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Vertex Pharmaceuticals Inc

VRTX
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0000875320

In the last 90 days, Vertex Pharmaceuticals Inc insiders filed 0 open-market purchases and 4 sales; 1,763 institutions reported holding it in 13F filings for Q2 2026, worth $119.7B in total; no superinvestor holds it.

13F holders, Q4 2024

Institutional positions in Vertex Pharmaceuticals Inc as of Dec 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
1,563
+45 vs. Q3 2024
Shares held
236.5M
+1.92M (+0.8%) vs. Q3 2024
Total value
$95.2B
−$13.7B (−12.6%) vs. Q3 2024
New holders
200
553 more added
Sold out
155
619 more reduced

33 institutions that held it in Q3 2024 haven't filed for Q4 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q3 2024: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting VRTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2024: 1,563 institutions
Q1 2021: 1,000 institutionsQ2 2021: 979 institutionsQ3 2021: 936 institutionsQ4 2021: 1,034 institutionsQ1 2022: 1,073 institutionsQ2 2022: 1,110 institutionsQ3 2022: 1,128 institutionsQ4 2022: 1,225 institutionsQ1 2023: 1,213 institutionsQ2 2023: 1,288 institutionsQ3 2023: 1,280 institutionsQ4 2023: 1,442 institutionsQ1 2024: 1,497 institutionsQ2 2024: 1,551 institutionsQ3 2024: 1,551 institutionsQ4 2024: 1,563 institutionsQ1 2025: 1,618 institutionsQ2 2025: 1,564 institutionsQ3 2025: 1,523 institutionsQ4 2025: 1,671 institutionsQ1 2026: 1,698 institutionsQ2 2026: 1,763 institutions
Value heldQ4 2024: $95.2B
Q1 2021: $50.6BQ2 2021: $46.8BQ3 2021: $41.9BQ4 2021: $50.4BQ1 2022: $60.9BQ2 2022: $66.1BQ3 2022: $68.5BQ4 2022: $68.3BQ1 2023: $75.0BQ2 2023: $83.3BQ3 2023: $81.9BQ4 2023: $95.7BQ1 2024: $98.0BQ2 2024: $109.9BQ3 2024: $109.1BQ4 2024: $95.2BQ1 2025: $116.3BQ2 2025: $107.2BQ3 2025: $90.8BQ4 2025: $109.5BQ1 2026: $106.1BQ2 2026: $119.7B
Institutions holding VRTX and their total value by quarter
QuarterHoldersValue
Q2 20261,763$119.7B
Q1 20261,698$106.1B
Q4 20251,671$109.5B
Q3 20251,523$90.8B
Q2 20251,564$107.2B
Q1 20251,618$116.3B
Q4 20241,563$95.2B
Q3 20241,551$109.1B
Q2 20241,551$109.9B
Q1 20241,497$98.0B
Q4 20231,442$95.7B
Q3 20231,280$81.9B
Q2 20231,288$83.3B
Q1 20231,213$75.0B
Q4 20221,225$68.3B
Q3 20221,128$68.5B
Q2 20221,110$66.1B
Q1 20221,073$60.9B
Q4 20211,034$50.4B
Q3 2021936$41.9B
Q2 2021979$46.8B
Q1 20211,000$50.6B

Institutions, Q4 2024

Shares, value and share of portfolio for each institution holding Vertex Pharmaceuticals Inc; share changes are against Q3 2024.

