Upstream Bio, Inc.
UPB- 交易所
- Nasdaq
- 產業
- Pharmaceutical Preparations
- SEC CIK
- 0002022626
近 90 天，Upstream Bio, Inc. 內部人申報 0 筆公開市場買進、5 筆賣出；2026 年第 2 季末有 148 家機構在 13F 申報持有，市值合計 $3.50 億；沒有大師持有。
2025 年第 4 季 13F 持有人
Upstream Bio, Inc. 在 2025/12/31 季末的機構持股。管理 1 億美元以上美股的機構，每季結束後 45 天內要用 13F 申報多頭部位。13F 是什麼
- 持有機構
- 133
- 較 2025 年第 3 季 +38 家
- 持有股數
- 5,118 萬
- 較 2025 年第 3 季 +671.5 萬 (+15.1%)
- 總市值
- $13.9 億
- 較 2025 年第 3 季 +$5.53 億 (+66.1%)
- 新進機構
- 46
- 另有 42 家加碼
- 清倉機構
- 8
- 另有 33 家減碼
歷季持有家數與市值
2021 年第 1 季起，每季在 13F 申報持有 UPB 的機構家數與合計市值。市值是各季季末的申報市值，也會跟著股價漲跌。
| 季度 | 家數 | 市值 |
|---|---|---|
| 2026 年第 2 季 | 148 | $3.50 億 |
| 2026 年第 1 季 | 140 | $4.04 億 |
| 2025 年第 4 季 | 133 | $13.9 億 |
| 2025 年第 3 季 | 95 | $8.36 億 |
| 2025 年第 2 季 | 83 | $5.31 億 |
| 2025 年第 1 季 | 79 | $2.67 億 |
| 2024 年第 4 季 | 70 | $6.90 億 |
| 2024 年第 3 季 | 0 | $0 |
| 2024 年第 2 季 | 0 | $0 |
| 2024 年第 1 季 | 0 | $0 |
| 2023 年第 4 季 | 0 | $0 |
| 2023 年第 3 季 | 0 | $0 |
| 2023 年第 2 季 | 0 | $0 |
| 2023 年第 1 季 | 0 | $0 |
| 2022 年第 4 季 | 0 | $0 |
| 2022 年第 3 季 | 0 | $0 |
| 2022 年第 2 季 | 0 | $0 |
| 2022 年第 1 季 | 0 | $0 |
| 2021 年第 4 季 | 0 | $0 |
| 2021 年第 3 季 | 0 | $0 |
| 2021 年第 2 季 | 0 | $0 |
| 2021 年第 1 季 | 0 | $0 |
2025 年第 4 季持有機構
每家機構持有 Upstream Bio, Inc. 的股數、市值與佔組合比重；股數變化跟 2025 年第 3 季比。
| 機構 | 股數 | 市值 | 佔組合 % | 股數變化 | 動作 |
|---|---|---|---|---|---|
| FMR LLC | 7,518,202 | $2.04 億 | 0.01% | −568,211−7.0% | 減碼 |
| OrbiMed Advisors LLC | 5,693,589 | $1.55 億 | 3.16% | 00.0% | 不變 |
| BlackRock, Inc. | 3,344,504 | $9,080 萬 | 0.00% | +740,798+28.5% | 加碼 |
| Decheng Capital LLC | 3,143,078 | $8,533 萬 | 11.48% | −142,215−4.3% | 減碼 |
| Norges Bank | 2,882,647 | $7,826 萬 | 0.01% | +2,882,647 | 新進 |
| Enavate Sciences GP, LLC | 2,459,703 | $6,678 萬 | 13.18% | 00.0% | 不變 |
| Vanguard Group Inc | 2,388,439 | $6,485 萬 | 0.00% | −54,112−2.2% | 減碼 |
| UBS Group AG | 1,806,243 | $4,904 萬 | 0.01% | +1,533,972+563.4% | 加碼 |
| Janus Henderson Group PLC | 1,527,958 | $4,142 萬 | 0.02% | +1,527,958 | 新進 |
| Altshuler Shaham Ltd | 1,341,540 | $3,642 萬 | 0.56% | −75,282−5.3% | 減碼 |
| Bain Capital Life Sciences Investors, LLC | 1,329,544 | $3,610 萬 | 2.76% | −1,109,994−45.5% | 減碼 |
| Omega Fund Management, LLC | 1,326,293 | $3,601 萬 | 12.57% | −30,000−2.2% | 減碼 |
| State Street Corp | 1,319,226 | $3,582 萬 | 0.00% | +204,645+18.4% | 加碼 |
| VR Adviser, LLC | 1,169,298 | $3,175 萬 | 1.57% | 00.0% | 不變 |
| Wellington Management Group LLP | 894,733 | $2,429 萬 | 0.00% | −230,662−20.5% | 減碼 |
| Geode Capital Management, LLC | 851,908 | $2,313 萬 | 0.00% | +34,799+4.3% | 加碼 |
| Parkman Healthcare Partners LLC | 834,559 | $2,266 萬 | 2.16% | −8,943−1.1% | 減碼 |
| Pictet Asset Management Holding SA | 773,148 | $2,099 萬 | 0.02% | +773,148 | 新進 |
| Woodline Partners LP | 760,252 | $2,064 萬 | 0.08% | +158,000+26.2% | 加碼 |
| Integral Health Asset Management, LLC | 750,000 | $2,036 萬 | 1.03% | +175,000+30.4% | 加碼 |
| TCG Crossover Management, LLC | 743,886 | $2,020 萬 | 0.67% | −1,373,217−64.9% | 減碼 |
