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Vertex Pharmaceuticals Inc

VRTX
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0000875320

In the last 90 days, Vertex Pharmaceuticals Inc insiders filed 0 open-market purchases and 3 sales; 1,763 institutions reported holding it in 13F filings for Q2 2026, worth $119.7B in total; no superinvestor holds it.

13F holders, Q3 2025

Institutional positions in Vertex Pharmaceuticals Inc as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
1,523
−13 vs. Q2 2025
Shares held
232.3M
−4.81M (−2.0%) vs. Q2 2025
Total value
$90.8B
−$14.7B (−14.0%) vs. Q2 2025
New holders
143
553 more added
Sold out
156
617 more reduced

28 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q2 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting VRTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ3 2025: 1,523 institutions
Q1 2021: 1,000 institutionsQ2 2021: 979 institutionsQ3 2021: 936 institutionsQ4 2021: 1,034 institutionsQ1 2022: 1,073 institutionsQ2 2022: 1,110 institutionsQ3 2022: 1,128 institutionsQ4 2022: 1,225 institutionsQ1 2023: 1,213 institutionsQ2 2023: 1,288 institutionsQ3 2023: 1,280 institutionsQ4 2023: 1,442 institutionsQ1 2024: 1,497 institutionsQ2 2024: 1,551 institutionsQ3 2024: 1,551 institutionsQ4 2024: 1,563 institutionsQ1 2025: 1,618 institutionsQ2 2025: 1,564 institutionsQ3 2025: 1,523 institutionsQ4 2025: 1,671 institutionsQ1 2026: 1,698 institutionsQ2 2026: 1,763 institutions
Value heldQ3 2025: $90.8B
Q1 2021: $50.6BQ2 2021: $46.8BQ3 2021: $41.9BQ4 2021: $50.4BQ1 2022: $60.9BQ2 2022: $66.1BQ3 2022: $68.5BQ4 2022: $68.3BQ1 2023: $75.0BQ2 2023: $83.3BQ3 2023: $81.9BQ4 2023: $95.7BQ1 2024: $98.0BQ2 2024: $109.9BQ3 2024: $109.1BQ4 2024: $95.2BQ1 2025: $116.3BQ2 2025: $107.2BQ3 2025: $90.8BQ4 2025: $109.5BQ1 2026: $106.1BQ2 2026: $119.7B
Institutions holding VRTX and their total value by quarter
QuarterHoldersValue
Q2 20261,763$119.7B
Q1 20261,698$106.1B
Q4 20251,671$109.5B
Q3 20251,523$90.8B
Q2 20251,564$107.2B
Q1 20251,618$116.3B
Q4 20241,563$95.2B
Q3 20241,551$109.1B
Q2 20241,551$109.9B
Q1 20241,497$98.0B
Q4 20231,442$95.7B
Q3 20231,280$81.9B
Q2 20231,288$83.3B
Q1 20231,213$75.0B
Q4 20221,225$68.3B
Q3 20221,128$68.5B
Q2 20221,110$66.1B
Q1 20221,073$60.9B
Q4 20211,034$50.4B
Q3 2021936$41.9B
Q2 2021979$46.8B
Q1 20211,000$50.6B

Institutions, Q3 2025

Shares, value and share of portfolio for each institution holding Vertex Pharmaceuticals Inc; share changes are against Q2 2025.

