Upstream Bio, Inc.
UPB- 交易所
- Nasdaq
- 產業
- Pharmaceutical Preparations
- SEC CIK
- 0002022626
近 90 天，Upstream Bio, Inc. 內部人申報 0 筆公開市場買進、5 筆賣出；2026 年第 2 季末有 148 家機構在 13F 申報持有，市值合計 $3.50 億；沒有大師持有。
2025 年第 3 季 13F 持有人
Upstream Bio, Inc. 在 2025/9/30 季末的機構持股。管理 1 億美元以上美股的機構，每季結束後 45 天內要用 13F 申報多頭部位。13F 是什麼
- 持有機構
- 95
- 較 2025 年第 2 季 +13 家
- 持有股數
- 4,446 萬
- 較 2025 年第 2 季 −292.2 萬 (−6.2%)
- 總市值
- $8.36 億
- 較 2025 年第 2 季 +$3.16 億 (+60.7%)
- 新進機構
- 22
- 另有 38 家加碼
- 清倉機構
- 9
- 另有 22 家減碼
另有 1 家機構在 2025 年第 2 季持有、還沒有申報 2025 年第 3 季 13F：沒申報不算清倉，也不計入上面的變化。
歷季持有家數與市值
2021 年第 1 季起，每季在 13F 申報持有 UPB 的機構家數與合計市值。市值是各季季末的申報市值，也會跟著股價漲跌。
| 季度 | 家數 | 市值 |
|---|---|---|
| 2026 年第 2 季 | 148 | $3.50 億 |
| 2026 年第 1 季 | 140 | $4.04 億 |
| 2025 年第 4 季 | 133 | $13.9 億 |
| 2025 年第 3 季 | 95 | $8.36 億 |
| 2025 年第 2 季 | 83 | $5.31 億 |
| 2025 年第 1 季 | 79 | $2.67 億 |
| 2024 年第 4 季 | 70 | $6.90 億 |
| 2024 年第 3 季 | 0 | $0 |
| 2024 年第 2 季 | 0 | $0 |
| 2024 年第 1 季 | 0 | $0 |
| 2023 年第 4 季 | 0 | $0 |
| 2023 年第 3 季 | 0 | $0 |
| 2023 年第 2 季 | 0 | $0 |
| 2023 年第 1 季 | 0 | $0 |
| 2022 年第 4 季 | 0 | $0 |
| 2022 年第 3 季 | 0 | $0 |
| 2022 年第 2 季 | 0 | $0 |
| 2022 年第 1 季 | 0 | $0 |
| 2021 年第 4 季 | 0 | $0 |
| 2021 年第 3 季 | 0 | $0 |
| 2021 年第 2 季 | 0 | $0 |
| 2021 年第 1 季 | 0 | $0 |
2025 年第 3 季持有機構
每家機構持有 Upstream Bio, Inc. 的股數、市值與佔組合比重；股數變化跟 2025 年第 2 季比。
| 機構 | 股數 | 市值 | 佔組合 % | 股數變化 | 動作 |
|---|---|---|---|---|---|
| FMR LLC | 8,086,413 | $1.52 億 | 0.01% | +149,533+1.9% | 加碼 |
| OrbiMed Advisors LLC | 5,693,589 | $1.07 億 | 2.57% | 00.0% | 不變 |
| Decheng Capital LLC | 3,285,293 | $6,180 萬 | 10.78% | 00.0% | 不變 |
| BlackRock, Inc. | 2,603,706 | $4,898 萬 | 0.00% | +507,200+24.2% | 加碼 |
| Enavate Sciences GP, LLC | 2,459,703 | $4,627 萬 | 14.13% | 00.0% | 不變 |
| Vanguard Group Inc | 2,442,551 | $4,594 萬 | 0.00% | +271,718+12.5% | 加碼 |
| Bain Capital Life Sciences Investors, LLC | 2,439,538 | $4,589 萬 | 3.05% | 00.0% | 不變 |
| TCG Crossover Management, LLC | 2,117,103 | $3,982 萬 | 1.96% | −684,660−24.4% | 減碼 |
| Altshuler Shaham Ltd | 1,416,822 | $2,665 萬 | 0.44% | −1,977,619−58.3% | 減碼 |
| Omega Fund Management, LLC | 1,356,293 | $2,551 萬 | 11.47% | −680,000−33.4% | 減碼 |
| VR Adviser, LLC | 1,169,298 | $2,199 萬 | 1.24% | −1,126,021−49.1% | 減碼 |
| Wellington Management Group LLP | 1,125,395 | $2,117 萬 | 0.00% | −99,900−8.2% | 減碼 |
| State Street Corp | 1,114,581 | $2,097 萬 | 0.00% | +633,206+131.5% | 加碼 |
| Samsara BioCapital, LLC | 962,154 | $1,810 萬 | 2.36% | −481,077−33.3% | 減碼 |
| Marshall Wace, LLP | 867,999 | $1,633 萬 | 0.02% | +577,473+198.8% | 加碼 |
| Parkman Healthcare Partners LLC | 843,502 | $1,587 萬 | 1.74% | +127,998+17.9% | 加碼 |
| Geode Capital Management, LLC | 817,109 | $1,537 萬 | 0.00% | +170,474+26.4% | 加碼 |
| Siren, L.L.C. | 788,450 | $1,483 萬 | 0.58% | 00.0% | 不變 |
| Woodline Partners LP | 602,252 | $1,133 萬 | 0.05% | +44,000+7.9% | 加碼 |
| Nantahala Capital Management, LLC | 594,971 | $1,119 萬 | 0.69% | 00.0% | 不變 |