| Samsara BioCapital, LLC | 736,047 | $1,998 萬 | 2.06% | −226,107−23.5% | 減碼 |
| Vestal Point Capital, LP | 720,000 | $1,955 萬 | 0.72% | +720,000 | 新進 |
| Siren, L.L.C. | 588,450 | $1,598 萬 | 0.48% | −200,000−25.4% | 減碼 |
| Barclays PLC | 524,499 | $1,424 萬 | 0.01% | +439,184+514.8% | 加碼 |
| Millennium Management LLC | 517,264 | $1,404 萬 | 0.01% | +477,151+1,189.5% | 加碼 |
| Nantahala Capital Management, LLC | 494,971 | $1,344 萬 | 0.80% | −100,000−16.8% | 減碼 |
| Marshall Wace, LLP | 343,791 | $933.4 萬 | 0.01% | −524,208−60.4% | 減碼 |
| Goldman Sachs Group Inc | 333,481 | $905.4 萬 | 0.00% | +110,267+49.4% | 加碼 |
| Great Point Partners LLC | 300,000 | $814.5 萬 | 2.64% | 00.0% | 不變 |
| Alyeska Investment Group, L.P. | 298,329 | $810.0 萬 | 0.02% | +298,329 | 新進 |
| Jennison Associates LLC | 288,847 | $784.2 萬 | 0.00% | +288,847 | 新進 |
| Charles Schwab Investment Management Inc | 284,931 | $773.6 萬 | 0.00% | +1030.0% | 加碼 |
| Northern Trust Corp | 236,799 | $642.9 萬 | 0.00% | −17,920−7.0% | 減碼 |
| Squadron Capital Management LLC | 230,650 | $626.2 萬 | 2.79% | +230,650 | 新進 |
| Invesco Ltd. | 163,186 | $443.1 萬 | 0.00% | +145,996+849.3% | 加碼 |
| Boxer Capital Management, LLC | 150,000 | $407.3 萬 | 0.89% | +150,000 | 新進 |
| Deutsche Bank AG | 127,815 | $347.0 萬 | 0.00% | +101,078+378.0% | 加碼 |
| Morgan Stanley | 122,068 | $331.4 萬 | 0.00% | +34,533+39.5% | 加碼 |
| SummitTX Capital, L.P. | 116,724 | $316.9 萬 | 0.10% | +4,320+3.8% | 加碼 |
| Schonfeld Strategic Advisors LLC | 115,807 | $314.4 萬 | 0.02% | −74,437−39.1% | 減碼 |
| JPMorgan Chase & Co | 110,280 | $299.4 萬 | 0.00% | +80,333+268.3% | 加碼 |
| American Century Companies Inc | 87,756 | $238.3 萬 | 0.00% | +16,216+22.7% | 加碼 |
| Bank of America Corp | 86,384 | $234.5 萬 | 0.00% | +30,911+55.7% | 加碼 |
| Bank of New York Mellon Corp | 84,853 | $230.4 萬 | 0.00% | −6,668−7.3% | 減碼 |
| Nuveen, LLC | 78,568 | $213.3 萬 | 0.00% | +8,686+12.4% | 加碼 |
| ExodusPoint Capital Management, LP | 75,402 | $204.7 萬 | 0.02% | +75,402 | 新進 |
| Artia Global Partners LP | 68,653 | $186.4 萬 | 0.30% | +68,653 | 新進 |
| Exome Asset Management LLC | 64,845 | $176.1 萬 | 0.87% | +12,885+24.8% | 加碼 |
| Ameriprise Financial Inc | 56,557 | $153.6 萬 | 0.00% | +56,557 | 新進 |
| Susquehanna International Group, LLP | 55,841 | $151.6 萬 | 0.00% | +55,841 | 新進 |
| Seven Grand Managers, LLC | 50,000 | $135.8 萬 | 0.10% | +50,000 | 新進 |
| Y-Intercept (Hong Kong) Ltd | 46,559 | $126.4 萬 | 0.03% | +46,559 | 新進 |
| Alps Advisors Inc | 44,376 | $120.5 萬 | 0.01% | +18,414+70.9% | 加碼 |
| Rhumbline Advisers | 41,523 | $112.7 萬 | 0.00% | −7,883−16.0% | 減碼 |
| Rafferty Asset Management, LLC | 38,683 | $105.0 萬 | 0.00% | +4,162+12.1% | 加碼 |
| Wells Fargo & Company | 36,794 | $99.9 萬 | 0.00% | +11,634+46.2% | 加碼 |
| Trexquant Investment LP | 31,049 | $84.3 萬 | 0.01% | +31,049 | 新進 |
| Alliancebernstein L.P. | 31,010 | $84.2 萬 | 0.00% | +11,160+56.2% | 加碼 |
| AQR Capital Management LLC | 30,503 | $82.8 萬 | 0.00% | +549+1.8% | 加碼 |
