Vertex Pharmaceuticals Inc
VRTX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000875320
No open-market purchases or sales by Vertex Pharmaceuticals Inc insiders were filed in the last 90 days; 1,762 institutions reported holding it in 13F filings for Q2 2026, worth $119.7B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Vertex Pharmaceuticals Inc as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 1,671
- +174 vs. Q3 2025
- Shares held
- 241.6M
- +9.62M (+4.1%) vs. Q3 2025
- Total value
- $109.5B
- +$18.8B (+20.7%) vs. Q3 2025
- New holders
- 274
- 620 more added
- Sold out
- 100
- 566 more reduced
26 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting VRTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 1,762 | $119.7B |
| Q1 2026 | 1,698 | $106.1B |
| Q4 2025 | 1,671 | $109.5B |
| Q3 2025 | 1,523 | $90.8B |
| Q2 2025 | 1,563 | $107.2B |
| Q1 2025 | 1,617 | $116.3B |
| Q4 2024 | 1,563 | $95.2B |
| Q3 2024 | 1,551 | $109.1B |
| Q2 2024 | 1,551 | $109.9B |
| Q1 2024 | 1,497 | $98.0B |
| Q4 2023 | 1,442 | $95.7B |
| Q3 2023 | 1,280 | $81.9B |
| Q2 2023 | 1,287 | $83.3B |
| Q1 2023 | 1,212 | $75.0B |
| Q4 2022 | 1,224 | $68.3B |
| Q3 2022 | 1,127 | $68.5B |
| Q2 2022 | 1,109 | $66.1B |
| Q1 2022 | 1,072 | $60.9B |
| Q4 2021 | 1,034 | $50.4B |
| Q3 2021 | 936 | $41.9B |
| Q2 2021 | 979 | $46.8B |
| Q1 2021 | 1,000 | $50.6B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Vertex Pharmaceuticals Inc; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| The PNC Financial Services Group, Inc. | 69,425 | $31.5M | 0.02% | −347−0.5% | Reduced |
| State of Michigan Retirement System | 69,223 | $31.4M | 0.15% | −2,800−3.9% | Reduced |
| Erste Asset Management GmbH | 67,363 | $31.0M | 0.26% | −154−0.2% | Reduced |
| Rafferty Asset Management, LLC | 68,082 | $30.9M | 0.11% | −13,046−16.1% | Reduced |
| Comerica Bank | 67,686 | $30.7M | 0.12% | −339−0.5% | Reduced |
| La Banque Postale Asset Management SA | 67,197 | $30.5M | 0.35% | +22,918+51.8% | Added |
| Czech National Bank | 66,902 | $30.3M | 0.20% | +1,784+2.7% | Added |
| Gateway Investment Advisers LLC | 66,108 | $30.0M | 0.28% | +182+0.3% | Added |
| Xponance, Inc. | 65,773 | $29.8M | 0.22% | +3,282+5.3% | Added |
| GF Fund Management Co. Ltd. | 65,411 | $29.7M | 0.51% | +2,620+4.2% | Added |
| Davidson Investment Advisors | 64,227 | $29.1M | 1.21% | +1,806+2.9% | Added |
| Hardman Johnston Global Advisors LLC | 63,806 | $28.9M | 1.38% | −15,346−19.4% | Reduced |
| Mackenzie Financial Corp | 63,299 | $28.7M | 0.03% | +8,956+16.5% | Added |
| Trillium Asset Management, LLC | 62,693 | $28.6M | 0.87% | −5,692−8.3% | Reduced |
| Sumitomo Mitsui DS Asset Management Company, Ltd | 62,761 | $28.5M | 0.22% | +7,767+14.1% | Added |
| Natixis | 60,218 | $27.3M | 0.11% | +30,412+102.0% | Added |
| Motley Fool Wealth Management, LLC | 59,537 | $27.0M | 2.09% | −11,812−16.6% | Reduced |
| Commonwealth of Pennsylvania Public School Empls Retrmt Sys | 59,016 | $26.8M | 0.14% | −2,553−4.1% | Reduced |
| Ofi Invest Asset Management | 69,124 | $26.7M | 0.38% | +68,832+23,572.6% | Added |
| Foster Dykema Cabot & Partners, LLC | 58,344 | $26.5M | 1.63% | −2,345−3.9% | Reduced |
| Zacks Investment Management | 56,626 | $25.7M | 0.20% | −1,400−2.4% | Reduced |