| Integral Health Asset Management, LLC | 575,000 | $1,082 萬 | 0.79% | +575,000 | 新進 |
| Great Point Partners LLC | 300,000 | $564.3 萬 | 2.36% | 00.0% | 不變 |
| Charles Schwab Investment Management Inc | 284,828 | $535.8 萬 | 0.00% | +106,575+59.8% | 加碼 |
| UBS Group AG | 272,271 | $512.1 萬 | 0.00% | +39,384+16.9% | 加碼 |
| Northern Trust Corp | 254,719 | $479.1 萬 | 0.00% | +25,416+11.1% | 加碼 |
| Goldman Sachs Group Inc | 223,214 | $419.9 萬 | 0.00% | +223,214 | 新進 |
| Schonfeld Strategic Advisors LLC | 190,244 | $357.8 萬 | 0.02% | −175,546−48.0% | 減碼 |
| Ikarian Capital, LLC | 161,113 | $303.1 萬 | 0.69% | +161,113 | 新進 |
| SummitTX Capital, L.P. | 112,404 | $211.4 萬 | 0.09% | +112,404 | 新進 |
| Bank of New York Mellon Corp | 91,521 | $172.2 萬 | 0.00% | +11,755+14.7% | 加碼 |
| Morgan Stanley | 87,535 | $164.7 萬 | 0.00% | −11,773−11.9% | 減碼 |
| Barclays PLC | 85,315 | $160.5 萬 | 0.00% | −11,675−12.0% | 減碼 |
| Balyasny Asset Management LLC | 73,131 | $137.6 萬 | 0.00% | +73,131 | 新進 |
| American Century Companies Inc | 71,540 | $134.6 萬 | 0.00% | +49,178+219.9% | 加碼 |
| Nuveen, LLC | 69,882 | $131.4 萬 | 0.00% | −4,054−5.5% | 減碼 |
| Boothbay Fund Management, LLC | 61,299 | $115.3 萬 | 0.03% | +61,299 | 新進 |
| Bank of America Corp | 55,473 | $104.3 萬 | 0.00% | +37,442+207.7% | 加碼 |
| Exome Asset Management LLC | 51,960 | $97.7 萬 | 0.65% | +51,960 | 新進 |
| Rhumbline Advisers | 49,406 | $92.9 萬 | 0.00% | +1,340+2.8% | 加碼 |
| Verition Fund Management LLC | 47,001 | $88.4 萬 | 0.01% | +13,496+40.3% | 加碼 |
| Citigroup Inc | 42,037 | $79.1 萬 | 0.00% | +30,342+259.4% | 加碼 |
| Millennium Management LLC | 40,113 | $75.5 萬 | 0.00% | +40,113 | 新進 |
| Rafferty Asset Management, LLC | 34,521 | $64.9 萬 | 0.00% | +34,521 | 新進 |
| AQR Capital Management LLC | 29,954 | $56.3 萬 | 0.00% | +202+0.7% | 加碼 |
| JPMorgan Chase & Co | 29,947 | $56.3 萬 | 0.00% | +13,478+81.8% | 加碼 |
| Nomura Holdings Inc | 28,290 | $53.2 萬 | 0.00% | +28,290 | 新進 |
| Deutsche Bank AG | 26,737 | $50.3 萬 | 0.00% | +3,334+14.2% | 加碼 |
| Alps Advisors Inc | 25,962 | $48.8 萬 | 0.00% | −3,014−10.4% | 減碼 |
| Wells Fargo & Company | 25,160 | $47.3 萬 | 0.00% | +2,796+12.5% | 加碼 |
| MetLife Investment Management | 21,691 | $40.8 萬 | 0.00% | 00.0% | 不變 |
| Alliancebernstein L.P. | 19,850 | $37.3 萬 | 0.00% | −4,710−19.2% | 減碼 |
| Price T Rowe Associates Inc | 18,501 | $34.9 萬 | 0.00% | +1,053+6.0% | 加碼 |
| Caption Management, LLC | 18,196 | $34.2 萬 | 0.02% | +18,196 | 新進 |
| Invesco Ltd. | 17,190 | $32.3 萬 | 0.00% | +890+5.5% | 加碼 |
| Mirae Asset Global ETFs Holdings Ltd. | 16,863 | $31.5 萬 | 0.00% | −2,221−11.6% | 減碼 |
| Prelude Capital Management, LLC | 15,735 | $29.6 萬 | 0.02% | +15,735 | 新進 |
| Commonwealth Equity Services, LLC | 15,503 | $29.2 萬 | 0.00% | −23−0.1% | 減碼 |
| Quantinno Capital Management LP | 14,889 | $28.0 萬 | 0.00% | +4,275+40.3% | 加碼 |
| Creative Planning | 14,266 | $26.8 萬 | 0.00% | +236+1.7% | 加碼 |