| D. E. Shaw & Co., Inc. | 27,091 | $73.6 萬 | 0.00% | +27,091 | 新進 |
| Swiss National Bank | 26,600 | $72.2 萬 | 0.00% | +26,600 | 新進 |
| Diadema Partners LP | 20,500 | $55.7 萬 | 0.33% | +20,500 | 新進 |
| MetLife Investment Management | 19,678 | $53.4 萬 | 0.00% | −2,013−9.3% | 減碼 |
| Price T Rowe Associates Inc | 19,636 | $53.4 萬 | 0.00% | +1,135+6.1% | 加碼 |
| PSP Research LLC | 17,634 | $47.9 萬 | 0.42% | +17,634 | 新進 |
| Mirae Asset Global ETFs Holdings Ltd. | 17,491 | $47.5 萬 | 0.00% | +628+3.7% | 加碼 |
| Prelude Capital Management, LLC | 16,560 | $45.0 萬 | 0.03% | +825+5.2% | 加碼 |
| Renaissance Technologies LLC | 16,400 | $44.5 萬 | 0.00% | +16,400 | 新進 |
| Quantinno Capital Management LP | 15,415 | $41.9 萬 | 0.00% | +526+3.5% | 加碼 |
| XTX Topco Ltd | 15,091 | $41.0 萬 | 0.01% | +15,091 | 新進 |
| California State Teachers Retirement System | 14,652 | $39.8 萬 | 0.00% | +12,476+573.3% | 加碼 |
| Profund Advisors LLC | 14,582 | $39.6 萬 | 0.01% | +14,582 | 新進 |
| Graham Capital Management, L.P. | 13,712 | $37.2 萬 | 0.01% | +13,712 | 新進 |
| Legal & General Group Plc | 13,709 | $37.2 萬 | 0.00% | +10,785+368.8% | 加碼 |
| Citadel Advisors LLC | 13,420 | $36.4 萬 | 0.00% | +13,420 | 新進 |
| DnB Asset Management AS | 12,793 | $34.7 萬 | 0.00% | +12,793 | 新進 |
| Virtu Financial LLC | 12,246 | $33.2 萬 | 0.01% | +12,246 | 新進 |
| Verition Fund Management LLC | 12,020 | $32.6 萬 | 0.00% | −34,981−74.4% | 減碼 |
| Mariner, LLC | 11,830 | $32.1 萬 | 0.00% | +897+8.2% | 加碼 |
| Creative Planning | 11,749 | $31.9 萬 | 0.00% | −2,517−17.6% | 減碼 |
| New York State Common Retirement Fund | 11,700 | $31.8 萬 | 0.00% | +5,400+85.7% | 加碼 |
| Two Sigma Investments, LP | 10,500 | $28.5 萬 | 0.00% | 00.0% | 不變 |
| Intech Investment Management LLC | 10,396 | $28.2 萬 | 0.00% | 00.0% | 不變 |
| Manufacturers Life Insurance Company, The | 10,147 | $27.5 萬 | 0.00% | −1,945−16.1% | 減碼 |
| Virtus Investment Advisers, Inc. | 9,801 | $26.6 萬 | 0.07% | −42−0.4% | 減碼 |
| STRS Ohio | 9,800 | $26.6 萬 | 0.00% | +9,800 | 新進 |
| VARCOV Co. | 9,619 | $26.1 萬 | 0.10% | +9,619 | 新進 |
| Police & Firemen's Retirement System of New Jersey | 9,456 | $25.7 萬 | 0.00% | +9+0.1% | 加碼 |
| Persistent Asset Partners Ltd | 8,907 | $24.2 萬 | 0.12% | +8,907 | 新進 |
| China Universal Asset Management Co., Ltd. | 8,806 | $23.9 萬 | 0.02% | +8,806 | 新進 |
| ProShare Advisors LLC | 8,354 | $22.7 萬 | 0.00% | +8,354 | 新進 |
| SEI Investments Co | 8,087 | $22.0 萬 | 0.00% | +8,087 | 新進 |
| Citigroup Inc | 6,949 | $18.9 萬 | 0.00% | −35,088−83.5% | 減碼 |
| SG Americas Securities, LLC | 5,518 | $15.0 萬 | 0.00% | +5,518 | 新進 |
| BNP Paribas Arbitrage, SA | 4,976 | $13.5 萬 | 0.00% | −1,551−23.8% | 減碼 |
| CWM, LLC | 3,360 | $9.10 萬 | 0.00% | +19+0.6% | 加碼 |
| KLP Kapitalforvaltning AS | 2,900 | $7.87 萬 | 0.00% | +2,900 | 新進 |
| Russell Investments Group, Ltd. | 2,823 | $7.66 萬 | 0.00% | −211−7.0% | 減碼 |
| Ameritas Investment Partners, Inc. | 2,741 | $7.44 萬 | 0.00% | 00.0% | 不變 |