| Nisa Investment Advisors, LLC | 56,594 | $25.7M | 0.08% | +816+1.5% | Added |
| Atwood & Palmer Inc | 55,392 | $25.1M | 1.43% | +95+0.2% | Added |
| Amalgamated Bank | 55,120 | $25.0M | 0.18% | −1,394−2.5% | Reduced |
| Moody Lynn & Lieberson, LLC | 54,992 | $24.9M | 1.32% | −1,567−2.8% | Reduced |
| Edgemoor Investment Advisors, Inc. | 54,839 | $24.9M | 1.93% | −355−0.6% | Reduced |
| Commonwealth Equity Services, LLC | 54,143 | $24.5M | 0.03% | −4,142−7.1% | Reduced |
| Retirement Systems of Alabama | 53,976 | $24.5M | 0.08% | −717−1.3% | Reduced |
| Reynders McVeigh Capital Management, LLC | 53,905 | $24.4M | 1.15% | −1,445−2.6% | Reduced |
| Harvest Fund Management Co., Ltd | 54,198 | $24.4M | 0.92% | +3,527+7.0% | Added |
| Forsta Ap-Fonden | 53,480 | $24.2M | 0.14% | −1,520−2.8% | Reduced |
| Smith Group Asset Management, LLC | 52,051 | $23.6M | 1.25% | +3,194+6.5% | Added |
| Cullinan Associates Inc | 51,312 | $23.3M | 1.58% | −100−0.2% | Reduced |
| Hemenway Trust Co LLC | 51,017 | $23.1M | 1.77% | −4,108−7.5% | Reduced |
| Hallmark Capital Management Inc | 50,951 | $23.1M | 1.48% | +1,132+2.3% | Added |
| Ci Investments Inc. | 49,891 | $22.6M | 0.10% | +38,900+353.9% | Added |
| Sanctuary Advisors, LLC | 49,804 | $22.6M | 0.12% | +3,551+7.7% | Added |
| IFM Investors Pty Ltd | 49,780 | $22.6M | 0.19% | +296+0.6% | Added |
| PensionDanmark Pensionsforsikringsaktieselskab | 49,381 | $22.4M | 0.20% | +49,381 | New |
| Lido Advisors, LLC | 53,597 | $22.1M | 0.09% | −98−0.2% | Reduced |
| Zurich Insurance Group Ltd | 48,699 | $22.1M | 0.15% | +48,699 | New |
| China Universal Asset Management Co., Ltd. | 48,047 | $21.8M | 1.67% | +2,933+6.5% | Added |
| Nomura Holdings Inc | 47,862 | $21.7M | 0.06% | −20,392−29.9% | Reduced |
| Rakuten Investment Management, Inc. | 47,185 | $21.7M | 0.07% | −195,277−80.5% | Reduced |
| CIBC World Markets Corp | 47,710 | $21.6M | 0.11% | +47,710 | New |
| HighTower Advisors, LLC | 47,559 | $21.6M | 0.02% | +3,544+8.1% | Added |
| O'Shaughnessy Asset Management, LLC | 47,245 | $21.4M | 0.12% | +11,564+32.4% | Added |
| Credit Agricole S A | 46,894 | $21.3M | 0.06% | −15,493−24.8% | Reduced |
| Illinois Municipal Retirement Fund | 46,786 | $21.2M | 0.27% | −6,015−11.4% | Reduced |
| Oddo BHF Asset Management SAS | 46,633 | $21.1M | 0.79% | +13,355+40.1% | Added |
| C WorldWide Group Holding A/S | 46,057 | $20.9M | 0.36% | 00.0% | Unchanged |
| Trexquant Investment LP | 46,053 | $20.9M | 0.19% | +40,637+750.3% | Added |
| Pathstone Holdings, LLC | 45,604 | $20.7M | 0.08% | +7,725+20.4% | Added |
| British Columbia Investment Management Corp | 45,496 | $20.6M | 0.11% | −86,351−65.5% | Reduced |
| USS Investment Management Ltd | 45,393 | $20.6M | 0.10% | +1,294+2.9% | Added |
| Macquarie Group Ltd | 44,736 | $20.3M | 0.09% | −178,820−80.0% | Reduced |
| W.G. Shaheen & Associates DBA Whitney & Co | 44,164 | $20.0M | 1.59% | +608+1.4% | Added |
| Calamos Advisors LLC | 43,969 | $19.9M | 0.08% | −1,784−3.9% | Reduced |
| Advisor Group Holdings, Inc. | 43,752 | $19.8M | 0.03% | −40,498−48.1% | Reduced |
| Gradient Investments LLC | 43,595 | $19.8M | 0.31% | +2,618+6.4% | Added |
| Citizens Financial Group Inc | 43,403 | $19.7M | 0.26% | +522+1.2% | Added |