Institutions holding VRTX in Q4 2024
InstitutionSharesValue% of portfolioChange in sharesAction
Capital World Investors28,325,695$11.4B1.73%+1,514,993+5.7%Added
Vanguard Group Inc23,258,288$9.37B0.16%+98,654+0.4%Added
BlackRock, Inc.21,825,470$8.79B0.18%+37,924+0.2%Added
State Street Corp11,979,405$4.82B0.19%+163,156+1.4%Added
Capital Research Global Investors10,428,951$4.20B0.86%+1,426,746+15.8%Added
FMR LLC9,219,046$3.71B0.22%−1,305,967−12.4%Reduced
JPMorgan Chase & Co6,313,107$2.54B0.20%−615,480−8.9%Reduced
Wellington Management Group LLP5,916,084$2.38B0.44%+1,117,214+23.3%Added
Geode Capital Management, LLC5,648,236$2.27B0.18%−287,652−4.8%Reduced
Jennison Associates LLC4,317,762$1.74B1.06%−1,232,624−22.2%Reduced
Alliancebernstein L.P.3,920,020$1.58B0.54%−3,452,747−46.8%Reduced
Loomis Sayles & Co L P3,772,789$1.52B1.92%+704,575+23.0%Added
Norges Bank3,414,324$1.37B0.18%+4,542+0.1%Added
Amundi3,281,205$1.35B0.47%−478,031−12.7%Reduced
Morgan Stanley3,171,387$1.28B0.09%+132,950+4.4%Added
Edgewood Management LLC2,956,608$1.19B3.42%+1,410,238+91.2%Added
Janus Henderson Group PLC2,833,889$1.14B0.58%+317,058+12.6%Added
Northern Trust Corp2,721,049$1.10B0.16%+355,057+15.0%Added
Bank of America Corp2,419,353$974.3M0.09%−189,604−7.3%Reduced
UBS Asset Management Americas Inc2,329,219$938.0M0.22%−112,249−4.6%Reduced
Massachusetts Financial Services Co2,288,498$921.6M0.29%−617,207−21.2%Reduced
Ameriprise Financial Inc2,015,523$811.6M0.21%+143,713+7.7%Added
Invesco Ltd.1,898,457$764.5M0.14%−45,147−2.3%Reduced
Legal & General Group Plc1,884,153$758.7M0.20%−21,159−1.1%Reduced
Clearbridge Investments, LLC1,850,858$745.3M0.60%−121,197−6.1%Reduced
Parnassus Investments1,815,950$731.3M1.62%+1,815,950New
Bank of New York Mellon Corp1,759,216$708.4M0.13%−27,512−1.5%Reduced
Price T Rowe Associates Inc1,690,700$680.8M0.08%−77,310−4.4%Reduced
Charles Schwab Investment Management Inc1,663,849$670.0M0.12%+37,502+2.3%Added
Royal Bank of Canada1,450,959$584.3M0.13%−116,677−7.4%Reduced
Goldman Sachs Group Inc1,401,734$564.5M0.11%+43,200+3.2%Added
Renaissance Technologies LLC1,397,209$562.7M0.83%−234,284−14.4%Reduced
Deutsche Bank AG1,389,605$559.6M0.22%+76,695+5.8%Added
WCM Investment Management, LLC1,091,522$435.9M1.03%+1,091,522New
Nuveen Asset Management, LLC1,051,111$423.3M0.12%+261,891+33.2%Added
DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main970,662$390.9M0.42%−66,586−6.4%Reduced
California Public Employees Retirement System880,214$354.5M0.24%−87,637−9.1%Reduced
HSBC Holdings PLC873,755$351.7M0.22%+18,739+2.2%Added
UBS Group AG863,036$347.5M0.08%+88,821+11.5%Added
Barclays PLC843,075$339.5M0.17%−96,261−10.2%Reduced
Assenagon Asset Management S.A.839,672$338.1M0.61%+528,029+169.4%Added
Harding Loevner LP823,627$331.7M2.24%−328,998−28.5%Reduced
Franklin Resources Inc760,517$306.3M0.09%+283,684+59.5%Added
Swiss National Bank729,200$293.6M0.20%−36,800−4.8%Reduced
Voya Investment Management LLC698,706$281.3M0.29%−239,345−25.5%Reduced
Wells Fargo & Company689,652$277.7M0.07%−140,568−16.9%Reduced
Artisan Partners Limited Partnership664,523$267.6M0.41%+114,250+20.8%Added
Sumitomo Mitsui Trust Holdings, Inc.659,533$265.6M0.18%−12,565−1.9%Reduced
Dimensional Fund Advisors LP627,517$252.7M0.06%−20,291−3.1%Reduced
BNP Paribas Arbitrage, SA596,555$240.2M0.19%+153,786+34.7%Added
Bank of Montreal581,181$234.0M0.12%+23,964+4.3%Added
