | 0.00% | −39,297−16.0% | Reduced |
| Samsara BioCapital, LLC | 207,901 | $3.55M | 0.46% | −102,399−33.0% | Reduced |
| Algert Global LLC | 207,926 | $3.55M | 0.06% | +89,822+76.1% | Added |
| Hillsdale Investment Management Inc. | 216,422 | $3.70M | 0.11% | +11,400+5.6% | Added |
| Squarepoint Ops LLC | 219,948 | $3.76M | 0.01% | +64,349+41.4% | Added |
| Qube Research & Technologies Ltd | 255,002 | $4.36M | 0.01% | +185,128+264.9% | Added |
| Silvercrest Asset Management Group LLC | 272,797 | $4.66M | 0.03% | −7,929−2.8% | Reduced |
| Arrowstreet Capital, Limited Partnership | 313,753 | $5.36M | 0.00% | +313,753 | New |
| Granahan Investment Management Inc | 345,331 | $5.90M | 0.24% | −35,452−9.3% | Reduced |
| Northern Trust Corp | 348,253 | $5.95M | 0.00% | −1,546−0.4% | Reduced |
| Jupiter Asset Management Ltd | 350,660 | $5.99M | 0.05% | −18,839−5.1% | Reduced |
| Renaissance Technologies LLC | 431,700 | $7.37M | 0.01% | −101,600−19.1% | Reduced |
| Goldman Sachs Group Inc | 443,525 | $7.58M | 0.00% | +14,668+3.4% | Added |
| Adage Capital Partners GP, L.L.C. | 564,000 | $9.63M | 0.02% | +88,000+18.5% | Added |
| Nuveen, LLC | 565,385 | $9.66M | 0.00% | −89,531−13.7% | Reduced |
| Geode Capital Management, LLC | 678,636 | $11.6M | 0.00% | −26,728−3.8% | Reduced |
| Prosight Management, LP | 749,611 | $12.8M | 3.07% | −560,293−42.8% | Reduced |
| State Street Corp | 1,081,189 | $18.5M | 0.00% | −7,270−0.7% | Reduced |
| Tang Capital Management LLC | 1,100,000 | $18.8M | 0.72% | 00.0% | Unchanged |
| Millennium Management LLC | 1,104,813 | $18.9M | 0.01% | +988,711+851.6% | Added |
| Nextech Invest, Ltd. | 1,113,946 | $19.0M | 2.90% | 00.0% | Unchanged |
| Dimensional Fund Advisors LP | 1,190,838 | $20.3M | 0.00% | −1,594−0.1% | Reduced |
| Assenagon Asset Management S.A. | 1,326,774 | $22.7M | 0.03% | +833,994+169.2% | Added |
| Deutsche Bank AG | 1,544,898 | $26.4M | 0.01% | +1350.0% | Added |
| Blackstone Group Inc. | 1,616,290 | $27.6M | 0.12% | −40,500−2.4% | Reduced |
| UBS Asset Management Americas Inc | 1,710,463 | $29.2M | 0.01% | −749,050−30.5% | Reduced |
| Vestal Point Capital, LP | 1,765,000 | $30.1M | 1.37% | +615,000+53.5% | Added |
| Perceptive Advisors LLC | 2,090,663 | $35.7M | 1.03% | +815,389+63.9% | Added |
| Vanguard Group Inc | 2,154,434 | $36.8M | 0.00% | −310,259−12.6% | Reduced |
| Redmile Group, LLC | 3,705,750 | $63.3M | 6.16% | −444,877−10.7% | Reduced |
| BVF Inc | 3,938,641 | $67.3M | 2.73% | −370,294−8.6% | Reduced |
| Morgan Stanley | 3,984,585 | $68.1M | 0.00% | −193,029−4.6% | Reduced |
| BlackRock, Inc. | 3,989,533 | $68.1M | 0.00% | +195,261+5.1% | Added |
| Rubric Capital Management LP | 4,710,551 | $80.5M | 1.08% | 00.0% | Unchanged |
| EcoR1 Capital, LLC | 22,970,388 | $392.3M | 18.87% | 00.0% | Unchanged |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0 | $0 | 0.00% | −2,039,656−100.0% | Sold out |
| Trexquant Investment LP | 0 | $0 | 0.00% | −220,982−100.0% | Sold out |
| AXA S.A. | 0 | $0 | 0.00% | −175,121−100.0% | Sold out |
| Cubist Systematic Strategies, LLC | 0 | $0 | 0.00% | −119,962−100.0% | Sold out |
| Weiss Asset Management LP | 0 | $0 | 0.00% | −54,171−100.0% | Sold out |
| ExodusPoint Capital Management, LP | 0 | $0 | 0.00% | −51,669−100.0% | Sold out |
| XTX Topco Ltd | 0 | $0 | 0.00% | −31,021−100.0% | Sold out |
| Landscape Capital Management, L.L.C. | 0 | $0 | 0.00% | −26,667−100.0% | Sold out |
| Graham Capital Management, L.P. | 0 | $0 | 0.00% | −21,660−100.0% | Sold out |
| Voya Investment Management LLC | 0 | $0 | 0.00% | −14,887−100.0% | Sold out |
| Ieq Capital, LLC | 0 | $0 | 0.00% | −14,169−100.0% | Sold out |
| Magnetar Financial LLC | 0 | $0 | 0.00% | −12,168−100.0% | Sold out |
| Cresset Asset Management, LLC | 0 | $0 | 0.00% | −12,153−100.0% | Sold out |
| Quantinno Capital Management LP | 0 | $0 | 0.00% | −11,746−100.0% | Sold out |
| Teacher Retirement System of Texas | 0 | $0 | 0.00% | −10,368−100.0% | Sold out |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | $0 | 0.00% | −6,311−100.0% | Sold out |