| Manufacturers Life Insurance Company, The | 12,092 | $22.7 萬 | 0.00% | −1,098−8.3% | 減碼 |
| Mariner, LLC | 10,933 | $20.6 萬 | 0.00% | +10,933 | 新進 |
| Two Sigma Investments, LP | 10,500 | $19.8 萬 | 0.00% | +10,500 | 新進 |
| Intech Investment Management LLC | 10,396 | $19.6 萬 | 0.00% | −10,894−51.2% | 減碼 |
| Virtus Investment Advisers, Inc. | 9,843 | $18.5 萬 | 0.05% | +1,709+21.0% | 加碼 |
| Police & Firemen's Retirement System of New Jersey | 9,447 | $17.8 萬 | 0.00% | +1,614+20.6% | 加碼 |
| BNP Paribas Arbitrage, SA | 6,527 | $12.3 萬 | 0.00% | +3,430+110.8% | 加碼 |
| New York State Common Retirement Fund | 6,300 | $11.9 萬 | 0.00% | +1,600+34.0% | 加碼 |
| CWM, LLC | 3,341 | $6.30 萬 | 0.00% | +29+0.9% | 加碼 |
| Russell Investments Group, Ltd. | 3,034 | $5.71 萬 | 0.00% | +2,887+1,963.9% | 加碼 |
| Legal & General Group Plc | 2,924 | $5.50 萬 | 0.00% | −250−7.9% | 減碼 |
| Ameritas Investment Partners, Inc. | 2,741 | $5.16 萬 | 0.00% | −817−23.0% | 減碼 |
| Sterling Capital Management LLC | 2,264 | $4.26 萬 | 0.00% | +1,323+140.6% | 加碼 |
| California State Teachers Retirement System | 2,176 | $4.09 萬 | 0.00% | +2+0.1% | 加碼 |
| Tower Research Capital LLC (TRC) | 1,868 | $3.51 萬 | 0.00% | −1,183−38.8% | 減碼 |
| Group One Trading, L.P. | 1,305 | $2.45 萬 | 0.00% | +1,305 | 新進 |
| Aster Capital Management (DIFC) Ltd | 1,141 | $2.15 萬 | 0.01% | +1,141 | 新進 |
| GAMMA Investing LLC | 890 | $1.67 萬 | 0.00% | +197+28.4% | 加碼 |
| Royal Bank of Canada | 832 | $1.60 萬 | 0.00% | −2,258−73.1% | 減碼 |
| Amalgamated Bank | 594 | $1.10 萬 | 0.00% | 00.0% | 不變 |
| Versant Capital Management, Inc | 548 | $1.03 萬 | 0.00% | −10−1.8% | 減碼 |
| US Bancorp | 531 | $9,988 | 0.00% | −128−19.4% | 減碼 |
| Global Retirement Partners, LLC | 332 | $6,245 | 0.00% | +332 | 新進 |
| EverSource Wealth Advisors, LLC | 310 | $5,831 | 0.00% | +1+0.3% | 加碼 |
| Clearstead Advisors, LLC | 163 | $3,067 | 0.00% | 00.0% | 不變 |
| SRS Capital Advisors, Inc. | 149 | $2,803 | 0.00% | +149 | 新進 |
| The PNC Financial Services Group, Inc. | 130 | $2,446 | 0.00% | +130 | 新進 |
| J.Safra Asset Management Corp | 128 | $2,408 | 0.00% | +128 | 新進 |
| Essential Partners LLC | 97 | $1,825 | 0.00% | 00.0% | 不變 |
| Nisa Investment Advisors, LLC | 96 | $1,806 | 0.00% | 00.0% | 不變 |
| Allworth Financial LP | 67 | $1,261 | 0.00% | +1+1.5% | 加碼 |
| N.E.W. Advisory Services LLC | 60 | $1,129 | 0.00% | +60 | 新進 |
| Signaturefd, LLC | 51 | $959 | 0.00% | +2+4.1% | 加碼 |
| Sunbelt Securities, Inc. | 19 | $357 | 0.00% | +19 | 新進 |
| Parallel Advisors, LLC | 2 | $38 | 0.00% | 00.0% | 不變 |
| IFP Advisors, Inc | 2 | $38 | 0.00% | +1+100.0% | 加碼 |
| Deep Track Capital, LP | 0 | $0 | 0.00% | −1,442,767−100.0% | 清倉 |
| Lynx1 Capital Management LP | 0 | $0 | 0.00% | −219,247−100.0% | 清倉 |
| Velan Capital Investment Management LP | 0 | $0 | 0.00% | −107,000−100.0% | 清倉 |
| Alyeska Investment Group, L.P. | 0 | $0 | 0.00% | −85,000−100.0% | 清倉 |
| Susquehanna International Group, LLP | 0 | $0 | 0.00% | −42,263−100.0% | 清倉 |