Institutions holding VRTX in Q3 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Creative Capital Management Investments LLC24$9.40K0.00%00.0%Unchanged
Tanglewood Legacy Advisors, LLC25$9.79K0.00%00.0%Unchanged
Main Street Group, LTD25$9.79K0.00%00.0%Unchanged
Bare Financial Services, Inc25$9.79K0.00%+4+19.0%Added
AllSquare Wealth Management LLC26$10.2K0.01%00.0%Unchanged
Team Financial Group, LLC27$10.6K0.00%00.0%Unchanged
SJS Investment Consulting Inc.27$10.6K0.00%−56−67.5%Reduced
Tidemark, LLC28$11.0K0.00%+4+16.7%Added
Lummis Asset Management, LP29$11.4K0.01%00.0%Unchanged
FWL Investment Management, LLC30$11.7K0.00%00.0%Unchanged
Innovative Advisory Group, LLC30$11.7K0.01%00.0%Unchanged
Centerpoint Advisors, LLC32$12.0K0.00%+32New
Caitlin John, LLC31$12.1K0.01%+31New
Orion Capital Management LLC32$12.5K0.00%00.0%Unchanged
City Holding Co32$12.5K0.00%+32New
Wealth Watch Advisors, INC32$12.5K0.01%+32New
Marquette Asset Management, LLC32$12.5K0.00%+32New
Beaird Harris Wealth Management, LLC33$12.9K0.00%+5+17.9%Added
Indiana Trust & Investment Management CO35$13.7K0.00%−15−30.0%Reduced
Highline Wealth Partners LLC38$14.9K0.00%−5−11.6%Reduced
Cedar Mountain Advisors, LLC38$14.9K0.00%+3+8.6%Added
North Capital, Inc.38$14.9K0.01%+4+11.8%Added
Trust Co39$15.3K0.00%00.0%Unchanged
Archer Investment Corp39$15.3K0.00%00.0%Unchanged
Measured Wealth Private Client Group, LLC39$15.3K0.00%+39New
Quarry LP39$15.3K0.00%+39New
Private Wealth Management Group, LLC42$16.4K0.00%00.0%Unchanged
North Star Investment Management Corp.43$16.8K0.00%+1+2.4%Added
Binnacle Investments Inc44$17.2K0.01%−38−46.3%Reduced
DT Investment Partners, LLC44$17.2K0.00%00.0%Unchanged
Scarborough Advisors, LLC44$17.3K0.00%00.0%Unchanged
Optimum Investment Advisors46$18.0K0.01%00.0%Unchanged
Evelyn Partners Asset Management Ltd47$18.4K0.00%+38+422.2%Added
South State Corp.47$18.4K0.00%−31−39.7%Reduced
Quaker Wealth Management, LLC47$18.4K0.01%−1−2.1%Reduced
Sachetta, LLC49$19.2K0.01%−56−53.3%Reduced
Center for Financial Planning, Inc.50$19.6K0.00%00.0%Unchanged
West Oak Capital, LLC50$19.6K0.01%−2−3.8%Reduced
Fortitude Family Office, LLC51$20.0K0.01%−3−5.6%Reduced
Capital Advisors, Ltd. LLC50$20.0K0.00%+2+4.2%Added
Aventura Private Wealth, LLC52$20.4K0.01%00.0%Unchanged
Valued Wealth Advisors LLC53$20.7K0.01%−16−23.2%Reduced
Raffa Wealth Management, LLC53$20.8K0.00%+4+8.2%Added
BFSG, LLC54$21.1K0.00%00.0%Unchanged
Pinnacle Bancorp, Inc.54$21.1K0.01%+54New
Howard Hughes Medical Institute55$21.5K0.01%00.0%Unchanged
Riverview Trust Co55$21.5K0.03%00.0%Unchanged
Meeder Asset Management Inc56$21.9K0.00%00.0%Unchanged
Bullock Wealth Management Group55$22.2K0.01%+5+10.0%Added
Strategic Investment Solutions, Inc.58$22.7K0.01%+38+190.0%Added
Cape Investment Advisory, Inc.60$23.5K0.02%+16+36.4%Added
Access Investment Management LLC60$23.5K0.01%00.0%Unchanged
Proffitt & Goodson Inc60$23.5K0.00%+60New
Canton Hathaway, LLC62$24.0K0.00%00.0%Unchanged
NVWM, LLC62$24.3K0.01%−2,305−97.4%Reduced
United Community Bank62$24.3K0.01%+34+121.4%Added
Clayton Financial Group LLC62$24.3K0.02%+62New
Chesapeake Asset Management LLC63$24.7K0.02%+33+110.0%Added
Pingora Partners LLC65$25.5K0.02%00.0%Unchanged
Legacy Wealth Managment, LLC66$25.8K0.01%00.0%Unchanged
Solstein Capital, LLC67$26.2K0.01%−22−24.7%Reduced
High Note Wealth, LLC68$26.6K0.01%+2+3.0%Added
Ogorek Anthony Joseph70$27.0K0.01%+2+2.9%Added
Estabrook Capital Management69$27.0K0.00%00.0%Unchanged
Abound Wealth Management70$27.3K0.01%−2−2.8%Reduced
Colonial Trust Co70$27.3K0.00%+38+118.8%Added
First Command Advisory Services, Inc.70$27.4K0.00%00.0%Unchanged
Rational Advisors LLC74$29.0K0.00%+2+2.8%Added
TD Capital Management LLC75$29.4K0.00%00.0%Unchanged
Founders Capital Management75$29.4K0.02%00.0%Unchanged
Stone House Investment Management, LLC75$29.4K0.00%+1+1.4%Added
American National Bank76$29.8K0.00%−4−5.0%Reduced
Financial Management Professionals, Inc.76$29.8K0.00%+16+26.7%Added
Prestige Wealth Management Group LLC77$30.2K0.01%00.0%Unchanged
SOA Wealth Advisors, LLC.78$30.5K0.01%−11−12.4%Reduced
Brown, Lisle/Cummings, Inc.82$32.1K0.01%00.0%Unchanged
Clear Street Markets LLC84$32.9K0.01%+84New
Financial Network Wealth Advisors LLC86$33.7K0.04%+29+50.9%Added
JFS Wealth Advisors, LLC89$34.9K0.00%00.0%Unchanged
Wolff Wiese Magana LLC89$34.9K0.02%00.0%Unchanged
Itau Unibanco Holding S.A.91$35.6K0.00%00.0%Unchanged
Evermay Wealth Management LLC93$36.4K0.00%00.0%Unchanged
Spirit of America Management Corp100$39.2K0.01%00.0%Unchanged
Future Financial Wealth Managment LLC100$39.2K0.02%00.0%Unchanged
GoalVest Advisory LLC100$39.2K0.01%00.0%Unchanged
MPWM Advisory Solutions, LLC100$39.2K0.02%00.0%Unchanged
Wall Street Access Asset Management, LLC100$39.2K0.01%+100New
Midwest Capital Advisors, LLC101$39.6K0.02%00.0%Unchanged
Bell Investment Advisors, Inc105$41.1K0.01%−10−8.7%Reduced
GHP Investment Advisors, Inc.105$41.3K0.00%00.0%Unchanged
Kilter Group LLC109$42.7K0.02%−3−2.7%Reduced
Capital Analysts, LLC116$45.0K0.00%+29+33.3%Added
Geneos Wealth Management Inc.117$45.8K0.00%−1,775−93.8%Reduced
MTM Investment Management, LLC117$45.8K0.01%00.0%Unchanged
Exane Asset Management100$46.0K0.02%+100New
Gables Capital Management Inc.121$47.4K0.02%00.0%Unchanged
Smallwood Wealth Investment Management, LLC121$47.4K0.02%00.0%Unchanged
Catalyst Capital Advisors LLC124$48.6K0.00%−33−21.0%Reduced
Financial Avengers, Inc.125$49.0K0.02%−15−10.7%Reduced
Atlantic Edge Private Wealth Management, LLC125$49.0K0.01%00.0%Unchanged