Vertex Pharmaceuticals Inc
VRTX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000875320
In the last 90 days, Vertex Pharmaceuticals Inc insiders filed 0 open-market purchases and 3 sales; 1,763 institutions reported holding it in 13F filings for Q2 2026, worth $119.7B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Vertex Pharmaceuticals Inc as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 1,671
- +174 vs. Q3 2025
- Shares held
- 241.6M
- +9.62M (+4.1%) vs. Q3 2025
- Total value
- $109.5B
- +$18.8B (+20.7%) vs. Q3 2025
- New holders
- 274
- 620 more added
- Sold out
- 100
- 566 more reduced
26 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting VRTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 1,763 | $119.7B |
| Q1 2026 | 1,698 | $106.1B |
| Q4 2025 | 1,671 | $109.5B |
| Q3 2025 | 1,523 | $90.8B |
| Q2 2025 | 1,564 | $107.2B |
| Q1 2025 | 1,618 | $116.3B |
| Q4 2024 | 1,563 | $95.2B |
| Q3 2024 | 1,551 | $109.1B |
| Q2 2024 | 1,551 | $109.9B |
| Q1 2024 | 1,497 | $98.0B |
| Q4 2023 | 1,442 | $95.7B |
| Q3 2023 | 1,280 | $81.9B |
| Q2 2023 | 1,288 | $83.3B |
| Q1 2023 | 1,213 | $75.0B |
| Q4 2022 | 1,225 | $68.3B |
| Q3 2022 | 1,128 | $68.5B |
| Q2 2022 | 1,110 | $66.1B |
| Q1 2022 | 1,073 | $60.9B |
| Q4 2021 | 1,034 | $50.4B |
| Q3 2021 | 936 | $41.9B |
| Q2 2021 | 979 | $46.8B |
| Q1 2021 | 1,000 | $50.6B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Vertex Pharmaceuticals Inc; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Capital World Investors | 25,510,182 | $11.6B | 1.57% | −400,405−1.5% | Reduced |
| Vanguard Group Inc | 24,105,823 | $10.9B | 0.16% | −111,042−0.5% | Reduced |
| BlackRock, Inc. | 23,751,989 | $10.8B | 0.18% | +1,498,942+6.7% | Added |
| Capital Research Global Investors | 17,316,344 | $7.85B | 1.45% | +763,063+4.6% | Added |
| State Street Corp | 11,689,539 | $5.30B | 0.18% | +83,539+0.7% | Added |
| Invesco Ltd. | 7,852,733 | $3.56B | 0.34% | +5,755,936+274.5% | Added |
| JPMorgan Chase & Co | 6,039,481 | $2.74B | 0.18% | −395,297−6.1% | Reduced |
| Geode Capital Management, LLC | 5,981,905 | $2.70B | 0.17% | +8,160+0.1% | Added |
| Capital International Investors | 4,733,596 | $2.15B | 0.34% | +44,537+0.9% | Added |
| Alliancebernstein L.P. | 4,496,482 | $2.04B | 0.64% | −26,104−0.6% | Reduced |
| Loomis Sayles & Co L P | 4,033,525 | $1.83B | 2.20% | −88,603−2.1% | Reduced |
| Wellington Management Group LLP | 3,821,731 | $1.73B | 0.30% | −950,311−19.9% | Reduced |
| Victory Capital Management Inc | 3,356,766 | $1.52B | 0.86% | +1,109,200+49.4% | Added |
| Jennison Associates LLC | 3,249,541 | $1.47B | 0.88% | −205,406−5.9% | Reduced |
| Norges Bank | 3,176,613 | $1.44B | 0.15% | +3,176,613 | New |
| Morgan Stanley | 3,120,310 | $1.41B | 0.08% | +11,905+0.4% | Added |
| UBS Asset Management Americas Inc | 3,000,778 | $1.36B | 0.29% | +113,661+3.9% | Added |
| Bank of America Corp | 2,937,030 | $1.33B | 0.10% | +96,606+3.4% | Added |
| Clearbridge Investments, LLC | 2,860,176 | $1.30B | 1.04% | +214,412+8.1% | Added |
| Northern Trust Corp | 2,579,457 | $1.17B | 0.15% | −48,430−1.8% | Reduced |
| Price T Rowe Associates Inc | 2,278,958 | $1.03B | 0.11% | −764,847−25.1% | Reduced |
| Ameriprise Financial Inc | 2,263,732 | $1.03B | 0.23% | −13,195−0.6% | Reduced |