| Martingale Asset Management L P | 43,221 | $19.6M | 0.50% | +6,699+18.3% | Added |
| Wealthfront Advisers LLC | 43,169 | $19.6M | 0.04% | +5,796+15.5% | Added |
| Utah Retirement Systems | 42,490 | $19.3M | 0.18% | −90.0% | Reduced |
| Varma Mutual Pension Insurance Co | 40,626 | $18.4M | 0.11% | +5,700+16.3% | Added |
| Teachers Retirement System of the State of Kentucky | 40,323 | $18.3M | 0.14% | −2,258−5.3% | Reduced |
| Osmosis Investment Management UK Ltd | 40,294 | $18.3M | 0.46% | +40,294 | New |
| Segall Bryant & Hamill, LLC | 39,819 | $18.1M | 0.24% | −1,152−2.8% | Reduced |
| William Blair Investment Management, LLC | 39,735 | $18.0M | 0.05% | +39,139+6,566.9% | Added |
| Police & Firemen's Retirement System of New Jersey | 39,473 | $17.9M | 0.15% | −1,903−4.6% | Reduced |
| JustInvest LLC | 39,165 | $17.8M | 0.17% | +2,165+5.9% | Added |
| Tweedy, Browne Co LLC | 39,148 | $17.7M | 1.43% | +83+0.2% | Added |
| Ilmarinen Mutual Pension Insurance Co | 38,800 | $17.6M | 0.14% | 00.0% | Unchanged |
| Aristotle Atlantic Partners, LLC | 38,391 | $17.4M | 0.80% | −1,413−3.5% | Reduced |
| MML Investors Services, LLC | 38,004 | $17.2M | 0.04% | +3,773+11.0% | Added |
| iA Global Asset Management Inc. | 37,685 | $17.1M | 0.22% | +1,843+5.1% | Added |
| Shelton Capital Management | 37,241 | $16.9M | 0.33% | +562+1.5% | Added |
| Virginia Retirement Systems Et Al | 37,100 | $16.8M | 0.10% | 00.0% | Unchanged |
| New York Life Investment Management LLC | 36,818 | $16.7M | 0.14% | −614−1.6% | Reduced |
| Flputnam Investment Management Co | 36,791 | $16.7M | 0.24% | +2,115+6.1% | Added |
| Vestcor Inc | 36,690 | $16.6M | 0.47% | +1,424+4.0% | Added |
| Allianz Asset Management GmbH | 36,276 | $16.4M | 0.02% | −73,885−67.1% | Reduced |
| Andra AP-fonden | 35,940 | $16.3M | 0.20% | +40+0.1% | Added |
| McRae Capital Management Inc | 35,558 | $16.1M | 3.29% | +2,399+7.2% | Added |
| Sapient Capital LLC | 34,324 | $15.6M | 0.22% | +130.0% | Added |
| Galvin, Gaustad & Stein, LLC | 34,309 | $15.6M | 1.21% | +1,167+3.5% | Added |
| Rhenman & Partners Asset Management AB | 34,255 | $15.5M | 1.45% | −12,700−27.0% | Reduced |
| Bailard, Inc. | 33,975 | $15.4M | 0.34% | −664−1.9% | Reduced |
| AIA Group Ltd | 33,821 | $15.3M | 0.23% | −22,233−39.7% | Reduced |
| Huntington National Bank | 32,999 | $15.0M | 0.09% | +3,552+12.1% | Added |
| State of Alaska, Department of Revenue | 32,915 | $14.9M | 0.16% | −2,938−8.2% | Reduced |
| Public Sector Pension Investment Board | 32,851 | $14.9M | 0.05% | +10,433+46.5% | Added |
| Foster Victor Wealth Advisors, LLC | 32,929 | $14.5M | 0.85% | −928−2.7% | Reduced |
| Elo Mutual Pension Insurance Co | 31,613 | $14.3M | 0.22% | −2,170−6.4% | Reduced |
| Jefferies Financial Group Inc. | 31,372 | $14.2M | 0.12% | +15,372+96.1% | Added |
| Fideuram - Intesa Sanpaolo Private Banking S.P.A. | 31,281 | $14.2M | 0.51% | +31,281 | New |
| Barlow Wealth Partners, Inc. | 30,087 | $14.0M | 1.51% | +207+0.7% | Added |
| Louisiana State Employees Retirement System | 30,000 | $13.6M | 0.23% | −2,200−6.8% | Reduced |
| US Bancorp | 29,850 | $13.5M | 0.02% | −1,006−3.3% | Reduced |
| Washington Trust Bank | 29,839 | $13.5M | 0.95% | +30+0.1% | Added |