Natixis Advisors, L.P.557,644$224.6M0.42%+95,758+20.7%Added
Manufacturers Life Insurance Company, The545,366$219.6M0.19%−76,859−12.4%Reduced
National Pension Service527,474$212.4M0.20%+16,427+3.2%Added
Lazard Asset Management LLC526,119$211.9M0.31%+518,132+6,487.2%Added
Pictet Asset Management Holding SA519,668$209.3M0.23%+1,665+0.3%Added
DekaBank Deutsche Girozentrale506,457$205.0M0.38%00.0%Unchanged
Bellevue Group AG487,434$196.3M3.78%−83,972−14.7%Reduced
American Century Companies Inc473,360$190.6M0.11%−11,453−2.4%Reduced
Raymond James Financial Inc471,906$190.0M0.07%+471,906New
TD Asset Management Inc469,068$188.9M0.17%−53,137−10.2%Reduced
Citigroup Inc462,068$186.1M0.18%−126,352−21.5%Reduced
Swedbank AB456,587$183.9M0.23%−121,926−21.1%Reduced
Chevy Chase Trust Holdings, Inc.444,701$179.1M0.55%−2,160−0.5%Reduced
Mitsubishi UFJ Kokusai Asset Management Co., Ltd.438,091$178.4M0.17%+32,739+8.1%Added
Rhumbline Advisers442,361$178.1M0.16%−7,335−1.6%Reduced
Neuberger Berman Group LLC434,311$174.9M0.14%+5,173+1.2%Added
Envestnet Asset Management Inc422,698$170.2M0.05%+19,630+4.9%Added
Public Employees Retirement Association of Colorado418,563$168.6M0.67%−9,910−2.3%Reduced
California State Teachers Retirement System400,670$161.3M0.19%−11,807−2.9%Reduced
Principal Financial Group Inc396,532$159.7M0.09%−13,827−3.4%Reduced
Bank Julius Baer & Co. Ltd, Zurich368,967$159.0M0.49%+33,322+9.9%Added
BNP PARIBAS ASSET MANAGEMENT Holding S.A.389,657$156.9M0.39%−6,362−1.6%Reduced
Canada Pension Plan Investment Board369,354$148.7M0.14%+85,350+30.1%Added
Royal London Asset Management Ltd363,278$146.3M0.36%+1480.0%Added
New York State Common Retirement Fund362,334$145.9M0.20%+2,855+0.8%Added
Zurcher Kantonalbank (Zurich Cantonalbank)349,477$140.7M0.40%+29,333+9.2%Added
APG Asset Management N.V.359,285$139.7M0.39%+235,265+189.7%Added
Standard Life Aberdeen plc347,570$139.4M0.26%−23,519−6.3%Reduced
ProShare Advisors LLC344,526$138.7M0.32%+53,116+18.2%Added
Capital International Investors342,512$137.9M0.03%+342,512New
Nordea Investment Management AB342,429$137.8M0.14%+55,739+19.4%Added
Universal- Beteiligungs- und Servicegesellschaft mbH339,508$136.7M0.27%+339,508New
Millennium Management LLC310,643$125.1M0.11%+151,349+95.0%Added
Victory Capital Management Inc305,146$122.9M0.12%−5,268−1.7%Reduced
Handelsbanken Fonder AB296,036$119.2M0.46%−115,479−28.1%Reduced
Robeco Institutional Asset Management B.V.286,756$115.5M0.22%−9,812−3.3%Reduced
SEI Investments Co275,135$110.8M0.14%+61,234+28.6%Added
Ensign Peak Advisors, Inc275,082$110.8M0.20%+97,611+55.0%Added
Great West Life Assurance Co269,878$108.6M0.19%−48,403−15.2%Reduced
D. E. Shaw & Co., Inc.265,684$107.0M0.12%+127,276+92.0%Added
Candriam Luxembourg S.C.A.258,622$104.1M0.60%−52,685−16.9%Reduced
Allianz Asset Management GmbH255,623$102.9M0.15%−3,262−1.3%Reduced
State Board of Administration of Florida Retirement System248,049$99.9M0.19%−13,526−5.2%Reduced
AQR Capital Management LLC245,785$99.0M0.13%−235,076−48.9%Reduced
Cerity Partners LLC238,029$97.5M0.21%+8,987+3.9%Added
Russell Investments Group, Ltd.239,342$96.3M0.13%+9,377+4.1%Added
Armistice Capital, LLC224,016$90.2M2.10%+177,887+385.6%Added
New York State Teachers Retirement System221,252$89.1M0.19%−10,729−4.6%Reduced
Macquarie Group Ltd229,933$88.7M0.11%−96,583−29.6%Reduced