| Janus Henderson Group PLC | 2,221,953 | $1.01B | 0.45% | +102,846+4.9% | Added |
| FMR LLC | 2,212,596 | $1.00B | 0.05% | −1,091,172−33.0% | Reduced |
| Legal & General Group Plc | 1,970,105 | $893.2M | 0.20% | +17,808+0.9% | Added |
| Charles Schwab Investment Management Inc | 1,859,221 | $842.9M | 0.13% | +29,290+1.6% | Added |
| Deutsche Bank AG | 1,768,881 | $801.9M | 0.26% | +168,425+10.5% | Added |
| Goldman Sachs Group Inc | 1,754,118 | $795.2M | 0.11% | +269,460+18.1% | Added |
| Bank of New York Mellon Corp | 1,527,586 | $692.5M | 0.12% | −41,579−2.6% | Reduced |
| Amundi | 1,304,161 | $591.3M | 0.16% | +185,190+16.6% | Added |
| Royal Bank of Canada | 1,194,512 | $541.5M | 0.10% | +803+0.1% | Added |
| WCM Investment Management, LLC | 1,129,145 | $512.3M | 1.05% | −20,987−1.8% | Reduced |
| Edgewood Management LLC | 1,060,075 | $480.6M | 2.29% | −427,467−28.7% | Reduced |
| Nuveen, LLC | 1,042,397 | $472.6M | 0.12% | −35,313−3.3% | Reduced |
| Dimensional Fund Advisors LP | 945,660 | $428.7M | 0.09% | +162,074+20.7% | Added |
| Winslow Capital Management, LLC | 887,640 | $405.1M | 1.36% | +887,640 | New |
| American Century Companies Inc | 848,639 | $384.7M | 0.19% | +399,446+88.9% | Added |
| Barclays PLC | 847,758 | $384.3M | 0.15% | +105,271+14.2% | Added |
| Assenagon Asset Management S.A. | 832,853 | $377.6M | 0.57% | +69,150+9.1% | Added |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 803,773 | $364.4M | 0.32% | −537,697−40.1% | Reduced |
| Pictet Asset Management Holding SA | 752,425 | $342.2M | 0.33% | −39,033−4.9% | Reduced |
| Wells Fargo & Company | 741,813 | $336.3M | 0.07% | +24,487+3.4% | Added |
| Swiss National Bank | 702,600 | $318.5M | 0.19% | −37,700−5.1% | Reduced |
| Bellevue Group AG | 681,120 | $308.8M | 5.85% | +175,315+34.7% | Added |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 669,807 | $303.7M | 0.35% | +213,474+46.8% | Added |
| Sumitomo Mitsui Trust Holdings, Inc. | 654,470 | $296.7M | 0.17% | −46,203−6.6% | Reduced |
| HSBC Holdings PLC | 630,289 | $285.9M | 0.16% | −7,043−1.1% | Reduced |
| Arrowstreet Capital, Limited Partnership | 593,947 | $269.3M | 0.16% | +212,752+55.8% | Added |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 566,227 | $256.0M | 0.17% | +21,249+3.9% | Added |
| Voya Investment Management LLC | 562,352 | $254.4M | 0.25% | +130,095+30.1% | Added |
| BNP Paribas Arbitrage, SA | 559,543 | $253.7M | 0.16% | +305,200+120.0% | Added |
| Manufacturers Life Insurance Company, The | 557,713 | $252.9M | 0.21% | +47,548+9.3% | Added |
| California Public Employees Retirement System | 556,064 | $252.1M | 0.14% | −56,443−9.2% | Reduced |
| UBS Group AG | 555,982 | $252.1M | 0.05% | −217,066−28.1% | Reduced |
| Franklin Resources Inc | 550,600 | $249.6M | 0.06% | +87,646+18.9% | Added |
| Neuberger Berman Group LLC | 545,897 | $247.5M | 0.18% | +18,406+3.5% | Added |
| Citigroup Inc | 539,930 | $244.8M | 0.17% | −650.0% | Reduced |
| National Pension Service | 530,841 | $240.7M | 0.18% | +18,728+3.7% | Added |
| Natixis Advisors, L.P. | 527,864 | $239.3M | 0.34% | −9,330−1.7% | Reduced |
| B. Metzler seel. Sohn & Co. AG | 515,269 | $233.6M | 2.04% | +199,847+63.4% | Added |
| Renaissance Technologies LLC | 505,048 | $229.0M | 0.36% | −230,840−31.4% | Reduced |
| DekaBank Deutsche Girozentrale | 506,457 | $219.8M | 0.41% | 00.0% | Unchanged |
| Envestnet Asset Management Inc | 471,643 | $213.8M | 0.06% | +888+0.2% | Added |
| ProShare Advisors LLC | 457,046 | $207.2M | 0.37% | +123,314+37.0% | Added |
| Nordea Investment Management AB | 447,169 | $202.6M | 0.17% | +86,084+23.8% | Added |
| Rhumbline Advisers | 431,262 | $195.5M | 0.16% | −16,666−3.7% | Reduced |
| Manning & Napier Advisors LLC | 427,603 | $194.0M | 2.52% | −47,219−9.9% | Reduced |
| Bank of Montreal | 427,480 | $193.8M | 0.08% | +8,022+1.9% | Added |
| Citadel Advisors LLC | 427,060 | $193.6M | 0.13% | +253,558+146.1% | Added |
| Raymond James Financial Inc | 418,131 | $189.6M | 0.06% | −117,554−21.9% | Reduced |
| Principal Financial Group Inc | 415,100 | $188.2M | 0.10% | +8,600+2.1% | Added |
| Chevy Chase Trust Holdings, Inc. | 408,363 | $185.1M | 0.50% | −10,146−2.4% | Reduced |
| Robeco Institutional Asset Management B.V. | 394,200 | $178.7M | 0.25% | +14,829+3.9% | Added |
| Harding Loevner LP | 391,865 | $177.7M | 1.56% | −64,123−14.1% | Reduced |
| Squarepoint Ops LLC | 389,020 | $176.4M | 0.36% | −218,816−36.0% | Reduced |
| California State Teachers Retirement System | 385,751 | $174.9M | 0.17% | −8,831−2.2% | Reduced |
| Russell Investments Group, Ltd. | 381,462 | $173.0M | 0.19% | +40,414+11.8% | Added |
| Man Group plc | 380,735 | $172.6M | 0.33% | +17,961+5.0% | Added |
| Life Cycle Investment Partners Ltd | 366,854 | $166.3M | 1.16% | +366,854 | New |
| Bank Julius Baer & Co. Ltd, Zurich | 366,341 | $166.1M | 0.46% | −10,154−2.7% | Reduced |
| Millennium Management LLC | 365,664 | $165.8M | 0.12% | +324,622+791.0% | Added |
| SEI Investments Co | 364,023 | $165.0M | 0.16% | +187,496+106.2% | Added |
| Alyeska Investment Group, L.P. | 354,334 | $160.6M | 0.45% | +87,165+32.6% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 353,488 | $160.3M | 0.35% | −34,823−9.0% | Reduced |
| Connor, Clark & Lunn Investment Management Ltd. | 345,383 | $156.6M | 0.41% | +124,582+56.4% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 334,898 | $151.8M | 0.25% | +15,431+4.8% | Added |
| Public Employees Retirement Association of Colorado | 329,745 | $149.5M | 0.55% | −6,346−1.9% | Reduced |
| Ensign Peak Advisors, Inc | 303,784 | $137.7M | 0.24% | −8,214−2.6% | Reduced |
| New York State Common Retirement Fund | 297,414 | $134.8M | 0.18% | −11,163−3.6% | Reduced |
| LPL Financial LLC | 276,878 | $125.5M | 0.03% | +12,696+4.8% | Added |
| Royal London Asset Management Ltd | 273,433 | $124.0M | 0.26% | −3,763−1.4% | Reduced |
| Adage Capital Partners GP, L.L.C. | 272,474 | $123.5M | 0.19% | −210,021−43.5% | Reduced |
| Los Angeles Capital Management LLC | 293,301 | $123.2M | 0.42% | +257,829+726.9% | Added |
| Standard Life Aberdeen plc | 262,057 | $118.8M | 0.18% | −52,832−16.8% | Reduced |
| Cerity Partners LLC | 261,553 | $118.6M | 0.17% | +2,745+1.1% | Added |
| Swedbank AB | 260,743 | $118.2M | 0.11% | +6,647+2.6% | Added |
| National Bank of Canada | 238,548 | $108.1M | 0.11% | −9,393−3.8% | Reduced |
| State Board of Administration of Florida Retirement System | 226,000 | $102.5M | 0.18% | −7,612−3.3% | Reduced |
| Candriam Luxembourg S.C.A. | 225,292 | $102.1M | 0.51% | +50,725+29.1% | Added |
| Welch & Forbes LLC | 218,198 | $98.9M | 1.20% | −2,148−1.0% | Reduced |